Strain

EUROPE_HS_2000_NC_002645 (Region: Europe;  Strain: Human coronavirus 229E, complete genome.;  Date: 2000)

Gene

nucleocapsid protein

Description

Annotated in NCBI,  nucleocapsid protein

Location

NC_002645(+):25686-26855

GenBank Accession

NP_073556.1

Full name

Nucleoprotein      

Alternative Name

Nucleocapsid protein

CDS

ATGGCTACAGTCAAATGGGCTGATGCATCTGAACCACAACGTGGTCGTCAGGGTAGAATACCTTATTCTCTTTATAGCCCTTTGCTTGTTGATAGTGAACAACCTTGGAAGGTGATACCTCGTAATTTGGTACCCATCAACAAGAAAGACAAAAATAAGCTTATAGGCTATTGGAATGTTCAAAAACGTTTCAGAACTAGAAAGGGCAAACGGGTGGATTTGTCACCCAAGCTGCATTTTTATTATCTTGGCACAGGACCCCATAAAGATGCAAAATTTAGAGAGCGTGTTGAAGGTGTCGTCTGGGTTGCTGTTGATGGTGCTAAAACTGAACCTACAGGTTACGGTGTTAGGCGCAAGAATTCAGAACCAGAGATACCACACTTCAATCAAAAGCTCCCAAATGGTGTTACTGTTGTTGAAGAACCTGACTCCCGTGCTCCTTCCCGGTCTCAGTCGAGGTCGCAGAGTCGCGGTCGTGGTGAATCCAAACCTCAATCTCGGAATCCTTCAAGTGACAGAAACCATAACAGTCAGGATGACATCATGAAGGCAGTTGCTGCGGCTCTTAAATCTTTAGGTTTTGACAAGCCTCAGGAAAAAGATAAAAAGTCAGCGAAAACGGGTACTCCTAAGCCTTCTCGTAATCAGAGTCCTGCTTCTTCTCAAACTTCTGCCAAGAGTCTTGCTCGTTCTCAGAGTTCTGAAACAAAAGAACAAAAGCATGAAATGCAAAAGCCACGGTGGAAAAGACAGCCTAATGATGATGTGACATCTAATGTCACACAATGTTTTGGCCCCAGAGACCTTGACCACAACTTTGGAAGTGCAGGTGTTGTGGCCAATGGTGTTAAAGCTAAAGGCTATCCACAATTTGCTGAGCTTGTGCCGTCAACAGCTGCTATGCTGTTTGATAGTCACATTGTTTCCAAAGAGTCAGGCAACACTGTGGTCTTGACTTTCACTACTAGAGTGACTGTGCCCAAAGACCATCCACACTTGGGTAAGTTTCTTGAGGAGTTAAATGCATTCACTAGAGAAATGCAACAACATCCTCTTCTTAACCCTAGTGCACTAGAATTCAACCCATCTCAAACTTCACCTGCAACTGCTGAACCAGTGCGTGATGAAGTTTCTATTGAAACTGACATAATTGATGAAGTAAACTAA

Protein

MATVKWADASEPQRGRQGRIPYSLYSPLLVDSEQPWKVIPRNLVPINKKDKNKLIGYWNVQKRFRTRKGKRVDLSPKLHFYYLGTGPHKDAKFRERVEGVVWVAVDGAKTEPTGYGVRRKNSEPEIPHFNQKLPNGVTVVEEPDSRAPSRSQSRSQSRGRGESKPQSRNPSSDRNHNSQDDIMKAVAAALKSLGFDKPQEKDKKSAKTGTPKPSRNQSPASSQTSAKSLARSQSSETKEQKHEMQKPRWKRQPNDDVTSNVTQCFGPRDLDHNFGSAGVVANGVKAKGYPQFAELVPSTAAMLFDSHIVSKESGNTVVLTFTTRVTVPKDHPHLGKFLEELNAFTREMQQHPLLNPSALEFNPSQTSPATAEPVRDEVSIETDIIDEVN

Function

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.

Subunit

Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.

Similarity

Belongs to the alphacoronavirus nucleocapsid protein family.

Keywords

ADP-ribosylation   Host Golgi apparatus   Phosphoprotein   Reference proteome   Ribonucleoprotein   RNA-binding   Transcription   Transcription regulation   Viral nucleoprotein   Virion  

