Strain

Porcine_MG742313 (Region: China: Guangzhou; Strain: Porcine enteric Alphacoronavirus strain PEAV-GD-CH/2017, complete genome.; Date: 14-Mar-17)

Gene

membrane protein

Description

Annotated in NCBI, membrane protein

Location

MG742313(+):24777-25463

GenBank Accession

AWJ64266.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGACTGATTCTAACAACACGGTCCCTGTGACCGAAGTTTTAGAACATCTTAGAAACTGGAACTTCAGCTGGAATATCATAGTGACAGTATTTATTGCAGTGCTTCAGTATGGTAACATGAAGTACAGTTTCTTTCTCTATGGAGTTAAGATGTTAATCATGTGGCTCCTATGGCCCCTAGTCATTGCTCTGAGCATTTTTAATGCCTATGCTGAATTTGGTGTTAATTGGTGGTTCTTCTCCTTCAGCATTCTGATGCTTGTCATAACGCTAGTTCTCTGGCTTATGTACATAATTAATAGTTTTAAGCTTTATCGCAGAACGCGAACGTTTTGGGCATTTAACCCCGAAACAGACGCCATTGCTGTCATTTCAGTCTTTGGTAGATCCTACTCGATACCTATGCCAGTGGCACCAACAGGTATTACTCTGACGATTTTAAGTGGAACACTCTTTTTCGATGGCATCAGAATTGGTACTGGTGTGCAGCCTGCACACTTACCGCAATTTGTGACTGTCGCCAAACCTGGCACGACTATAATTTATACTCGTGCGGGGCGTTCCCTTAATGCAAGCACCAACACTGGTTGGGCTTTTTATGTCAGAAGTAAGCATGGTGACTATTCTGCTTTATCAAATAGTAGTGATAACTTGACAGAAAATGACAGATTGCTGCATTTAGTCTAA

Protein

MTDSNNTVPVTEVLEHLRNWNFSWNIIVTVFIAVLQYGNMKYSFFLYGVKMLIMWLLWPLVIALSIFNAYAEFGVNWWFFSFSILMLVITLVLWLMYIINSFKLYRRTRTFWAFNPETDAIAVISVFGRSYSIPMPVAPTGITLTILSGTLFFDGIRIGTGVQPAHLPQFVTVAKPGTTIIYTRAGRSLNASTNTGWAFYVRSKHGDYSALSNSSDNLTENDRLLHLV

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the alphacoronaviruses M protein family.

Uniprot

A0A2K9VP32

EMBL

KY649107 MF807952 MG546689 MH061337 MH061343 MH726370 + More
MK656468 MK656469 AUV64202.1 AXK47361.1 AYP73642.1 AZL47201.1 AZL47237.1 QCQ19849.1 QFG71731.1 QFG71732.1

Pfam

PF01635 Corona_M

Interpro

IPR002574 Corona_M
IPR042551 ALPHA_CORONA_M

ProteinModelPortal

A0A2K9VP32

Ontologies

GO:0039660  F:structural constituent of virion
GO:0019058  P:viral life cycle
GO:0016021  C:integral component of membrane
GO:0019031  C:viral envelope
GO:0055036  C:virion membrane
GO:0044178  C:host cell Golgi membrane

Subcellular Location

From MSLVP

Host nucleus. Host cytoplasm.

Topology

Length:

228

Number of predicted TMHs:

Exp number of AAs in TMHs:

77.61454

Exp number, first 60 AAs:

33.47915

Total prob of N-in:

0.20322

POSSIBLE N-term signal

sequence

outside

1 - 19

TMhelix

20 - 38

inside

39 - 44

TMhelix

45 - 67

outside

68 - 76

TMhelix

77 - 99

inside

100 - 228