Strain

Human_MERS_MK462251 (Region: Saudi Arabia; Strain: Middle East respiratory syndrome-related coronavirus strain Hu/Northern-KSA-1847784/2018, complete genome.; Date: 18-Jul-18)

Gene

M protein

Description

Annotated in NCBI, M protein

Location

MK462251(+):27853-28512

GenBank Accession

QBF80549.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGTCTAATATGACGCAACTCACTGAGGCGCAGATTATTGCCATTATTAAAGACTGGAACTTTGCATGGTCCCTGATCTTTCTCTTAATTACTATCGTACTACAGTATGGATACCCATCCCGTAGTATGACTGTCTATGTCTTTAAAATGTTTGTTTTATGGCTCCTATGGCCATCTTCCATGGCGCTATCAATATTTAGCGCCATTTATCCAATTGATCTAGCTTCCCAGATAATTTCTGGCATTGTAGCAGCTGTTTCAGCTATGATGTGGATTTCCTACTTTGTGCAGAGTATCCGGCTGTTTATGAGAACTGGATCATGGTGGTCATTCAATCCTGAGACTAATTGCCTTTTGAACGTTCCAATTGGTGGTACAACTGTCGTACGTCCACTCGTAGAGGACTCTACCAGTGTAACTGCTGTTGTAACCAATGGTCACCTCAAAATGGCTGGCATGCATTTCGGTGCTTGTGACTACGACAGACTTCCTAATGAAGTCACCGTGGCCAAACCCAATGTGCTGATTGCTTTAAAAATGGTGAAGCGGCAAAGCTATGGAACTAATTCCGGCGTTGCCATTTACCATAGATATAAGGCAGGTAATTACAGGAGTCCGCCTATTACGGCGGATATTGAACTTGCATTGCTTCGAGCTTAG

Protein

MSNMTQLTEAQIIAIIKDWNFAWSLIFLLITIVLQYGYPSRSMTVYVFKMFVLWLLWPSSMALSIFSAIYPIDLASQIISGIVAAVSAMMWISYFVQSIRLFMRTGSWWSFNPETNCLLNVPIGGTTVVRPLVEDSTSVTAVVTNGHLKMAGMHFGACDYDRLPNEVTVAKPNVLIALKMVKRQSYGTNSGVAIYHRYKAGNYRSPPITADIELALLRA

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the betacoronaviruses M protein family.

Uniprot

A0A0K2RVN4

Pubmed

26271151

EMBL

LC061273 LC061274 BAS18859.1 BAS18869.1

Proteomes

UP000130220 UP000155347

Pfam

PF01635 Corona_M

Interpro

IPR002574 Corona_M

ProteinModelPortal

A0A0K2RVN4

Ontologies

GO:0044178  C:host cell Golgi membrane
GO:0030683  P:evasion or tolerance by virus of host immune response
GO:0019058  P:viral life cycle
GO:0039660  F:structural constituent of virion
GO:0055036  C:virion membrane
GO:0019031  C:viral envelope
GO:0016021  C:integral component of membrane

Subcellular Location

From MSLVP

Host nucleus. Host cytoplasm.

Topology

Length:

219

Number of predicted TMHs:

Exp number of AAs in TMHs:

62.08004

Exp number, first 60 AAs:

30.64011

Total prob of N-in:

0.69622

POSSIBLE N-term signal

sequence

inside

1 - 20

TMhelix

21 - 40

outside

41 - 49

TMhelix

50 - 72

inside

73 - 78

TMhelix

79 - 101

outside

102 - 219