Strain
Bat_MK211374
(Region: China; Strain: Coronavirus BtRl-BetaCoV/SC2018, complete genome.; Date: 16-Aug)
Gene
small envelope protein
Description
Annotated in NCBI,
small envelope protein
Full name
Envelope small membrane protein
Sequence
CDS
ATGTACTCATTCGTTTCGGAAGAAACAGGTACGTTAATAGTTAATAGCGTACTTCTTTTTCTTGCTTTCGTGGTATTCTTGCTAGTCACACTAGCCATCCTTACTGCGCTTCGATTGTGTGCGTACTGCTGCAATATTGTTAACGTGAGTTTAGTAAAACCAACGATTTACGTCTACTCGCGTGTTAAAAATCTGAACTCTTCTGAAGGAGTTCCTGATCTTTTGGTCTAA
Protein
MYSFVSEETGTLIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPTIYVYSRVKNLNSSEGVPDLLV
Summary
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit
Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Similarity
Belongs to the betacoronaviruses E protein family.
PDB
5X29
E-value=2e-14 Score=61.6 Identity=90.32%
Cov(Q)=81.58% Cov(P)=76.54%
Ontologies
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Host Golgi apparatus membrane
The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.
Topology
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
24.7755
Exp number, first 60 AAs:
24.75437
Total prob of N-in:
0.55484
POSSIBLE N-term signal
sequence