Strain
Bat_MG916903
(Region: China; Strain: Bat coronavirus BtCoV/Rh/YN2012 isolate BtCoV/Rh/YN2012_Rs4259, complete genome.; Date: 17-Apr-13)
Description
Annotated in NCBI,
E protein
Full name
Envelope small membrane protein
Sequence
CDS
ATGTTAACCCTAGTGGATGATCATGGTATGGTACTTAGTGCAGTCTTGTGGCTTTTAGTATTGTTGTTTGTCCTTTTAATCTGTATCACGATTATAAAGCTAATACAGCTTTGTTTTACGTGCCACAAACTTATGTCCAACACGGTTTACGTGCCTGTACATAATGCGTACAAAATGTACAAAGATTATATGCAAATTGCGCCCTGTCCCGTCTTAGATGTTTAA
Protein
MLTLVDDHGMVLSAVLWLLVLLFVLLICITIIKLIQLCFTCHKLMSNTVYVPVHNAYKMYKDYMQIAPCPVLDV
Summary
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit
Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Similarity
Belongs to the alphacoronaviruses E protein family.
Ontologies
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Host Golgi apparatus membrane
The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.
Topology
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
22.908
Exp number, first 60 AAs:
22.90731
Total prob of N-in:
0.04337
POSSIBLE N-term signal
sequence