Strain

CHINA_HS_2004_NC_006577 (Region: China: Hong Kong;  Strain: Human coronavirus HKU1, complete genome.;  Date: 2004)

Gene

hemagglutinin-esterase glycoprotein

Description

Annotated in NCBI,  hemagglutinin-esterase glycoprotein

Location

NC_006577(+):21773-22933

GenBank Accession

YP_173237.1

Full name

Hemagglutinin-esterase      

Alternative Name

E3 glycoprotein

CDS

ATGTTAATTATTTTTTTATTTTTTTATTTCTGTTATGGTTTTAATGAACCTCTTAATGTTGTGTCTCATTTAAACCATGACTGGTTTTTATTTGGTGATAGTCGTTCTGATTGTAACCATATTAATAATTTAAAAATTAAAAATTTTGATTATTTGGATATTCACCCTAGTTTGTGCAACAATGGTAAGATTTCATCTAGTGCCGGTGATTCTATTTTTAAGAGTTTTCATTTCACTCGATTTTATAATTACACTGGCGAAGGTGATCAAATTATTTTTTATGAGGGTGTTAATTTTAATCCTTATCATAGATTTAAGTGTTTTCCTAATGGTAGTAATGATGTATGGCTTCTTAACAAGGTAAGATTTTATCGTGCCTTATATTCTAATATGGCCTTTTTTCGTTATCTTACTTTTGTTGATATTCCTTATAATGTTTCTCTTTCTAAGTTTAATTCTTGTAAAAGTGATATTTTATCACTTAACAATCCTATTTTTATTAATTATTCTAAGGAAGTTTATTTTACTTTATTAGGTTGTTCTCTTTATTTAGTACCGCTTTGCCTTTTTAAATCTAACTTTAGTCAGTACTATTATAACATAGATACTGGCTCTGTTTATGGTTTTTCTAATGTTGTTTATCCTGATTTAGACTGTATTTATATTTCTCTTAAACCAGGTTCTTATAAAGTTTCCACCACTGCACCTTTTTTATCCTTACCTACTAAAGCTCTCTGTTTTGATAAATCTAAACAATTTGTACCTGTACAGGTTGTTGATTCTAGATGGAACAACGAGCGTGCCTCAGATATTTCTTTATCTGTTGCATGTCAATTGCCATATTGTTATTTTCGCAATTCTTCTGCTAATTATGTTGGCAAGTATGATATTAACCACGGTGATAGTGGTTTTATTTCTATTTTATCTGGTCTTTTATATAATGTTTCTTGTATTTCATATTATGGTGTATTTTTATATGATAATTTTACATCCATTTGGCCCTATTATTCTTTTGGTAGGTGTCCTACATCTTCTATTATTAAACATCCAATTTGTGTTTATGATTTTTTGCCTATTATTTTACAAGGTATTTTATTATGTTTAGCTTTACTTTTTGTTGTTTTTCTATTATTTTTGTTATATAACGATAAATCTCATTAA

Protein

MLIIFLFFYFCYGFNEPLNVVSHLNHDWFLFGDSRSDCNHINNLKIKNFDYLDIHPSLCNNGKISSSAGDSIFKSFHFTRFYNYTGEGDQIIFYEGVNFNPYHRFKCFPNGSNDVWLLNKVRFYRALYSNMAFFRYLTFVDIPYNVSLSKFNSCKSDILSLNNPIFINYSKEVYFTLLGCSLYLVPLCLFKSNFSQYYYNIDTGSVYGFSNVVYPDLDCIYISLKPGSYKVSTTAPFLSLPTKALCFDKSKQFVPVQVVDSRWNNERASDISLSVACQLPYCYFRNSSANYVGKYDINHGDSGFISILSGLLYNVSCISYYGVFLYDNFTSIWPYYSFGRCPTSSIIKHPICVYDFLPIILQGILLCLALLFVVFLLFLLYNDKSH

Function

Structural protein that makes short spikes at the surface of the virus. Contains receptor binding and receptor-destroying activities. Mediates de-O-acetylation of N-acetyl-4-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells. This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell. May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one. May become a target for both the humoral and the cellular branches of the immune system.

