Strain

CHINA_HS_2004_NC_006577 (Region: China: Hong Kong;  Strain: Human coronavirus HKU1, complete genome.;  Date: 2004)

Gene

small membrane protein

Description

Annotated in NCBI,  small membrane protein

Location

NC_006577(+):27373-27621

GenBank Accession

YP_173240.1

Full name

Envelope small membrane protein      

CDS

ATGGTTGATTTATTTTTCAATGATACTGCTTGGTACATAGGACAGATTTTAGTTTTAGTTTTATTTTGTCTTATTTCTTTAATCTTTGTTGTTGCTTTTTTAGCAACTATTAAGCTTTGTATGCAACTTTGTGGTTTTTGTAATTTCTTTATTATTTCACCTTCGGCTTACGTTTATAAAAGAGGTATGCAGTTGTATAAGTCTTATAGTGAACAAGTTATACCACCCACTTCAGATTATTTAATCTAA

Protein

MVDLFFNDTAWYIGQILVLVLFCLISLIFVVAFLATIKLCMQLCGFCNFFIISPSAYVYKRGMQLYKSYSEQVIPPTSDYLI

Function

Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.

Subunit

Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.

Miscellaneous

Isolate N1 belongs to genotype A.
Isolate N5 belongs to genotype C. Genotype C probably arose from recombination between genotypes A and B.
Isolate N2 belongs to genotype B.

Similarity

Belongs to the betacoronaviruses E protein family.

Keywords

Apoptosis   Host Golgi apparatus   Host membrane   Membrane   Transmembrane   Transmembrane helix   Reference proteome  

Feature

chain  Envelope small membrane protein

Uniprot

Q0ZJ83   Q5MQC8   Q0ZJB5   Q0ZJD1   A0A224ANC8   Q0ZJ91   + More
Q0ZME5   Q14EA8   A0A3G3NGX9   A0A2H4MX05   A0A096XNH9   A0A2H4MWX2   A0A096XNG6   A0A2H4MXY9   C0KYZ2   Q6QX39   A0A2S0SZ10   C6GHS4   D7PJY3   I1TMH9   Q9IKC8   P29076   C0KYX2   I1TMG9   H9BZY1   C0KYW4   O72005   C0KYS4   C0KYU3   C0KYV4   I7AWD0   P06591   Q77NM9   Q77NQ6   O72006   D4QFK4   O72008   Q84733   Q2QKN0   A0A096XNI3   A0A2H4MWY9   A0A3G3NH48   A0A0A7UXR5   O72007   A4ZU45   A0A2R4STU8   A0A096XNF4   A0A5J6NRL9   A8HB20   C6GHM9   A4ZU23   B7U2R9   A0A2P1IQB5   A4ZU78   C6GHR4   C6GHP1   A4ZU12   B7U2N7   A4ZU67   B7U2M6   C6GHQ2   C6GHL7   A4ZTX9   B7U2P7   B7TYH3   A4ZTZ0   A4ZU34   B7U2L5   Q0PL35   A4ZU56   A4ZU01   Q4U3S8   X2JQI8   A0A0U2GN18   B7U2Q8   A0A1V0IGI6   P0C2Q7   P0C2Q6   P0C2Q5   P0C2Q4   P0C2Q3   P0C2Q2   P15775   P0C2Q1   Q84731   V5N926   Q6W360   Q6W352   Q4U3T0   A0A1V0IG71   A7BKC6   A0A2D1CED6   A8R4D4   Q4U3S9   C0KYT3   C0KYR3   C0KYY1  

Pubmed

16809319    20719951    24394697    29217279    15613317    30285857    + More
25463600    12970410    20519394    10882653    1654456    17041219    9733825    20631137    17079303    12663803    3838338    11582515    11502093    15507445    8757985    16809333    25552712    31534035    17916374    17434558    18842722    29508550    17344285    16604443    24655427    26678874    11774548    11376845    9778786    11714968    2320429    17374765    17706262    26271151    10438865    15709029   

