Strain
Avian_MK309398
(Region: China; Strain: Infectious bronchitis virus isolate CK/CH/GD/HY16, complete genome.; Date: 5-Jul-17)
Gene
1a polyprotein
Description
Annotated in NCBI,
1a polyprotein
Location
GenBank Accession
Full name
Replicase polyprotein 1a
Alternative Name
ORF1a polyprotein
Sequence
CDS
ATGGCTTCAAGCCTAAAACAGGGAGTATCTTCCCAAAACCAGAGGAATGTCATTCTTGTTGCCAAAGACATTCCCGACCAACTTTGTGACGCTTTGTTTTTCTATACGTCACATAACCCAAAAGATTACGCTGATGCTTTCGCCTTTAGGCAGAAGTTCGACCGTAATCTCGGTGCTGGGAAGCAGTTTAAATTTGAAACTGTGTGTGGTCCATTCTTTTTAAAAGGAGTGGACAAAATAACACCAGGTGTCCCAGCCAAAGCTTTAAAGGCCACTTCTAAGTTGGCTGATTTAGAAGACATCTTCGGTGTCTCTCCTTTTGCACGGAAATACCGTGAATTGTTGAAGACAGCATGCCATTGGTCTATGACTGTAGAAACACTGGATGCTCGTGCACAAACTCTTGAAGAAATCTTTGATTCATCTGAGATACTTTGGCTCCAGGTTGCTGCAAAGATTCAAGTTTCAGCCATGGCAATGCGCAGACTTGTTGGTGAGGTTACTGCAAAAGTCATGGATTCACTTGGCTCAAATTTGAGCGCTCTATTCCAAGTTGTTAAGGAAACAATGGCCAGAATCTTTCAAAAGGCTCTGGCCATTTTCGAGAGTGTGAGTGAATTGCCACAGCGTATTGCTGCACTTAAGATGGCTTTTGCCAAGTGTGCAAGATCAATTACAGTTGTGGTTGTTGGACATGCTCTCACTATTAGAGAGTTTGCTGGAACTTGTCTTGCGAGCATTAATGGTGCAGTTGCAAAATTCTTTGAAGAACTTCCAACTGGCTTTATGGGCGCTAAGGTCTTTTCAACTCTTGCCTTTTTTAAAGAAGCAGCAGTAAAGATCGTAGAAAATATACCAAACGCGCCAAGAGGTACTAAAGGTTTTGAAGTCGTTGGCAATGCCAAAGGTACACAAGTTGTTGTCCGTGGCATGCGAAATGACTTAACTCTGCTTGACCAAAAAGCTGAAGTTCCTGTTGAATCAGAAGGTTGGTCTGCAATTTTAGAGGGACATCTTTGTTATGTCTTTAAGAGTGGTGATCGCTTTTATGCGGCACCCCTTTCAGGAAACTTTGCATTGCATGATGTGCATTGCTGCGAGCGTGTAGTCTGTCTGGCTGATGGTGTAACACCGGAGATAAATGATGGGCTTGTTCTTGCTGCAATTTACTCATCTTTTAATGTTTCGGAACTTGTGGCAGCACTTAAAAAAGGTGAACCATTCAAGTTCTTGGGGCATAAATTTGTTTATGCGAAGGAAGCGGCAGTTTCTTTCACCTTGGCAAAAGCAGCAACCATTGAAGATGTCCTGAAGCTGTTTCAATCAGCAAGAGTAAAGACGAGAGATGTGTGGTCTGCACTTACTGAACAGTCTTTTGAATTCTGGAAACTTGCGTACAATAGAGTGCGCAATCTTGAAGAAGTTCTGAAGACTCATTTTTGTAAAGCTCAAATGTCAGTTGTGATCTTAGCAGCAGTGCTTGGTGAGGGCATTTGGCATCTCTGTTCACAAGTCATTTATAAATTGAGTGGCTTGTTTTCCAAAGTTGTTGACTTTTGTGAAAAACACTGGAAAGGTTTCTGCACACAGTTGCGAAAAGTTAGGCTTGTTGTTACAGAAAACCTCTGCGTGTTGAAAGGAATTGCTCAGCATTGTTTTCAACTTTTGCTGGAAGCAATACATTCTATGTACAAGAGTTTTAAGAAATGTGCACTTGGTAGGATTTCCGGTGACTTGTTCTTCTGGAAAGGAGGTGTGCATAAAATAATTCACGATGGCGATGAAATCTGGTTTGACGCCGTCGACACCATTGAAGTTGAAGATTTGGGTACCGTCCAAGAAAAACCTATAGATTTTGAGGTTTGTGAAGACGTGATACTTCCAGAAAATCAACCTGGCCACATGGTTCAAATCCAGGATGACGGAAAGAACTATATGTTCTTCCGTTTCAAGAAGGATGAGAACATTTATTATACACCAATGTCACAACTTGGTGCTATTAATGTTATTTGCAAAGCGGGTGGCAAGACTGTCACGTTTGGTGAAATAACTGTAAAGGAAATACCATCACCTGATGTTGTGCCTATTAAAGTAAGCATTGAGTGCTGTGGTGAACCATGGAATACAATCTTCAAGAAGGCTTATAAAGAGCCCATTGAAGTTGAGACAGATCTCACAGTAGAACAACTGCTCACTGTGATCTATGATAAAATGTGTGAAGATCTCAAACTGTTTCCAGAGGCACCAGAACCTCCACCATTTGAGAATGTCGCACTTGTTGATAAAAACGGTAAAGCTCTAGATTGCATAAAATCATGCCATCTCATCTACCGTGATTATGAGAGCGATGATGACATCGAGGAAGACGATGCTGAGGAGTGTGATACAGATCCAGCTGATGCTGAGGAATGTGATACTGCTTCAGAGTGTGAACAGGAAGATGAGGATACAAAGGTGCTGTCTCTTTTGCAAGACCCAGCTAGTAACAAGTATCCTCTACCTCTTGATGATGATTATAGTGTCTATAATGGATGTATTGTTCATAAGGACGCTCTAGATGTTGTTAATTTACCATCTGGTGAAGAAACTTTTGTTGTCAATAACTGTTTTGAAGGGGCTGTGAAACCGCTTCCGCAGATGGTTGTTGATGTTCTAGGAGATTGGGGAGAGGCCGTTGATGCACAAGAACAATTGTGTGAACAAGAGTCTGAATCTGTTAAAGAACCAGTTGAGAAACCTACTGGTATTGGTGGTTCAGCAGTTGAAGAAGCTGTTGTCGTGGAGCAGGAGGTGGTTCCTGTTGTTGAAGAGTCTCAAGAATTAGTTGTTTTTACACCTGCTGATTTAAAAGTTGTTAAAGAAACATCAGAGGATGTTGACGAGTTTGTTCTTGTTGCCGATGTTCCTACAGAAGAAGTTGTGCCTCAAGAAAAAGAAGAGCCACAAGTAGAACAGGAGCCTATTCAAGTTGTCAAATCACAACGTGAGAAAAAGGCTAAAAAATTCAAAGTCAGGCAAACCACATGTGAAAAACCCAAATTTTTGGAGTACACAACATGTGTAGGTGATTTGACCGTTGTAATTGCCAAAGCATTGGATGAGTTTAAAGAGTTCTGCGTTGTTAACGCCGCAAATGAGTATATGTCTCATGGTGGTGGCGTTGCGAAGGCAATTGCTGACTTTTGTGGACCTGATTTTGTGGAATATTGTGAGGACTATGTTAAGAAACATGGGCCACAACAAAGACTTGTCACACCTTCGTATGTCAAAGGCGTTCAATGTGTGAATAATGTTGTAGGACCCCGCCATGGTGATAAAGATTTGGAAGAAAAACTTGTCGCTGCCTACAAGAATGTTCTTGTAGATGGTGTGGTCAATTATGTTGTGCCAGTTCTCTCATCGGGAATTTTTGGTGTGGATTTTAAAACTTCAATAGACGCGATGCGTAAGGCCTTTGAAGGGCTTAACATACGCGTGCTTCTTTTTTCTCTGAGTCAAGAACACATTGAGTATTTCGATGCAACTTGTAAGCAGAAGAAAATTTATCTTACAGAAGATGGTGTTAAATACCGCTCTGTTGTAGTGAAACCTGGCGACTCTTTGGGTCAATTTGGTCAGGTTTTTGCAAAGAACAAGACAGTTTTTACAGCAGATGATGTTGAGGACGAAGAAGTTCTCTTCACTCCAACAACTGACAAAGCTGTTCTTGAATACTATGGATTGGATGCGCAAAAGTATGTAATATATTTGCAAACACTCGCGCAGAAATGGGAAGTCCAATATAGGGACAATTTTATCTTACTTAACTGGCGTGATGGAAACTGCTGGATTAGTTCAGCTATAGTGCTCCTTCAGGCTGCTAAGATTAGGTTTAGAGGTTTTCTTGCAGAGGCATGGGCTAAATTCTTGGGTGGAGACCCTACGGATTTTGTTGCTTGGTGCTATGCAAGTTGCAATGCTAAAGTTGGTGATTTTTCAGACTGCAATTGGCTTTTGGCTAACTTGGCAGAACACTTTGATGCAGATTACACAAATGCACTGCTTAAGAAGCGTGTGTCGTGTAACTGTGGTGTTAAGAGTTATGAACTTAGAGGCCTTGAAGCTTGTATTCAACCAGTAAGGGCTCCTAACCTTCTACATTTTAAGACGCAATACTCAAATTGTCCAACTTGTGGTGCAAATAGTATGGATGAAGTTGTTGAAGCATCACTCCCGTACTTGTTGCTTGTTGCTACTGATGGTCCTGCTGCAGTTGATTGTGATGAAAATGCTGCAGGAAATGTTGTTTTTATTGGGTCCACCAACAGTGGACACTGTTATACACAAGCTGTTGGAAAAGCTTTTGATAATTTGGCTCAAGATAGGAAATTTGGAAAGAGATCGCCTTACATTACTGCAATGTATATGCGCTTCTCTCTTAAGAGTAAAAATTCTCTGTCTGTTGCTAAAAAGAGTAAGAGCAAGAGTGATGTAGTAAAAGAAGATGTTTCCAATCTCGCTACAAGTTCAAAGTTCAGTTTTGATGATCTTACTGACTTTGAACAGTGGTATGATAGTAACATCTATGAAAGTCTTAAAGTGCAGGAAACACCTGATAATATGGATGAGTATGTGTCATTCACAATAAAGGAAGATTCCAAGTTGCCACTGACACTTAAAGTTAGAGGTATCAAATCAGTTGTTGACTTTAAGTCAAAGGATGGCTTTACTTATAAGTTAATACCTGACACTGATGAAAATTCAAAAGCACCAGTTTACTATCCTACCTTGGACTCTATAAGTCTTAAGGCAATATGGGTGGAAGGTAGTGCTAATTTTATCGTTGGACATCCCAACTATAATAGTAAAGTTCTGCGTGTTCCTACATTTTGGGAGTGTGCAGAGCGCTTTGTTAAAATAGGTGAAAAAGTTGATGGTGTAACTATGGGCCTCTGGCGTGTAAAACACCTTAATAGACTTAATTTGGAAAGAATTTTCAACGTCGTTAAGAAGACGATGGTTGGAACTAGTGTTGTTACTACACAATGTGGTAAATTAATTAGTAAAGCAGCTACATTCGTTGCCGATAAAGTAGGAGATGGTGTAGTTCGCAATGTTTCTGATAGAATTAAAGGGTGTTTTGGGTCTACTAGGGAGCATTTTGAAAGAAGAGTGTCTCCGCAGTTCTTAAAAACCCTCTTTTTCTTCGTCTTTTGTTTTTTTAAGGCTAGTGTTAAGGGTTTAATGGCTAGCTACAAGAGTGTGTTATGTAAAGTGTTATTTACTGCTTTACTTATATTGTGGATTGTCTACACTAGCGACCCAGTTATATCTACTGGAATACGTGTGTTAGATTTCCTATTTGAAGGTTCATTTTGTAGTCCTTATGCGGATTATGGTAAAGAGTCTTTTGATGTTTTACGCTATTGTGGAAGTGATTTTACTTGTCGTGTTTGTTTACATGGTAAGGATTCTCTTCATTTGTATAAACATGCCTATAGCGTAGAACAGTTTTATAAAGATGCAGTTAATGGTATCAGTTTTACATGGAATTGGCTTTATATGCTGTTTCTATTATTGTTTGTTAAGCCAGTAGCAGGTTTTGTTATTATTTGCTACTGTATAAGGTACTTGGTTTTGAGCACAACTGTTTTACAAACTGGTGTAGGATTTTTAGACTGGTTTATCCAAACAGTGTTTGCTAACTTTAATTTTATGGGTGCAGGATTTTATTTCTGGCTTTTTTATAAGGTATATATACAGGTGCATCATATTATGTACTGTAAGGATATAACATGTGAAGTGTGTAAGCGAGTTGCACGTAGTAATAGACATGAGGTTAGTGTTGTTGTTAACGGGCGTAAACAGCTTGTTCACGTCTACACTAACTCAGGCTATACTTTCTGTAAGAGACATAATTGGTACTGTAGAAATTGTGATAAGTATGGCCACCAAAATACATTTATGTCTCCTGAAGTTGCTGGCGAGCTTTCTGAAAAGCTTAAGCGCCATGTTAAACCTACAGCATTCGCATACCACGTAGTGGATGATGCGTGCTTAGTTGATGACTTTGTTAATTTGAAGTATAATGCTGCCACTCCAGGTAAGGAAGGTGTGCATTCTGCTGTTAAATGTTTTAGTGTATCTGACTTCTTAAAGAAAGCTGTTTTTCTTAAGGATGCACAAAAATGTGAGCAAATATCTAATGATAGTTTTATAGTTTGTAATACACACAGTGCGCATGCATTAGAGGAAGCAAAAAATGCTGCCATCTATTATGCGCAATGTCTCTGTAAACCAATTCTTATACTTGATCAGGCCCTTTATGAACAATTGGTTGTAGAACCTGTGTCAAAAAGTGTAGTAGATAAGGTTTGTAGTATCCTGTCTAATATAACATCTGTAGACTCTGCAGCTTTGAATTATAAGGCCGGCACACTTCGTGATGCTCTCCTTTCTGTTACTAAAGATGAAGAAGCCGTCGATATGGCTATCTTCTGTCATAATAATGATGTTGAATATACTAGTGATGGTTTTACTAATGTTGTGCCGTCATATGGTATAGATACTGATAAATTAACACCTCGTGATAGAGGCTTTTTAATAAATGCAGATGCCTCCATTGCTAATTTGAAAGTGAAAAATTCACCGCCAGTAGTATGGAAGTATTCTGATCTTATAAAACTGTCTGACAGTTGTCTTAAGTATTTAATATCGGCAACTGTCAAATCAGGAGGTAGATTTTTCATAACAAGATCTGGTGCTAAGCAAGTTATTTCTTGTTACACTCAGAAATTGTTAGTGGAAAAGAAGGCTGGTGGTGTCGTTAGTAGCACTATTAGTAGTTTTAAGAGTTGTTGTAAATGGCTCTTAGTGTTTTATTTAATCTTTACAGTGTGTTGTTTGGGTTATTATCAATGGGAAATGAGTAGAGAGTTTTCTCACCCCATGTATGATGTTAATTCCACAATGCATGTAGAAGGGTTTAAGGTTATAGATAAGGGTGTACTTCGTGATATTGTGCCAGAAGACACGTGCTTTTCTAATAAGTATGTCAATTTTGACTCATTTTGGGGAAAATCTTATGTGAATAGTAGGGACTGTCCTATTGTAACCGCTATTATAGACGGTTCTGGAACAGTAGCTGCTGGTGTGCCTGGTTTCGTACAGTGGGTTATGGATGGTGTAATGTTTATCCATATGACACAGACTGAGCGAAAACCGTGGTATATTCCTACTTGGTTTAATAGAGAAATTGTTGGTTACACCCACGATTCTATTATTACAGAAGGTGAGTTTTATACTTCCATAGCATTGTTTGCTTCTAGATGTTTGTATTTAACATCTAGTAACACACCACAGCTTTATTGCTTTAATGGTGATAATGATGCTCCTGGTGCTCTACCATTTGCAAGTATACTTCCTCATAGAGTATACTTTCAACCTAATGGAGTCAGGCTTATTGTGCCTCAGCAAATTATGCACACACCATACGTAGTTAAGTTAGTTTCAGACAGCTATTGTAGAGGTAGTGTTTGTGAGGTTACTAAATCAGGTTATTGTGTCTCTATGAACTCTCAATGGGTTTTGTTTAATGATGAATACACAATTAAACCTGGTGTATTTTGTGGTTCTACTGTTAGAGAACTTTTGTTTAGTATGGTTAGCACATTCTTTACGGGTGTTAACCCAAACATCTATATGCAATTGGCAACTATGTTCTTAACACTTGTTGCTGTTGTGTTAGTTTTTGCAATGGTTATAAAGTTTCAAGGTGTTTTTAAAGCTTATGCAACCACTGTATTTACTATAATGCTTGTTTGGCTTATTAATGCATTTATATTATGTGTGCATAGTTATAATGGTGTTTTAGCTATTATACTACTTGTACTCTATTGTTATGCATCACTTGTGACGAGTCGTAATACTGCCATAATAATGCACTGTTGGCTCGTTTTTACATTTGGTTTAATAGTACCTAATTGGCTAGCTTGTGTCTACTTAGGTTTTGTGCTATATATGTATACACCGCTGTTCTTGTGGTGCTATGGTACAACTAAAAATTGCCGCAAGCTTTATGAAGGCAATGATTTTGTTGGTAATTATGATCTTGCTGCGAAGAGTACGTTTGTAATTCGCGGCCCTGAATTTGTTAAACTTACTAATGAGATAGGTGATAAATTTGAACATTACCTCTCAGCGTATGCTAGGCTTAAATATTACTCTGGCACTGGCAGTGAGCAAGATTACTTGCAAGCCTGTCGTGCATGGTTGGCCTATGCACTAGACCAATTTAGAAGCAGTGGTGTAGAAGTGGTTTATACTCCACCACGATATTCAATTGGTGTTAGTAGATTACAAGCTGGTTTTAAGAAACTAGTATCTCCTAGTAGTGCTGTTGAGAAGTGCATTGTTAGTGTATCCTATAGGGGTAATAATCTTAATGGATTGTGGTTGGGTGACTCCATCTACTGTCCACGTCATGTGTTAGGTAAGTTTAGTGGTGACCAATGGGGTGATGTACTTAATCTTGCTAATAATCATGAGTTTGAAGTAGTAACTGGAAATGGTGTTACTTTGAGTGTTGTCAGTAGGCGTTTGAAAGGTGCAGTTTTAATTTTACAAACTGCAATTGTCAATGCTGATACACCGAAGTATAAATTTTTGAAAGCAAATTGTGGTGATAGTTTCACAATAGCTTGCTCTTATGGTGGTATAGTTATAGGACTCTACCCTGTTACTATGCGTTCTAATGGAACTATTAGAGCATCTTTTCTTGCTGGAGCATGTGGTTCAGTAGGTTTTAATATAGAAAAGGGTGTAGTAAATTTTTACTACATGCACCATCTAGAGTTACCTAACGCATTACACACAGGGACTGATCTAATGGGTGAGTTTTATGGTGGTTATATAGATGAAGAGGTTGCTCAGAAAGTTCAACCCGATAAATTAGTTACTAATAATATTTTGGCATGGCTTTATGCAGCAATTATTAGTGTTAAAGAGAGTAGTTTTTCAACACCAAAATGGCTTGAAAGTACTACTATCAGTACTGATGATTATAATAAGTGGGCAGGTGATAATGGTTTTACATCATTTGTAAGCTGCACTGCTATTACTAAGTTAAGTGCTATTACAGGAGTAGATGTTTGTAAACTCCTTCGTACTATTATGGTAAAAAGTGCACAATGGGGTAGTGACCCTATTTTGGGACAATATAATTTTGAGGATGAAATGACACCGGAATCTGTTTTTAATCAGGTGGGTGGTGTTAGGTTACAATCTTCTGTTGTAAAGAGAGCCGCATCTTGGTTTTGGAGTAGATGTGTGCTAGCTTGCTTCTTGTTTGTCTTGTGTTCTATAGTTCTGTTTACAGCTATACCATATAGATATTATTTATATGGTGCTGTTGTCTTATTTGCAACTGTGCTTTTTGTGTCGTTTACTGTGAAACATGTTATGGCATATATGGATACCTTCCTTTTGCCGACATTGATTACGGTTATTATAGGGGTTTGTGCTGAAGTGCCTTTCATCTATAATACTCTAATTAGTCAAATTGTTATTTTCTTTAGCCAATGGTATGACCCAGTAGTTTTTGACACTGTAGTACCGTGGATGTTTCTACCATTAGTCTTGTACACAGCTTTTAAATGTATACAAGGTTGTTATAGTGTAAATTCCTTTAATACTTCTCTGTTAGTGTTGTATCAGTTTATGAAGTTGGGTTTTGTTATATATACCTCTTCTAATACCCTTACAGCCTACTCAGAAGGTAATTGGGAGTTATTCTTTGAGTTAGTTCACACAACTGTGTTGGCTAATGTTAGTAGTAATTCTTTAATTGGTTTAATTGTGTTTAAATTTGCTAATTGGATGTTGTATTATTGTAATGCTTCATACCTTAATAACTATGTCCTAATGGCTGTTATTGTTAATGGTGTAGGTTGGATGTTTACTTGTTACTTTGGATTCTATTGGTGGATTAATAAGGTTTTTGGTTTAACCTTAGGTAAATATAGCTTCAAAGTTTCAGTAGATCAATATAGGTATATGTGTCTTCATAAGATTAATCCACCTAAAACTGTGTGGGAAGTCTTTTCTACAAATATACTTATACAAGGTATAGGTGGTGACCGTGTGTTGCCTATAGCTACAGTGCAATCTAAATTGAGTGATGTAAAGTGTACAACTGTTGTCTTAATGCAGCTTTTGACTAAGCTTAATGTCGAAGCAAACTCAAAAATGCATGCTTATCTTGTAGAGTTACACAATAAAATTCTTGCCTCTGATGATGTTAATGAGTGCATGGACAATTTGTTGGGTATGCTTGTAACACTATTCTGTGTAGATAGTACTATTGATTTAAGTGAGTATTGTGATGATATACTTAAGAGGTCAACTGTTTTACAATCAGTTACTCAGGAGTTTTCACACATTCCTTCTTATGCGGAGTACGAAAGAGCTAAAGATCTTTATGAAAAGGTTTTAGCTGATTCTAAAAATGGTAGTGTTACACAGCAAGAGCTTGCTGCATATCGTAAAGCTGCTAATATTGCAAAGTCAGTTTTTGACAGAGATCTGGCTGTTCAGAAAAAGTTAGATAGCATGGCCGAACGTGCTATGACAACAATGTATAAAGAAGCGCGTGTTACTGATAGAAGGGCGAAACTTGTTTCATCATTACATGCGCTATTATTTTCAATGCTTAAGAAGATAGATTCTGAAAAGCTTAATGTACTATTTGATCAAGCAAGCAGTGGTGTTGTACCGCTAGCTACTGTTCCAATAGTTTGTAGTAATAAGCTTACTCTTGTATTGCCAGATCCAGAGACGTGGATCAAGTGCGTAGAGGGTATGCATGTTACATATTCAACAGTTGTTTGGAATATTGATAATGTCATTGATGCAGATGGCACTGAATTGCAACCAATTTCTACAGGTAATGGTTTAATTTACTGTATAAGTGGTGATAATATAGCATGGCCTCTTAAGGTCAATTTGACTAGGAATGTGCATAATAAAGTTGATGCAGTATTGCAGAACAATGAGCTTATGCCTCATGGTGTTAAAACAAAGGCATGCGTGGCAGGTGTAGACCAAGCACACTGCAGCGTAGAGTCTAAATGTTATTATACTAATATTAGTGGTAATTCAGTAGTGGCTGCTATTACCTCCTCAAATCCTAATTTGAAAGTTGCCTCATTTTTAAATGAAGCAGGCAATCAAATTTATGTTGACTTAGACCCACCATGTAAATTTGGTATGAAGGTGGGTGATAAAGTAGAAGTTGTTTACTTGTATTTTATAAAGAATACAAGGTCAATTGTCAGAGGTATGGTACTTGGTGCTACATCTAATGTTGTTGTTTTACAGTCTAAAGGATATGAGACAGAGGAAGTTGATGCTGTTGGCATACTATCACTTTGTTCTTTTGCAGTAGATCCGGCTGACACGTATATTAAATATGTGGCTGCAGGTAACCAACCTTTAGGTAACTGTGTAAAAATGTTGACAGTTCATAATGGTAGTGGCTTTGCTATAACATCAAAGCCAAGCCCAACTCCTGACCAAGATTCTTACGGAGGGGCTTCTGTGTGTCTCTATTGTAGGGCACATATAGCTCACCCGGGAAGTGCAGGAAATTTAGATGGACGTTGTCAATTTAAAGGTTCTTTTGTACAAATACCTACTACAGAGAAAGACCCTGTGGGATTCTGTCTACGTAATAAGGTTTGCACTGTTTGCCAGTGTTGGATAGGTCATGGATGTCAATGTGATTCACTTAGACAACCAAGACCTTCAGTTCAGTCAGATGCTGGTGCACCTGGTTTTGATAAGAATTATTTAAACGGGTACGGGGTAGCAGTGAGGCTCGGCTGA
Protein
MASSLKQGVSSQNQRNVILVAKDIPDQLCDALFFYTSHNPKDYADAFAFRQKFDRNLGAGKQFKFETVCGPFFLKGVDKITPGVPAKALKATSKLADLEDIFGVSPFARKYRELLKTACHWSMTVETLDARAQTLEEIFDSSEILWLQVAAKIQVSAMAMRRLVGEVTAKVMDSLGSNLSALFQVVKETMARIFQKALAIFESVSELPQRIAALKMAFAKCARSITVVVVGHALTIREFAGTCLASINGAVAKFFEELPTGFMGAKVFSTLAFFKEAAVKIVENIPNAPRGTKGFEVVGNAKGTQVVVRGMRNDLTLLDQKAEVPVESEGWSAILEGHLCYVFKSGDRFYAAPLSGNFALHDVHCCERVVCLADGVTPEINDGLVLAAIYSSFNVSELVAALKKGEPFKFLGHKFVYAKEAAVSFTLAKAATIEDVLKLFQSARVKTRDVWSALTEQSFEFWKLAYNRVRNLEEVLKTHFCKAQMSVVILAAVLGEGIWHLCSQVIYKLSGLFSKVVDFCEKHWKGFCTQLRKVRLVVTENLCVLKGIAQHCFQLLLEAIHSMYKSFKKCALGRISGDLFFWKGGVHKIIHDGDEIWFDAVDTIEVEDLGTVQEKPIDFEVCEDVILPENQPGHMVQIQDDGKNYMFFRFKKDENIYYTPMSQLGAINVICKAGGKTVTFGEITVKEIPSPDVVPIKVSIECCGEPWNTIFKKAYKEPIEVETDLTVEQLLTVIYDKMCEDLKLFPEAPEPPPFENVALVDKNGKALDCIKSCHLIYRDYESDDDIEEDDAEECDTDPADAEECDTASECEQEDEDTKVLSLLQDPASNKYPLPLDDDYSVYNGCIVHKDALDVVNLPSGEETFVVNNCFEGAVKPLPQMVVDVLGDWGEAVDAQEQLCEQESESVKEPVEKPTGIGGSAVEEAVVVEQEVVPVVEESQELVVFTPADLKVVKETSEDVDEFVLVADVPTEEVVPQEKEEPQVEQEPIQVVKSQREKKAKKFKVRQTTCEKPKFLEYTTCVGDLTVVIAKALDEFKEFCVVNAANEYMSHGGGVAKAIADFCGPDFVEYCEDYVKKHGPQQRLVTPSYVKGVQCVNNVVGPRHGDKDLEEKLVAAYKNVLVDGVVNYVVPVLSSGIFGVDFKTSIDAMRKAFEGLNIRVLLFSLSQEHIEYFDATCKQKKIYLTEDGVKYRSVVVKPGDSLGQFGQVFAKNKTVFTADDVEDEEVLFTPTTDKAVLEYYGLDAQKYVIYLQTLAQKWEVQYRDNFILLNWRDGNCWISSAIVLLQAAKIRFRGFLAEAWAKFLGGDPTDFVAWCYASCNAKVGDFSDCNWLLANLAEHFDADYTNALLKKRVSCNCGVKSYELRGLEACIQPVRAPNLLHFKTQYSNCPTCGANSMDEVVEASLPYLLLVATDGPAAVDCDENAAGNVVFIGSTNSGHCYTQAVGKAFDNLAQDRKFGKRSPYITAMYMRFSLKSKNSLSVAKKSKSKSDVVKEDVSNLATSSKFSFDDLTDFEQWYDSNIYESLKVQETPDNMDEYVSFTIKEDSKLPLTLKVRGIKSVVDFKSKDGFTYKLIPDTDENSKAPVYYPTLDSISLKAIWVEGSANFIVGHPNYNSKVLRVPTFWECAERFVKIGEKVDGVTMGLWRVKHLNRLNLERIFNVVKKTMVGTSVVTTQCGKLISKAATFVADKVGDGVVRNVSDRIKGCFGSTREHFERRVSPQFLKTLFFFVFCFFKASVKGLMASYKSVLCKVLFTALLILWIVYTSDPVISTGIRVLDFLFEGSFCSPYADYGKESFDVLRYCGSDFTCRVCLHGKDSLHLYKHAYSVEQFYKDAVNGISFTWNWLYMLFLLLFVKPVAGFVIICYCIRYLVLSTTVLQTGVGFLDWFIQTVFANFNFMGAGFYFWLFYKVYIQVHHIMYCKDITCEVCKRVARSNRHEVSVVVNGRKQLVHVYTNSGYTFCKRHNWYCRNCDKYGHQNTFMSPEVAGELSEKLKRHVKPTAFAYHVVDDACLVDDFVNLKYNAATPGKEGVHSAVKCFSVSDFLKKAVFLKDAQKCEQISNDSFIVCNTHSAHALEEAKNAAIYYAQCLCKPILILDQALYEQLVVEPVSKSVVDKVCSILSNITSVDSAALNYKAGTLRDALLSVTKDEEAVDMAIFCHNNDVEYTSDGFTNVVPSYGIDTDKLTPRDRGFLINADASIANLKVKNSPPVVWKYSDLIKLSDSCLKYLISATVKSGGRFFITRSGAKQVISCYTQKLLVEKKAGGVVSSTISSFKSCCKWLLVFYLIFTVCCLGYYQWEMSREFSHPMYDVNSTMHVEGFKVIDKGVLRDIVPEDTCFSNKYVNFDSFWGKSYVNSRDCPIVTAIIDGSGTVAAGVPGFVQWVMDGVMFIHMTQTERKPWYIPTWFNREIVGYTHDSIITEGEFYTSIALFASRCLYLTSSNTPQLYCFNGDNDAPGALPFASILPHRVYFQPNGVRLIVPQQIMHTPYVVKLVSDSYCRGSVCEVTKSGYCVSMNSQWVLFNDEYTIKPGVFCGSTVRELLFSMVSTFFTGVNPNIYMQLATMFLTLVAVVLVFAMVIKFQGVFKAYATTVFTIMLVWLINAFILCVHSYNGVLAIILLVLYCYASLVTSRNTAIIMHCWLVFTFGLIVPNWLACVYLGFVLYMYTPLFLWCYGTTKNCRKLYEGNDFVGNYDLAAKSTFVIRGPEFVKLTNEIGDKFEHYLSAYARLKYYSGTGSEQDYLQACRAWLAYALDQFRSSGVEVVYTPPRYSIGVSRLQAGFKKLVSPSSAVEKCIVSVSYRGNNLNGLWLGDSIYCPRHVLGKFSGDQWGDVLNLANNHEFEVVTGNGVTLSVVSRRLKGAVLILQTAIVNADTPKYKFLKANCGDSFTIACSYGGIVIGLYPVTMRSNGTIRASFLAGACGSVGFNIEKGVVNFYYMHHLELPNALHTGTDLMGEFYGGYIDEEVAQKVQPDKLVTNNILAWLYAAIISVKESSFSTPKWLESTTISTDDYNKWAGDNGFTSFVSCTAITKLSAITGVDVCKLLRTIMVKSAQWGSDPILGQYNFEDEMTPESVFNQVGGVRLQSSVVKRAASWFWSRCVLACFLFVLCSIVLFTAIPYRYYLYGAVVLFATVLFVSFTVKHVMAYMDTFLLPTLITVIIGVCAEVPFIYNTLISQIVIFFSQWYDPVVFDTVVPWMFLPLVLYTAFKCIQGCYSVNSFNTSLLVLYQFMKLGFVIYTSSNTLTAYSEGNWELFFELVHTTVLANVSSNSLIGLIVFKFANWMLYYCNASYLNNYVLMAVIVNGVGWMFTCYFGFYWWINKVFGLTLGKYSFKVSVDQYRYMCLHKINPPKTVWEVFSTNILIQGIGGDRVLPIATVQSKLSDVKCTTVVLMQLLTKLNVEANSKMHAYLVELHNKILASDDVNECMDNLLGMLVTLFCVDSTIDLSEYCDDILKRSTVLQSVTQEFSHIPSYAEYERAKDLYEKVLADSKNGSVTQQELAAYRKAANIAKSVFDRDLAVQKKLDSMAERAMTTMYKEARVTDRRAKLVSSLHALLFSMLKKIDSEKLNVLFDQASSGVVPLATVPIVCSNKLTLVLPDPETWIKCVEGMHVTYSTVVWNIDNVIDADGTELQPISTGNGLIYCISGDNIAWPLKVNLTRNVHNKVDAVLQNNELMPHGVKTKACVAGVDQAHCSVESKCYYTNISGNSVVAAITSSNPNLKVASFLNEAGNQIYVDLDPPCKFGMKVGDKVEVVYLYFIKNTRSIVRGMVLGATSNVVVLQSKGYETEEVDAVGILSLCSFAVDPADTYIKYVAAGNQPLGNCVKMLTVHNGSGFAITSKPSPTPDQDSYGGASVCLYCRAHIAHPGSAGNLDGRCQFKGSFVQIPTTEKDPVGFCLRNKVCTVCQCWIGHGCQCDSLRQPRPSVQSDAGAPGFDKNYLNGYGVAVRLG
Summary
Function
The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc (By similarity).