Catalytic Activity

H2O + N-acetyl-4-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate
H2O + N-acetyl-9-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate

Subunit

Homodimer; disulfide-linked. Forms a complex with the M protein in the pre-Golgi. Associates then with S-M complex to form a ternary complex S-M-HE.

Miscellaneous

Isolate N1 belongs to genotype A.
Isolate N2 belongs to genotype B.
Isolate N5 belongs to genotype C. Genotype C probably arose from recombination between genotypes A and B.

Similarity

Belongs to the influenza type C/coronaviruses hemagglutinin-esterase family.

Keywords

Disulfide bond   Glycoprotein   Hemagglutinin   Host cell membrane   Host membrane   Hydrolase   Membrane   Signal   Transmembrane   Transmembrane helix   Viral envelope protein   Virion   3D-structure   Reference proteome  

Feature

chain  Hemagglutinin-esterase

Uniprot

Q0ZJB8   Q5MQD1   S5ZBQ3   E0YJ43   Q0ZJC6   A0A140H1H0   + More
Q0ZJ86   A0A1Y0EV02   A0A3Q9JNH8   Q0ZJB0   A0A3G2KXK9   Q14EB1   Q0ZJI2   S5YGE4   Q0ZJA2   Q0ZME8   Q0ZJ94   Q0ZJL4   A0A2H4MWZ5   A0A3G3NHQ1   A0A3G3NHB2   A0A2H4MZ25   A0A096XNG5   A0A2H4N008   U3M7K0   A0A2H4MWY2   A0A482K8Y4   A0A1S6KXR2   G5CJB0   U3M7J8   D4QFK0   U3M823   A0A0K0L8U2   Q5ICX3   O92367   U3M7I4   A0A0K0L8G7   A0A0K0KP40   A0A0B4Q7Z8   A0A5B9MYI1   A0A0B4Q9K4   U3M809   A0A2R3TWT8   U3M7J6   A0A1W6DZQ9   U3M7Y9   U3M821   A0A0K0L8E4   A0A482K8X4   A0A0K0KPJ7   A0A0K0KPP1   B8RIQ6   A0A0K0L8T5   A0A0K0L8U3   A0A2D1QW73   U3M829   U3M7J2   A0A1W6DZR7   A0A0B4Q7Z5   A0A0B4Q8M6   A0A0K0KP42   D0EY72   A0A0K0KPE0   A0A0K0KPN9   A0A411D561   D0EY92   Q4VIE5   A0A1V0E0X2   G5CJB8   P30215   A0A0K0KP17   A0A385H7F6   A0A0K0KQ35   Q4VID6   A0A0K0KQ45   U3M7Z3   A0A0K0KPN4   A0A482KB11   A0A0K0KPL2   A0A0K0L9C4   A0A0K0KPI4   A3E2F1   A0A1S5VGE8   B9TXU2   A0A0A0YP42   D0EY82   A0A0K0L8A5   A0A0K0KQ48   A0A0K0L8E7   A0A482KA41   A0A0K0KP12   A0A0K0KPI9   A0A482KDP9   A0A0K0L8A6   A0A140E064   A0A385H745   A0A482K8T1   A0A0K0KQ19   A0A385H5X6   A0A482KEQ8  

EC Number

3.1.1.53

Pubmed

16809319    24394697    15613317    20719951    30285857    25463600    + More
21849456    25530469    15507445    19162098    15914223    1727608    15280490    15650185    28279346    28050020    17092595    23405345   

