Strain

EUROPE_MURINE_2004_AY700211 (Region: Europe;  Strain: Murine hepatitis virus strain A59, complete genome.;  Date: 2004)

Gene

envelope protein

Description

Annotated in NCBI,  envelope protein

Location

AY700211(+):28707-28958

GenBank Accession

AAU06359.1

Full name

Envelope small membrane protein      

CDS

ATGTTTAATTTATTCCTTACAGACACAGTATGGTATGTGGGGCAGATTATTTTTATATTCGCAGTGTGTTTGATGGTCACCATAATTGTGGTTGCCTTCCTTGCGTCTATCAAACTTTGTATTCAACTTTGCGGTTTATGTAATACTTTGGTGCTGTCCCCTTCTATTTATTTGTATGATAGGAGTAAGCAGCTTTATAAGTATTATAATGAAGAAATGAGACTGCCCCTATTAGAGGTGGATGATATCTAA

Protein

MFNLFLTDTVWYVGQIIFIFAVCLMVTIIVVAFLASIKLCIQLCGLCNTLVLSPSIYLYDRSKQLYKYYNEEMRLPLLEVDDI

Function

Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Component of the viral envelope that plays a central role in virus morphogenesis and assembly. It is sufficient to form virus-like particles. Seems to be important for creating the membrane curvature needed to acquire the rounded, stable and infectious particle phenotype. Acts as a viroporin, inducing the formation of hydrophilic pores in cellular membranes. Also induces apoptosis.

Subunit

Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.

Similarity

Belongs to the betacoronaviruses E protein family.

Keywords

Apoptosis   Host Golgi apparatus   Host membrane   Membrane   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Envelope small membrane protein

Uniprot

C0KYT3   C0KYR3   C0KYY1   C0KZ02   C3VPF1   Q66193   + More
S5YGD9   P0C2R0   A0A2D1CED6   A0A2D1CEE9   O72007   A0A2S0SZ10   Q6QX39   D7PJY3   P29076   H9BZY1   O72008   C0KYZ2   C0KYX2   C0KYS4   C0KYU3   C0KYV4   I7AWD0   P06591   C6GHS4   I1TMH9   Q9IKC8   I1TMG9   Q77NM9   Q77NQ6   O72006   C0KYW4   O72005   A0A096XNI3   D4QFK4   V5N926   A0A3G3NGX9   A0A2H4MX05   A0A096XNH9   A0A096XNG6   A0A2H4MWX2   A0A2H4MXY9   A0A1V0IG71   Q4VID3   U3M6Z1   U3M6J8   Q04854   U3M703   Q4VIE2   A0A5J6NRU1   A0A1V0IG06   A0A1C8Z4R7   A0A482K8W1   Q84731   U3M6Q3   U3M6Z8   A0A2H4N004   Q2QKN0   A0A191URB5   A0A166MX78   P0C2Q9   P0C2Q8   A0A140E067   Q84733   A0A5B9MRZ0   A0A5J6NU83   H9AA36   U3M734   A0A5J6NRZ8   A4ZU45   A0A2R4STU8   A8HB20   C6GHM9   A4ZU23   B7U2R9   A0A2P1IQB5   A4ZU78   C6GHR4   C6GHP1   A4ZU12   B7U2N7   A4ZU67   B7U2M6   C6GHQ2   C6GHL7   A4ZTX9   B7U2P7   B7TYH3   A4ZTZ0   A4ZU34   B7U2L5   Q0PL35   A4ZU56   A4ZU01   Q4U3S8   B7U2Q8   A0A1V0IGI6   P0C2Q7   P0C2Q6   P0C2Q5  

Pubmed

10438865    15709029    17079303    8392595    3029985    11582515    + More
16341254    9426441    10544100    10438879    10666264    11277690    15963987    9733825    20519394    1654456    15507445    12970410    12663803    3838338    10882653    11502093    17041219    20631137    25463600    30285857    15914223    21849456    28050020    29950583    29217279    8517026    15280490    15650185    31534035    8757985    25530469    16809333    27274850    12237422    22398294    17916374    17434558    18842722    29508550    17344285    16604443    11774548    11376845    9778786   

