Strain
Avian_MN096598
(Region: China: Yunnan; Strain: Infectious bronchitis virus strain ck/CH/YNSL/160501, complete genome.; Date: 2016)
Gene
1a polyprotein
Description
Annotated in NCBI,
1a polyprotein
Location
GenBank Accession
Full name
Replicase polyprotein 1a
Alternative Name
ORF1a polyprotein
Sequence
CDS
ATGGCTTCAAGCCTAAAACAGGGAGTATCTTCCCAAAACCAGAGGAGTGTCGTTCTTGTTGCCAAAGACATTCCCGCCCAACTTCGTGACGCTTTGTTTTTCTATACGTCACACAATCCAAAAGATTACGCTGATGCTTTTGCTGTTAGGCAGAAGTTCGACCGTAATCTGGGAGCTGGGAAACAGTTTAAATTTGAAACTGTGTGTGGTCCATTCCTCTTGAAAGGGGTGGACAAAATAACACCAGGTGTCCCAGCAAAAGTTTTGAAAGCCACTGCAAAGTTGGCTGATATAGAAGACATCTTTGGTGTCTCTCCCCTTGCACGGAAATACCGTGAATTGTTGAAAAGTGCATCTCAGTGGTCGCTCAATGTAGAAACTCTAGATGCTCAGGCACAAACTCTTGATGAGATTTTTGAACCAACTGAAATACTTTGGCTTCAAGTGGTTTCAAAGATCCAGGTCGCAGCTATGGCAATGCGCAGGCTTGTTGGTGAAGTAACTGCAAAAGTCATGGATGCTCTCGGCTCAAGTTTGGGTTCTCTTTTTCAAATTGTTAAAGACACAATGTCCAGAATCTTCCAAAAGGCCCTGGCCATTTTTGAAAATGTGAGTGAGCTACCACAGCGTATCTTGGCACTTAAAATGGCTTTTGCTAAATGTGCCAAATCAATTACTGTTGTGGTCGTTGAAAGAGCTCTTGTGATTAGAGAGTTTGCGGGAACTTGTCTTGCAAGTATTAATGGTGCCGTTGCTAAATTCTTTGAAGAACTTCCAAACGGCTTTATGGGAGCAAAGGTGTTTTCAACTCTAGCCTTCTTTAAGGAAGCGGTTGTGAAGATCGTAGAAAATATACCTAATGCACCAAGAGGTACTAAGGGTTTTGAAGTTGTTGGCAATGCGAAAGGTACACAAGTTGTTGTCCGTGGCATGCGAAATGACTTAACTCTGCTTGACCAAAAAGCTGAGATTCCAGTTGAACCAGAAGGTTGGTCTGCAATTTTGGAGGGACATCTTTGCTATGTCTTTAAGAGCGGTGATCGATTTTATGCGACGCCTCTTTCAGGAAATTTTGCATTGCATGATGTGCATTGCTGCGAGCGTGTTGTCTGTCTGCCTGATGGTGTTACACCAGAGATAAATGATGGACTCATTCTTGCTGCAATTTACTCATCCTTTAGCATCTCTGAACTTGTGGCTGCACTTAAAAAAGGTGAACCATTCAAGTTCTTGGGACATAAATTTGTGTATGTGAAGGAAGCAGCGGTTTCTTTCACTTTGGGAAAAGCAGCAACCATTGCTGATGTCTTGAAGCTGTTTCAATCAGCCAGAGTAAAGACAGAAGATTGTTGGTCTGCACTTACTGAAAGGTCTTTTGACTTCTGGAGACTCGCATATGGGAAAGTGCGTAACCTTGAAGAATTTCTGAAGACTCACTTTTGTAAAGCTCAAATGTCAATTGTGATCCTGGCAGCAGTGCTAGGTGAAGGCATTTGGCAACTTTGTTCTCAAGTCATCTATAAATTGGGTGGTTTGTTTACTAAAGTTGTTGATTTTTGTGAAAAACACTGGAAGGGTTTCTGTGCACAACTTAAAAGAGCAAAGCTCATTGTGACTGAAAAACTTTGTGTTTTGAAAGGAATTGCACAGCATTGTTTTCAACTACTGCTGGATGCAATACACTCCATGTATTTGGGTTTTAAAAAATGTGCACTCGGTAGAATCCATGGAGATTTGCTCTTCTGGAGAGGGGGTGTGCACAAGATTGTTCAAGATGGCGATGAAATTTGGTTTGACGCCATTGACAGTATTGATGTTGATGATCTGGGTGTTGTTCAAGAAAAACCTGTAGATTTTGAGGTCTGTGATGACGTGACACTTCCAGAAAATCAACCAGGACACATGGTTCAAATCGTTGATGATGGAAAGAACTATATGTTCTTTCGCTTCAAAAAAGATGAGAACATTTATTATACACCAATGTCACAACTTGGTGCAATTAACGTAGTCTGCAAAGCAGGTGGCAAAACTGTCACTTTTGGTGAAACTACTGTGAAGGAGATACCACCACCCGACGTCGTGTCTATTAAGGTGGGCATTGAGTGTTGTGGTGAACCATGGAATACAATCTTCAAGAAAGCTTATAAAGAGCCCATTGAAGTTGAGACAGACCTCACAGTAGAACAATTGCTCTCTGTGATCTATGAGAAAATGTGTGACGATCTTAAATTGTTTCCAGAGGCTCCAGAACCTCCACCATTTGAGAATGTTGCACTTGTGGATAAAAACGGTAAAGACTTGGATTGCATTAAATCATGCTACCTTGTTTACCGTGATTATGAAAGTGATGATGACATCGAGGAAGACGAAGAAGAGGAGTGCAACACGGCTTCAGATGATGCTGAGGAGTGTGACACAGCTTCGGAATGTGACGAAGAAGACGAGGCTACTAAGGTGCTGGCTCTTATACAAGACCCAGCAAGTAATAAGTACCCTCTGCCTCTTGATGATGATTACAGCGTTTATAATGGTACAATTGTCCATAAAGACGCTCTTGATGTCGTTAACCTTCCATCAGGTGAAGAGACTTATGTCATTAACAATTGCTTTGATGGAGCTGTTAAACCACTCCCAAAAGCTGTCGTTGATGTGCTTGGAGACTGGGGTGCAGCTGTTGATGCTCAGGAGAAATCTCTGAATCAAGAGGCTGCACATGATAATGTTGTTTCATGTGAAGAGACATCAATTGTTGAGGAGGTTGTTGTACAAATAGCTACTCCTGTTGTAGAACGAGAGCAGGAAGTTGTCGTTTACACGCCTGCTTCTGTTGATACTATAAAGGAAACGTCTGAGGAAGTAGATGAGTTTATCTTAATTCCTGATGTTCTTACTGATGAAGAAGTATCTTCAGCACAAGAAGATTCTAGTGTTGTTTCAGTTGAAATTGCAACTGGCGCTAGTCAAAAAACTTCTCCTACCGAACAAGAAGTAGTGCAGGAGGAAGAAGAAAAAGTTGAAGTGCCTACTCAAGTTGCTAAACCACAACGTGAGAAGAAGGCAAAGAAGTTTAAAGTCAAATCAACTACGCAAAAGCCTCCTAAGGATTTGGAGTATAAAACATGTGTAGGTGACTTGACTGTTGTAATAGCCAAAGCTTTGGACGAGTTTAAAGAGTTTTGCATTGTAAACGCTGCAAATGAGCATATGTCTCATGGGGGTGGCGTTGCTAAAGCAATTGCAGACCTTTGTGGTCCTGATTTTGTGGAGTACTGTGAAGACTATGTTAAGAAACATGGTCCACAGCAAAGACTTGTTACACCTTCTTATGTCAAAGGCATTCAATGTGTTAACAATGTTGTTGGACCACGCCATGGAGATTGCGACTTGTTTAATAAACTTGTCGCTGCCTACAAGAATGTTCTTGTAGATGGTGTGGTTAATTATGTTGTTCCAGTGCTATCTTCAGGCATTTTTGGAGTTGATTTCAAATTGTCAATAGACGCTATGCGTGAAGCTTTTAATGGCTGCAACATACGTGTCCTGCTCTTTTCTCTGTTGCAAGAACACATCAATTATTTTGATGCAACTTGCAGACAGAAGACAATTTATATTACGGAGGACGGTGTTAAATTCCGTTCTGTTATTGTTAAACCTGGTGATTCTTTGGGTCAATTTGGACAGGTTTTTACGAGACACAAGACAGTCTTTACTGCTGATGATGTAGAGGATAATGAAATTCTCTTTGTTCCAACGACAGATAAGGCTGTGCTTGATTATTATGGTTTAGATGCGCAAAAGTATGTGAAATTTTTACATACACTTGCGCAGAAATGGAATATTCTTTATAAGGACAATTTTGTTATACTTGAGTGGCGTGATGGAAATTGCTGGATAAATGCAGCGATTGTAATCCTTCAGGCTGCTAAGATTAGGTTTAGAGGTTTTCTTGCAGAAGCATGGGCTAAGCTGTTGGGTGGAGACCCCACTGACTTTGTAGCTTGGTGCTATGCAAGTTGCAATGCTAATGTTGGTGAGTTTTCAGATGCTAATTGGCTTTTGGCCAATTTAGCTGAATATTTTGATGCAGATTACACTAATGCACTTCTTAAGAGGCGTGTTATGTGCAACTGTGGTGTTAAAGTTCAGGAGTTTAGGGGCCTTGAAGCTTGTATTCAACCAGTAAAGGCACCTAACCTTCTACATTTTAAGACGCAATATTCAAATTGCCCTGTTTGTGGTTCAAATAGTACAGATGAAGTAGTTGATGCTACACTTCCTTATCTGCTACTAGTAGCTACAGATGGACCTGCAACAGTCGATTGTGATGAAAATGCTGTAGGGAACGTTGTATTTATAGGTTCCACCAATAGTGGTCATTGTTATACTCAAGCCGTAGGTAAGGCTTTTGACAATCTTGCTAAGGATAGAAAATATGGAAGGAGGTCGCCTTACATTACAGCAATGTACACGCGTTTCTCCCTTAAGAATGAAAGTTCTTTACCTGTTGCTACTAAAAAGAGCAAGGGTAAAGATAAAGTAGTAAAAGAAGATGTTTCTAACCTTGCCACTAGTTCAAAGGCCAGTTTTGATGATCTTACTGACTTTGAAAGGTGGTATGATAGTAATATCTATGAGAGTCTTAAAGTGCAGGAAACACTTGAGAATTTTGATGAATATGTGTCATTCACAACAAAGGAAGATTCTAAGTTGCCACTGACACTTAAAGTTAGAGGCATCAAGTCAGTTGTCAACTTTAAGTCAAAAGATGGTTTTACTTACAATTTGACACCTGACACTGATGAAAATTCAAAAGCACCAATTTACTATCCAGTCTTAGATTCTGTTAGTCTTAAGGCGATATGGGTAGAAGGCAGTGCTAATTTTGTTGTGGGACACCCCAACTATAATAGTAGAGCTCTGCGTATCCCTACATTTTGGGAGTGTGCAGAGAGCTTTGTTAAAATAGGTGAGAAAGTTGATGGTGTTACTATGGGCATATGGCGTGTAGAATGCCTTAATAAACCTAATTTAGAAAAGATGTTCAGCATCATTAAGAAAATGATTGCTGGATCAAGTGTTGTTACTACACACTGTGGCAAATTAATTGGCAATGCAGCTATATTCGTTGCTGATAAACTTGGCGGTGGTGTAGTGCGTAATGTTACAGATAGAATTAAGGGCGTTTATGGAAGTACACGTGGACATTTTGAAAGAAAAATGTCACCACAATTCCTAAGAACACTCTTTTTCTTTTTCTTTTATCTCTTAAAGGCAGGCGCTAAGAGTTTGGTTGCTAGCTATAAGAGTGTGTTATGTAAAGTAGTCTTTACTACTTTATTTATATTATGGTTTTTATACACAAGTAATCCAGTAATGTTTACTGGTATACGGGTGTTAGACTTCCTATTTGAAGGCTCATTCTGTAGTCCTTATCAAGATTATGGGAGGGATTCGTTTGATGTTTTACGCTATTGTGCAGAAGATTTTACTTGTCGTGTGTGTTTACATGACAGGGATTCACTTCATTTGTACAAACATGCTTATAGCGTAGAACAAATTTATAAGGCTGCAGCTTCTGGCATTAGTTTTAATTGGAATTGGCTTTATTTAGTCTTTCTAATATTGTTTGTTAAGCCAGTAGCAGGTTTTGTTATTATTTGTTATTGTGTTAAGTATTTGGTATTGAGTTCAACTGTCCTTCAAACTGGTGTAAGTTTTCTTGACTGGTTTATTCAAACAGTCTTTACTCACTTTAATTTCATGGGTGCAGGATTTTACTTCTGGCTCTTTTATAAGATATACATACAGGTGCATCATATACTGTATTGTAAGGATATAACATGTGAAGTGTGCAAGAGAGTTGCGCGCAGCAACAGACATGAGGTTAGCGTTGTTGTAAGTGGACGCAAACAAATTGTGCATGTGTACACTAATTCTGGCTACAATTTTTGTAAGAGACATAACTGGTATTGTAAGAATTGTGATGAGTATGGTCATCAAAATACATTTATGTCTCCTGAAGTTGCTGGCGAGCTTTCTGAAAAGCTTAAACGCCATGTTAAACCTACAGCTCATGCTTACCACATTGTGGATGAGGCGTGTTTAGTTGAGGATTTTGTTAATCTAAAGTACAAAGCTGCAGTTCCTGGTAAGGATAGTGCAGCTCCTGCAGTTAAATGTTTCAGTGTTACAGACTTTTTGAAAAAAGCTGTATTCCTTAAGGATGCACTGAAATGTGAACAAATCTCTAATGATGGTTTTATAGTGTGTAATACACAGAGTGCGCATGCATTGGAAGAAGCAAAGAATGCTGCCATCTATTATGCGCAATATCTGTGTAAACCAATACTTATACTTGATCAGGCACTTTACGAGCAATTAGTAGTGGAACCTGTGTCTAAGAGTGTTGTAGATAAGGTGTGTAGCATCTTGTCTAATATAATTTCTGTAGATACTGCTGCTTTAAATTATAAGGCGGGTACACTACGTGATGCTCTCCTTTCTATTACTAAAGATGAAGAAGCTGTTGATATGGCTATCTTCTGTCATAATCATGAAGTGGAACACACTACACGCAGATGCTTCCGTATCCAACCTAAGAGTCAAAAATGCTCCACCGGTGGTATGGAAGTTTTCTGTCTTATTAAGTTGTCTGACAGTTGCCTTAAATATTTAATTTCAGCAACTGTCAAGTCAGGAGGTCGTTTCTTTATTACAAGGTCTGGTGCTAAACAAATTATTTCGTGTCACACACAGAAATTGTTGGTAGAGAAAAAGGCTGGCGGTCTCGTTAGCAGCACTTGTAAAAAGGTTAGGAGTGGTTGTAAATGGCTCTTGATCTTTTATATATCATTTATAGCATGTTGTTTGGGTTACTATCACATGGAGATGGGTAGAAGTTTTGATCATCCTATGTATGATGTTAACTCTACACTGCATGTTGAAGGTTTTAAGGTTATAGATAAAGGTGTTATTAGGGACATTGTGCCAGAAGACACCTGCTTTTCTAATAAGTTTGTTAATTTTGATGCCTTTTGGGGTAAACCATATGAAAATAGTAGAGACTGTCCAATTGTAACAGCCATTATAGATGGTGCTGGAACAGTAGCTGCTGGAGTTCCTGGTTTCGTACAGTGGGTAATGGATGGAGTTATGTTTGTACACATGACACAAACTGAGCGAAAACCTTGGTATATTCCTACTTGGTTTAATAGAGAAATTGTTGGTTACACTCAGGACTCAATTATTACTGAGGGTAGTTTTTATACATCTATAGCGTTGTTTTCAGCTAGGTGCTTATATTTAACAGCCAGCAATACACCACAGTTGTATTGTTTTAACGGCGACAATGATGCTCCTGGTGCTTTACCATTTGGAAGTATAGTCCCACACAGGGTCTACTTTCAACCAAATGGGGTTAGACTTATAGTTCCTCAGCAAATACTGCACACACCCTACATAGTAAAGTTTGTATCAGACAGCTATTGTAGAGGTAGTGTATGTGAGTACACTAGGCCAGGTTACTGTGTGTCATTGGACTCTAAATGGGTCTTGTTTAATGATGAGTACACGGTTAAACCAGGTGTGTTTTGTGGTTCTACTGTTAGAGAACTTATGTTTAATATGGTTAATACATTTTTTACTGGTGTTAACCCTAATATTTATATGCAACTGGCAACTATGTTTTTAATATTAGTTGTTGTTGTATTAATTTTTGCAATGGTTATAAAGTTTCAAGGTGTATTTAAAGCATATGCCACCATTGTGTTTACAATAATGTTAGTTTGGGTTATTAATGCATTTATTCTTTGTGTACATAGTTATAATAGTGTTTTAGCTGTTATATTACTTGTACTCTATTGCTATGCATCATTGGTTACAAGCCGCAATACTTCTATAATAATGCATTGCTGGCTTGTGTTTACTTTTGGTTTAATAGTGCCTATGTGGATAGCCTGTTGCTATTTGGCATTTGTACTTTATGTCTATACACCATTTTTCTTTTGGTGTTATGGTACTACTAAAAATATTCGTAAGCTTTATGATGGCAATGAGTTTGTTGGTAATTATGATCTTGCTGCGAAGAGCACTTTTGTGATTCGTGGTTCTGAATTTGTTAAGCTTATGAATGAGATAGGTGATAAATTTGATGCCTATCTTTCTGCGTACGCTAGACTTAAATATTACTCAGGCACTGGAAGTGAACAGGACTACATTCAAGCCTGTCGTGCTTGGTTGGCTTATGCACTTGACCAATATAGAAATAGTGGTGTAGAAATGGTTTATACTCCACCTCGTTACTCAATTGGTGTTAGTAGATTACAAGCTGGTTTTAAGAAACTAGTATCTCCTAGTAGTGCTGTTGAGAAGTGCATTGTTAGTGTATCCTATAGGGGTAATAATCTTAATGGATTGTGGTTGGGTGACTCCATCTACTGTCCACGTCATGTGGTAGGTAAGTTTAGTGGTGACCAATGGGGTGATGTTCTTAACCTTGCTAATAACTATGAGTTTGAAGTTACGACTCAAAATGGAAGCACTTTGAATGTTGTCAGTAGGCGTTTGAAAGGTGCAGTTTTAATATTGCAAACTGCTGTTGCTAATGCTGAAACTCCAAAGTATAAATTTTTGAAGGCAAATTGTGGTGATAGTTTCACTATAGCTTGTTCTTATGGTGGTACAGTTATTGGACTTTACCCTGTTACTATGCGTTCTAATGGTACTATTAGAGCATCTTTCCTTGCTGGAGCCTGTGGTTCAGTAGGTTTTACTATAGAAAAGGGTGTAGTTAATTTCTTTTATATGCACCATCTTGAGCTACCTAATGCATTACACACTGGAACTGACCTAATGGGTGAATTCTATGGTGGTTATGTGGATGAAGAGGTTGCACAAAGAGTGCCACCAGATAACTTAGTTACTAACAATATTGTTGCATGGCTTTATGCTGCAATTATTAGTGTTAAAGAGAGTAGTTTTTCAAACCCTAAATGGATTGAGAGTACTACTGTTAGTGTTGATGATTATAATAGGTGGGCTGGTGATAATGGTTTTACACCATTTTCTACTAGTACTGCTATTACTAAATTAAGTGCTATTACGGGAGTTGATGTTTGTAAGCTCCTTCGCACTATTATGGTGAAAAACGGTCAGTGGGGTGATGAACCCATTTTAGGCCAATACAATTTTGAAGATGAGCTAACACCAGAATCTGTTTTTAATCAGGTTGGTGGTGTAAGGTTACAATCTTCTTTTGTGAAAAAAGCTACATCTTGGTTTTGGAGTAGATGTGTTTTAGCTTGTTTCTTGTTTGTGTTGTGTGCTATTGTCTTATTTACGGCAGTGCCACTTAGGTTTTATGTACATGCGGCTGTTATTTTGTTATCAGCTGTTCTGTTTATTTCTTTTACTGTGAAACATGTTATGGCATATATGGATACTTTCTTATTGCCGACATTGCTTACAGTTATTATTGGAGTTTGTGCTGAAGTACCTTTCATCTACAATACTCTAATTAGTCAAGTTGTTATATTCTTTAGTCAATGGTATGACCCAGTAATGTTTGATACTATGGTACCATGGATGTTCTTACCATTAGTCTTGTATACTGCTTTTAAGTGTGTACAGGGCTGTTATAGTGTGAATTCCTTTAGTACTTCTCTGTTAGTGTTGTATCAGTTTATGAAGTTAGGTTTTGTTATTTATGCCTCTTCTAATACGCTGGCAGCATACTCAGAGGGTAATTGGGAATTATTCTTTGAATTAGTTCATACTACTGTTTTGGCTAATATTAGTAGCAACTCTTTAGTTGGTTTAATTGTGTTTAAGTTTGCTAAATGGATGCTGTGTTATTGTAATGCAACATACTTTAATAATTATGTGCTAATGGCGGTCATTGTTAATGTCCTAGGTTGGCTTTTTACTTGTTACTATGCGTTCTATTGGTGGATTAATAAGGTTTTTGGTTTAACCTTAGGTAAATATAGTTTCAAAGTTTCAGTAGATCAATATAGGTATATGTGTCTCCATAAGATTAACCCACCTAAAACTGTGTGGGAAGTCTTTTCTACAAATATACTTATACAAGGTATAGGTGGTGACCGTGTGTTGCCTATAGCTACAGTGCAATCTAAATTGAGTGATGTAAAGTGTACAACTGTTGTCTTAATGCAGCTTTTGACTAAGCTTAATGTTGAAGCAAACTCAAAAATGCATGCTTATCTTGTAGAGTTACACAATAAAATTCTTGCCTCAGATGATGTTAATGAGTGCATGGATAATTTATTGGGTATGCTTGTAACACTATTTTGTGTAGATAGTACTATTGATTTAAGTGAGTATTGTGATGATATACTTAAGAGGTCTACTGTTTTACAGTCAGTCACTCAAGAGTTTTCACACATACCTTCTTATGCAGAGTATGAAAGAGCTAAAGACCTCTATGAAAAGGTTTTAGCTGAGTCTAAAAATGGTGGTGTTACACAGCAAGAGCTTGCTGCATATCGTAAAGCTGCCAATATTGCAAAGTCAATCTTTGATAGAGACTTGGCTGTTCAGAAGAAGTTGGATAGCATGGCTGAACGTGCTATGACAACTATGTATAAGGAAGCGCGTGTTACTGATAGAAGAGCTAAACTTGTTTCGTCATTACATGCGCTACTATTTTCTATGCTTAAGAAGATAGATTCTGAAAAGCTTAATGTACTATTTGACCAGGCAAGTAGTGGTGTTGTACCGCTAGCTACTGTTCCAATAGTTTGTAGTAATAAGCTTACTCTTGTAGTGCCAGATCCAGAGACTTGGGTCAAGTGTGTAGAGGGCATGCATGTTACATATTCAACAGTTGTTTGGAATATTGATAATGTCATTGATGCAGATGGCACTGAATTGCAACCAATTTCTACAGGTAATGGTTTAATTTACTGTATAAGTGGTGATAATATAGCATGGCCTCTTAAGGTCAATTTAACTAGGAATGTGCATAATAAAGTTGATGCAGTATTGCAGAACAACGAGCTTATGCCTCATGGTGTTAAAACAAAGGCATGCGTGGCAGGTGTAGATCAAGCACACTGCAGCGTAGAGTCTAAATGTTATTATACTAATATTAGTGGTAATTCAGTAGTGGCTGCTATTACCTCTTCAAATCCTAATTTGAGAGTTGCCTCATTTCTAAATGAAGCAGGCAATCAAATTTATGTTGACTTAGACCCGCCATGTAAATTTGGCATGAAGGTGGGTGATAAAGTAGAAGTTGTTTACTTGTATTTTATAAAGAATACAAGGTCAATTGTCAGAGGTATGGTACTTGGTGCTATATCTAATGTTGTGGTTTTACAGTCTAAAGGGTATGAGACAGAGGAAGTTGATGCTGTTGGCATACTATCACTTTGTTCTTTTGCAGTAGATCCGGCTGACACGTATATTAAATATGTGGCTGCAGGTAACCAACCTTTAGGTAACTGTGTAAAAATGTTGACAGTTCATAATGGTAGTGGCTTTGCTATAACATCAAAGCCAAGTCCAACTCCTGACCAGGATTCTTACGGAGGGGCTTCTGTGTGTCTCTATTGCAGGGCACATATAGCTCACCCGGGAAGTGCAGGAAATTTAGATGGACGTTGTCAATTTAAAGGTTCTTTTGTACAAATACCTACTACGGAGAAAGACCCTGTGGGATTCTGTCTACGTAATAAGGTTTGCACTGTTTGTCAGTGCTGGATAGGTCATGGATGTCAATGTGATTCACTTAGACAACCAAAACCTTCAGTTCAATCAGATGCTGGTGCACCCGGTTTTGATAAGAATTATTTAAACGGGTACGGGGTAGCAGTGAGGCTCGGCTGA
Protein
MASSLKQGVSSQNQRSVVLVAKDIPAQLRDALFFYTSHNPKDYADAFAVRQKFDRNLGAGKQFKFETVCGPFLLKGVDKITPGVPAKVLKATAKLADIEDIFGVSPLARKYRELLKSASQWSLNVETLDAQAQTLDEIFEPTEILWLQVVSKIQVAAMAMRRLVGEVTAKVMDALGSSLGSLFQIVKDTMSRIFQKALAIFENVSELPQRILALKMAFAKCAKSITVVVVERALVIREFAGTCLASINGAVAKFFEELPNGFMGAKVFSTLAFFKEAVVKIVENIPNAPRGTKGFEVVGNAKGTQVVVRGMRNDLTLLDQKAEIPVEPEGWSAILEGHLCYVFKSGDRFYATPLSGNFALHDVHCCERVVCLPDGVTPEINDGLILAAIYSSFSISELVAALKKGEPFKFLGHKFVYVKEAAVSFTLGKAATIADVLKLFQSARVKTEDCWSALTERSFDFWRLAYGKVRNLEEFLKTHFCKAQMSIVILAAVLGEGIWQLCSQVIYKLGGLFTKVVDFCEKHWKGFCAQLKRAKLIVTEKLCVLKGIAQHCFQLLLDAIHSMYLGFKKCALGRIHGDLLFWRGGVHKIVQDGDEIWFDAIDSIDVDDLGVVQEKPVDFEVCDDVTLPENQPGHMVQIVDDGKNYMFFRFKKDENIYYTPMSQLGAINVVCKAGGKTVTFGETTVKEIPPPDVVSIKVGIECCGEPWNTIFKKAYKEPIEVETDLTVEQLLSVIYEKMCDDLKLFPEAPEPPPFENVALVDKNGKDLDCIKSCYLVYRDYESDDDIEEDEEEECNTASDDAEECDTASECDEEDEATKVLALIQDPASNKYPLPLDDDYSVYNGTIVHKDALDVVNLPSGEETYVINNCFDGAVKPLPKAVVDVLGDWGAAVDAQEKSLNQEAAHDNVVSCEETSIVEEVVVQIATPVVEREQEVVVYTPASVDTIKETSEEVDEFILIPDVLTDEEVSSAQEDSSVVSVEIATGASQKTSPTEQEVVQEEEEKVEVPTQVAKPQREKKAKKFKVKSTTQKPPKDLEYKTCVGDLTVVIAKALDEFKEFCIVNAANEHMSHGGGVAKAIADLCGPDFVEYCEDYVKKHGPQQRLVTPSYVKGIQCVNNVVGPRHGDCDLFNKLVAAYKNVLVDGVVNYVVPVLSSGIFGVDFKLSIDAMREAFNGCNIRVLLFSLLQEHINYFDATCRQKTIYITEDGVKFRSVIVKPGDSLGQFGQVFTRHKTVFTADDVEDNEILFVPTTDKAVLDYYGLDAQKYVKFLHTLAQKWNILYKDNFVILEWRDGNCWINAAIVILQAAKIRFRGFLAEAWAKLLGGDPTDFVAWCYASCNANVGEFSDANWLLANLAEYFDADYTNALLKRRVMCNCGVKVQEFRGLEACIQPVKAPNLLHFKTQYSNCPVCGSNSTDEVVDATLPYLLLVATDGPATVDCDENAVGNVVFIGSTNSGHCYTQAVGKAFDNLAKDRKYGRRSPYITAMYTRFSLKNESSLPVATKKSKGKDKVVKEDVSNLATSSKASFDDLTDFERWYDSNIYESLKVQETLENFDEYVSFTTKEDSKLPLTLKVRGIKSVVNFKSKDGFTYNLTPDTDENSKAPIYYPVLDSVSLKAIWVEGSANFVVGHPNYNSRALRIPTFWECAESFVKIGEKVDGVTMGIWRVECLNKPNLEKMFSIIKKMIAGSSVVTTHCGKLIGNAAIFVADKLGGGVVRNVTDRIKGVYGSTRGHFERKMSPQFLRTLFFFFFYLLKAGAKSLVASYKSVLCKVVFTTLFILWFLYTSNPVMFTGIRVLDFLFEGSFCSPYQDYGRDSFDVLRYCAEDFTCRVCLHDRDSLHLYKHAYSVEQIYKAAASGISFNWNWLYLVFLILFVKPVAGFVIICYCVKYLVLSSTVLQTGVSFLDWFIQTVFTHFNFMGAGFYFWLFYKIYIQVHHILYCKDITCEVCKRVARSNRHEVSVVVSGRKQIVHVYTNSGYNFCKRHNWYCKNCDEYGHQNTFMSPEVAGELSEKLKRHVKPTAHAYHIVDEACLVEDFVNLKYKAAVPGKDSAAPAVKCFSVTDFLKKAVFLKDALKCEQISNDGFIVCNTQSAHALEEAKNAAIYYAQYLCKPILILDQALYEQLVVEPVSKSVVDKVCSILSNIISVDTAALNYKAGTLRDALLSITKDEEAVDMAIFCHNHEVEHTTRRCFRIQPKSQKCSTGGMEVFCLIKLSDSCLKYLISATVKSGGRFFITRSGAKQIISCHTQKLLVEKKAGGLVSSTCKKVRSGCKWLLIFYISFIACCLGYYHMEMGRSFDHPMYDVNSTLHVEGFKVIDKGVIRDIVPEDTCFSNKFVNFDAFWGKPYENSRDCPIVTAIIDGAGTVAAGVPGFVQWVMDGVMFVHMTQTERKPWYIPTWFNREIVGYTQDSIITEGSFYTSIALFSARCLYLTASNTPQLYCFNGDNDAPGALPFGSIVPHRVYFQPNGVRLIVPQQILHTPYIVKFVSDSYCRGSVCEYTRPGYCVSLDSKWVLFNDEYTVKPGVFCGSTVRELMFNMVNTFFTGVNPNIYMQLATMFLILVVVVLIFAMVIKFQGVFKAYATIVFTIMLVWVINAFILCVHSYNSVLAVILLVLYCYASLVTSRNTSIIMHCWLVFTFGLIVPMWIACCYLAFVLYVYTPFFFWCYGTTKNIRKLYDGNEFVGNYDLAAKSTFVIRGSEFVKLMNEIGDKFDAYLSAYARLKYYSGTGSEQDYIQACRAWLAYALDQYRNSGVEMVYTPPRYSIGVSRLQAGFKKLVSPSSAVEKCIVSVSYRGNNLNGLWLGDSIYCPRHVVGKFSGDQWGDVLNLANNYEFEVTTQNGSTLNVVSRRLKGAVLILQTAVANAETPKYKFLKANCGDSFTIACSYGGTVIGLYPVTMRSNGTIRASFLAGACGSVGFTIEKGVVNFFYMHHLELPNALHTGTDLMGEFYGGYVDEEVAQRVPPDNLVTNNIVAWLYAAIISVKESSFSNPKWIESTTVSVDDYNRWAGDNGFTPFSTSTAITKLSAITGVDVCKLLRTIMVKNGQWGDEPILGQYNFEDELTPESVFNQVGGVRLQSSFVKKATSWFWSRCVLACFLFVLCAIVLFTAVPLRFYVHAAVILLSAVLFISFTVKHVMAYMDTFLLPTLLTVIIGVCAEVPFIYNTLISQVVIFFSQWYDPVMFDTMVPWMFLPLVLYTAFKCVQGCYSVNSFSTSLLVLYQFMKLGFVIYASSNTLAAYSEGNWELFFELVHTTVLANISSNSLVGLIVFKFAKWMLCYCNATYFNNYVLMAVIVNVLGWLFTCYYAFYWWINKVFGLTLGKYSFKVSVDQYRYMCLHKINPPKTVWEVFSTNILIQGIGGDRVLPIATVQSKLSDVKCTTVVLMQLLTKLNVEANSKMHAYLVELHNKILASDDVNECMDNLLGMLVTLFCVDSTIDLSEYCDDILKRSTVLQSVTQEFSHIPSYAEYERAKDLYEKVLAESKNGGVTQQELAAYRKAANIAKSIFDRDLAVQKKLDSMAERAMTTMYKEARVTDRRAKLVSSLHALLFSMLKKIDSEKLNVLFDQASSGVVPLATVPIVCSNKLTLVVPDPETWVKCVEGMHVTYSTVVWNIDNVIDADGTELQPISTGNGLIYCISGDNIAWPLKVNLTRNVHNKVDAVLQNNELMPHGVKTKACVAGVDQAHCSVESKCYYTNISGNSVVAAITSSNPNLRVASFLNEAGNQIYVDLDPPCKFGMKVGDKVEVVYLYFIKNTRSIVRGMVLGAISNVVVLQSKGYETEEVDAVGILSLCSFAVDPADTYIKYVAAGNQPLGNCVKMLTVHNGSGFAITSKPSPTPDQDSYGGASVCLYCRAHIAHPGSAGNLDGRCQFKGSFVQIPTTEKDPVGFCLRNKVCTVCQCWIGHGCQCDSLRQPKPSVQSDAGAPGFDKNYLNGYGVAVRLG
Summary
Function
The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc (By similarity).
