Strain
Fish_MH938449
(Region: Italy; Strain: Alphacoronavirus Bat-CoV/P.kuhlii/Italy/3398-19/2015, complete genome.; Date: 2015)
Gene
nucleocapsid protein
Description
Annotated in NCBI,
nucleocapsid protein
Location
GenBank Accession
Full name
Nucleoprotein
Sequence
CDS
ATGGCTGTCAGTTTTGACAATGCTGCCAGAGGTCGCTCTGGGCGTGTCCCCTTTTCTTACTATATGCCTGTTATAAATAACTCTGCACAACCTTTTTACAAGGTTATGCCGCAAAATGCAGTCCCTACAGGAATGGGCAACCAAAGCCAACAAATTGGTTACTGGAATGAACAGGTCCGTTGGCGTATGTCTAAGGGTCAGCGTAAAGACCTTCCATCCAAGTGGCATTTTTACTACTTGGGAACTGGGCCTCATGCTGAGCTACCCTACAGGCAGCGCCAACAAGGTGTGTTTTGGGTTGCTAAAGAAGGCGCTAAAACTCAACCTACTGGACTTGGCAGTCGTGGCAGAAACGCAGAGCTTATTAACCCTCGTTTCTCTGCGAAGTTGCCTGACTCAATCGAGATCGTTGACAATAACTCAAGGCCCTCATCACGTGCCAATTCACGTGCTAGGAGCCAGAGTAGTGATAACACCAATAGATCGCGATCTCAGAGCAGTAACCGCTCACAAAATCCACGCTCGCAGAGCCGAGGCAGACAGCCTAATCAAGCCAATGGATCTAACAACAATGGTGGCCGAGGCAACCAGCAGCGTAATAGATCCAATTCACGGAACCGTGGTAATTCCAACCAGAACAGCAACAACCACCAAGACCTGGTTGCTGCCGTCCGTGAAGCTCTTGCTGGATTAGGCATTAAACCAAGCAACAGCAACAAGTCTACACCTGCTACTAGCGGTCATAGCACACCTAAGAGGTCTAACTCTTCTCAACCTGCGGAGAAGAAGAACATCAGACAAGTCGACAAACCTACCTGGAAGCGCGTGCCGCATTCACAAGAAAGTGTCGACAAATGTTTCGGACCTCGTTCCACTTCAATGAACTTTGGTGATGCTCAGCTAGTCAGACTTGGTGTCGACTACCCTCACTTCCCGCAAATTGCAGAACTTGTACCAACTCAGGCTGCATTGCTTTTCGGAAGTGAAATTACAGCACATGAGGTCGGTGATGACATCGAAATCACCTACGTGTACAAGATGCGTGTACCAAAATCTAATCGATCTTTGGTGCGCTTCCTGCCACACGTTGGTGCGTATGCTGATGACACTCAGGATGTCACACTTGACCCTTCTGCTCCTCCTTTCACACCCAGACCACAACGCACACCAAGATCAGTTGCAGTTGTGGATGGCAGTGTTGATGCTGTTGAAGATGTCATTGTTGAAGCTGACTCTGCAGATGGTGAAGGCCAATTTGAAGAAGTAGTTGATGATGTCGTTGATGAAACCACTGCGTAA
Protein
MAVSFDNAARGRSGRVPFSYYMPVINNSAQPFYKVMPQNAVPTGMGNQSQQIGYWNEQVRWRMSKGQRKDLPSKWHFYYLGTGPHAELPYRQRQQGVFWVAKEGAKTQPTGLGSRGRNAELINPRFSAKLPDSIEIVDNNSRPSSRANSRARSQSSDNTNRSRSQSSNRSQNPRSQSRGRQPNQANGSNNNGGRGNQQRNRSNSRNRGNSNQNSNNHQDLVAAVREALAGLGIKPSNSNKSTPATSGHSTPKRSNSSQPAEKKNIRQVDKPTWKRVPHSQESVDKCFGPRSTSMNFGDAQLVRLGVDYPHFPQIAELVPTQAALLFGSEITAHEVGDDIEITYVYKMRVPKSNRSLVRFLPHVGAYADDTQDVTLDPSAPPFTPRPQRTPRSVAVVDGSVDAVEDVIVEADSADGEGQFEEVVDDVVDETTA
Summary
Function
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
Subunit
Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.
Uniprot
EMBL
Proteomes
Pfam
PF00937
Corona_nucleoca
ProteinModelPortal
PDB
5N4K
E-value=6e-45 Score= 153 Identity=55.22%
Cov(Q)=31.02% Cov(P)=89.33%
3D Structure
Ontologies
KEGG
GO
Subcellular Location
From MSLVP
Nucleus
From Uniprot
Host Golgi apparatus
Host endoplasmic reticulum-Golgi intermediate compartment
Virion
Host endoplasmic reticulum-Golgi intermediate compartment
Virion
Topology
Length:
432
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00871
Exp number, first 60 AAs:
0.00805
Total prob of N-in:
0.00822
outside
1 - 432
