Sequence

CDS

ATGATGAATGTACTGAATAAGTCGCTACAGGAGAACGGAAGTTTTCTAACAGCACTTTATGTATTTGTGGGCTTTATAGCACTCTATCTATTAGGAAGAGCGCTACAAGCATTTGTACAAGCAGCTGATGCTTGTTGCTTATTCTGGTACACATGGGTAGTAGTTCCTGGATCTAAGGGCACAGCCTTTGTGTACAAGCATACATATGGTAAAAAACTTAACAATCCGGAATTAGAAGCGGTTATTGTTAACGAGTTCCCAAAGAACGGTTGGAATAATAAAAATCCATCAAATTTTCAAGATGTCCAATGTGACAAATTGCACACTTGA

Protein

MMNVLNKSLQENGSFLTALYVFVGFIALYLLGRALQAFVQAADACCLFWYTWVVVPGSKGTAFVYKHTYGKKLNNPELEAVIVNEFPKNGWNNKNPSNFQDVQCDKLHT

Summary

Function

Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.

Subunit

Homooligomer. Interacts with the M membrane protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. The cytoplasmic tails of both proteins are important for this function. Interacts with Nucleoprotein.

Similarity

Belongs to the gammacoronaviruses E protein family.

Uniprot

A0A1P8NTN8

EMBL

KX185057 APX44050.1

Pfam

PF03620 IBV_3C

Interpro

IPR005296 IBV_3C

ProteinModelPortal

A0A1P8NTN8

Ontologies

GO:0046760  P:viral budding from Golgi membrane
GO:0044178  C:host cell Golgi membrane
GO:0044662  P:disruption by virus of host cell membrane
GO:0016021  C:integral component of membrane

Subcellular Location

From MSLVP

From Uniprot

Host Golgi apparatus membrane The cytoplasmic tail functions as a Golgi complex-targeting signal. With evidence from 1 publications.

Topology

Length:

109

Number of predicted TMHs:

Exp number of AAs in TMHs:

34.69603

Exp number, first 60 AAs:

32.05747

Total prob of N-in:

0.58937

POSSIBLE N-term signal

sequence

outside

1 - 14

TMhelix

15 - 32

inside

33 - 109