Strain

Human_2019-nCoV_MN996529 (Region: China: Wuhan; Strain: Wuhan seafood market pneumonia virus isolate WIV05, complete genome.; Date: 30-Dec-19)

Gene

membrane protein

Description

Annotated in NCBI, membrane protein

Location

MN996529(+):26511-27179

GenBank Accession

QHR63273.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGGCAGATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTTGAACAATGGAACCTAGTAATAGGTTTCCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATGCCAACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTCCTCTGGCTGTTATGGCCAGTAACTTTAGCTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAATTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGCGCGTACGCGTTCCATGTGGTCATTCAATCCAGAAACTAACATTCTTCTCAACGTGCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTGAACTCGTAATCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGACACCATCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTCTTATTACAAATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAGGATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATATTGCTTTGCTTGTACAGTAA

Protein

MADSNGTITVEELKKLLEQWNLVIGFLFLTWICLLQFAYANRNRFLYIIKLIFLWLLWPVTLACFVLAAVYRINWITGGIAIAMACLVGLMWLSYFIASFRLFARTRSMWSFNPETNILLNVPLHGTILTRPLLESELVIGAVILRGHLRIAGHHLGRCDIKDLPKEITVATSRTLSYYKLGASQRVAGDSGFAAYSRYRIGNYKLNTDHSSSSDNIALLVQ

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the betacoronaviruses M protein family.

Uniprot

Q6V584

EMBL

AY350750 AAR14804.1

Proteomes

UP000170944

Pfam

PF01635 Corona_M

Interpro

IPR002574 Corona_M

ProteinModelPortal

Q6V584

Ontologies

GO:0030683  P:evasion or tolerance by virus of host immune response
GO:0039660  F:structural constituent of virion
GO:0016021  C:integral component of membrane
GO:0019031  C:viral envelope
GO:0019058  P:viral life cycle
GO:0055036  C:virion membrane
GO:0044178  C:host cell Golgi membrane

Subcellular Location

From MSLVP

Host nucleus. Host cytoplasm.

Topology

Length:

222

Number of predicted TMHs:

Exp number of AAs in TMHs:

64.90522

Exp number, first 60 AAs:

30.89455

Total prob of N-in:

0.12113

POSSIBLE N-term signal

sequence

outside

1 - 19

TMhelix

20 - 39

inside

40 - 50

TMhelix

51 - 73

outside

74 - 77

TMhelix

78 - 100

inside

101 - 222