The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK.
The peptide p16 might be involved in the EGF signaling pathway.
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.
Nsp9 is a ssRNA-binding protein.
The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK.
The peptide p16 might be involved in the EGF signaling pathway.
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.
Nsp9 is a ssRNA-binding protein.
Subunit
3CL-PRO exists as monomer and homodimer. The three peptides nsp2, nsp3 and nsp4 may form a complex. Nsp9 is a dimer. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp10 forms a dodecamer (By similarity).
Miscellaneous
Produced by conventional translation.
Similarity
Belongs to the coronaviruses polyprotein 1ab family.
Keywords
Activation of host autophagy by virus
Host cytoplasm
Host membrane
Host-virus interaction
Hydrolase
Membrane
Metal-binding
Protease
Repeat
Ribosomal frameshifting
RNA-binding
Thiol protease
Transmembrane
Transmembrane helix
Zinc
Zinc-finger
Feature
chain Replicase polyprotein 1a
Uniprot
EMBL
Proteomes
Pfam
Interpro
IPR018995
RNA_synth_NSP10_coronavirus
IPR036499 NSP9_sf
IPR014829 NSP8
IPR009003 Peptidase_S1_PA
IPR014822 NSP9
IPR014827 Viral_protease
IPR013016 Peptidase_C30/C16
IPR002589 Macro_dom
IPR037230 NSP8_sf
IPR038123 NSP4_C_sf
IPR014828 NSP7
IPR040795 Nsp1a_N
IPR036333 NSP10_sf
IPR032505 Corona_NSP4_C
IPR037204 NSP7_sf
IPR008740 Peptidase_C30
IPR036499 NSP9_sf
IPR014829 NSP8
IPR009003 Peptidase_S1_PA
IPR014822 NSP9
IPR014827 Viral_protease
IPR013016 Peptidase_C30/C16
IPR002589 Macro_dom
IPR037230 NSP8_sf
IPR038123 NSP4_C_sf
IPR014828 NSP7
IPR040795 Nsp1a_N
IPR036333 NSP10_sf
IPR032505 Corona_NSP4_C
IPR037204 NSP7_sf
IPR008740 Peptidase_C30
SUPFAM
Gene 3D
ProteinModelPortal
PDB
3LD1
E-value=0.0 Score= 664 Identity=88.83%
Cov(Q)=9.06% Cov(P)=99.72%
3D Structure
Ontologies
GO
GO:0003968 F:RNA-directed 5'-3' RNA polymerase activity
GO:0019082 P:viral protein processing
GO:0008270 F:zinc ion binding
GO:0044220 C:host cell perinuclear region of cytoplasm
GO:0003723 F:RNA binding
GO:0008242 F:omega peptidase activity
GO:0016021 C:integral component of membrane
GO:0004197 F:cysteine-type endopeptidase activity
GO:0039520 P:induction by virus of host autophagy
GO:0033644 C:host cell membrane
GO:0019079 P:viral genome replication
GO:0019082 P:viral protein processing
GO:0008270 F:zinc ion binding
GO:0044220 C:host cell perinuclear region of cytoplasm
GO:0003723 F:RNA binding
GO:0008242 F:omega peptidase activity
GO:0016021 C:integral component of membrane
GO:0004197 F:cysteine-type endopeptidase activity
GO:0039520 P:induction by virus of host autophagy
GO:0033644 C:host cell membrane
GO:0019079 P:viral genome replication
Subcellular Location
From MSLVP
Capsid
From Uniprot
Host membrane
nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). With evidence from 1 publications.
nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). With evidence from 1 publications.
Topology
Length:
3953
Number of predicted TMHs:
16
Exp number of AAs in TMHs:
393.883259999999
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00227
outside
1 - 1740
TMhelix
1741 - 1763
inside
1764 - 1849
TMhelix
1850 - 1872
outside
1873 - 1886
TMhelix
1887 - 1909
inside
1910 - 2281
TMhelix
2282 - 2300
outside
2301 - 2558
TMhelix
2559 - 2581
inside
2582 - 2585
TMhelix
2586 - 2608
outside
2609 - 2611
TMhelix
2612 - 2631
inside
2632 - 2643
TMhelix
2644 - 2666
outside
2667 - 2888
TMhelix
2889 - 2906
inside
2907 - 3096
TMhelix
3097 - 3119
outside
3120 - 3123
TMhelix
3124 - 3141
inside
3142 - 3153
TMhelix
3154 - 3176
outside
3177 - 3190
TMhelix
3191 - 3213
inside
3214 - 3225
TMhelix
3226 - 3248
outside
3249 - 3257
TMhelix
3258 - 3280
inside
3281 - 3299
TMhelix
3300 - 3322
outside
3323 - 3953
