Strain
Harrisii_MK521914
(Region: Australia: wukalina/Mt William National Park, Tasmania; Strain: Torovirus sp. isolate Tasmania/Sarcophilus_harrisii/2016/DN128115, complete genome.; Date: 2017)
Gene
polyprotein
Description
Annotated in NCBI,
polyprotein
Location
GenBank Accession
Sequence
CDS
ATGATTAAACGTGTTAAAGATCAACATGAATTTGCCCTTGCAAAGACTGCGTTTTTACCATCAATAATACCTCACCATATTGTACATCAAAATGGTGAGTGGTTTTTGGTGCGCGGTCCTACAACACAATGGAGTTTAGGTGACCTTGCCTATGCTATTTGGCTTGGTGACCAGGCGTATCTTGATGAATGTGGTTTTGTTTTTAATCCATCTAGAGATGAGTTTCTTGAAGATGCCAATCAGAGATCTTATTTGGCAAATTTGCTTGAGCCTGCTATTTTGGGTTTTTGTGAGATTTTTCAGTGTGTGAAAGATTGCCAAGTGCCATATAAAATAACATTGGATAATTTGGATCTAAAAGGACAACTCTATGATTTTGGAGATTATCCGTGTCCTAATAAAGTAGATAACCAGTCTGCCTTGTTTGTTTTAGCTGAAGTTTGGTCAATGACACGTAAACCTTTTCCTACCAAGTTTGCACAAGTACTTGCAAAAGAGATGAATGTTCCTGCTGACTTTCAAATGTATTTCCAGCATATACTTTTGTCAGGCAAGTATTTTGATAAAGCAATGTGTTTAAATAATGTTAGACCATTCTTGAGAGACCCAGCCAATTTAACAACAACACCTTTTTTTTCACAACATAGTGGTGTGTGGACACATTTTTATAATCCCATATATGGCCTTGTTGAATGTGATTTGGAGGAGTTTTCTAACCTGCCTGAAGTCTTACAGCAGCTTATTACTGTGCAGGGACCTATAACCAGTGCCATGACACCTGCCATTTCCATTGGTGAGGGTGTGTATGCAGCTAATGTGCCACCTGCTGCTGCAGCGAAACAAAAGATACCCCTCTATGATGTTGGCTTGTGCCAAGAACTTACTGATGCGGGTGTGGACTGTGGGGAGGCATTTAAGTATTTTTACTATTTGTCAAATCCTGCAGGGGCACTTGCTGATGTTTGTTTTTATGATTATCAGGGCACTGGATTTTATTCACCTAAATTGCTTGCTGGAGTTTATGATTTTATGAAAAGGGTAACAGCTTGTTATAAAACTGATGAGAGGTTTACTTATGAGCAAGCAAAACCAAGAAAGTCATCCATGGGCATTAATATTACAGGTTATCAACAAGATGCAGTTTATCGTGCCTTAGGTCCTGAAAATATTACTAAATTGTTTGAGTATGCACAGAAGGCTCCATTGCCATTTTGTACTAAGATTATAACAAAGTTTGCATTGTCAGCAAAAGCAAGAGCTAGAACAGTGTCATCATGCTCCTTTATAGCATCAACCATTTTTAGGTTTGCACATAAACCAGTAACATCCAAAATGGTAGAAGTTGCACAAAATTCACAAGGATTTTGTCTTATAGGTGTTTCCAAGTATGGTTTGAAATTTTCCAAGTTTCTTAAGGACAAGTATGGTGCTATTGAACAATTTGATGTTTTTGGGAGTGACTATACCAAGTGTGATCGAACATTTCCCTTGTCCTTTAGAGCATTGACAGCTGCCTTACTTTATGAACTTGGAGGTTGGGAGGAAGATTCTTGGTTGTACCTAAATGAGGTGAATTCCTATATGTTAGACACAATGCTTTGTGATGGCATGCTGTTGAATAAACCCGGAGGGACGTCCTCAGGTGATGCCACAACTGCACATTCTAATACACTTTATAATTATATGGTGCATTATGTAGTAGCTTTTAAGACAATTTTATCAGATTTGTCTGACTTCAACAAGGTTATGAGAATAGCTGCTCATAACGCCTATACTACTGGTGATTATGGCATTTTTAACACCTTGCTTGAAGAACAGTTTCAGACGAATTATTTTTTAAACTTTTTGTCTGATGATTCGTTTATATTCTCAAAGCCTGGTGCATTGAAAATATTTACTTGTGAAAATTTTTCAAATAAATTGCAGACCATCTTGCATACTAAAGTCGATCAAACAAAATCATGGGCTACAACTGGTCATATTGAAGAGTTTTGTTCTGCACATATAATTAAAACTGATGGAGAATACCACTTTTTGCCATCTCGTGGTAGGTTGTTGGCATCTCTGTTGATATTGGACAAACTTTCAGATGTAGATATTTATTATATGAGATTTGTTGCACTTCTTTGTGAGTCAGCAGTTTATTCTAGATACCAACCAGAGTTTTTTAATGGCTTGTTTCAAGTGTTTTTAGATAAAGTGCAGCAATTTAGGAAGGACTATTGTTGTGATCCGTGTCCCCCTCAACTTCTTGATCGCCAGTTCTATGAGAACTTGGTGTTTACATCTAATACAGAAGTTGGATTGGTTGATTGCTATTTAGAAAACTTTAAGTTGCAATGTGACGTTAAACTACAGGCAGGGTTTGATAGAGTGTGTTTTTGTTGTCCGAATCCAGCAGTTTCTGTTTGTGAGGAGTGCTATGTGCCCCTACCCCTTTGTGCTTATTGTTATTATGTACATGTTGTAATTAGTGGTCATTGTAAAATAGAAGATAAGTTTAAGTGTCCTTGTGGGCAAGATGATATAAGAGAATTATTTATAGTGTTAAATAATAGTATTTGTATATATCAGTGTAGAAGTTGTGTTGAAAGTGATAGATTAAGGATTAGTTTGTTAAGTGATGTTGATCAAGTTGTGAGATTGCCCGGCTTTAAAGCAAACTCAGCCTCCATTGCAAAGAATGGAGTTGCTCAACTTTTAACACCTGTTGATAATGTTGATGTGTCTTTGGATTGGAACCATCAAGAAAATGTTCAACAGAATGTTGCAAGGATTGTCTACCATTCTGCAAATATGACACAAATGTCAATTGAGGTTGTTTATGTAAATTTTAGTCTTGTGCGGAATGATGGGTCATCAGCAATTTTAGACATTCCTAATTTTAAATGTCCCGATACATCTTATTGTCTCTTTTATAAGCCGGGCAAGACAGGTGCCTTGAAGTTTACAGGGAAGGGAACTTTAACGTCGTGTTATGATAGCAATAATTTAACTTGGTTTAAGGTTACTTGCCCAGATTTTAATCAACCATGGAGACTTGCAACATGTTTTGTTATTCAGCAGCATGATGCAGTTTACCCACCAATAAAGTCAACACAGTATGAGAATGTTACCTTTGTTATGGGACCACCTGGAACAGGAAAGACTACATTTGTTTATAATACATATTTGTCAAAGGCATCCCCATCCAACCGCTTTGTCTATTGTGCACCAACTCATAGACTTGTAGGTGATATGGATGAGAAAGTTGATGGTGCAGTTGTTGTGTCAGCTTACAATGATAGGACATACCGTAATCCAGTTTGGAAGAAAGATGATTCCTATGATGTCCTACTCTGCACACACAATACATTGCCTTTTATTAAGAGTGCTGTATTGATTGTTGATGAAGTCTCCCTTATACCACCACATGTGATGATTAAAATTTTGTCCATGGGTTTTAAAAAAGTTGTTCTTTTGGGAGATCCATTTCAGCTAAGTCCAGTTTATAAAAATCATAAAGTGCATTTTAAGTATGATACTTTTTATTTATTACAGCTTGCTACTCAGAAGCGGTATTTGACAGCGTGTTACCGCTGCCCACCACAGATTTTGGGTGCATTTTCGAAACCATATTGTGATGTTGGTGTTGATTTAGTTTCATTTAATAATAAGCCTGGAAAGTTTGATATTATAGTCAGCAAACAATTAGCCAACATGCAGGATTTTAGTGTGTTATCTATCCTGTCAAAGGAGTATCCAGGCTATGTAATTCTTGTGAATTACAGAGCAGCTGTTGATTATGCAATGCAGAATGGACTTGGTGATGTAACTACAATTGATTCCTCCCAGGGGACTACTGCTGCTAATCATTTATTAGTGTTGTTTGGGGCATCTAATTTTTCTAAGACCATTAACCGTGTCATTGTCGGCTGTTCACGATCAACAACCCATTTGGTGGTGGTTTGTTGCCCAGAATTGTACAAACACTTCCAGCCAATACTTAACTGGCCAGAACCAGTTTATAGGTACTTTGGCATGGAGAAACAGTCTGATTTTAATATAATACCAGAAGTAGCATCCCTGGTTTTTTGTGATATTGAGTTTTGGCATTATAAAGCAGACCCAAGTTCAAAAACCCGCACTGTTTACCCTGGGCAGATTGCTGTAGTAACATCGCAGACTTTACAACTATACCTTGGTGTCTTCGACGATGCTGGTTATAAATCGGCTCTTCGAGGGTTGCCTAAGGATGTTTTTGTACCACCTAATTGGGTTTGGATGAGAAAGCATTATCCATCATTTGAACAACATGCTTATAATATGCAGCGGTTATTTAAGTTTATAATTGATACAACTTGTGGACAACCTTGGTTTATTTTGTATAGTTGTAGTAATGATTTGAAAAGTTTAAAATTTTATGTAGAGTTTGGTACTAATTATTTTTGTAGCTGTGGTGAGTTAGCCATTTGCCTGATGCGCGATGGCTTTTATAAATGTAGAAATTGTTATGGTAATATGTCAATAAGTAAGTTAGTTAATTGTAAATATTTAGATGTACAAAAGGAAAGGATTAAGTTACAAGATGCCCATGATGCTATCTGTCAACAATTTCATGGTGATTCCCATGAGGCATTGTGTGATGCAGTTATGACAAAATGTCTGTATTTGGCAAGCTATGATGCTGCATTTAAGGACACAATACATGTTAAGTATAAAGATCTTTGTTTGGAAATACAGTATAAAATAACAAGTCCTTATGTCAGATATGATGGCGTAAATAAACGCTATTTGTATCGTGACCATGGAGCCATGTACTATTTTAAAACACCTAAGTCTCCTATGCAGAATGTGTATAGGTATGAGGTTGGTGCCCACACAGAGTATAGCATTAATATTTGTAATAGTTATGAGGGGTGTCAGTCCTTTGGAAAGACTTGTACTAAATGTATTCACATTCATTGCATTGTTGAGCAGTTTATGGCTGATGATAGGTATAGGGACTTCATTCTTGTGTCCGTTGTAAAATCTGATTTTGTTGAACAGGCATTGTCACCTGCAGCAAGAGCTTTGATGTTAACGGTCACTAGGGTTGAGGGTAAGAGTTTTTACACCTCTAACGGACAGCGCTATGACTTATATGACTATGACTTGAGTAAGTCGGTTATGCGAGTTGTAGGTGCAAGTGTTAAACCCCTCCCTTTGTATTCCGTTGTTGTGGGCTTAGGTATTAACTGTACTGTTGGTTGTGTATTACCAAATGTGCCAATGAAGTTAAAGGATGAGTTGTTAAGTACCGACGTACCACTTTCAACTCTAAGGCTTGATTTGCCTACATGGTACTATGTTACCTGGCCCACATTAAGTAACAAAACCTCCCGCTGGAAGTTAGCTGGTGCTCAAGTTTATGATTGTTCTGTGCATATTTATGTTGAGGCTACAGGAGAACAACCGTTGTATTATTTACAGCTTGGCAATGGTGAAAGCCTCCGAGAGCTACCTGAAACTTTGTTTTCTACTGGCAGACTCTACAACTTGGAACATGACCCGTCTAAGAATTTTAATGTGCTACAGTTAGCCATTGAGACAATACCTAAGAACCACCATGTCTTTGCAGGAGATTTTACAGACGTTGGAACAGACATAGGTGGAGTGCATCATGTTGTTGCACTGAATGGCTATAAAGGTAGTATAATACCCAATTATGTAAAGCCAGTTGCAACAGGCTTGATAAATGTTGGGAGATCTGTCAAGAGAACTACTTTAGTTGATGTTTGTGCCAACCAGCTGTATGAGAAAGTGAAACAGCAAATAGCGGGTGTAAAAGTGAGTAAAGTTATTTTTGTAAATATTGATTTTCAAGAGGTTCAGTTTATGGTATTTGCCAAGGGCGAGGACGATATACAGACCTTTTATCCTCAAAAGGAGTTTATAAGGTCGTATTATGAATGGCCAACTATTTTACCAGAATTAGAATCCCATTATGACCTTAAGAATTATGGTCAAGACCCCCAATTTATGCCTCAACCTGTTAATTTTGCAAAATATACACAGATTTGCACCTTTATTCAAGATCATGTTAAGGTTGCAAGGAATTCTTTAATATGGCATGTTGGTGCGGCAGGGATTGATGGCTGTTCGCCTGGTGATATTGTGCTGTCCTCTTTTTTTAAAGAATGTTTAGTTTATAGTTGGGATGTTAAGGATTATGATACATTGTTGGAAAAGCATAATTATGATTGTAATTTTAGGCCTAATTTAGTAGTTAGTGATATTTATAATGTAAGTAGTAATGTAAGTGAAGTGTTAGAAGATTGCGTGCATAGACTTGCATTGGGTGGAACTATCATATTTAAGACAACCGAGAGTTCAAGACCAGATATACAGTTAAGTAAAGTTACTAAATATTTTGCTGCTGTGCATTTTTTTACAGCAGGAGTAAATACCTCTTCATCGGAGGTTTTTGTTGTCTTGAAATATAAGCTACACTCCGAACCAATTGGTGAGGAGTTGTGTTCCCCCAATATTTTGCGACGAATTGCCGCATATAGAAATAAGTTTTGCATAGTGCCTAATTTTAAGGTTTTTAGTACTAGTTTGAGTTATAGGTTTAGTAGTGTTAAGTTTGTGCAAAAATGTTTTTATGTTTCTGTACCGCGGCAATTTTGTGCCTCTGGGTTAATTCAGGAGGTGCCGTTGTTGTGTCAAATGAAACATTAG
Protein
MIKRVKDQHEFALAKTAFLPSIIPHHIVHQNGEWFLVRGPTTQWSLGDLAYAIWLGDQAYLDECGFVFNPSRDEFLEDANQRSYLANLLEPAILGFCEIFQCVKDCQVPYKITLDNLDLKGQLYDFGDYPCPNKVDNQSALFVLAEVWSMTRKPFPTKFAQVLAKEMNVPADFQMYFQHILLSGKYFDKAMCLNNVRPFLRDPANLTTTPFFSQHSGVWTHFYNPIYGLVECDLEEFSNLPEVLQQLITVQGPITSAMTPAISIGEGVYAANVPPAAAAKQKIPLYDVGLCQELTDAGVDCGEAFKYFYYLSNPAGALADVCFYDYQGTGFYSPKLLAGVYDFMKRVTACYKTDERFTYEQAKPRKSSMGINITGYQQDAVYRALGPENITKLFEYAQKAPLPFCTKIITKFALSAKARARTVSSCSFIASTIFRFAHKPVTSKMVEVAQNSQGFCLIGVSKYGLKFSKFLKDKYGAIEQFDVFGSDYTKCDRTFPLSFRALTAALLYELGGWEEDSWLYLNEVNSYMLDTMLCDGMLLNKPGGTSSGDATTAHSNTLYNYMVHYVVAFKTILSDLSDFNKVMRIAAHNAYTTGDYGIFNTLLEEQFQTNYFLNFLSDDSFIFSKPGALKIFTCENFSNKLQTILHTKVDQTKSWATTGHIEEFCSAHIIKTDGEYHFLPSRGRLLASLLILDKLSDVDIYYMRFVALLCESAVYSRYQPEFFNGLFQVFLDKVQQFRKDYCCDPCPPQLLDRQFYENLVFTSNTEVGLVDCYLENFKLQCDVKLQAGFDRVCFCCPNPAVSVCEECYVPLPLCAYCYYVHVVISGHCKIEDKFKCPCGQDDIRELFIVLNNSICIYQCRSCVESDRLRISLLSDVDQVVRLPGFKANSASIAKNGVAQLLTPVDNVDVSLDWNHQENVQQNVARIVYHSANMTQMSIEVVYVNFSLVRNDGSSAILDIPNFKCPDTSYCLFYKPGKTGALKFTGKGTLTSCYDSNNLTWFKVTCPDFNQPWRLATCFVIQQHDAVYPPIKSTQYENVTFVMGPPGTGKTTFVYNTYLSKASPSNRFVYCAPTHRLVGDMDEKVDGAVVVSAYNDRTYRNPVWKKDDSYDVLLCTHNTLPFIKSAVLIVDEVSLIPPHVMIKILSMGFKKVVLLGDPFQLSPVYKNHKVHFKYDTFYLLQLATQKRYLTACYRCPPQILGAFSKPYCDVGVDLVSFNNKPGKFDIIVSKQLANMQDFSVLSILSKEYPGYVILVNYRAAVDYAMQNGLGDVTTIDSSQGTTAANHLLVLFGASNFSKTINRVIVGCSRSTTHLVVVCCPELYKHFQPILNWPEPVYRYFGMEKQSDFNIIPEVASLVFCDIEFWHYKADPSSKTRTVYPGQIAVVTSQTLQLYLGVFDDAGYKSALRGLPKDVFVPPNWVWMRKHYPSFEQHAYNMQRLFKFIIDTTCGQPWFILYSCSNDLKSLKFYVEFGTNYFCSCGELAICLMRDGFYKCRNCYGNMSISKLVNCKYLDVQKERIKLQDAHDAICQQFHGDSHEALCDAVMTKCLYLASYDAAFKDTIHVKYKDLCLEIQYKITSPYVRYDGVNKRYLYRDHGAMYYFKTPKSPMQNVYRYEVGAHTEYSINICNSYEGCQSFGKTCTKCIHIHCIVEQFMADDRYRDFILVSVVKSDFVEQALSPAARALMLTVTRVEGKSFYTSNGQRYDLYDYDLSKSVMRVVGASVKPLPLYSVVVGLGINCTVGCVLPNVPMKLKDELLSTDVPLSTLRLDLPTWYYVTWPTLSNKTSRWKLAGAQVYDCSVHIYVEATGEQPLYYLQLGNGESLRELPETLFSTGRLYNLEHDPSKNFNVLQLAIETIPKNHHVFAGDFTDVGTDIGGVHHVVALNGYKGSIIPNYVKPVATGLINVGRSVKRTTLVDVCANQLYEKVKQQIAGVKVSKVIFVNIDFQEVQFMVFAKGEDDIQTFYPQKEFIRSYYEWPTILPELESHYDLKNYGQDPQFMPQPVNFAKYTQICTFIQDHVKVARNSLIWHVGAAGIDGCSPGDIVLSSFFKECLVYSWDVKDYDTLLEKHNYDCNFRPNLVVSDIYNVSSNVSEVLEDCVHRLALGGTIIFKTTESSRPDIQLSKVTKYFAAVHFFTAGVNTSSSEVFVVLKYKLHSEPIGEELCSPNILRRIAAYRNKFCIVPNFKVFSTSLSYRFSSVKFVQKCFYVSVPRQFCASGLIQEVPLLCQMKH
Summary
Catalytic Activity
ATP + H2O = ADP + H(+) + phosphate
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)
Similarity
Belongs to the coronaviruses polyprotein 1ab family.