EMBL

DQ415896    DQ415900    DQ415901    DQ415903    DQ415904    DQ415905    + More
DQ415906    DQ415907    DQ415909    DQ415914    HM034837    KF430201    KF686340    KF686341    KF686342    KF686343    KF686344    KF686346    KT779555    KT779556    KY674941    KY674942    KY674943    KY983584    LC315650    ABD75499.1    ABD75531.1    ABD75539.1    ABD75555.1    ABD75563.1    ABD75571.1    ABD75579.1    ABD75587.1    ABD75603.1    ABD75643.1    ADN03341.1    AGT17771.1    AGW27838.1    AGW27847.1    AGW27856.1    AGW27865.1    AGW27874.1    AGW27883.1    AMN88688.1    AMN88696.1    ARB07601.1    ARB07610.1    ARB07619.1    ARU07579.1    BBA20984.1    AY597011    DQ415910    ABD75611.1    DQ415908    ABD75595.1    LC315651    BBA20987.1    DQ415897    DQ415898    DQ415899    DQ415902    DQ415911    DQ415912    DQ415913    KY674921    MH940245    MK167038    ABD75507.1    ABD75515.1    ABD75523.1    ABD75547.1    ABD75619.1    ABD75627.1    ABD75635.1    ARB07440.1    AYN64563.1    AZS52620.1    DQ339101    AY884001    MH687968    MH687970    AYR18601.1    AYR18619.1    KY370048    ATP66757.1    KF294370    AID16650.1    KY370043    ATP66728.1    KF294371    AID16656.1    KY370051    ATP66774.1    FJ647226    ACN89766.1    AY522570    AAS17640.1    MF416379    AWB14613.1    FJ938068    ACT11044.1    GU593319    ADI59791.1    JF792617    AFG25767.1    AF207551    M64835    FJ647224    ACN89744.1    JF792616    AFG25757.1    JQ173883    AFD97613.1    FJ647223    ACN89738.1    AF051146    EF682498    AAC36594.1    ABS87267.1    FJ647219    ACN89698.1    FJ647221    ACN89719.1    FJ647222    ACN89726.1    JX169866    JX169867    AFO11510.1    AFO11520.1    X04997    AF207902    AAF68928.1    AF201929    AAF19391.1    AF051147    AF208066    AAC36595.1    AAF69336.1    AB551247    BAJ04699.1    AF051149    AY771998    AAC36597.1    AAW47243.1    X89862    CAA61960.1    DQ011855    AAY68300.1    KF294372    AID16662.1    KY370047    ATP66751.1    MH687971    MH687972    MH687973    MH687974    MH687975    MH687976    MH687977    MH687978    AYR18628.1    AYR18637.1    AYR18646.1    AYR18655.1    AYR18664.1    AYR18673.1    AYR18682.1    AYR18691.1    KM349742    KM349743    KM349744    AJA91199.1    AJA91210.1    AJA91220.1    AF051148    AAC36596.1    EF424621    ABP38300.1    MH043953    AVZ61113.1    KF294357    AID16632.1    MN514964    QEY10643.1    EU019216    ABV74058.1    FJ938064    ACT10999.1    EF424619    ABP38281.1    FJ425189    ACJ67004.1    MG518518    AVN88328.1    EF424624    ABP38337.1    FJ938067    ACT11034.1    FJ938065    ACT11011.1    EF424618    ABP38264.1    FJ425186    ACJ66969.1    EF424623    ABP38326.1    FJ425185    ACJ66960.1    FJ938066    ACT11022.1    FJ938063    ACT10987.1    EF424615    ABP38230.1    FJ425187    ACJ66980.1    FJ415324    ACJ35487.1    EF424616    ABP38244.1    EF424620    ABP38292.1    FJ425184    ACJ66951.1    DQ811784    ABG89286.1    EF424622    ABP38309.1    EF424617    ABP38260.1    AH014866    AH014867    AH014868    AH014869    AH014871    AH014875    KM985635    KU886219    KX982264    MG757138    MG757139    MG757140    MG757141    MG757142    MH043952    MH043954    MH043955    AAY33929.1    AAY33932.1    AAY33935.1    AAY33938.1    AAY33944.1    AAY33956.1    AJL33724.1    ANJ04978.1    ARD06003.1    AVI15004.1    AVI15015.1    AVI15026.1    AVI15037.1    AVI15048.1    AVZ61103.1    AVZ61123.1    AVZ61133.1    KF906249    KF906250    KF906251    AHN64776.1    AHN64785.1    AHN64794.1    KT368891    MF593476    ALA50082.1    ATI09451.1    FJ425188    FJ425190    ACJ66994.1    KY419106    KY419107    KY419109    KY419111    KY419113    ARC95229.1    ARC95237.1    ARC95245.1    ARC95261.1    ARC95276.1    AF220295    AF239312    AF239313    AF239314    AF239315    AF239316    AF239310    AF239311    AF058944    AF058942    AF391542    AF058943    X51347    AF391541    X89863    CAA61962.1    KF850449    AHA83610.1    AY316299    AAQ67200.1    AY316300    AAQ67208.1    AH014873    AAY33950.1    KY419104    KY419105    KY419110    KY419112    ARC95213.1    ARC95221.1    ARC95253.1    ARC95269.1    AB354579    BAF75635.1    MF618252    ATN37890.1    EF446615    LC061272    LC061274    ABP87993.1    BAS18848.1    BAS18868.1    DQ016112    DQ016116    AAY33941.1    AAY33953.1    FJ647220    ACN89712.1    FJ647218    ACN89687.1    FJ647225    ACN89756.1   

