Strain
Bat_MK720946
(Region: Hong Kong; Strain: Rhinolophus bat coronavirus HKU32 strain TLC28A, complete genome.; Date: 6-Aug-15)
Description
Annotated in NCBI,
envelope protein
Full name
Envelope small membrane protein
Sequence
CDS
ATGCTGACTTTAGTTAATGATAATGGCATGCTTCTCAATGCCATACTATGGATGTTTTTGCTACTATTTGTTTTGTTAGTAGCAACTACAATTATTAAACTCGTGCAACTTTGCTTCACGTGTCACCAGCTTATGTCTCGCACTATTTATGTGCCTGTGCATAATGCTTACAAAATTTATAAAGACTATATGCAAATAGCTCCTTGTCCTATTATCGAAGTCTAA
Protein
MLTLVNDNGMLLNAILWMFLLLFVLLVATTIIKLVQLCFTCHQLMSRTIYVPVHNAYKIYKDYMQIAPCPIIEV
Summary
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit
Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Similarity
Belongs to the alphacoronaviruses E protein family.
Ontologies
Subcellular Location
From MSLVP
Host nucleus. Host cytoplasm.
From Uniprot
Host Golgi apparatus membrane
The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.
Topology
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
22.83802
Exp number, first 60 AAs:
22.83743
Total prob of N-in:
0.04358
POSSIBLE N-term signal
sequence