Uniprot
Pubmed
EMBL
Proteomes
Pfam
Interpro
IPR042515
Nsp15_N
IPR009461 Coronavirus_NSP16
IPR002589 Macro_dom
IPR014827 Viral_protease
IPR014829 NSP8
IPR036499 NSP9_sf
IPR007094 RNA-dir_pol_PSvirus
IPR027351 (+)RNA_virus_helicase_core_dom
IPR009466 NSP11
IPR027417 P-loop_NTPase
IPR038123 NSP4_C_sf
IPR037230 NSP8_sf
IPR009003 Peptidase_S1_PA
IPR014822 NSP9
IPR037227 EndoU-like
IPR018995 RNA_synth_NSP10_coronavirus
IPR029063 SAM-dependent_MTases
IPR008740 Peptidase_C30
IPR037204 NSP7_sf
IPR032505 Corona_NSP4_C
IPR009469 RNA_pol_N_coronovir
IPR036333 NSP10_sf
IPR001205 RNA-dir_pol_C
IPR027352 CV_ZBD
IPR014828 NSP7
IPR009461 Coronavirus_NSP16
IPR002589 Macro_dom
IPR014827 Viral_protease
IPR014829 NSP8
IPR036499 NSP9_sf
IPR007094 RNA-dir_pol_PSvirus
IPR027351 (+)RNA_virus_helicase_core_dom
IPR009466 NSP11
IPR027417 P-loop_NTPase
IPR038123 NSP4_C_sf
IPR037230 NSP8_sf
IPR009003 Peptidase_S1_PA
IPR014822 NSP9
IPR037227 EndoU-like
IPR018995 RNA_synth_NSP10_coronavirus
IPR029063 SAM-dependent_MTases
IPR008740 Peptidase_C30
IPR037204 NSP7_sf
IPR032505 Corona_NSP4_C
IPR009469 RNA_pol_N_coronovir
IPR036333 NSP10_sf
IPR001205 RNA-dir_pol_C
IPR027352 CV_ZBD
IPR014828 NSP7
SUPFAM
ProteinModelPortal
PDB
6NUS
E-value=6e-24 Score= 110 Identity=23.39%
Cov(Q)=20.87% Cov(P)=48.80%
3D Structure
Ontologies
KEGG
GO
GO:0032259 P:methylation
GO:0003968 F:RNA-directed 5'-3' RNA polymerase activity
GO:0006351 P:transcription, DNA-templated
GO:0008242 F:omega peptidase activity
GO:0003723 F:RNA binding
GO:0044220 C:host cell perinuclear region of cytoplasm
GO:0003724 F:RNA helicase activity
GO:0039520 P:induction by virus of host autophagy
GO:0004197 F:cysteine-type endopeptidase activity
GO:0008168 F:methyltransferase activity
GO:0044165 C:host cell endoplasmic reticulum
GO:0019082 P:viral protein processing
GO:0008270 F:zinc ion binding
GO:0005524 F:ATP binding
GO:0016021 C:integral component of membrane
GO:0016896 F:exoribonuclease activity, producing 5'-phosphomonoesters
GO:0039694 P:viral RNA genome replication
GO:0033644 C:host cell membrane
GO:0003968 F:RNA-directed 5'-3' RNA polymerase activity
GO:0006351 P:transcription, DNA-templated
GO:0008242 F:omega peptidase activity
GO:0003723 F:RNA binding
GO:0044220 C:host cell perinuclear region of cytoplasm
GO:0003724 F:RNA helicase activity
GO:0039520 P:induction by virus of host autophagy
GO:0004197 F:cysteine-type endopeptidase activity
GO:0008168 F:methyltransferase activity
GO:0044165 C:host cell endoplasmic reticulum
GO:0019082 P:viral protein processing
GO:0008270 F:zinc ion binding
GO:0005524 F:ATP binding
GO:0016021 C:integral component of membrane
GO:0016896 F:exoribonuclease activity, producing 5'-phosphomonoesters
GO:0039694 P:viral RNA genome replication
GO:0033644 C:host cell membrane
Subcellular Location
From MSLVP
Capsid
From Uniprot
Host cytoplasm
Host perinuclear region
Host endoplasmic reticulum
Host membrane
Host perinuclear region
Host endoplasmic reticulum
Host membrane
Topology
Length:
2233
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.355090000000002
Exp number, first 60 AAs:
0.22111
Total prob of N-in:
0.01275
outside
1 - 2233
