Strain

Human_IBV_MH779860 (Region: USA; Strain: Infectious bronchitis virus isolate Ark99_pathogenic_field_virus, complete genome.; Date: 2014)

Gene

membrane protein

Description

Annotated in NCBI, membrane protein

Location

MH779860(+):24487-25158

GenBank Accession

AYA44735.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGGCGGATAATTGCACACTTGATTCGGAGCAGGCAGTTCTGCTTTTTAAAGAATATAATTTATTTATAACCGCCTTCCTATTGTTTCTTACCATACTACTTCAGTATGGGTACGCAACTAGGAGTCGGCTTATTTATGTACTGAAAATGATAGTGTTATGGTGCTTTTGGCCCCTTAACATTGCAGTAGGTGTAATTTCATGTATATATCCACCAAATACAGGAGGTCTTGTCGCAGCGATAATACTTACTGTGTTTGCTTGTCTTTCTTTTGTAGGTTATTGGATTCAGAGTTGTAGACTCTTTAAAAGGTGTAGGTCTTGGTGGTCTTTTAACCCCGAGTCTAATGCCGTAGGTTCAATACTCCTTACAAATGGTCAACAATGTAATTTTGCTATAGAGAGTGTGCCTATGGTGCTTGCTCCAATTATAAAGAATGGTGTTCTTTATTGTGAGGGCCAGTGGCTTGCTAAGTGTGAACCAGACCACTTGCCTAAAGATATATTTGTTTGTACACCGGATAGACGTAATATCTATCGTATGGTGCAGAAATACACTGGTGACCAAAGCGGAAATAAGAAAAGGTTTGCTACATTTGTCTATGCAAAGCAGTCAGTAGACACTGGCGAGCTAGAAAGTGTAGCAACAGGAGGAAGTAGTCTTTACACATAA

Protein

MADNCTLDSEQAVLLFKEYNLFITAFLLFLTILLQYGYATRSRLIYVLKMIVLWCFWPLNIAVGVISCIYPPNTGGLVAAIILTVFACLSFVGYWIQSCRLFKRCRSWWSFNPESNAVGSILLTNGQQCNFAIESVPMVLAPIIKNGVLYCEGQWLAKCEPDHLPKDIFVCTPDRRNIYRMVQKYTGDQSGNKKRFATFVYAKQSVDTGELESVATGGSSLYT

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the gammacoronaviruses M protein family.

Uniprot

A0A1P8VEW6

EMBL

KX302871 APZ73755.1

Pfam

PF01635 Corona_M

Interpro

IPR042550 GAMMA_CORONA_M
IPR002574 Corona_M

ProteinModelPortal

A0A1P8VEW6

Ontologies

GO:0039660  F:structural constituent of virion
GO:0019058  P:viral life cycle
GO:0016021  C:integral component of membrane
GO:0019031  C:viral envelope
GO:0055036  C:virion membrane
GO:0044178  C:host cell Golgi membrane

Subcellular Location

From MSLVP

Host nucleus. Host cytoplasm.

Topology

Length:

223

Number of predicted TMHs:

Exp number of AAs in TMHs:

63.93313

Exp number, first 60 AAs:

34.53621

Total prob of N-in:

0.05917

POSSIBLE N-term signal

sequence

outside

1 - 19

TMhelix

20 - 39

inside

40 - 50

TMhelix

51 - 70

outside

71 - 73

TMhelix

74 - 96

inside

97 - 223