Feature

chain  Nucleoprotein

Uniprot

Q1HVQ0   P15130   A0A059SGB0   Q1HVP9   Q1HVP2   Q1HVP0   + More
S5YAG2   A0A384QXL5   J9V7P0   A0A384QZB4   Q1HVM9   S5ZJ09   A0A1Z1R303   A0A384QXL7   A0A1V0E0Z0   Q1HVN3   S5Z1H9   Q1HVN7   A0A384RBS5   A0A384QXY0   A0A1W6DZN2   A0A127AWS1   A0A127AUU5   Q1HVN9   A0A384R2L0   A0A1L7B946   A0A127ATJ8   A0A1L7B959   A0A1B3TN93   A0A127ATP2   A0A127ATJ5   A0A127ATJ0   A0A127AUT5   A0A127ATI4   A0A127ATM6   A0A127ATM8   A0A127ATJ6   A0A127AU31   A0A127ATI5   A0A127AWT0   A0A384RBS7   Q1HVM8   Q1HVP1   A0A1L7B917   A0A1L7B914   A0A384R2K5   A0A223FUI1   A0A1L7B932   A0A1V0BZ85   Q1HVM7   A0A127ATI6   A0A384RHP2   A0A127ATJ4   A0A5C2D3C6   Q1HVP6   A0A127ATI8   A0A127AU35   Q1HVP5   Q1HVP3   J9V7P5   Q1HVP8   A0A097ZMN9   A0A097ZMP3   A0A097ZMR3   A0A097ZMP2   A0A097ZMP1   A0A0P0KXM1   A0A0P0KBE2   A0A097ZMN8   A0A0P0KMP3   I1VWF9   A0A1C8YZ39   A0A0U2GMT2   A0A0U2GRP0   A0A0U2GR32   A0A0U2GMD8   A0A0U2GMI4   A0A0U2GRD7   A0A1C8YZ17   A0A1C8YZ40   A0A0U2GN51   A0A0U2GNG7   A0A0U2GMP7   A0A0U2GQA6   A0A1B3TNB1   C0LI68   A0A0N7J131   A0A1L2KGF4   A0A1L2KGE7   A0A1L2KGB9   U3M7G3   Q06Y06   A0A384RBU9   A0A2U8JDM2  

Pubmed

16603522    2922924    2167350    11369870    15890900    22926811    + More
28893443    26928836    27528677    29167251    26378164    26678874    19788804    17054987    29741740   

EMBL

DQ243939    KF293664    KF293665    ABB90482.1    AGW80937.1    J04419    + More
X51325    AF304460    KF293666    AGW80953.1    DQ243940    ABB90483.1    DQ243947    ABB90490.1    DQ243949    ABB90492.1    KF514429    AGT21342.1    KM055515    AIW52712.1    JX503060    AFR79254.1    KM055501    KM055502    KM055503    KM055504    KM055505    KM055506    KM055509    KM055510    KM055512    KM055514    KM055517    KM055519    KM055520    KM055521    KM055522    KM055530    AIW52698.1    AIW52699.1    AIW52700.1    AIW52701.1    AIW52702.1    AIW52703.1    AIW52706.1    AIW52707.1    AIW52709.1    AIW52711.1    AIW52714.1    AIW52716.1    AIW52717.1    AIW52718.1    AIW52719.1    AIW52727.1    DQ243951    DQ243954    DQ243955    DQ243957    DQ243958    DQ243959    DQ243960    KF514431    KM055523    ABB90494.1    ABB90497.1    ABB90498.1    ABB90500.1    ABB90501.1    ABB90502.1    ABB90503.1    AGT21357.1    AIW52720.1    KF514430    KF514432    AGT21349.1    AGT21364.1    KY996417    ARX11400.1    KM055525    AIW52722.1    KY674919    ARB07429.1    DQ243956    ABB90499.1    KF514433    AGT21371.1    DQ243952    ABB90495.1    KM055507    KM055508    AIW52704.1    AIW52705.1    KM055511    KM055527    AIW52708.1    AIW52724.1    KY967357    KY983587    ARK08646.1    ARU07605.1    KT359755    AMM42514.1    KT359768    AMM42527.1    DQ243950    ABB90493.1    KM055526    AIW52723.1    KY369913    APT69887.1    KT359762    AMM42521.1    KY369912    KY369914    APT69880.1    APT69891.1    KM055513    KM055528    KM055529    KU291448    MN306046    AIW52710.1    AIW52725.1    AIW52726.1    AOG74787.1    QEG03789.1    KT359760    AMM42519.1    KT359766    AMM42525.1    KT359752    AMM42511.1    KT359758    AMM42517.1    KT359756    AMM42515.1    KT359761    AMM42520.1    KT359763    AMM42522.1    KT359764    AMM42523.1    KT359757    AMM42516.1    KT359753    AMM42512.1    KT359765    AMM42524.1    KM055518    AIW52715.1    DQ243961    ABB90504.1    DQ243948    ABB90491.1    KY369909    KY674914    KY621348    APT69860.1    ARB07396.1    ARK08624.1    KY369908    APT69853.1    KM055516    AIW52713.1    MF542265    AST12968.1    KY369910    KY369911    APT69866.1    APT69873.1    KY684760    ARA15433.1    DQ243962    ABB90505.1    KT359759    AMM42518.1    KM055524    AIW52721.1    KT359769    AMM42528.1    MN369046    QEO75989.1    DQ243943    ABB90486.1    KT359754    AMM42513.1    KT359767    AMM42526.1    DQ243944    ABB90487.1    DQ243942    DQ243945    DQ243946    ABB90485.1    ABB90488.1    ABB90489.1    JX503061    AFR79261.1    DQ243941    ABB90484.1    LC005738    BAP75908.1    LC005739    BAP75909.1    LC005740    BAP75910.1    LC005737    BAP75907.1    LC005741    BAP75911.1    KT253269    ALK28779.1    KT253270    ALK28785.1    LC005736    BAP75906.1    KT253272    ALK28797.1    JQ410000    AFI49435.1    KT253327    AOI28287.1    KT368900    KT368904    KT368905    KT368908    KT368916    ALA50148.1    ALA50176.1    ALA50183.1    ALA50204.1    ALA50260.1    KT368907    ALA50197.1    KT368892    KT368893    KT368894    ALA50092.1    ALA50099.1    ALA50106.1    KT368898    KT368899    ALA50134.1    ALA50141.1    KT368901    ALA50155.1    KT368911    ALA50225.1    KT253325    KT253326    AOI28271.1    AOI28279.1    KT253324    KT253328    AOI28262.1    AOI28294.1    KT368895    KT368896    KT368897    KT368902    KT368906    KT368909    KT368910    KT368913    KT368914    MF593473    ALA50113.1    ALA50120.1    ALA50127.1    ALA50162.1    ALA50190.1    ALA50211.1    ALA50218.1    ALA50239.1    ALA50246.1    ATI09441.1    KT368915    ALA50253.1    KT368912    ALA50232.1    KT368903    ALA50169.1    KU291449    AOG74793.1    FJ710055    ACN78943.1    KT253271    ALK28791.1    KY073747    APD51503.1    KY073748    APD51511.1    KY073744    APD51479.1    KF530105    AGT51335.1    DQ445912    ABE97134.1    KM055598    AIW52795.1    MG428705    AWK59971.1   