EMBL

FJ647220    ACN89712.1    FJ647218    ACN89687.1    FJ647225    ACN89756.1    + More
FJ647227    ACN89773.1    FJ884686    FJ884687    ACO72886.1    M16602    AF208067    AY700211    AAA66620.1    AAF69347.1    AAU06359.1    KF268336    KF268337    KF268338    KF268339    AGT17719.1    AGT17730.1    AGT17741.1    AGT17752.1    AF029248    MF618252    ATN37890.1    MF618253    ATN37900.1    AF051148    AAC36596.1    MF416379    AWB14613.1    AY522570    AAS17640.1    GU593319    ADI59791.1    M64835    JQ173883    AFD97613.1    AF051149    AY771998    AAC36597.1    AAW47243.1    FJ647226    ACN89766.1    FJ647224    ACN89744.1    FJ647219    ACN89698.1    FJ647221    ACN89719.1    FJ647222    ACN89726.1    JX169866    JX169867    AFO11510.1    AFO11520.1    X04997    FJ938068    ACT11044.1    JF792617    AFG25767.1    AF207551    JF792616    AFG25757.1    AF207902    AAF68928.1    AF201929    AAF19391.1    AF051147    AF208066    AAC36595.1    AAF69336.1    FJ647223    ACN89738.1    AF051146    EF682498    AAC36594.1    ABS87267.1    KF294372    AID16662.1    AB551247    BAJ04699.1    KF850449    AHA83610.1    MH687968    MH687970    AYR18601.1    AYR18619.1    KY370048    ATP66757.1    KF294370    AID16650.1    KF294371    AID16656.1    KY370043    ATP66728.1    KY370051    ATP66774.1    KY419104    KY419105    KY419110    KY419112    ARC95213.1    ARC95221.1    ARC95253.1    ARC95269.1    AY903460    JN129834    JN129835    KF530069    KF530084    KF530098    KF530099    KJ958218    KJ958219    KY369905    KY369906    KY369907    KX538964    KX538965    KX538966    KX538967    KX538968    KX538969    KX538970    KX538971    KX538972    KX538973    KX538974    KX538975    KX538976    KX538977    KX538978    KX538979    KY684759    KY554972    KY554973    KY554974    KY554975    KY967356    KY967358    KY967359    KY967361    KY983583    KY983585    KY983588    MF374983    MF374984    MF374985    MG977444    MG977445    MG977446    MG977447    MG977448    MG977449    MG977450    MG977451    MG977452    MH121121    LC315646    LC315647    LC315648    MK303620    MK303622    MN026164    MN306036    MN306041    MN306053    MN310476    AAX85680.1    AEN19360.1    AEN19368.1    AGT51503.1    AGT51652.1    AGT51792.1    AGT51802.1    AIX09801.1    AIX09809.1    APU51915.1    APU51925.1    APU51944.1    AQN78658.1    AQN78666.1    AQN78674.1    AQN78682.1    AQN78690.1    AQN78698.1    AQN78706.1    AQN78714.1    AQN78722.1    AQN78730.1    AQN78738.1    AQN78746.1    AQN78754.1    AQN78762.1    AQN78770.1    AQN78778.1    ARA15423.1    ARE29997.1    ARE30006.1    ARE30015.1    ARE30024.1    ARK08637.1    ARK08653.1    ARK08663.1    ARK08681.1    ARU07570.1    ARU07589.1    ARU07612.1    ATN39866.1    ATN39874.1    ATN39881.1    AWW13513.1    AWW13521.1    AWW13529.1    AWW13537.1    AWW13545.1    AWW13553.1    AWW13561.1    AWW13568.1    AWW13577.1    AZP73842.1    BBA20974.1    BBA20977.1    BBA20980.1    QBP84715.1    QBP84733.1    QDH43717.1    QEG03742.1    QEG03759.1    QEG03796.1    QEG03808.1    KF530063    MK303619    MK303621    MK303623    MK303624    MN306042    AGT51443.1    QBP84706.1    QBP84724.1    QBP84742.1    QBP84751.1    