Strain

CHINA_HS_2019_MN908947 (Region: China: Wuhan;  Strain: Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome.;  Date: 2019)

Gene

surface glycoprotein

Description

Annotated in NCBI,  surface glycoprotein

Location

MN908947(+):21563-25384

GenBank Accession

QHD43416.1

Full name

Spike glycoprotein      

Alternative Name

E2
Peplomer protein

CDS

ATGTTTGTTTTTCTTGTTTTATTGCCACTAGTCTCTAGTCAGTGTGTTAATCTTACAACCAGAACTCAATTACCCCCTGCATACACTAATTCTTTCACACGTGGTGTTTATTACCCTGACAAAGTTTTCAGATCCTCAGTTTTACATTCAACTCAGGACTTGTTCTTACCTTTCTTTTCCAATGTTACTTGGTTCCATGCTATACATGTCTCTGGGACCAATGGTACTAAGAGGTTTGATAACCCTGTCCTACCATTTAATGATGGTGTTTATTTTGCTTCCACTGAGAAGTCTAACATAATAAGAGGCTGGATTTTTGGTACTACTTTAGATTCGAAGACCCAGTCCCTACTTATTGTTAATAACGCTACTAATGTTGTTATTAAAGTCTGTGAATTTCAATTTTGTAATGATCCATTTTTGGGTGTTTATTACCACAAAAACAACAAAAGTTGGATGGAAAGTGAGTTCAGAGTTTATTCTAGTGCGAATAATTGCACTTTTGAATATGTCTCTCAGCCTTTTCTTATGGACCTTGAAGGAAAACAGGGTAATTTCAAAAATCTTAGGGAATTTGTGTTTAAGAATATTGATGGTTATTTTAAAATATATTCTAAGCACACGCCTATTAATTTAGTGCGTGATCTCCCTCAGGGTTTTTCGGCTTTAGAACCATTGGTAGATTTGCCAATAGGTATTAACATCACTAGGTTTCAAACTTTACTTGCTTTACATAGAAGTTATTTGACTCCTGGTGATTCTTCTTCAGGTTGGACAGCTGGTGCTGCAGCTTATTATGTGGGTTATCTTCAACCTAGGACTTTTCTATTAAAATATAATGAAAATGGAACCATTACAGATGCTGTAGACTGTGCACTTGACCCTCTCTCAGAAACAAAGTGTACGTTGAAATCCTTCACTGTAGAAAAAGGAATCTATCAAACTTCTAACTTTAGAGTCCAACCAACAGAATCTATTGTTAGATTTCCTAATATTACAAACTTGTGCCCTTTTGGTGAAGTTTTTAACGCCACCAGATTTGCATCTGTTTATGCTTGGAACAGGAAGAGAATCAGCAACTGTGTTGCTGATTATTCTGTCCTATATAATTCCGCATCATTTTCCACTTTTAAGTGTTATGGAGTGTCTCCTACTAAATTAAATGATCTCTGCTTTACTAATGTCTATGCAGATTCATTTGTAATTAGAGGTGATGAAGTCAGACAAATCGCTCCAGGGCAAACTGGAAAGATTGCTGATTATAATTATAAATTACCAGATGATTTTACAGGCTGCGTTATAGCTTGGAATTCTAACAATCTTGATTCTAAGGTTGGTGGTAATTATAATTACCTGTATAGATTGTTTAGGAAGTCTAATCTCAAACCTTTTGAGAGAGATATTTCAACTGAAATCTATCAGGCCGGTAGCACACCTTGTAATGGTGTTGAAGGTTTTAATTGTTACTTTCCTTTACAATCATATGGTTTCCAACCCACTAATGGTGTTGGTTACCAACCATACAGAGTAGTAGTACTTTCTTTTGAACTTCTACATGCACCAGCAACTGTTTGTGGACCTAAAAAGTCTACTAATTTGGTTAAAAACAAATGTGTCAATTTCAACTTCAATGGTTTAACAGGCACAGGTGTTCTTACTGAGTCTAACAAAAAGTTTCTGCCTTTCCAACAATTTGGCAGAGACATTGCTGACACTACTGATGCTGTCCGTGATCCACAGACACTTGAGATTCTTGACATTACACCATGTTCTTTTGGTGGTGTCAGTGTTATAACACCAGGAACAAATACTTCTAACCAGGTTGCTGTTCTTTATCAGGATGTTAACTGCACAGAAGTCCCTGTTGCTATTCATGCAGATCAACTTACTCCTACTTGGCGTGTTTATTCTACAGGTTCTAATGTTTTTCAAACACGTGCAGGCTGTTTAATAGGGGCTGAACATGTCAACAACTCATATGAGTGTGACATACCCATTGGTGCAGGTATATGCGCTAGTTATCAGACTCAGACTAATTCTCCTCGGCGGGCACGTAGTGTAGCTAGTCAATCCATCATTGCCTACACTATGTCACTTGGTGCAGAAAATTCAGTTGCTTACTCTAATAACTCTATTGCCATACCCACAAATTTTACTATTAGTGTTACCACAGAAATTCTACCAGTGTCTATGACCAAGACATCAGTAGATTGTACAATGTACATTTGTGGTGATTCAACTGAATGCAGCAATCTTTTGTTGCAATATGGCAGTTTTTGTACACAATTAAACCGTGCTTTAACTGGAATAGCTGTTGAACAAGACAAAAACACCCAAGAAGTTTTTGCACAAGTCAAACAAATTTACAAAACACCACCAATTAAAGATTTTGGTGGTTTTAATTTTTCACAAATATTACCAGATCCATCAAAACCAAGCAAGAGGTCATTTATTGAAGATCTACTTTTCAACAAAGTGACACTTGCAGATGCTGGCTTCATCAAACAATATGGTGATTGCCTTGGTGATATTGCTGCTAGAGACCTCATTTGTGCACAAAAGTTTAACGGCCTTACTGTTTTGCCACCTTTGCTCACAGATGAAATGATTGCTCAATACACTTCTGCACTGTTAGCGGGTACAATCACTTCTGGTTGGACCTTTGGTGCAGGTGCTGCATTACAAATACCATTTGCTATGCAAATGGCTTATAGGTTTAATGGTATTGGAGTTACACAGAATGTTCTCTATGAGAACCAAAAATTGATTGCCAACCAATTTAATAGTGCTATTGGCAAAATTCAAGACTCACTTTCTTCCACAGCAAGTGCACTTGGAAAACTTCAAGATGTGGTCAACCAAAATGCACAAGCTTTAAACACGCTTGTTAAACAACTTAGCTCCAATTTTGGTGCAATTTCAAGTGTTTTAAATGATATCCTTTCACGTCTTGACAAAGTTGAGGCTGAAGTGCAAATTGATAGGTTGATCACAGGCAGACTTCAAAGTTTGCAGACATATGTGACTCAACAATTAATTAGAGCTGCAGAAATCAGAGCTTCTGCTAATCTTGCTGCTACTAAAATGTCAGAGTGTGTACTTGGACAATCAAAAAGAGTTGATTTTTGTGGAAAGGGCTATCATCTTATGTCCTTCCCTCAGTCAGCACCTCATGGTGTAGTCTTCTTGCATGTGACTTATGTCCCTGCACAAGAAAAGAACTTCACAACTGCTCCTGCCATTTGTCATGATGGAAAAGCACACTTTCCTCGTGAAGGTGTCTTTGTTTCAAATGGCACACACTGGTTTGTAACACAAAGGAATTTTTATGAACCACAAATCATTACTACAGACAACACATTTGTGTCTGGTAACTGTGATGTTGTAATAGGAATTGTCAACAACACAGTTTATGATCCTTTGCAACCTGAATTAGACTCATTCAAGGAGGAGTTAGATAAATATTTTAAGAATCATACATCACCAGATGTTGATTTAGGTGACATCTCTGGCATTAATGCTTCAGTTGTAAACATTCAAAAAGAAATTGACCGCCTCAATGAGGTTGCCAAGAATTTAAATGAATCTCTCATCGATCTCCAAGAACTTGGAAAGTATGAGCAGTATATAAAATGGCCATGGTACATTTGGCTAGGTTTTATAGCTGGCTTGATTGCCATAGTAATGGTGACAATTATGCTTTGCTGTATGACCAGTTGCTGTAGTTGTCTCAAGGGCTGTTGTTCTTGTGGATCCTGCTGCAAATTTGATGAAGACGACTCTGAGCCAGTGCTCAAAGGAGTCAAATTACATTACACATAA

