Strain
Bat_MH002338
(Region: China; Strain: Tylonycteris bat coronavirus HKU4; Date: 2012/11/1)
Gene
E protein
Description
Annotated in NCBI,
E protein
Location
GenBank Accession
Full name
Envelope small membrane protein
Sequence
CDS
ATGTTACCTTTTGTCCATGAACAAATAGGTACTATCATAGTAAATTTTTTCATTTTAACCGTAGTATGCGCTATTACATTAGTGGTGTGTTTAGCAATCCTTACGGCTATTAGATTATGTGTGCAATGTGCTTCGGGTGTTAACACTCTTTTGTTTGTACCCGCGTTCTACATCTATAATACTGGGCGTAATGCCTATTTTAAGTTTCAAGAGAATCGTCCACCCTTTCCTCCTGAGGACTGGGTTTAA
Protein
MLPFVHEQIGTIIVNFFILTVVCAITLVVCLAILTAIRLCVQCASGVNTLLFVPAFYIYNTGRNAYFKFQENRPPFPPEDWV
Summary
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit
Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Similarity
Belongs to the betacoronaviruses E protein family.
Uniprot
EMBL
Pfam
PF02723
NS3_envE
Interpro
IPR003873
NS3/E
ProteinModelPortal
PDB
5X29
E-value=6e-07 Score=42.7 Identity=41.27%
Cov(Q)=76.83% Cov(P)=77.78%
3D Structure
Ontologies
GO
Subcellular Location
From MSLVP
From Uniprot
Host Golgi apparatus membrane
The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.
Topology
Length:
82
Number of predicted TMHs:
2
Exp number of AAs in TMHs:
43.03169
Exp number, first 60 AAs:
41.91225
Total prob of N-in:
0.42328
POSSIBLE N-term signal
sequence
outside
1 - 9
TMhelix
10 - 32
inside
33 - 38
TMhelix
39 - 61
outside
62 - 82
