Strain

Human_2019-nCoV_MT135043 (Region: China_Beijing; Strain: Severe acute respiratory syndrome-related coronavirus; Date: 2020/1/28)

Gene

M protein

Description

Annotated in NCBI, M protein

Location

MT135043(+):26523-27191

GenBank Accession

QIH45046.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGGCAGATTCCAACGGTACTATTACCGTTGAAGAGCTTAAAAAGCTCCTTGAACAATGGAACCTAGTAATAGGTTTCCTATTCCTTACATGGATTTGTCTTCTACAATTTGCCTATGCCAACAGGAATAGGTTTTTGTATATAATTAAGTTAATTTTCCTCTGGCTGTTATGGCCAGTAACTTTAGCTTGTTTTGTGCTTGCTGCTGTTTACAGAATAAATTGGATCACCGGTGGAATTGCTATCGCAATGGCTTGTCTTGTAGGCTTGATGTGGCTCAGCTACTTCATTGCTTCTTTCAGACTGTTTGCGCGTACGCGTTCCATGTGGTCATTCAATCCAGAAACTAACATTCTTCTCAACGTGCCACTCCATGGCACTATTCTGACCAGACCGCTTCTAGAAAGTGAACTCGTAATCGGAGCTGTGATCCTTCGTGGACATCTTCGTATTGCTGGACACCATCTAGGACGCTGTGACATCAAGGACCTGCCTAAAGAAATCACTGTTGCTACATCACGAACGCTTTCTTATTACAAATTGGGAGCTTCGCAGCGTGTAGCAGGTGACTCAGGTTTTGCTGCATACAGTCGCTACAGGATTGGCAACTATAAATTAAACACAGACCATTCCAGTAGCAGTGACAATATTGCTTTGCTTGTACAGTAA

Protein

MADSNGTITVEELKKLLEQWNLVIGFLFLTWICLLQFAYANRNRFLYIIKLIFLWLLWPVTLACFVLAAVYRINWITGGIAIAMACLVGLMWLSYFIASFRLFARTRSMWSFNPETNILLNVPLHGTILTRPLLESELVIGAVILRGHLRIAGHHLGRCDIKDLPKEITVATSRTLSYYKLGASQRVAGDSGFAAYSRYRIGNYKLNTDHSSSSDNIALLVQ

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the betacoronaviruses M protein family.

Uniprot

D2E210

Pubmed

14569023 20463816

EMBL

FJ882941 ACZ71980.1

Proteomes

UP000180369

Pfam

PF01635 Corona_M

Interpro

IPR002574 Corona_M

ProteinModelPortal

D2E210

Ontologies

GO:0030683  P:evasion or tolerance by virus of host immune response
GO:0044178  C:host cell Golgi membrane
GO:0039660  F:structural constituent of virion
GO:0019058  P:viral life cycle
GO:0055036  C:virion membrane
GO:0016021  C:integral component of membrane
GO:0019031  C:viral envelope

Subcellular Location

From MSLVP

Topology

Length:

222

Number of predicted TMHs:

Exp number of AAs in TMHs:

64.90522

Exp number, first 60 AAs:

30.89455

Total prob of N-in:

0.12113

POSSIBLE N-term signal

sequence

outside

1 - 19

TMhelix

20 - 39

inside

40 - 50

TMhelix

51 - 73

outside

74 - 77

TMhelix

78 - 100

inside

101 - 222