Proteomes

UP000006716    UP000105041    UP000110267    UP000137891    UP000139984    UP000143565    + More
UP000118770    UP000122373    UP000130985    UP000146121    UP000103248    UP000104585    UP000120649    UP000136940    UP000152663    UP000151210    UP000108758    UP000110675    UP000115399    UP000116691    UP000136947    UP000173458    UP000100137    UP000101679    UP000115199    UP000124352    UP000128900    UP000147133    UP000152773    UP000169049    UP000171347    UP000173795    UP000153625    UP000153580    UP000103783    UP000096398    UP000204102    UP000171901    UP000138462   

PRIDE

P15130   

Pfam

PF00937   Corona_nucleoca

Interpro

IPR037179   Nucleocapsid_C
IPR001218   Corona_nucleocap
IPR037195   Nucleocapsid_N
IPR042548   ALPHA_CORONA_NCAP

SUPFAM

SSF110304   SSF110304
SSF103068   SSF103068

ProteinModelPortal

Q1HVQ0   P15130   A0A059SGB0   Q1HVP9   Q1HVP2   Q1HVP0   + More
S5YAG2   A0A384QXL5   J9V7P0   A0A384QZB4   Q1HVM9   S5ZJ09   A0A1Z1R303   A0A384QXL7   A0A1V0E0Z0   Q1HVN3   S5Z1H9   Q1HVN7   A0A384RBS5   A0A384QXY0   A0A1W6DZN2   A0A127AWS1   A0A127AUU5   Q1HVN9   A0A384R2L0   A0A1L7B946   A0A127ATJ8   A0A1L7B959   A0A1B3TN93   A0A127ATP2   A0A127ATJ5   A0A127ATJ0   A0A127AUT5   A0A127ATI4   A0A127ATM6   A0A127ATM8   A0A127ATJ6   A0A127AU31   A0A127ATI5   A0A127AWT0   A0A384RBS7   Q1HVM8   Q1HVP1   A0A1L7B917   A0A1L7B914   A0A384R2K5   A0A223FUI1   A0A1L7B932   A0A1V0BZ85   Q1HVM7   A0A127ATI6   A0A384RHP2   A0A127ATJ4   A0A5C2D3C6   Q1HVP6   A0A127ATI8   A0A127AU35   Q1HVP5   Q1HVP3   J9V7P5   Q1HVP8   A0A097ZMN9   A0A097ZMP3   A0A097ZMR3   A0A097ZMP2   A0A097ZMP1   A0A0P0KXM1   A0A0P0KBE2   A0A097ZMN8   A0A0P0KMP3   I1VWF9   A0A1C8YZ39   A0A0U2GMT2   A0A0U2GRP0   A0A0U2GR32   A0A0U2GMD8   A0A0U2GMI4   A0A0U2GRD7   A0A1C8YZ17   A0A1C8YZ40   A0A0U2GN51   A0A0U2GNG7   A0A0U2GMP7   A0A0U2GQA6   A0A1B3TNB1   C0LI68   A0A0N7J131   A0A1L2KGF4   A0A1L2KGE7   A0A1L2KGB9   U3M7G3   Q06Y06   A0A384RBU9   A0A2U8JDM2  

PDB

5N4K     E-value=3.30731e-35,     Score=372