Protein

MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT

Function

Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.
Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.
Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 and CLEC4M/DC-SIGNR receptors and internalization of the virus into the endosomes of the host cell induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.
mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.

Subunit

Homotrimer; each monomer consists of a S1 and a S2 subunit. The resulting peplomers protrude from the virus surface as spikes.
Homotrimer; each monomer consists of a S1 and a S2 subunit. The resulting peplomers protrude from the virus surface as spikes (By similarity). Binds to human and palm civet ACE2 and human CLEC4M/DC-SIGNR. Interacts with the accessory proteins 3a and 7a.

Miscellaneous

Tor2 is the prototype of the virus isolated during the severe SARS outbreak in 2002-2003. GD03 has been isolated from the second mild SARS outbreak in winter 2003-2004. SZ3 has been isolated from palm civet, the presumed animal reservoir. The spike proteins from those three isolates display a strong affinity for palm civet ACE2 receptor, whereas only the Tor2 spike protein efficiently binds human ACE2. This may explain the high pathogenicity of Tor2 virus, whose spike is highly adapted to the human host. Therefore, the lack of severity of disease during the 2003-2004 outbreak could be due to the incomplete adaptation of GD03 virus to bind human ACE2. Mutation Asn-479 and Thr-487 in palm civet coronavirus seems necessary and sufficient for the virus to acquire the ability to efficiently infect humans.

Similarity

Belongs to the betacoronaviruses spike protein family.

Keywords

3D-structure   Coiled coil   Disulfide bond   Fusion of virus membrane with host endosomal membrane   Fusion of virus membrane with host membrane   Glycoprotein   Host cell membrane   Host membrane   Host-virus interaction   Lipoprotein   Membrane   Palmitate   Reference proteome   Signal   Transmembrane   Transmembrane helix   Viral attachment to host cell   Viral envelope protein   Viral penetration into host cytoplasm   Virion   Virulence   Virus entry into host cell  

Feature

chain  Spike protein S1

Uniprot

A0A2R3SUW7   A0A2R3SUW9   A0A2D1PXA9   A0A2D1PX97   A0A0U2IWM2   A0A2D1PX29   + More
U5WLK5   Q6TPE8   U5WHZ7   U5WI05   A0A2D1PXC0   A0A4Y6GL47   A0A2D1PXD5   Q5GDB6   Q6DSU4   Q4JDM4   Q6GYR1   Q1EFP5   Q1EFN2   Q5DIC5   Q5GDB4   D2E206   A4ZF26   D2E1K6   Q6T7X5   Q3ZTC8   A4ZF28   Q202F5   Q202F4   Q5GDB3   Q4JDN5   Q4JDN2   Q3ZTC5   Q3ZTE0   D2E250   Q4JDM7   Q5GDJ7   Q4JDM9   Q4JDN0   Q4JDN3   Q202G5   Q202G3   Q202G8   A4ZF27   Q3ZTC7   Q4JDM6   Q6RD20   Q4JDN1   Q6RD64   Q6VAA0   Q6UZF4   Q6VA78   Q6UZF0   Q6RCY7   Q6RD31   Q6RD09   Q202H5   Q6JH38   Q6RCX6   Q3S2D2   Q6RD42   Q6VA89   Q6RCZ8   Q6RCW5   Q6RD53   Q6WGP3   Q6V585   Q202E9   A7J8L4   Q309G9   A0A3G5BJ39   D2E1E7   D2E1D2   D3KDQ3   P59594   Q202E6   Q4JDN4   Q5Y187   Q6T7Y1   Q5GDB5   D2E2T4   D2E2D8   Q6R7Y6   A4ZF30   Q5GDB7   Q4JDP0   Q6JH46   Q4JDP1   Q5GDJ6   D2E1Z1   D2E2M5   D2E1H7   Q3ZTF3   Q202F2   Q4JDN9   Q4JDM5   A4ZF29   Q4JDN8   Q4JDM3   Q692E4  