QEG03769.1    KF530067    KF530071    KF530076    KF530079    KF530082    KF530088    KF530089    KF530091    KF530094    KF530095    KF530096    AGT51483.1    AGT51523.1    AGT51572.1    AGT51602.1    AGT51632.1    AGT51692.1    AGT51702.1    AGT51722.1    AGT51752.1    AGT51762.1    AGT51772.1    M99576    AY585228    AY585229    AY391777    KF530060    KF530061    KF530065    KF530066    KF530073    KF530074    KF530077    KF530083    KF530085    KF530086    KF530087    KF530090    KF530093    KF530097    AGT51414.1    AGT51424.1    AGT51463.1    AGT51473.1    AGT51543.1    AGT51553.1    AGT51582.1    AGT51642.1    AGT51662.1    AGT51672.1    AGT51682.1    AGT51712.1    AGT51742.1    AGT51782.1    AY903459    KF530068    KF530070    KF530081    MK303625    MN306043    AAX85671.1    AGT51493.1    AGT51513.1    AGT51622.1    QBQ01841.1    QEG03781.1    MN514965    QEY10651.1    KY419103    ARC95205.1    KX344031    AOL02455.1    MK327281    QBP84761.1    X89863    CAA61962.1    KF530059    KF530062    KF530075    KF530078    KF530080    KF530092    KP198610    KP198611    KY967360    KY014281    KY014282    MF314143    MN026165    AGT51404.1    AGT51433.1    AGT51563.1    AGT51592.1    AGT51612.1    AGT51732.1    AJC98129.1    AJC98137.1    ARK08672.1    ATP16759.1    ATP16769.1    AVQ05266.1    QDH43728.1    KF530064    AGT51453.1    KY370046    ATP66745.1    DQ011855    AAY68300.1    KU558922    KU558923    ANJ04721.1    ANJ04732.1    KU127229    KY994645    MF083115    ANA52019.1    AUF40276.1    AVV64337.1    AF481863    X89861    AY078417    KU131570    AMK59679.1    X89862    CAA61960.1    MN310478    QEG03816.1    MN514967    QEY10667.1    JN874559    JN874560    JN874561    JN874562    AFE48797.1    AFE48807.1    AFE48819.1    AFE48829.1    KF530072    AGT51533.1    MN514966    QEY10659.1    EF424621    ABP38300.1    MH043953    AVZ61113.1    EU019216    ABV74058.1    FJ938064    ACT10999.1    EF424619    ABP38281.1    FJ425189    ACJ67004.1    MG518518    AVN88328.1    EF424624    ABP38337.1    FJ938067    ACT11034.1    FJ938065    ACT11011.1    EF424618    ABP38264.1    FJ425186    ACJ66969.1    EF424623    ABP38326.1    FJ425185    ACJ66960.1    FJ938066    ACT11022.1    FJ938063    ACT10987.1    EF424615    ABP38230.1    FJ425187    ACJ66980.1    FJ415324    ACJ35487.1    EF424616    ABP38244.1    EF424620    ABP38292.1    FJ425184    ACJ66951.1    DQ811784    ABG89286.1    EF424622    ABP38309.1    EF424617    ABP38260.1    AH014866    AH014867    AH014868    AH014869    AH014871    AH014875    KM985635    KU886219    KX982264    MG757138    MG757139    MG757140    MG757141    MG757142    MH043952    MH043954    MH043955    AAY33929.1    AAY33932.1    AAY33935.1    AAY33938.1    AAY33944.1    AAY33956.1    AJL33724.1    ANJ04978.1    ARD06003.1    AVI15004.1    AVI15015.1    AVI15026.1    AVI15037.1    AVI15048.1    AVZ61103.1    AVZ61123.1    AVZ61133.1    FJ425188    FJ425190    ACJ66994.1    KY419106    KY419107    KY419109    KY419111    KY419113    ARC95229.1    ARC95237.1    ARC95245.1    ARC95261.1    ARC95276.1    AF220295    AF239312    AF239313    AF239314    AF239315    AF239316    AF239310    AF239311    AF058944   

