Strain
Porcine_MN249445
(Region: China; Strain: Coronavirus HKU15; Date: 2017/12/11)
Gene
ORF1a protein
Description
Annotated in NCBI,
ORF1a protein
Location
GenBank Accession
Sequence
CDS
ATGGCCAAGAACAAGTCCAAGCGCGACGCTATCGCGTTGCCTGAAAATGTACCACCACCTCTGCAACTTTTCATCCACGTTGCAGCTGCTGAAGAGGGTCACCCTAAGGTTACTACTTACCTTGGCAACTATAACCTCTACGCCACCAAGGCTCCGCCTGGCATGCAGGTTCTTAGTGCTAAAACCTCTCTTACTGATTTTGAGAATGTCTTTGGAGCTCAACCCACCTTGCGATCAATTCGTAATCTGGTGTGTGAGGCTCGCTCGGCTGAATGGACAACTTCCAAGAATGCTTTTGCACTCAAAGCTACTCAACTTGACTACTCTGATGCCGTTTTGAGGGCAATGATTCGTTTCTGCCCTCCAAAGGTGTCCACACTCGCTGCCTTTGCTCTTTTTGGCCGATTGGTTAGAATTGAGGACAAGGAACTTGCTGAGTTAGCTCGTGATACTGCCCTTGAGTTGGCGTACACTGCTAAAATTGGTACATCTCTTGCTGACACGAGATCTGTCTCACTTATTCATAAGGACGCCTATCTAACTCTCAGTAACGATGTTGTTGGCGTAACTTTTACTGCCGCACTTATGGCAAAGGCTACCACTGTTAATGGAGCAATGCAATACTCAAACTTTTACCTCTACCCTCGCGCCACTATCAAGGTGACCGATGGTAAGGCTGAAGCAATTGCAACTAAGCCTCTGCCTGCTGCCACTAAAGGCAAGCCAATCACAGAGGATGTCAACCTCCTCCCTGACTATCAGCAGCTGCTTGTTGATCAAGTGACTGGCACTGAGGTTAAGGTTGGAGCCTTAACTTATGTTAAGACCACTGACCTACCACCCCTTTACTTTCCCAAAGTTAAAGGCGGTGTTGTTGGTATTGCACTTAAGCAGCAGGGCACTGCGGCTAAGAAGCTCAATGTAGTCTTCCATGCTCAACCTGATGATGTCCTGCTAGCTTTCATACAACTTCAGCAATTCTTGAACCGCACTTCGGATTCAAGTGTTGAAATTACTGATTGCCAGAGTTATGAAGTCTCTCCAACTGTGACGGTAAAAATTGGCCCGTCTAAACCTGGAGATGTCATCGTGGCTACTGATGAGGAATACCTTAAATGCTTTGAAACCCCCGAGGTAGGTAGGCTCTATAAGGTTTTCCAAACTCAATCTTGGGCTATCATTGAGCGTTCCTTCTCCAGGATCCGCGTGTCCAAAGCTTTATCAGCATTTATAAGTTTTCTGCAAAACCTTGCAGATAACTTTACTGCACTAAGTGGTGTTGTCACTGCACTCATTCGTGAACTCCAGAATCTCACCCTGGATGTGGCGACACGTATTACTAACATACAATTTGTCTACCGTGCTGGTAAGCTTATTGTCGACACGACAAGTGTCATAGCTAAACTTTTCCAGCCATTTTGTGATTTTATATCACCTTTCCTTCGGAAAGTGGCTGGTTTTGCAATTTACACTGTTGGTAATCGCATGCTTATGTTTACCAGCACTGGCACTTTTCTTCTCACAAAGGCAACTACTAAGATACTCAATAAGGCAAAGTACATCTTTGATGTGGATCCTGAGTACCCAGTAGATGTAACGACATCCAAAGTTGTAGTACATGAAGCACTCCAGCAAACCGACACTAAACCTACTAGAGCTCTAGAGGCTGTTGATGTCGTTGTTGGTAATACTGTACTGCAAATGGCTACTGATGGCACTGCGTTCTACCCATCGGATGGTGCGCACGCCTCTCTTCCAGGATTCAAAGCAGGCTCGGATGAGCTTTTCATAAGCTTCAACTGCGACCTCTTTGATGATGAGACTAATGCTCAAATCAACGAAACACTCGCTGCATATGAGCTTAACCAACTAGTGGCTCCAGGTGATTCTACACCGCGTCAAATTGCGACGTTGGTTGTCGATACACTTGCAGATGCTATAACAGACCATTTTCCGGAGAAAACCATTGATCTACCTGAAGACTATCAAGTCTTTTCTGACCATGATGACCTCCCACTCGCACAATACCACATCCCTGATCACCTGAGCCTGTATATTCAGGCTATGGAAGGTGAAGATGATAGTGGTGATGAAATATGTATTGAGGACGATGATTACGACTGTCCTCAAGCCGACGAAGACACAGAAGGAGTAATTCCCCAACAGTGGGAACTTCCTGATGTTGATAAATTTTTACTCAAGATCCAGGAACGGAAGACCAGCAGCGACGAAGTACTTAGCGTTGACGTCTATCCTAAACCAGAGCCGGTCGGCAATGTTGGGATTGACGACAGCGCGTCGGAAAAGAAGCCAAATGGGGACCCAGTACTGGATCCTGAGGTTCACCCAACACTAGAGAGTGTGGATGTTGAACGACCAACCGGAACAGCAAACCAGGCTGTTGAAGACAAACCTTCTGATACCACCTTTGTGGTTGATGAGGTACAATTACAAGAATCAACACCAGAACCTGAACCCCGCTCCTATGAGGTGGAGTTTGATTCTGATGATGAAATTATTATTCCTATAGTACCAGTAACACCTGCGGATTTAAAACCACAGACTATTACTATAAAGGAGTACTTTAAGTCTGAAAAACTTGAGACTATTAACGAAGGATCCACAGAGTCAGTTACACAATCTGACGATTCGTTTGACGAGTCATTTATTGATGCTGAGTCTGATGATCCACAAGACCCTGCTGTATATGATGATACAACAATTATAACGGACAGCACTGATGTAGGCGATGAGCCTGAAACAACTCTAGCTACCATCGTTAACACACCTCTGACACTCGATAATAACTTGCCATCTGAAGCCATTAAACAACCCAGCCCGACTAAGGTTGAGTTAGTTGTTGGTGAATTGGCAAGTATTAAATTTGACAATTCTGTCCTAGTCAACCCTGCTAATGCGCAATTAACAAATGGCGGTGGAGCTGCCCGTGCAATTGCAAAATTAGCTGGTCCAAAATACCAAGAGTACTGTAATAGTGTGGCTCCTATCTCAGGACCGCTTACCACGGACTCTTTTGATGCCAAGAAACTTGGTGTAGCCTGCATCTTGCATGTAGTGCCACCCAAAGGTTCTGACCCTAATGTACAAGAACTCCTGTATCAAGCTTACAAGAGTATCCTTACTGAACCAGCACACTATGTTATACCTATACTAGGTGCTGGTATCTTTGGATGCAACCCAGTCCACTCTCTGGATGCGTTCAGGAAAGCATGTCCAAGTGACATAGGTCGTGTGACCCTTGTCACTATGAACAAAAACCATTTGCAGGTGTGGGATGCTCTCAATAGGACCATTGTACGCACCACTACTGATTATGATCAAGTCACCACCAAGGCCCTTACACCCCAGGGAGTGTTAGAAGCCAATCTCTTTGATGGTGAGGACTTTGTTCAAGAACCAAAACCCGGTCAAATCTACCTTGAGGTTACTGAAGAAGTTCAGAACCAAGCCAAGGAACTTGACCTTAACCTTCAGCAATACTGTGTCTACCTGAAGACTTGCCACCATAAATGGGTTGTGAGTCGTACGAACGGGTTGATGCATCTAAAACAAAAAGATAACAATTGTTTTGTTAGTGCAGGTGTAAACCTGTTTCAAAACACTGCTTATCAACTTAGACCTGCTATTGATGCTCTCTATAGGGAGTATCTCAATGGTAATCCAAACAGATTTGTTGCTTGGATCTACGCATCCACTAACCGTCGTGTTGGTGAGATGGGTTGTCCACAGCAAGTTATTTCTTTGCTCGTTAGTAATTCTGACGCAGCATTTTCAGCAACTACAGCCTGTTGTAACACCTACTTTAACCACACAGGTGTTATTTCAGTAGCTTGTGAATATGACCCAATACAACCAAAGGTCTACTGCATGAAGTGTGATGTGTGGACTCCCTTTACACCTCAGAGTGGAAAAGGTGCAGTTGCAATTGGTACTTCTGCAGATGAACCTACCGGTCCTGCCATTAAATTTGCCGCAGCTCACTGCTGGTACACTAATGGCAAGAAAACAGTTAATGGCTATGACACTAAAGCTAATGTTGTAGCTACCTATCATAGGTTTGACGTGCCTAAGCCTCAACTTGTCGAGGACGTGGTTGCGCTGCCTACTAAAAATGACTTTGAAGTTCTCAATGTTGAAGAACTGCCACAGGATAGTGTGCTCCATTTGGACCCACCTCCTGTACAGGCCTTACAACCTAAGGCTAACCAACACATTGAGATTCTAGAAAACCCAGATTATCTGGACATTTTGGATCTATGGATTCGTAAACCCAAATTCATCCTCGTAAAGTCGTGGAGTGTTTTGGGTAGAGCACTATGTAAGGCAGGTAAAGTTGTCTTTGTCAGTGCTTCGCTTTTGACCCGTTTCTACAATTACCTTGTAGAGATTGGTGCTCTTGACTCAACAATAAGGTTGTCAGTCGATCTTACCTGTAAATTTGTTAGAACGGTACTCCCATCGTCTAACACTGTACACAAAACTTGTCTTGGTTTGTATTATTCAGCCCAGACACTTTTTGTTTCTTTAGCACCCTTCCTTATGTTACCAGCTGTAGTTAGTCTGCTTAATTCAGGCTATACAATTGGCACATATTTGTATGCAAAAACTGGCTGGCCTTGTAATTACAATGCCACGCAACACTTTGATTATAATTCTTACTGTGCAGGTGACTTGGTTTGTCAAGCCTGTTTTGACGGTCAAGACTCCCTACATTTGTATCCGCATTTACGTGTTAATCAGCAGCCCCTTCAGACCACTGACTACACTGTTTATGCGCTTTCACTAATACTACTATTAGCTAACATGACTCTTGTCATGGGCACGCTAATAGTTACTTTCTTTGTGAACTTCTATGGTGTGCAAATACCATTTTATGGTACACTTTTGATAGATTATCAGTCCGCGCTGATGATGACTTTCTCAGTGTACTACTTTTATAAGGTAATGAAGTTTTTCCGCCATCTCACACATGGATGTAAAATTCCAACGTGTATGGTATGTGCTAAACTTCGTACCCCACCTACTATAACAGTTGAGACTGTCGTTCAAGGCAGGAAATACCCATCTGTTATTGAAACAAATGGCGGGTTTACAATTTGTAAAGAACACAACTTCTATTGTAAAGACTGCTCTCTACAAACACCCGGCACTTTCATCCCGACAGAAGCTATTGAGTCGCTCTCACGAGCTACCAGGCTTAGTGTCAAACCAACAGCACCAGCATTCTTACTTGCTAGAGATGTTGAGTGCCAAACTGATGTTGTCGTTGCTCGCGCAATGCATAACCAAGATGCGCATGTGTGCATTTCAAAATACTCTGATATCCGTACCGTAGACCAACTACTTAAGCCTACTCCACTGTTTTCATACACTCCCGATGTTATCATCGCGGCAGACTTTGACAACAGAGGTAGTCTTAAGACAGCTAAAGAATTAGCTGTGGTTTTGTCAATGGACCTTAAACGTACTATAATTATCATTGATCAGGCCTATTCTAGACCCATTGATAATTATCAGGAAATTGCTTCTCGTATTGAGAAGTATTACCCAGTTGCAAAGATTACACCCACAGGTGACATCTTTACAGACATTAAGCAAGCGACCAATGGCCAAGCTAGTGACTCTGCTATTAATGCAGCTGTTCTGGCTGTCCAGCGCGGTCTTGATTTTACAATTGACAACCCTAACAATATATTACCACATTACGCCTTTGACTTTTCAACCCTCAATGCAGAAGACCAGTCTACCATTTTGGAGAGTGGTTGTGCTAAAGGTAATCTCAAGGGCACTAATGTTGGTGTTGTTCTTTCAGCTAGCCTTGTTACACGTCTTAGTCAGCAGGCTATACGTGTGATTGCTAATGCTGCTTCACGTAATGGTGTAACATGCGCTGTTACTCCATCTACACTTGTTATGCGTGGGAATATTGCAACACAGCCCTTGACTCGCATCAAAGCTGGTGCACCTCCCATGCGTCAAAAAATTTTATGTGTTATCCTGGCACTTGCTATTGTGTACTTTGCTGCTATGGCTTTTGGCTTTTTGGCAAGTCAAATTACGCTTAATACAGTGCCTACGATTAAATCTGATATCCGCTCCTCTACCTTCTACGTTGTTAGAGATGGAGTCTTGGATACTGTTCGCTCAAATGACAAGTGCTTTGCAAATAAGTTTTTGGCATTTGATAGCTTCATTCAAGCACCTTACACTAATTCACCTGACTGTCCAGTCGTTGTGGGAGTTGTTGAAGTAACGACGCACTCTATTCCTGGAATTCCAGCAGGTGTCATTCATAGAGACGGTCTCATACTTAACATTTATGAACAGTCTCTTTATGAAACCCATCAGCGTCAGTCTATGGTTAGGGATGCGTTGTCACTCAAGACAGCAAATCTCTTTAACCTAGGCAAGCGTGTTGTAGTAGGATACACTCAACATGAAGTTGTTGTGGGTACCTCCTATTTTAATTCTCCTGCACTTTTTAACGCAAAGTGCACCTTCTTACAGTATCAGGACACTAGACAACTCTATTGCTATGATACTGTTCCTACTGAACATAAGCTTTACTCTGATGTGCTTCCGCACGTCGAGTATAAGGCTATTGACATTAATGGTGATCTTGTTCCTTTCAAGATACCAGAGCAGATAATGTTCTATCCACATATTGTGCGCTATACTAGCAATTCCTATTGCCGTATGGGGCATTGTTTTAATACTAACCCTGGTATTTGCATTTCATTTACGGACGAATTTCCGTATAGTGAAAATGTTAAACCCGGTGTATACTGTGCTGATACCTCTTTGCAGTTGTTTTCAAACCTCGTTTTGGGCACTGTATCTGGTATTCACATCTTTACATCAACAGCTGCATTGCTTGGATCTACTATTGTGATCATACTATGCGTTGTTGCTGTTCTTGCAGTTCAGCGATTCTTCAAGGAGTACACAACTTTTGTTATGTACACTTGTGGTCTTGCTCTTGTCAACATTGTGGGCATTGCACTTATGTACAAGTGCCTTGTCTTCGCGATTTTTTATTATGCAATCTACCTTTACTTTGTCCTTACTTTCCCCTCCTTTAAGAGGAATGTGGCATTGTTTTACTTCGCTGTAGTGATCGTGCCGCACGTGAGTAACATGCAATTGCTTGCGCTCATTGTGTGTAGCATTATTTACTTTCTCTACACCTATGTTCATACTGTAGCTAAGACAGCTGGGAAATTTTCTTCCTTCTTAGACGCAGCTAAAGCTACTTTTGTCATTGACAATGAAAAGTACGTGTTGCTTAAAGACCTTGCTGGTGCTGAATTTGACCAGTATCTAGCCTCTTACAACAAGTACAAATACTTTTCTGGTACTGCTTCTGATAAGGATTATGATAAGGTCTGTATGGCATTTCTTGCCCAGGCTTTGTCATCTTTTCGTGAAGGAGGCGGTTCACAGTTGTATACACCACCTAAATTTGCAGTTGTTCAGAGTCTTAAAACCAAGCTGCAAGCAGGTATCAAAATCCTCCTGCACCCTTCAGGTGTAGTTGAGCGATGTATGGTTTCAGTTGTCTACAATGGATCTGCATTGAATGGCATCTGGCTTAAGAATGTTGTCTACTGCCCACGCCATGTAATTGGAAAATTCCGTGGTGACCAGTGGACTCACATGGTCTCAATTGCTGATTGCCGCGACTTTATAGTCAAGTGTCCAATACAGGGTATTCAGCTAAATGTCCAATCAGTTAAGATGGTAGGAGCTCTCCTCCAGTTAACTGTTCATACCAACAACACAGCCACTCCAGACTATAAGTTTGAAAGGCTCCAACCGGGATCATCGATGACAATTGCTTGTGCCTATGATGGCATTGTACGTCATGTCTACCACGTGGTCCTCCAACTTAATAATCTTATTTATGCAAGCTTCCTTAACGGAGCTTGTGGTAGTGTGGGTTACACTCTTAAGGGTAAAACACTCTACTTACATTACATGCACCACATTGAGTTTAATAACAAAACTCATAGTGGTACAGATCTTGAAGGTAACTTCTATGGCCCCTATGTGGATGAGGAAGTTATTCAGCAGCAAACAGCATTCCAGTATTATACTGATAATGTTGTTGCTCAATTATATGCACACTTACTGACTGTTGATGCTAGACCAAAATGGCTGGCACAATCTCAGATAAGTATCGAGGATTTCAACTCATGGGCTGCTAACAATTCCTTTGCTAACTTCCCATGTGAACAAACTAATATGTCTTACATTATGGGACTCTCGCAAACTGCTCGAGTTCCGGTAGAACGTATCCTCAATACCATTATACAGCTAACCACCAATAGAGATGGTGCTTGTATTATGGGATCTTATGATTTCGAGTGCGATTGGACGCCAGAGATGGTATACAATCAGGCTCCAATTTCATTGCAGTCAGGAGTAGTTAAGAAAACTTGTACGTGGTTCTTCCACTTCGTGTTTATGGCTATTACCATGCTACTCGCTGCCATGCATGTTTTCCCTGTACACTTGTACCCAATAGTACTGCCATGCTTCACTGTTGTGGCATTCCTGTTGACTTTAACCATTAAACACACTGTTGTGTTTACCACTACATATTTGCTTCCGTCACTTTTGATGATGGTTGTAAATGCTAACACTTTTTGGATACCGAACACATTTCTGCGCACCTGCTACGAAACTATATTCGGTTCCCCAATTGCTCAGCGACTGTATGGTTACACTGTTGCTCTTTATATGCTGATCTATGCTGGACTTGCAATCAACTATACGTTGAAAACACTCCGGTATAGAGCAACTTCATTCTTATCTTTTTGCATGCAGTGGTTTCAATATGGTTATGTTGCACACATTGCGTACAAACTGCTTAATAAACCCTGGACAGAATCACTACTCTTCACAGCCTTCACAATGCTAACCAGTCATCCTTTGTTGGCTGCTCTTAGCTGGTGGCTAGCTGGTCGCGTAACTCTGCCCATTATCATGCCTGACTTAGCTATTCGTGTTTTGGCGTATAACGTCATTGGCTATGTCATATGTGTTCGATTTGGCCTTATGTGGCTTGCAAATCGATTCACAACTGTACCTATGGGCACATACCAGTATATGGTGTCTGTAGAGCAACTTAAGTACATGATGGCAGTTAAGATGTCCCCCCCGCGTAATGCGTTTGAGGTGCTTATAGCCAACATTAGACTTCTTGGTTTGGGTGGAAACCGTAACATTGCTGTTTCTACTGTCCAAAACAAAATTCTTGATGCAAAAGCTACTGCTGTTGTTGTTGCTAACCTTCTTGAAAAGGCTGGCGTCACAAACAAGCACGCTATTTGCAAAAAGATTGTGAAACTCCACAATGATACCCTTAAAGCCACCACTTATGAGGAGGTTGAGGTAGCACTTGTGAAACTTCTTTCTCACATAATTGAGTTCTTGCCAACTGATCAGATAGATGCTTATCTAGCTGATGCGGCCAATGCTCAACATGTTAATACCTATTTCGACAACTTGCTTGAGAACAAAGCTGTTGTTCAGGCTGTTGCCGATATCAACATTAATCTGGATTCTTATAGAATTTATAAGGAGGCAGATGCTATTTACAAACGATCTGTTGAGATGAACGAATCTCCACAGGAGCAAAAGAAAAAGCTTAAAGCTGTTAACATTGCAAAGGCGGAATGGGAGCGTGAGGCTGCTTCTCAGCGTAAGCTTGAAAAGCTTGCTGATGCTGCTATGAAGTCTATGTATCTTGCAGAACGTGCTGAGGATCGTCGCATTAAGCTAACCTCTGGACTTACTGCAATGCTTTACCATATGCTTAGACGTCTTGACTCAGATAGGGTAAAAGCTCTGTTTGAGTGCGCTAAGGCACAAATCTTGCCAATACATGCTGTAGTTGGAATTTCTAATGATAACCTTAAAGTTATCTTTAACGATAAGGATAGCTACTCTCATTATGTAGAGGGCAACACACTTATACATAAGGGAGTTCGCTACACTATTGTGAAGAAACTCTCCTTAGATAATGCACCTATTGAAGGCGTACCAGAAGAATTCCCTGTGGTTGTTGAGACTGTTAGGGAAGGTGTGCCCCAGTTGCAAAACAATGAGCTATGTTTGCGCAATGTTTTCACTGCTCAGAACACAGCTCAGGACTTCAATGGCAATGAATCAACTGTAAAATCTTTTTATGTTACTAGAACCGGTAAGAAGATTTTGGTTGCCATTACATCAACTAAAGACAATCTTAAGACTGTGACCTGCCTTACTGAGACCGGTAAGACAGTCCTTAACTTGGACCCTCCTATGCGCTTCGCACATACTGTAGGTGGAAAACAGTCTGTTGTCTATCTCTATTTTATTCAGAATATTAGTTCACTCAACAGAGGTATGGTTATTGGCCACATCTCTGAAACTACTATCCTTCAGGCAAGTGGCACTCAAATTGAGTACCAGCAAAACGCCTCTCTTCTGACCTATTTGGCTTTCGCTGTAGACCCTAAGACAGCCTACCTTAAGCATCTTGCTGATGGTGGGTCTCCTATACAGGGTTGTATTCAGATGATTGCTACTATGGGTCCTGGATTTGCAGTTACTACTAAACCACAACCTAATGAGCATCAGTATTCTTATGGTGGTGCTTCAATTTGTCTTTATTGCCGTGCTCATATACCACATCCTGGTGTTGATGGACGGTGCCCCTACAAAGGCCGCTTTGTTCACATCGACAAAGATAAGGAACCTGTTTCCTTCGCCTTGACTCATGAGCCATGCAGTTCTTGTCAACGGTGGGTCAATTATGACTGCACCTGTGGATCTAGTCTGCAGAATTCGGCTTATTTAAACGAGTAA
Protein
MAKNKSKRDAIALPENVPPPLQLFIHVAAAEEGHPKVTTYLGNYNLYATKAPPGMQVLSAKTSLTDFENVFGAQPTLRSIRNLVCEARSAEWTTSKNAFALKATQLDYSDAVLRAMIRFCPPKVSTLAAFALFGRLVRIEDKELAELARDTALELAYTAKIGTSLADTRSVSLIHKDAYLTLSNDVVGVTFTAALMAKATTVNGAMQYSNFYLYPRATIKVTDGKAEAIATKPLPAATKGKPITEDVNLLPDYQQLLVDQVTGTEVKVGALTYVKTTDLPPLYFPKVKGGVVGIALKQQGTAAKKLNVVFHAQPDDVLLAFIQLQQFLNRTSDSSVEITDCQSYEVSPTVTVKIGPSKPGDVIVATDEEYLKCFETPEVGRLYKVFQTQSWAIIERSFSRIRVSKALSAFISFLQNLADNFTALSGVVTALIRELQNLTLDVATRITNIQFVYRAGKLIVDTTSVIAKLFQPFCDFISPFLRKVAGFAIYTVGNRMLMFTSTGTFLLTKATTKILNKAKYIFDVDPEYPVDVTTSKVVVHEALQQTDTKPTRALEAVDVVVGNTVLQMATDGTAFYPSDGAHASLPGFKAGSDELFISFNCDLFDDETNAQINETLAAYELNQLVAPGDSTPRQIATLVVDTLADAITDHFPEKTIDLPEDYQVFSDHDDLPLAQYHIPDHLSLYIQAMEGEDDSGDEICIEDDDYDCPQADEDTEGVIPQQWELPDVDKFLLKIQERKTSSDEVLSVDVYPKPEPVGNVGIDDSASEKKPNGDPVLDPEVHPTLESVDVERPTGTANQAVEDKPSDTTFVVDEVQLQESTPEPEPRSYEVEFDSDDEIIIPIVPVTPADLKPQTITIKEYFKSEKLETINEGSTESVTQSDDSFDESFIDAESDDPQDPAVYDDTTIITDSTDVGDEPETTLATIVNTPLTLDNNLPSEAIKQPSPTKVELVVGELASIKFDNSVLVNPANAQLTNGGGAARAIAKLAGPKYQEYCNSVAPISGPLTTDSFDAKKLGVACILHVVPPKGSDPNVQELLYQAYKSILTEPAHYVIPILGAGIFGCNPVHSLDAFRKACPSDIGRVTLVTMNKNHLQVWDALNRTIVRTTTDYDQVTTKALTPQGVLEANLFDGEDFVQEPKPGQIYLEVTEEVQNQAKELDLNLQQYCVYLKTCHHKWVVSRTNGLMHLKQKDNNCFVSAGVNLFQNTAYQLRPAIDALYREYLNGNPNRFVAWIYASTNRRVGEMGCPQQVISLLVSNSDAAFSATTACCNTYFNHTGVISVACEYDPIQPKVYCMKCDVWTPFTPQSGKGAVAIGTSADEPTGPAIKFAAAHCWYTNGKKTVNGYDTKANVVATYHRFDVPKPQLVEDVVALPTKNDFEVLNVEELPQDSVLHLDPPPVQALQPKANQHIEILENPDYLDILDLWIRKPKFILVKSWSVLGRALCKAGKVVFVSASLLTRFYNYLVEIGALDSTIRLSVDLTCKFVRTVLPSSNTVHKTCLGLYYSAQTLFVSLAPFLMLPAVVSLLNSGYTIGTYLYAKTGWPCNYNATQHFDYNSYCAGDLVCQACFDGQDSLHLYPHLRVNQQPLQTTDYTVYALSLILLLANMTLVMGTLIVTFFVNFYGVQIPFYGTLLIDYQSALMMTFSVYYFYKVMKFFRHLTHGCKIPTCMVCAKLRTPPTITVETVVQGRKYPSVIETNGGFTICKEHNFYCKDCSLQTPGTFIPTEAIESLSRATRLSVKPTAPAFLLARDVECQTDVVVARAMHNQDAHVCISKYSDIRTVDQLLKPTPLFSYTPDVIIAADFDNRGSLKTAKELAVVLSMDLKRTIIIIDQAYSRPIDNYQEIASRIEKYYPVAKITPTGDIFTDIKQATNGQASDSAINAAVLAVQRGLDFTIDNPNNILPHYAFDFSTLNAEDQSTILESGCAKGNLKGTNVGVVLSASLVTRLSQQAIRVIANAASRNGVTCAVTPSTLVMRGNIATQPLTRIKAGAPPMRQKILCVILALAIVYFAAMAFGFLASQITLNTVPTIKSDIRSSTFYVVRDGVLDTVRSNDKCFANKFLAFDSFIQAPYTNSPDCPVVVGVVEVTTHSIPGIPAGVIHRDGLILNIYEQSLYETHQRQSMVRDALSLKTANLFNLGKRVVVGYTQHEVVVGTSYFNSPALFNAKCTFLQYQDTRQLYCYDTVPTEHKLYSDVLPHVEYKAIDINGDLVPFKIPEQIMFYPHIVRYTSNSYCRMGHCFNTNPGICISFTDEFPYSENVKPGVYCADTSLQLFSNLVLGTVSGIHIFTSTAALLGSTIVIILCVVAVLAVQRFFKEYTTFVMYTCGLALVNIVGIALMYKCLVFAIFYYAIYLYFVLTFPSFKRNVALFYFAVVIVPHVSNMQLLALIVCSIIYFLYTYVHTVAKTAGKFSSFLDAAKATFVIDNEKYVLLKDLAGAEFDQYLASYNKYKYFSGTASDKDYDKVCMAFLAQALSSFREGGGSQLYTPPKFAVVQSLKTKLQAGIKILLHPSGVVERCMVSVVYNGSALNGIWLKNVVYCPRHVIGKFRGDQWTHMVSIADCRDFIVKCPIQGIQLNVQSVKMVGALLQLTVHTNNTATPDYKFERLQPGSSMTIACAYDGIVRHVYHVVLQLNNLIYASFLNGACGSVGYTLKGKTLYLHYMHHIEFNNKTHSGTDLEGNFYGPYVDEEVIQQQTAFQYYTDNVVAQLYAHLLTVDARPKWLAQSQISIEDFNSWAANNSFANFPCEQTNMSYIMGLSQTARVPVERILNTIIQLTTNRDGACIMGSYDFECDWTPEMVYNQAPISLQSGVVKKTCTWFFHFVFMAITMLLAAMHVFPVHLYPIVLPCFTVVAFLLTLTIKHTVVFTTTYLLPSLLMMVVNANTFWIPNTFLRTCYETIFGSPIAQRLYGYTVALYMLIYAGLAINYTLKTLRYRATSFLSFCMQWFQYGYVAHIAYKLLNKPWTESLLFTAFTMLTSHPLLAALSWWLAGRVTLPIIMPDLAIRVLAYNVIGYVICVRFGLMWLANRFTTVPMGTYQYMVSVEQLKYMMAVKMSPPRNAFEVLIANIRLLGLGGNRNIAVSTVQNKILDAKATAVVVANLLEKAGVTNKHAICKKIVKLHNDTLKATTYEEVEVALVKLLSHIIEFLPTDQIDAYLADAANAQHVNTYFDNLLENKAVVQAVADININLDSYRIYKEADAIYKRSVEMNESPQEQKKKLKAVNIAKAEWEREAASQRKLEKLADAAMKSMYLAERAEDRRIKLTSGLTAMLYHMLRRLDSDRVKALFECAKAQILPIHAVVGISNDNLKVIFNDKDSYSHYVEGNTLIHKGVRYTIVKKLSLDNAPIEGVPEEFPVVVETVREGVPQLQNNELCLRNVFTAQNTAQDFNGNESTVKSFYVTRTGKKILVAITSTKDNLKTVTCLTETGKTVLNLDPPMRFAHTVGGKQSVVYLYFIQNISSLNRGMVIGHISETTILQASGTQIEYQQNASLLTYLAFAVDPKTAYLKHLADGGSPIQGCIQMIATMGPGFAVTTKPQPNEHQYSYGGASICLYCRAHIPHPGVDGRCPYKGRFVHIDKDKEPVSFALTHEPCSSCQRWVNYDCTCGSSLQNSAYLNE
Summary
Catalytic Activity
ATP + H2O = ADP + H(+) + phosphate
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)
Similarity
Belongs to the coronaviruses polyprotein 1ab family.