Pubmed

29190287    26719272    24172901    15695582    16140765    16625834    + More
18987164    14569023    20463816    16485471    17112780    14983045    14654320    16269206    14527350    14733771    16112670    19370068    17184168    30393776    22412934    12730500    12730501    12853594    12876307    12958366    12781537    12917450    14647384    14670965    15518555    15450134    15496474    15313178    15890958    15831954    15791205    16081529    15194747    16840309    16519916    17134730    17166901    19321428    20861307    15345712    15604146    14511651    16166518    16698550    15757562   

EMBL

MG772933    AVP78031.1    MG772934    AVP78042.1    KY417146    ATO98157.1    + More
KY417150    ATO98205.1    KT444582    ALK02457.1    KY417144    ATO98132.1    KC881005    AGZ48806.1    AY390556    AAS00003.1    KC881006    AGZ48818.1    KC881007    KF367457    AGZ48828.1    AGZ48831.1    KY417151    ATO98218.1    MK211376    QDF43825.1    KY417152    ATO98231.1    AY627045    AAV49720.1    AY648300    AAT74874.1    AY687372    AAV98002.1    AY595412    AAT52330.1    AY864805    AAY60780.1    AY864806    AAY60793.1    AY772062    AAX16192.1    AY627047    AAV49722.1    FJ882941    ACZ71976.1    DQ514528    ABF68955.1    FJ882931    FJ882954    FJ882955    ACZ71826.1    ACZ72166.1    AY429078    AAR07630.1    AY572036    AAU04661.1    DQ514530    ABF68957.1    DQ412585    DQ412614    ABD72977.1    ABD72992.1    DQ412597    DQ412598    DQ412612    DQ412615    ABD72985.1    ABD72986.1    ABD72990.1    ABD72993.1    AY627048    AAV49723.1    AY687361    AAV97991.1    AY687364    AAV97994.1    AY572038    AAU04664.1    AY572035    AAU04649.1    FJ882944    ACZ72020.1    AY687369    AAV97999.1    AY613951    AAU93318.1    AY687367    AAV97997.1    AY687366    AAV97996.1    AY686864    AY687363    AAV49730.1    AAV97993.1    DQ412594    ABD72982.1    DQ412596    ABD72984.1    DQ412588    ABD72979.1    DQ514529    ABF68956.1    AY572037    AAU04662.1    AY687370    AAV98000.1    AY502927    AAR87545.1    AY687365    AAV97995.1    AY502923    AAR87501.1    AY345986    AAP94737.1    AY357075    AAR14807.1    AY345988    AAP94759.1    AY357076    AAR14811.1    AY502930    AAR87578.1    AY502926    AAR87534.1    AY502928    AAR87556.1    DQ412578    ABD72972.1    AY485278    AAR23258.1    AY502931    AAR87589.1    DQ182595    ABA02260.1    AY502925    AAR87523.1    AY345987    AAP94748.1    AY502929    AAR87567.1    AY502932    AAR87600.1    AY502924    AAR87512.1    AY286320    AAR33050.1    AY350750    AAR14803.1    DQ412574    DQ412581    DQ412587    DQ412589    DQ412590    DQ412595    DQ412605    DQ412611    DQ412613    DQ412616    DQ412618    DQ412624    