The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK.
The peptide p16 might be involved in the EGF signaling pathway.
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.
Nsp9 is a ssRNA-binding protein.
The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK.
The peptide p16 might be involved in the EGF signaling pathway.
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.
Nsp9 is a ssRNA-binding protein.
Subunit
3CL-PRO exists as monomer and homodimer. The three peptides nsp2, nsp3 and nsp4 may form a complex. Nsp9 is a dimer. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp10 forms a dodecamer (By similarity).
Miscellaneous
Produced by conventional translation.
Similarity
Belongs to the coronaviruses polyprotein 1ab family.
Keywords
Activation of host autophagy by virus
Host cytoplasm
Host membrane
Host-virus interaction
Hydrolase
Membrane
Metal-binding
Protease
Repeat
Ribosomal frameshifting
RNA-binding
Thiol protease
Transmembrane
Transmembrane helix
Zinc
Zinc-finger
Feature
chain Replicase polyprotein 1a
Uniprot
EMBL
Proteomes
Pfam
Interpro
IPR018995
RNA_synth_NSP10_coronavirus
IPR036499 NSP9_sf
IPR014829 NSP8
IPR009003 Peptidase_S1_PA
IPR014822 NSP9
IPR014827 Viral_protease
IPR013016 Peptidase_C30/C16
IPR002589 Macro_dom
IPR037230 NSP8_sf
IPR038123 NSP4_C_sf
IPR014828 NSP7
IPR040795 Nsp1a_N
IPR036333 NSP10_sf
IPR032505 Corona_NSP4_C
IPR037204 NSP7_sf
IPR008740 Peptidase_C30
IPR036499 NSP9_sf
IPR014829 NSP8
IPR009003 Peptidase_S1_PA
IPR014822 NSP9
IPR014827 Viral_protease
IPR013016 Peptidase_C30/C16
IPR002589 Macro_dom
IPR037230 NSP8_sf
IPR038123 NSP4_C_sf
IPR014828 NSP7
IPR040795 Nsp1a_N
IPR036333 NSP10_sf
IPR032505 Corona_NSP4_C
IPR037204 NSP7_sf
IPR008740 Peptidase_C30
SUPFAM
Gene 3D
ProteinModelPortal
PDB
3LD1
E-value=0.0 Score= 652 Identity=87.99%
Cov(Q)=9.07% Cov(P)=99.72%
3D Structure
Ontologies
GO
GO:0003968 F:RNA-directed 5'-3' RNA polymerase activity
GO:0019082 P:viral protein processing
GO:0008270 F:zinc ion binding
GO:0044220 C:host cell perinuclear region of cytoplasm
GO:0003723 F:RNA binding
GO:0008242 F:omega peptidase activity
GO:0016021 C:integral component of membrane
GO:0004197 F:cysteine-type endopeptidase activity
GO:0039520 P:induction by virus of host autophagy
GO:0033644 C:host cell membrane
GO:0019079 P:viral genome replication
GO:0019082 P:viral protein processing
GO:0008270 F:zinc ion binding
GO:0044220 C:host cell perinuclear region of cytoplasm
GO:0003723 F:RNA binding
GO:0008242 F:omega peptidase activity
GO:0016021 C:integral component of membrane
GO:0004197 F:cysteine-type endopeptidase activity
GO:0039520 P:induction by virus of host autophagy
GO:0033644 C:host cell membrane
GO:0019079 P:viral genome replication
Subcellular Location
From MSLVP
Capsid
From Uniprot
Host membrane
nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). With evidence from 1 publications.
nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity). With evidence from 1 publications.
Topology
Length:
3948
Number of predicted TMHs:
18
Exp number of AAs in TMHs:
420.096449999999
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00234
outside
1 - 1744
TMhelix
1745 - 1767
inside
1768 - 1773
TMhelix
1774 - 1796
outside
1797 - 1852
TMhelix
1853 - 1875
inside
1876 - 1881
TMhelix
1882 - 1904
outside
1905 - 1908
TMhelix
1909 - 1931
inside
1932 - 2276
TMhelix
2277 - 2295
outside
2296 - 2357
TMhelix
2358 - 2380
inside
2381 - 2553
TMhelix
2554 - 2576
outside
2577 - 2580
TMhelix
2581 - 2603
inside
2604 - 2609
TMhelix
2610 - 2627
outside
2628 - 2646
TMhelix
2647 - 2669
inside
2670 - 3091
TMhelix
3092 - 3114
outside
3115 - 3118
TMhelix
3119 - 3138
inside
3139 - 3149
TMhelix
3150 - 3172
outside
3173 - 3191
TMhelix
3192 - 3214
inside
3215 - 3220
TMhelix
3221 - 3243
outside
3244 - 3252
TMhelix
3253 - 3275
inside
3276 - 3294
TMhelix
3295 - 3317
outside
3318 - 3948