EMBL

DQ415900    DQ415901    DQ415903    DQ415904    DQ415905    DQ415906    + More
DQ415907    DQ415908    DQ415910    KF430198    KF430203    KF686344    ABD75528.1    ABD75536.1    ABD75552.1    ABD75560.1    ABD75568.1    ABD75576.1    ABD75584.1    ABD75592.1    ABD75608.1    AGT17762.1    AGT17776.1    AGW27871.1    AY597011    KF430201    KF686340    KF686341    KF686342    KF686343    KF686346    KY674941    KY674942    KY674943    AGT17768.1    AGW27835.1    AGW27844.1    AGW27853.1    AGW27862.1    AGW27880.1    ARB07598.1    ARB07607.1    ARB07616.1    HM034837    ADN03338.1    DQ415909    ABD75600.1    KT779555    KT779556    AMN88685.1    AMN88693.1    DQ415896    DQ415914    ABD75496.1    ABD75640.1    KY983584    ARU07576.1    MK167038    AZS52617.1    DQ415911    ABD75616.1    MH940245    AYN64560.1    AY884001    DQ415902    ABD75544.1    KF430197    KY674921    AGT17757.1    ARB07437.1    DQ415897    DQ415899    DQ415912    ABD75504.1    ABD75520.1    ABD75624.1    DQ339101    DQ415913    ABD75632.1    DQ415898    ABD75512.1    KY370049    ATP66761.1    MH687968    AYR18598.1    MH687970    AYR18615.1    KY370051    ATP66772.1    KF294370    AID16648.1    KY370048    ATP66755.1    KF530071    KF530076    KF530088    KF530091    AGT51520.1    AGT51569.1    AGT51689.1    AGT51719.1    KY370043    ATP66726.1    MK327281    QBP84758.1    KX432213    AQT26497.1    JN129834    KF572664    KF572671    KF572672    KF923899    KF923900    AEN19357.1    AIL49344.1    AIL49351.1    AIL49352.1    AIV41853.1    AIV41859.1    KF530068    KF530070    KF530084    KF530098    AGT51490.1    AGT51510.1    AGT51649.1    AGT51789.1    AB551247    BAJ04695.1    KF530096    AGT51769.1    KF572702    KF923923    AIL49382.1    AIV41998.1    AY771998    AAW47239.1    AF091734    KF530063    AGT51440.1    KF923905    AIV41890.1    KF572663    AIL49343.1    KF572665    KF572666    KF923896    AIL49345.1    AIL49346.1    AIV41835.1    MN306043    QEG03775.1    KF572658    KF572661    KF923887    KF923888    AIL49338.1    AIL49341.1    AIV41782.1    AIV41788.1    KF530082    KF530089    KF530094    AGT51629.1    AGT51699.1    AGT51749.1    MF314143    AVQ05263.1    KF530069    AGT51500.1    KY967360    MN026165    ARK08669.1    QDH43725.1    KF530079    AGT51599.1    KF530095    AGT51759.1    KF923894    AIV41824.1    MK303624    QBP84748.1    KF572655    KF923886    AIL49335.1    AIV41776.1    KF572627    KF572705    AIL49307.1    AIL49385.1    EU999954    ACL12995.1    KF923925    AIV42010.1    KF923922    AIV41992.1    KY014282    ATP16766.1    KF530099    AGT51799.1    KF530067    AGT51480.1    KY967356    ARK08634.1    KF572628    KF572630    KF572631    KF572634    KF572635    KF572636    KF572637    KF572647    KF572648    KF572649    KF572650    KF572651    KF572673    KF572674    KF572675    KF572676    KF572677    KF572678    KF572679    KF572680    KF572681    KF572682    KF572683    KF572684    KF572685    KF572686    KF572687    KF572688    KF572689    KF572690    KF572691    KF572692    KF572693    KF572694    KF572696    KF572697    KF572698    KF572699    KF572701    KF572703    KF572704    KF572706    KF572707    KF923890    KF923891    KF923892    KF923901    KF923907    KF923908    KF923909    KF923910    KF923911    KF923912    KF923913    KF923914    KF923915    KF923916    KF923917    KF923918    KF923919    KF923920    KF923921    KF923924    KX344031    KY674917    KY674918    KY554972    KY554973    AIL49308.1    AIL49310.1    AIL49311.1    AIL49314.1    AIL49315.1    AIL49316.1    AIL49317.1    AIL49327.1    AIL49328.1    AIL49329.1    AIL49330.1    AIL49331.1    AIL49353.1    AIL49354.1    AIL49355.1    AIL49356.1    AIL49357.1    AIL49358.1    AIL49359.1    AIL49360.1    AIL49361.1    AIL49362.1    AIL49363.1    AIL49364.1    AIL49365.1    AIL49366.1    AIL49367.1    AIL49368.1    AIL49369.1    AIL49370.1    AIL49371.1    AIL49372.1    AIL49373.1    AIL49374.1    AIL49376.1    AIL49377.1    AIL49378.1    AIL49379.1    AIL49381.1    AIL49383.1    AIL49384.1    AIL49386.1    AIL49387.1    AIV41800.1    AIV41806.1    AIV41812.1    AIV41865.1    AIV41902.1    AIV41908.1    AIV41914.1    AIV41920.1    AIV41926.1    AIV41932.1    AIV41938.1    AIV41944.1    AIV41950.1    AIV41956.1    AIV41962.1    AIV41968.1    AIV41974.1    AIV41980.1    AIV41986.1    AIV42004.1    AOL02452.1    ARB07413.1    ARB07419.1    ARE29996.1    ARE30005.1    KF923906    AIV41896.1    KF572669    AIL49349.1    GQ918141    ACX46839.1    KF572656    AIL49336.1    KF572700    AIL49380.1    MH249786    QAY30019.1    GQ918143    ACX46859.1    AY903459    AAX85668.1    KY674920    KY554974    KY554975    ARB07432.1    ARE30014.1    ARE30023.1    JN129835    AEN19365.1    M76373    AY391777    AY585228    AY585229    KF572644    AIL49324.1    MG197712    AXX83314.1    KF572652    AIL49332.1    AY903460    AAX85677.1    KF572662    AIL49342.1    KF530081    AGT51619.1    KF572695    AIL49375.1    MK303623    QBP84739.1    KF572638    KF572641    KF572646    KF572670    KF923897    KF923903    KX538965    KX538967    KX538969    KX538971    KX538973    KX538974    KX538977    AIL49318.1    AIL49321.1    AIL49326.1    AIL49350.1    AIV41841.1    AIV41878.1    AQN78663.1    AQN78679.1    AQN78695.1    AQN78711.1    AQN78727.1    AQN78735.1    AQN78759.1    KF572668    KF923898    AIL49348.1    AIV41847.1    KF572640    KF923902    KX538970    KX538978    KX538979    MG197710    MG197713    MG197715    MG197716    MG197717    MG197722    MK303620    AIL49320.1    AIV41872.1    AQN78703.1    AQN78767.1    AQN78775.1    AXX83302.1    AXX83320.1    AXX83332.1    AXX83338.1    AXX83344.1    AXX83374.1    QBP84712.1    DQ682406    ABG78747.1    KX538968    AQN78687.1    EU401979    ACB30199.1    KF572633    KF572643    KF572660    KJ958219    AIL49313.1    AIL49323.1    AIL49340.1    AIX09806.1    GQ918142    JX860640    ACX46849.1    AFW97359.1    KF572653    KF572657    KF923889    AIL49333.1    AIL49337.1    AIV41794.1    KF572667    AIL49347.1    KF572629    KF923895    AIL49309.1    AIV41829.1    MK303625    QBQ01838.1    KF572639    KF572642    KF923904    KX538964    KX538966    KX538972    AIL49319.1    AIL49322.1    AIV41884.1    AQN78655.1    AQN78671.1    AQN78719.1    KF572645    AIL49325.1    MK303622    QBP84730.1    KF923893    AIV41818.1    KU131570    AMK59676.1    MG197711    MG197718    MG197720    MG197721    AXX83308.1    AXX83350.1    AXX83362.1    AXX83368.1    MK303621    QBP84721.1    KF572632    AIL49312.1    MG197709    AXX83296.1    MK303619    QBP84703.1   