Proteomes

UP000098534    UP000151686    UP000119015    UP000138757    UP000180349    UP000180350    + More
UP000113498    UP000155907    UP000112338    UP000164259    UP000171340    UP000171975    UP000007192    UP000117254    UP000118088    UP000148943    UP000167944    UP000158592    UP000133456    UP000142874    UP000114687    UP000149957    UP000007193    UP000173347    UP000161770    UP000175084    UP000163097    UP000139707    UP000143567    UP000159025    UP000154289    UP000099221    UP000100004    UP000109321    UP000126267    UP000130586    UP000155676    UP000159995    UP000168290    UP000173822    UP000172586    UP000097333    UP000104124    UP000109543    UP000114034    UP000119922    UP000122365    UP000140040    UP000143194    UP000150595    UP000158566    UP000160021    UP000007552    UP000100580    UP000180344    UP000096360    UP000105266    UP000106834    UP000136788    UP000143333    UP000147052    UP000147585    UP000149594    UP000159503    UP000165173    UP000167348    UP000168172    UP000170317    UP000117387    UP000119762    UP000140401    UP000161137    UP000100971    UP000126877    UP000133796    UP000134871    UP000149702    UP000165185    UP000115705    UP000125924    UP000007543    UP000007546    UP000147591    UP000107676    UP000124585    UP000125269    UP000145001    UP000154668    UP000136116    UP000136745    UP000134650    UP000133443    UP000147178    UP000164707    UP000139966    UP000173415    UP000140344    UP000163913    UP000104294    UP000162935    UP000172225    UP000121953    UP000158327    UP000158296    UP000127099    UP000170940    UP000174569    UP000147981    UP000139235    UP000151273    UP000102696    UP000148210    UP000008572   

Pfam

PF02723   NS3_envE

Interpro

IPR003873   NS3/E

ProteinModelPortal

C0KYT3   C0KYR3   C0KYY1   C0KZ02   C3VPF1   Q66193   + More
S5YGD9   P0C2R0   A0A2D1CED6   A0A2D1CEE9   O72007   A0A2S0SZ10   Q6QX39   D7PJY3   P29076   H9BZY1   O72008   C0KYZ2   C0KYX2   C0KYS4   C0KYU3   C0KYV4   I7AWD0   P06591   C6GHS4   I1TMH9   Q9IKC8   I1TMG9   Q77NM9   Q77NQ6   O72006   C0KYW4   O72005   A0A096XNI3   D4QFK4   V5N926   A0A3G3NGX9   A0A2H4MX05   A0A096XNH9   A0A096XNG6   A0A2H4MWX2   A0A2H4MXY9   A0A1V0IG71   Q4VID3   U3M6Z1   U3M6J8   Q04854   U3M703   Q4VIE2   A0A5J6NRU1   A0A1V0IG06   A0A1C8Z4R7   A0A482K8W1   Q84731   U3M6Q3   U3M6Z8   A0A2H4N004   Q2QKN0   A0A191URB5   A0A166MX78   P0C2Q9   P0C2Q8   A0A140E067   Q84733   A0A5B9MRZ0   A0A5J6NU83   H9AA36   U3M734   A0A5J6NRZ8   A4ZU45   A0A2R4STU8   A8HB20   C6GHM9   A4ZU23   B7U2R9   A0A2P1IQB5   A4ZU78   C6GHR4   C6GHP1   A4ZU12   B7U2N7   A4ZU67   B7U2M6   C6GHQ2   C6GHL7   A4ZTX9   B7U2P7   B7TYH3   A4ZTZ0   A4ZU34   B7U2L5   Q0PL35   A4ZU56   A4ZU01   Q4U3S8   B7U2Q8   A0A1V0IGI6   P0C2Q7   P0C2Q6   P0C2Q5  

PDB

6BRK     E-value=5.316,     Score=61