Strain

Avian_NC_016994 (Region: China: Hong Kong; Strain: Night-heron coronavirus HKU19, complete genome.; Date: 2007)

Gene

membrane protein

Description

Annotated in NCBI, membrane protein

Location

NC_016994(+):23310-23960

GenBank Accession

YP_005352865.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGTCTGACGCTGCAGAGTGGCAACTCATCGTATTTATCATCTTAATCTGGGCCTTAGGCTTCATACTCCAAGGAGGGTATGCAGCAAGACATAAGGTCATTTATGTAATAAAACTAATACTGCTTTGGCTGCTCCAGCCTTTCACACTAGTAGTCACTATCTGGACTGCAGTAGACAATGGAGCCCAACCAAGCAGTGCAGTGTTTATTATTGCTATTATCTTCGCCATACTAACTTTCGTTATATGGCTGAAGTACTGGTATGACTCCATCAGACTTGTAATCAAAACAAAGTCAGGTTGGAGTTTCTCTCCAGAAACTAGACTACTTGTGTGTGCAATTGATGGAATGGGTAATGTCAAATGTGCACCAGTAGATCATTTACCAACAGCTCTCACTCCTGTCCTTGTAATGGGAAGGTTTATGCTAAACGGGCAGCTCCTTATGGCACAACAAACTGTGCAGACAGCTCCTAGAGCTTTGTATGTCATGACACCGAGTCAGACATATCATTTTACTTTGAAGAAAACTTTTCAAGATCCAGACTTCAAAGACACAGCCACATTTTGTTACCTTGTCGACCGCATTTCCAAGGCAGATTTGCAGAGTGTGACAACAGGCAGCAATTACGCACTGTACAAACACCTTTAA

Protein

MSDAAEWQLIVFIILIWALGFILQGGYAARHKVIYVIKLILLWLLQPFTLVVTIWTAVDNGAQPSSAVFIIAIIFAILTFVIWLKYWYDSIRLVIKTKSGWSFSPETRLLVCAIDGMGNVKCAPVDHLPTALTPVLVMGRFMLNGQLLMAQQTVQTAPRALYVMTPSQTYHFTLKKTFQDPDFKDTATFCYLVDRISKADLQSVTTGSNYALYKHL

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the gammacoronaviruses M protein family.

Uniprot

A0A0N9QUP2

Pubmed

26262637

EMBL

KR231009 ALH21115.1

Proteomes

UP000097758

Pfam

PF01635 Corona_M

Interpro

IPR002574 Corona_M
IPR042550 GAMMA_CORONA_M

ProteinModelPortal

A0A0N9QUP2

Ontologies

GO:0019058  P:viral life cycle
GO:0039660  F:structural constituent of virion
GO:0044178  C:host cell Golgi membrane
GO:0019031  C:viral envelope
GO:0016021  C:integral component of membrane
GO:0055036  C:virion membrane

Subcellular Location

From MSLVP

Host nucleus > host nucleolus. Host cytoplasm. Secreted.

Topology

Length:

216

Number of predicted TMHs:

Exp number of AAs in TMHs:

65.89283

Exp number, first 60 AAs:

43.75767

Total prob of N-in:

0.00737

POSSIBLE N-term signal

sequence

outside

1 - 4

TMhelix

5 - 27

inside

28 - 33

TMhelix

34 - 56

outside

57 - 65

TMhelix

66 - 88

inside

89 - 216