ABD72968.1    ABD72975.1    ABD72978.1    ABD72980.1    ABD72981.1    ABD72983.1    ABD72987.1    ABD72989.1    ABD72991.1    ABD72994.1    ABD72996.1    ABD72998.1    DQ898174    JX163924    JX163928    ABI96958.1    AFR58686.1    AFR58742.1    DQ231462    EU371559    ABB29898.2    ACB69849.1    MK062179    MK062181    MK062183    AYV99803.1    FJ882927    FJ882932    FJ882933    FJ882934    FJ882935    FJ882936    FJ882937    FJ882938    FJ882939    FJ882946    FJ882947    JF292921    KF514388    KF514392    KF514394    KF514396    KF514397    KF514398    KF514399    KF514400    KF514404    KF514408    KF514409    KF514413    KF514415    KF514418    KF514419    KF514421    KF514422    KF514423    ACZ71767.1    ACZ71841.1    AEA10998.1    AGT20793.1    AGT20853.1    AGT20883.1    AGT20913.1    AGT20928.1    AGT20943.1    AGT20958.1    AGT20973.1    AGT21033.1    AGT21093.1    AGT21108.1    AGT21168.1    AGT21198.1    AGT21243.1    AGT21258.1    AGT21288.1    AGT21303.1    AGT21318.1    FJ882926    FJ882928    FJ882930    JF292922    KF514389    KF514390    KF514391    KF514393    KF514395    KF514401    KF514402    KF514403    KF514405    KF514406    KF514410    KF514411    KF514412    KF514414    KF514416    KF514417    KF514420    ACZ71752.1    AEA11013.1    AGT20808.1    AGT20823.1    AGT20838.1    AGT20868.1    AGT20898.1    AGT20988.1    AGT21003.1    AGT21018.1    AGT21048.1    AGT21063.1    AGT21123.1    AGT21138.1    AGT21153.1    AGT21183.1    AGT21213.1    AGT21228.1    AGT21273.1    GU553365    JQ316196    JN854286    ADC35511.1    AFD56973.1    AFK10254.1    AY278741    AY274119    AY282752    AY278554    AY278491    AY304495    AY304492    AY278487    AY278488    AY278490    AY279354    AY278489    AY283794    AY283795    AY283796    AY283797    AY283798    AY291451    AY310120    AY291315    AY304486    AY321118    AY323976    AY322207    AY338174    AY338175    AY348314    AP006557    AP006558    AP006559    AP006560    AP006561    AY323977    AY362698    AY362699    AY427439    AY463059    AY525636    DQ412628    ABD73001.1    AY687362    AAV97992.1    AY714217    AAU81608.1    AY429072    AAR07624.1    AY627046    AAV49721.1    FJ882960    ACZ72254.1    FJ882950    ACZ72108.1    AY508724    AAR91586.1    DQ514532    ABF68959.1    AY627044    AAV49719.1    AY687356    AAV97986.1    AY485277    AAR23250.1    AY687355    AAV97985.1    AY613952    AAU93319.1    FJ882940    ACZ71961.1    FJ882956    ACZ72195.1    FJ882929    ACZ71797.1    AY572034    AAU04646.1    DQ412617    ABD72995.1    AY687357    AAV97987.1    AY687371    AAV98001.1    DQ514531    ABF68958.1    AY687358    AAV97988.1    AY686863    AY687373    AAV91631.1    AAV98003.1    AY654624    AAT76147.1   

