Strain
Porcine_MK994936
(Region: China; Strain: Swine acute diarrhea syndrome coronavirus; Date: 18-Jul)
Gene
small membrane protein
Description
Annotated in NCBI,
small membrane protein
Full name
Envelope small membrane protein
Sequence
CDS
ATGTTTCTGAAGATTGTTGAGGATGATGGTTTGTTCATCAACACAGTCTTGTGGCTTTTAGTGTTGATACTTGTTCTCTTGGTGGCTATCACTGTTATTAAGCTCATACAGCTATGTTTTTCTTGTCATATGCTTATGAGTAATACCATATACATACCAGTGTATAATGCTTACCTTGTTTACAAGTCTTATATGGAAGTTGAACCATGCCCCATAATTAATGTCTAA
Protein
MFLKIVEDDGLFINTVLWLLVLILVLLVAITVIKLIQLCFSCHMLMSNTIYIPVYNAYLVYKSYMEVEPCPIINV
Summary
Function
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Subunit
Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Similarity
Belongs to the alphacoronaviruses E protein family.
Ontologies
Subcellular Location
From Uniprot
Host Golgi apparatus membrane
The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.
Topology
Number of predicted TMHs:
2
Exp number of AAs in TMHs:
38.31696
Exp number, first 60 AAs:
37.71503
Total prob of N-in:
0.08840
POSSIBLE N-term signal
sequence