Strain

Human_OC43_MH121121 (Region: USA: Little Rock, Arkansas; Strain: Human coronavirus OC43 isolate HCoV-OC43/USA/ACRI_0213/2016, complete genome.; Date: 19-Dec-16)

Gene

membrane protein

Description

Annotated in NCBI, membrane protein

Location

MH121121(+):28386-29078

GenBank Accession

AZP73843.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGAGTAGTAAACCTACACCAGCACCAGTTTATATCTGGACTGCTGATGAAGCTATTAAATTCCTAAAGGAATGGAATTTTTCTTTGGGTATTATACTACTTTTTATTACAATCATATTGCAATATGGATATACAAGTCGCAGTATGTTTGTTTATGTTATTAAGATGATTATTTTGTGGCTTATGTGGCCCATTACTATAATCTTAACTACTTTCAATTGCGTATACGCATTGAATAACGTGTATCTTGGCCTTTCTATAGTTTTTACCATAGTGGCCATTATTATGTGGATTGTGTATTTTGTGAATAGTATCAGGTTGTTTATTAGAACTGGAAGTTTTTGGAGTTTTAACCCAGAAACAAACAACTTGATGTGTATAGATATGAAAGGAACAATGTATGTTAGGCCGATAATTGAGGACTATCATACCCTGACGGTCACAATAATACGCGGTCATCTTTATATTCAAGGTATAAAACTAGGTATTGGCTATTCTTTGGCAGATTTGCCAGCTTATATGTCTGTTGCTAAGGTTACACACCTGTGCACATATAAGCGTGGTTTTCTTGACAGGATAAGCGATACTAGTGGTTTTGCTGTTTATGTTAAGTTCAAAGTCGGTAATTACCGACTGCCATCAACCCAAAAGGGTTCTGGCATGGACACCGCATTGTTGAGAAATAATATCTAA

Protein

MSSKPTPAPVYIWTADEAIKFLKEWNFSLGIILLFITIILQYGYTSRSMFVYVIKMIILWLMWPITIILTTFNCVYALNNVYLGLSIVFTIVAIIMWIVYFVNSIRLFIRTGSFWSFNPETNNLMCIDMKGTMYVRPIIEDYHTLTVTIIRGHLYIQGIKLGIGYSLADLPAYMSVAKVTHLCTYKRGFLDRISDTSGFAVYVKFKVGNYRLPSTQKGSGMDTALLRNNI

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the betacoronaviruses M protein family.

Uniprot

A0A3G3NH59

EMBL

MH687971 MH687972 MH687973 MH687974 MH687975 MH687976 + More
MH687977 MH687978 AYR18629.1 AYR18638.1 AYR18647.1 AYR18656.1 AYR18665.1 AYR18674.1 AYR18683.1 AYR18692.1

Pfam

PF01635 Corona_M

Interpro

IPR002574 Corona_M

ProteinModelPortal

A0A3G3NH59

Ontologies

GO:0019058  P:viral life cycle
GO:0039660  F:structural constituent of virion
GO:0044178  C:host cell Golgi membrane
GO:0030683  P:evasion or tolerance by virus of host immune response
GO:0019031  C:viral envelope
GO:0016021  C:integral component of membrane
GO:0055036  C:virion membrane

Subcellular Location

From MSLVP

Host nucleus. Host cytoplasm.

Topology

Length:

230

Number of predicted TMHs:

Exp number of AAs in TMHs:

65.24551

Exp number, first 60 AAs:

28.39693

Total prob of N-in:

0.33353

POSSIBLE N-term signal

sequence

outside

1 - 24

TMhelix

25 - 44

inside

45 - 48

TMhelix

49 - 71

outside

72 - 80

TMhelix

81 - 103

inside

104 - 230