Proteomes

UP000102058    UP000103177    UP000107950    UP000120443    UP000123677    UP000127413    + More
UP000147573    UP000148743    UP000164754    UP000168247    UP000008170    UP000098016    UP000098607    UP000139452    UP000143896    UP000173725    UP000173897    UP000108760    UP000174991    UP000122230    UP000134208    UP000118444    UP000161305    UP000162514    UP000006551    UP000124867    UP000134743    UP000143869    UP000168964    UP000001985    UP000156925    UP000107997    UP000097333    UP000119922    UP000150595    UP000160021    UP000119882    UP000121854    UP000173822    UP000100004    UP000117387    UP000119762    UP000168290    UP000154289    UP000158566    UP000112072    UP000172586    UP000128148    UP000174077    UP000104994    UP000143341    UP000104124    UP000109543    UP000114034    UP000155676    UP000143194    UP000140040    UP000123825    UP000114688    UP000173555    UP000114169    UP000109321    UP000122365    UP000107048    UP000108500    UP000115343    UP000115819    UP000116223    UP000117554    UP000119058    UP000119993    UP000128782    UP000130040    UP000130067    UP000132146    UP000136483    UP000136628    UP000137532    UP000142623    UP000143152    UP000150164    UP000152870    UP000166197    UP000173306    UP000161137    UP000130586    UP000007552    UP000100580    UP000180344    UP000159995    UP000140401    UP000154332    UP000162080    UP000142982    UP000101116    UP000099221    UP000137675    UP000137844    UP000161839    UP000165756    UP000149793    UP000147591   

PRIDE

O92367   

Pfam

PF03996   Hema_esterase
PF02710   Hema_HEFG

Interpro

IPR007142   Hemagglutn-estrase_core
IPR008980   Capsid_hemagglutn
IPR003860   Hemagglutn-estrase_hemagglutn
IPR042545   HEMA

SUPFAM

SSF49818   SSF49818

ProteinModelPortal

Q0ZJB8   Q5MQD1   S5ZBQ3   E0YJ43   Q0ZJC6   A0A140H1H0   + More
Q0ZJ86   A0A1Y0EV02   A0A3Q9JNH8   Q0ZJB0   A0A3G2KXK9   Q14EB1   Q0ZJI2   S5YGE4   Q0ZJA2   Q0ZME8   Q0ZJ94   Q0ZJL4   A0A2H4MWZ5   A0A3G3NHQ1   A0A3G3NHB2   A0A2H4MZ25   A0A096XNG5   A0A2H4N008   U3M7K0   A0A2H4MWY2   A0A482K8Y4   A0A1S6KXR2   G5CJB0   U3M7J8   D4QFK0   U3M823   A0A0K0L8U2   Q5ICX3   O92367   U3M7I4   A0A0K0L8G7   A0A0K0KP40   A0A0B4Q7Z8   A0A5B9MYI1   A0A0B4Q9K4   U3M809   A0A2R3TWT8   U3M7J6   A0A1W6DZQ9   U3M7Y9   U3M821   A0A0K0L8E4   A0A482K8X4   A0A0K0KPJ7   A0A0K0KPP1   B8RIQ6   A0A0K0L8T5   A0A0K0L8U3   A0A2D1QW73   U3M829   U3M7J2   A0A1W6DZR7   A0A0B4Q7Z5   A0A0B4Q8M6   A0A0K0KP42   D0EY72   A0A0K0KPE0   A0A0K0KPN9   A0A411D561   D0EY92   Q4VIE5   A0A1V0E0X2   G5CJB8   P30215   A0A0K0KP17   A0A385H7F6   A0A0K0KQ35   Q4VID6   A0A0K0KQ45   U3M7Z3   A0A0K0KPN4   A0A482KB11   A0A0K0KPL2   A0A0K0L9C4   A0A0K0KPI4   A3E2F1   A0A1S5VGE8   B9TXU2   A0A0A0YP42   D0EY82   A0A0K0L8A5   A0A0K0KQ48   A0A0K0L8E7   A0A482KA41   A0A0K0KP12   A0A0K0KPI9   A0A482KDP9   A0A0K0L8A6   A0A140E064   A0A385H745   A0A482K8T1   A0A0K0KQ19   A0A385H5X6   A0A482KEQ8  

PDB

5N11     E-value=1.45112e-105,     Score=978