Proteomes

UP000098016    UP000098607    UP000102058    UP000103177    UP000107950    UP000108760    + More
UP000118444    UP000120443    UP000122230    UP000123677    UP000127413    UP000134208    UP000139452    UP000143896    UP000147573    UP000148743    UP000161305    UP000173725    UP000173897    UP000174991    UP000008170    UP000168247    UP000164754    UP000107997    UP000124867    UP000134743    UP000143869    UP000156925    UP000162514    UP000168964    UP000001985    UP000006551    UP000148943    UP000173347    UP000117254    UP000161770    UP000167944    UP000175084    UP000118088    UP000159025    UP000158592    UP000133456    UP000142874    UP000114687    UP000149957    UP000007193    UP000163097    UP000139707    UP000143567    UP000154289    UP000125924    UP000144342    UP000153628    UP000174571    UP000136116    UP000136745    UP000134650    UP000133443    UP000147178    UP000164707    UP000139966    UP000173415    UP000140344    UP000163913    UP000104294    UP000162935    UP000172225    UP000121953    UP000158327    UP000158296    UP000127099    UP000170940    UP000174569    UP000147981    UP000139235    UP000151273    UP000121258    UP000145507    UP000149260    UP000158231    UP000102696    UP000148210    UP000008572    UP000008571    UP000008570    UP000168103    UP000103372    UP000155347    UP000166748    UP000098534    UP000151686    UP000119015   

Pfam

PF02723   NS3_envE

Interpro

IPR003873   NS3/E

ProteinModelPortal

Q0ZJ83   Q5MQC8   Q0ZJB5   Q0ZJD1   A0A224ANC8   Q0ZJ91   + More
Q0ZME5   Q14EA8   A0A3G3NGX9   A0A2H4MX05   A0A096XNH9   A0A2H4MWX2   A0A096XNG6   A0A2H4MXY9   C0KYZ2   Q6QX39   A0A2S0SZ10   C6GHS4   D7PJY3   I1TMH9   Q9IKC8   P29076   C0KYX2   I1TMG9   H9BZY1   C0KYW4   O72005   C0KYS4   C0KYU3   C0KYV4   I7AWD0   P06591   Q77NM9   Q77NQ6   O72006   D4QFK4   O72008   Q84733   Q2QKN0   A0A096XNI3   A0A2H4MWY9   A0A3G3NH48   A0A0A7UXR5   O72007   A4ZU45   A0A2R4STU8   A0A096XNF4   A0A5J6NRL9   A8HB20   C6GHM9   A4ZU23   B7U2R9   A0A2P1IQB5   A4ZU78   C6GHR4   C6GHP1   A4ZU12   B7U2N7   A4ZU67   B7U2M6   C6GHQ2   C6GHL7   A4ZTX9   B7U2P7   B7TYH3   A4ZTZ0   A4ZU34   B7U2L5   Q0PL35   A4ZU56   A4ZU01   Q4U3S8   X2JQI8   A0A0U2GN18   B7U2Q8   A0A1V0IGI6   P0C2Q7   P0C2Q6   P0C2Q5   P0C2Q4   P0C2Q3   P0C2Q2   P15775   P0C2Q1   Q84731   V5N926   Q6W360   Q6W352   Q4U3T0   A0A1V0IG71   A7BKC6   A0A2D1CED6   A8R4D4   Q4U3S9   C0KYT3   C0KYR3   C0KYY1  

KEGG

vg:3200430     vg:11273171     vg:22807884     vg:921685    

GO

GO:0044662  P:disruption by virus of host cell membrane
GO:0046760  P:viral budding from Golgi membrane
GO:0044178  C:host cell Golgi membrane
GO:0019031  C:viral envelope
GO:0016021  C:integral component of membrane

From MSLVP

Host nucleus. Host cytoplasm.

From Uniprot

Host Golgi apparatus membrane   The cytoplasmic tail functions as a Golgi complex-targeting signal.   With evidence from 1 publications.

Length:

82

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

37.85275

Exp number, first 60 AAs:

37.74578

Total prob of N-in:

0.21085

POSSIBLE N-term signal

sequence

outside

1  -  9

TMhelix

10  -  32

inside

33  -  38

TMhelix

39  -  58

outside

59  -  82