Strain

Avian_NC_016996 (Region: China: Hong Kong; Strain: Common-moorhen coronavirus HKU21, complete genome.; Date: 2007)

Gene

membrane protein

Description

Annotated in NCBI, membrane protein

Location

NC_016996(+):22973-23779

GenBank Accession

YP_005352883.1

Full name

Membrane protein

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

Sequence

CDS

ATGGCTTCTGAGAGTTCTTATCAGCTTCGTGCTGTTCAAGAATTTGAAGAGTGGTCTCTTATAATATTTATATCTATAATATGGGCATTATCTTCCATTTTACAAGGGGGTTATGCAACACGTTATAGATTTGTTTATGTTATTAAACTAGTACTTTTGTGGCTTTTGCAGCCACTTACTTTAGGTTTTAGCATATATGCAGCTGTGTATTTTGCTATGCCTGCCACTTATTTGAAGTTAACTGGTGAGTCTACTGATTATATTAACCAGACTAACGCACATTATCAAAGGAATTATCATACATCTAAACTTTACTCTCGTAAAGGTCTCGATAATTCTGAAACTATTGCTCAATTTACTCTAGCTATTCTATTTGCTGTACTTACATTTGTATCATGGTGTAAGTATATGTATGATAGTATTAGACTAGCTCTCAAAACTAAATCTGCCTGGTCCTTTTCCCCAGAAACTAGGCTTATTGCTGGTATTGTAGACATGATGGGCAATGGGAGGTGTGTTCCCTTAGACTACATGACGCCAATATTAGCACCAGTCATTAAACACGGTACGCTTAAGCTACATGGGCAAAAGCTAGCATCTGGTTTGAGCGTTAAAACTGTACCTAAACATATGGCAGTATTCACTCCTAGTGATACTTTCCATTATGTCCTCCGTAAAACTATTGAGAGTACGGAAGACGATAATATTGCAGTGCTCATATATCAGAGTGATCGTGCATCGAATGCTGGGCTTCACACCATAACCACATCTGGTTCTGGTAATTCCAGATTATATAAGTATATGTAA

Protein

MASESSYQLRAVQEFEEWSLIIFISIIWALSSILQGGYATRYRFVYVIKLVLLWLLQPLTLGFSIYAAVYFAMPATYLKLTGESTDYINQTNAHYQRNYHTSKLYSRKGLDNSETIAQFTLAILFAVLTFVSWCKYMYDSIRLALKTKSAWSFSPETRLIAGIVDMMGNGRCVPLDYMTPILAPVIKHGTLKLHGQKLASGLSVKTVPKHMAVFTPSDTFHYVLRKTIESTEDDNIAVLIYQSDRASNAGLHTITTSGSGNSRLYKYM

Summary

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Uniprot

H9BR19

Pubmed

22278237

EMBL

JQ065047 AFD29228.1

Proteomes

UP000132721

Pfam

PF01635 Corona_M

Interpro

IPR002574 Corona_M

ProteinModelPortal

H9BR19

Ontologies

KEGG

vg:11945656

GO:0019031  C:viral envelope
GO:0016021  C:integral component of membrane
GO:0055036  C:virion membrane
GO:0019058  P:viral life cycle
GO:0039660  F:structural constituent of virion
GO:0044178  C:host cell Golgi membrane

Subcellular Location

From MSLVP

Host nucleus > host nucleolus. Host cytoplasm. Secreted.

From Uniprot

Host Golgi apparatus membrane
Virion membrane

Topology

Length:

268

Number of predicted TMHs:

Exp number of AAs in TMHs:

64.2488000000002

Exp number, first 60 AAs:

31.48314

Total prob of N-in:

0.00775

POSSIBLE N-term signal

sequence

outside

1 - 14

TMhelix

15 - 37

inside

38 - 49

TMhelix

50 - 72

outside

73 - 114

TMhelix

115 - 134

inside

135 - 268