Sequence

CDS

ATGGTGAATATGTATGAACTCGCACTTAGTGTGCTTAGGGATTACAATTTAGCACTATCCACATTTCTGACTTTGATTATTTGTGTGTTACAGTTTGGTTATGCCTCTCGTAACAGGTTTTTTTATTGGATTAAAATTATTACATTGTGGCTTATGTGGCCATTTGCTATTGTTACTGCAGTGTTTTCGTGTTTGTACCCTCCGTGTTATGGGTATGGTTGGGCGGAGCAGCTCTTCCCTACACAGCACCCTACTACAAGCACAACTACTAATAGTACACCATTACCTGCTACCAAAGTACCTATACCCCAAGGTAACGGTCTATGGTCTTGTGGAACTTATGGTCATAATATTAACATTACTGCATTTGTGTTTGCTATAATTTTTGCAATTTTCACATGTGCGGCATGGCTATTTTATTGGATACAATCCACACGCCTGTATTTGAGAGTAAGATCATGGTGGGCTTTCTCACCAGACACTAACTATGTTGCTGTATTTAAAATGGCTAATGACCAGTATTTCACGCTGCCTTTGCTTGAAGTGCCTATGGTTCTTAGTCTTGTTTATAAGAATAATTTTGTTTATTGTAATGGTACATACCTCGGCCGAATTCCCAGTATGGGTTATCTGCCTGCTAGTTGTATAGTAGGCAGTGCTGAGAAGATTGCTAGATATAGGAAAATCACAGTGTCAGCAGCAGACGGCAGTGATGCTAATGTAGCTCGTTTTGGTACTGTGATATATGCGAAAGATAAATATATAAGTGCAGGACTTGCATATACTAAGAGAGAGAAAACTGAGACAGAGAAGCTTTATTCTGTTTAA

Protein

MVNMYELALSVLRDYNLALSTFLTLIICVLQFGYASRNRFFYWIKIITLWLMWPFAIVTAVFSCLYPPCYGYGWAEQLFPTQHPTTSTTTNSTPLPATKVPIPQGNGLWSCGTYGHNINITAFVFAIIFAIFTCAAWLFYWIQSTRLYLRVRSWWAFSPDTNYVAVFKMANDQYFTLPLLEVPMVLSLVYKNNFVYCNGTYLGRIPSMGYLPASCIVGSAEKIARYRKITVSAADGSDANVARFGTVIYAKDKYISAGLAYTKREKTETEKLYSV

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the gammacoronaviruses M protein family.

Uniprot

A0A346M361

EMBL

MG913343 AXQ05205.1

Pfam

PF01635 Corona_M

Interpro

IPR042550 GAMMA_CORONA_M
IPR002574 Corona_M

ProteinModelPortal

A0A346M361

Ontologies

GO:0019031  C:viral envelope
GO:0016021  C:integral component of membrane
GO:0055036  C:virion membrane
GO:0019058  P:viral life cycle
GO:0039660  F:structural constituent of virion
GO:0044178  C:host cell Golgi membrane

Subcellular Location

From MSLVP

Topology

Length:

275

Number of predicted TMHs:

Exp number of AAs in TMHs:

68.34376

Exp number, first 60 AAs:

39.0698

Total prob of N-in:

0.00723

POSSIBLE N-term signal

sequence

outside

1 - 14

TMhelix

15 - 34

inside

35 - 40

TMhelix

41 - 63

outside

64 - 119

TMhelix

120 - 142

inside

143 - 275