Uniprot
Pubmed
EMBL
Proteomes
Pfam
Interpro
IPR032505
Corona_NSP4_C
IPR009469 RNA_pol_N_coronovir
IPR008740 Peptidase_C30
IPR027352 CV_ZBD
IPR001205 RNA-dir_pol_C
IPR036333 NSP10_sf
IPR037227 EndoU-like
IPR014822 NSP9
IPR009003 Peptidase_S1_PA
IPR027417 P-loop_NTPase
IPR037230 NSP8_sf
IPR038123 NSP4_C_sf
IPR029063 SAM-dependent_MTases
IPR018995 RNA_synth_NSP10_coronavirus
IPR009466 NSP11
IPR014829 NSP8
IPR014827 Viral_protease
IPR042515 Nsp15_N
IPR009461 Coronavirus_NSP16
IPR002589 Macro_dom
IPR027351 (+)RNA_virus_helicase_core_dom
IPR007094 RNA-dir_pol_PSvirus
IPR036499 NSP9_sf
IPR009469 RNA_pol_N_coronovir
IPR008740 Peptidase_C30
IPR027352 CV_ZBD
IPR001205 RNA-dir_pol_C
IPR036333 NSP10_sf
IPR037227 EndoU-like
IPR014822 NSP9
IPR009003 Peptidase_S1_PA
IPR027417 P-loop_NTPase
IPR037230 NSP8_sf
IPR038123 NSP4_C_sf
IPR029063 SAM-dependent_MTases
IPR018995 RNA_synth_NSP10_coronavirus
IPR009466 NSP11
IPR014829 NSP8
IPR014827 Viral_protease
IPR042515 Nsp15_N
IPR009461 Coronavirus_NSP16
IPR002589 Macro_dom
IPR027351 (+)RNA_virus_helicase_core_dom
IPR007094 RNA-dir_pol_PSvirus
IPR036499 NSP9_sf
SUPFAM
Gene 3D
ProteinModelPortal
PDB
2Q6F
E-value=3e-71 Score= 242 Identity=44.44%
Cov(Q)=8.44% Cov(P)=99.03%
3D Structure
Ontologies
GO
GO:0039694 P:viral RNA genome replication
GO:0033644 C:host cell membrane
GO:0044165 C:host cell endoplasmic reticulum
GO:0005524 F:ATP binding
GO:0019082 P:viral protein processing
GO:0008270 F:zinc ion binding
GO:0016896 F:exoribonuclease activity, producing 5'-phosphomonoesters
GO:0016021 C:integral component of membrane
GO:0004197 F:cysteine-type endopeptidase activity
GO:0003724 F:RNA helicase activity
GO:0039520 P:induction by virus of host autophagy
GO:0008168 F:methyltransferase activity
GO:0003968 F:RNA-directed 5'-3' RNA polymerase activity
GO:0032259 P:methylation
GO:0006351 P:transcription, DNA-templated
GO:0003723 F:RNA binding
GO:0044220 C:host cell perinuclear region of cytoplasm
GO:0008242 F:omega peptidase activity
GO:0033644 C:host cell membrane
GO:0044165 C:host cell endoplasmic reticulum
GO:0005524 F:ATP binding
GO:0019082 P:viral protein processing
GO:0008270 F:zinc ion binding
GO:0016896 F:exoribonuclease activity, producing 5'-phosphomonoesters
GO:0016021 C:integral component of membrane
GO:0004197 F:cysteine-type endopeptidase activity
GO:0003724 F:RNA helicase activity
GO:0039520 P:induction by virus of host autophagy
GO:0008168 F:methyltransferase activity
GO:0003968 F:RNA-directed 5'-3' RNA polymerase activity
GO:0032259 P:methylation
GO:0006351 P:transcription, DNA-templated
GO:0003723 F:RNA binding
GO:0044220 C:host cell perinuclear region of cytoplasm
GO:0008242 F:omega peptidase activity
Subcellular Location
From MSLVP
From Uniprot
Host cytoplasm
Host perinuclear region
Host endoplasmic reticulum
Host membrane
Host perinuclear region
Host endoplasmic reticulum
Host membrane
Topology
Length:
3624
Number of predicted TMHs:
14
Exp number of AAs in TMHs:
326.34123
Exp number, first 60 AAs:
0.00504
Total prob of N-in:
0.07728
outside
1 - 1510
TMhelix
1511 - 1533
inside
1534 - 1598
TMhelix
1599 - 1621
outside
1622 - 1630
TMhelix
1631 - 1653
inside
1654 - 2001
TMhelix
2002 - 2024
outside
2025 - 2290
TMhelix
2291 - 2313
inside
2314 - 2333
TMhelix
2334 - 2356
outside
2357 - 2370
TMhelix
2371 - 2402
inside
2403 - 2822
TMhelix
2823 - 2842
outside
2843 - 2845
TMhelix
2846 - 2863
inside
2864 - 2869
TMhelix
2870 - 2892
outside
2893 - 2911
TMhelix
2912 - 2934
inside
2935 - 2940
TMhelix
2941 - 2958
outside
2959 - 2972
TMhelix
2973 - 2995
inside
2996 - 3006
TMhelix
3007 - 3029
outside
3030 - 3624
