Strain
Fish_MH938449
(Region: Italy; Strain: Alphacoronavirus Bat-CoV/P.kuhlii/Italy/3398-19/2015, complete genome.; Date: 2015)
Description
Annotated in NCBI,
envelope protein
Full name
Envelope small membrane protein
Sequence
CDS
ATGTTGCTGAAGTTGGTTGATGATAGTGGGTTGTTGATTAACGCTATCCTATGGGTTTTCTTATTAATCTTTGTTCTAATACTTTGTATCACTTTTATCAAGCTCGTACAACTTTGCTTCACTTGTCACCAGTTACTTTCTGGAGCAGTTTACCAACCTGTACATAGAGCTTATGTGATGTACAAAGATTTTATGCGAATAGACCCCGCACCTGTGTTTGATGTCTAA
Protein
MLLKLVDDSGLLINAILWVFLLIFVLILCITFIKLVQLCFTCHQLLSGAVYQPVHRAYVMYKDFMRIDPAPVFDV
Summary
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit
Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Similarity
Belongs to the alphacoronaviruses E protein family.
Ontologies
Subcellular Location
From MSLVP
Single-Pass Membrane
From Uniprot
Host Golgi apparatus membrane
The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.
Topology
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
22.66878
Exp number, first 60 AAs:
22.66512
Total prob of N-in:
0.04503
POSSIBLE N-term signal
sequence