Strain

Bat_MH687942 (Region: Viet Nam; Strain: Alphacoronavirus sp. strain VZ_AlphaCoV_16715_47_c2, complete genome.; Date: 17-Jun-14)

Gene

matrix protein

Description

Annotated in NCBI, matrix protein

Location

MH687942(+):25790-26326

GenBank Accession

AYR18451.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGTTTATCCTTTGGATTCTGTGGCCACTTGTGTTGGCACTTTCCATCTTTGACGCATGGGCCAGCTTTGGGGTTAATTGGGTGTTCTTTGCATTCAGCATCCTAATGGCCTGCATCACAGCTGTGTTGTGGATCATGTATTTCGTTAACAGTATCAGGTTGTGGCGACGCACCCATTCTTGGTGGTCCTTCAATCCTGAAACAGACTCCATTCTGTCCGTGTCCGTGCTGGGCCGGCATGTATGTCTCCCAATACTAGGTGCACCAACTGGCGTGACCCTCACACTGCTTAACGGCACATTGCTTGTAGAAGGCTATCAGGTTGCTACTGGCGTACAGGTAACTAATTTACCTGGTTTCGTCACAGTCGCCAAGTCCTCAACAACAATTGTCTACCAGCGTGTCGGACGCTCCATGAATGTTGCTTCTAGTACAGGCTGGGCCTTCTACGTGAAGTCCAAGCATGGCGACTACTATGCTGCTGCGAATCCAACAGAGGTTGTAACAGATAGTGAGAAAATTCTACATTTAGTCTAA

Protein

MFILWILWPLVLALSIFDAWASFGVNWVFFAFSILMACITAVLWIMYFVNSIRLWRRTHSWWSFNPETDSILSVSVLGRHVCLPILGAPTGVTLTLLNGTLLVEGYQVATGVQVTNLPGFVTVAKSSTTIVYQRVGRSMNVASSTGWAFYVKSKHGDYYAAANPTEVVTDSEKILHLV

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the alphacoronaviruses M protein family.

Uniprot

I6YQD5

Pubmed

23599287 26611909

EMBL

JX002685 JX002693 KC109141 KC210146 KP162057 KT323979 + More
AFN66538.1 AFN66546.1 AGD98688.1 AGG55743.1 AJW67221.1 ALS35471.1

Proteomes

UP000096075 UP000134644 UP000180353 UP000180354

Pfam

PF01635 Corona_M

Interpro

IPR042551 ALPHA_CORONA_M
IPR002574 Corona_M

ProteinModelPortal

I6YQD5

Ontologies

GO:0044178  C:host cell Golgi membrane
GO:0055036  C:virion membrane
GO:0016021  C:integral component of membrane
GO:0019031  C:viral envelope
GO:0039660  F:structural constituent of virion
GO:0019058  P:viral life cycle

Subcellular Location

From MSLVP

Host nucleus. Host cytoplasm.

Topology

Length:

178

Number of predicted TMHs:

Exp number of AAs in TMHs:

48.31685

Exp number, first 60 AAs:

43.3939

Total prob of N-in:

0.95231

POSSIBLE N-term signal

sequence

inside

1 - 1

TMhelix

2 - 24

outside

25 - 27

TMhelix

28 - 50

inside

51 - 178