Proteomes

UP000100289    UP000138593    UP000166164    UP000157984    UP000110240    UP000158790    + More
UP000133349    UP000149347    UP000156013    UP000180369    UP000180367    UP000180372    UP000180373    UP000153024    UP000141980    UP000180370    UP000126514    UP000174857    UP000148533    UP000133546    UP000118579    UP000115935    UP000147828    UP000125082    UP000148329    UP000124386    UP000168969    UP000132037    UP000163176    UP000139901    UP000129608    UP000099158    UP000110133    UP000166558    UP000170944    UP000135071    UP000166757    UP000180361    UP000099142    UP000097931    UP000121467    UP000125925    UP000128288    UP000150617    UP000151673    UP000151756    UP000153830    UP000155701    UP000157930    UP000161442    UP000161729    UP000162782    UP000164349    UP000169779    UP000173963    UP000174280    UP000180434    UP000180435    UP000180436    UP000180437    UP000180438    UP000180439    UP000180440    UP000180441    UP000180442    UP000180443    UP000180444    UP000180445    UP000180446    UP000097852    UP000106870    UP000117796    UP000119316    UP000119820    UP000124542    UP000125968    UP000130610    UP000133348    UP000141212    UP000143912    UP000145152    UP000149516    UP000166143    UP000171773    UP000180363    UP000180364    UP000180366    UP000180376    UP000180377    UP000180378    UP000112510    UP000152329    UP000180382    UP000000354    UP000103670    UP000109640    UP000116947    UP000121636    UP000131569    UP000131955    UP000137377    UP000138690    UP000143093    UP000145651    UP000146108    UP000146181    UP000146296    UP000148194    UP000153467    UP000160648    UP000164441    UP000172416    UP000171372    UP000180375    UP000180371    UP000117876    UP000123303    UP000180368    UP000180374    UP000180365    UP000127950    UP000115496    UP000101079   

PRIDE

P59594   

Pfam

PF01601   Corona_S2
PF09408   Spike_rec_bind
PF16451   Spike_NTD

Interpro

IPR036326   Spike_rcpt-bd_sf
IPR002552   Corona_S2
IPR018548   Spike_rcpt-bd
IPR027400   S_HR2
IPR032500   Spike_N
IPR042578   BETA_CORONA_SPIKE
IPR043002   Spike_N_sf

SUPFAM

SSF143587   SSF143587

Gene 3D

1.20.5.790     2.60.120.960    

ProteinModelPortal

A0A2R3SUW7   A0A2R3SUW9   A0A2D1PXA9   A0A2D1PX97   A0A0U2IWM2   A0A2D1PX29   + More
U5WLK5   Q6TPE8   U5WHZ7   U5WI05   A0A2D1PXC0   A0A4Y6GL47   A0A2D1PXD5   Q5GDB6   Q6DSU4   Q4JDM4   Q6GYR1   Q1EFP5   Q1EFN2   Q5DIC5   Q5GDB4   D2E206   A4ZF26   D2E1K6   Q6T7X5   Q3ZTC8   A4ZF28   Q202F5   Q202F4   Q5GDB3   Q4JDN5   Q4JDN2   Q3ZTC5   Q3ZTE0   D2E250   Q4JDM7   Q5GDJ7   Q4JDM9   Q4JDN0   Q4JDN3   Q202G5   Q202G3   Q202G8   A4ZF27   Q3ZTC7   Q4JDM6   Q6RD20   Q4JDN1   Q6RD64   Q6VAA0   Q6UZF4   Q6VA78   Q6UZF0   Q6RCY7   Q6RD31   Q6RD09   Q202H5   Q6JH38   Q6RCX6   Q3S2D2   Q6RD42   Q6VA89   Q6RCZ8   Q6RCW5   Q6RD53   Q6WGP3   Q6V585   Q202E9   A7J8L4   Q309G9   A0A3G5BJ39   D2E1E7   D2E1D2   D3KDQ3   P59594   Q202E6   Q4JDN4   Q5Y187   Q6T7Y1   Q5GDB5   D2E2T4   D2E2D8   Q6R7Y6   A4ZF30   Q5GDB7   Q4JDP0   Q6JH46   Q4JDP1   Q5GDJ6   D2E1Z1   D2E2M5   D2E1H7   Q3ZTF3   Q202F2   Q4JDN9   Q4JDM5   A4ZF29   Q4JDN8   Q4JDM3   Q692E4  

PDB

6ACK     E-value=0,     Score=4890