Strain
Human_HKU1_MK167038
(Region: USA; Strain: Human coronavirus HKU1 strain SC2521, complete genome.; Date: 2017)
Gene
small membrane protein
Description
Annotated in NCBI,
small membrane protein
Location
GenBank Accession
Full name
Envelope small membrane protein
Sequence
CDS
ATGGTTGATGTATTTTTCACTGATACTGCTTGGTATGTAGGTCAGATTTTCTTTTTAGTTTTATCTTGTGTCATTTTCTTAATTTTTGTTGTTGCTCTTTTAGCAACTATTAAACTTTGTATTCAAATTTGTGGTTTTTGTAATATTTTTATTATTTCACCTTCTGCCTATGTTTATAATAGAGGTAGACAGTTGTATAAGTCTTATAGTGAACATGTCATACCTTCTACTTTAGATGATTTAATTTAA
Protein
MVDVFFTDTAWYVGQIFFLVLSCVIFLIFVVALLATIKLCIQICGFCNIFIISPSAYVYNRGRQLYKSYSEHVIPSTLDDLI
Summary
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit
Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Similarity
Belongs to the betacoronaviruses E protein family.
Uniprot
Pubmed
EMBL
Proteomes
Pfam
PF02723
NS3_envE
Interpro
IPR003873
NS3/E
ProteinModelPortal
PDB
2MM4
E-value=6e-04 Score=34.7 Identity=27.59%
Cov(Q)=70.73% Cov(P)=100.00%
3D Structure
Ontologies
GO
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Host Golgi apparatus membrane
The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.
Topology
Length:
82
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
40.58322
Exp number, first 60 AAs:
40.4317
Total prob of N-in:
0.35031
POSSIBLE N-term signal
sequence
outside
1 - 14
TMhelix
15 - 37
inside
38 - 82
