Strain

CHINA_BAT_2006_NC_009019 (Region: China: Guangdong province;  Strain: Bat coronavirus HKU4-1, complete genome.;  Date: 2006)

Gene

orf1ab polyprotein

Description

Annotated in NCBI,  orf1ab polyprotein

Location

NC_009019(+):267-21625

GenBank Accession

YP_001039952.1

Full name

Replicase polyprotein 1ab      

Alternative Name

ORF1ab polyprotein

CDS

ATGCTTTCCAAGGCTAGTGTGACCACGCAAGGTGCGCGTGGTAAGTATCGAGCAGAGCTCTATAATGAAAAAAGAAGTGACCATGTTGCTTGCACAGTACCACTTTGTGATACTGATGACATGGCTTGTAAGCTCACACCATGGTTTGAAGATGGGGAAACTGCCTTCAACCAAGTGAGTTCTATTCTTAAAGAAAAAGGTAAAATCCTTTTTGTCCCAATGCATATGCAGAGGGCTATGAAGTTTCTCCCAGGCCCACGTGTTTACCTGGTAGAGAGACTTACTGGAGGTATGCTTTCAAAGCATTTCCTTGTTAACCAATTGGCTTACAAAGATCAAGTTGGTGCCGCAATGATGCGCACCACATTGAATGCTAAGCCTCTCGGTATGTTCTTTCCATATGATTCAAGTTTGGAGACTGGTGAATACACTTTTCTCCTACGTAAGAATGGTCTTGGAGGACAACTTTTCCGTGAACGACCATGGGATCGTAAGGAAACACCTTACGTGGAAATTTTAGATGATCTTGAGGCTGACCCTACTGGTAAGTACTCACAGAATCTTCTTAAGAAGTTGATTGGTGGTGATTGTATCCCAATCGACCAATATATGTGTGGCAAAAACGGTAAACCTATTGCTGATTATGCCAAAATAGTAGCTAAGGAAGGGTTGACCACCTTGGCTGACATTGAAGTTGATGTTAAATCTCGTATGGATTCAGATCGCTTCATTGTATTAAACAAAAAATTGTACCGTGTTGTTTGGAATGTTACACGTCGTAATGTGCCATATCCCAAACAAACGGCTTTTACTATTGTGAGTGTTGTTCAGTGTGATGACAAAGATTCTGTTCCTGAACATACATTTACTATTGGTTCACAAATTCTTATGGTGTCACCTCTAAAGGCCACTAATAATAAGAATTTTAATCTTAAACAGCGTTTGCTCTATACTTTTTATGGAAAAGATGCTGTTCAACAACCAGGTTACATTTACCACTCTGCTTATGTTGATTGTAATGCATGTGGTAGGGGTACGTGGTGTACTGGGAATGCTATACAGGGCTTTGCTTGTGATTGTGGTGCTAATTATAGTGCCAATGATGTTGATTTGCAATCTTCAGGTCTAGTACCTAGGAATGCGTTGTTCTTGGCTAATTGTCCTTGTGCTAACAATGGTGCATGCAGCCATAGTGCAGCACAGGTTTACAACATCTTAGATGGTAAAGCTTGTGTTGAAGTTGGTGGAAAGTCTTTCACTTTAACCTTTGGTGGCGTTGTTTATGCTTACATGGGTTGTTGTGATGGTACTATGTACTTTGTTCCTCGTGCTAAATCTTGTGTCTCACGCATAGGTGATGCAATCTTTACTGGTTGCACAGGCACTTGGGATAAAGTTGTTGAGACAGCAAATCTGTTTCTCGAAAAAGCCCAGCGTTCTCTTAATTTCTGTCAGCAGTTTGCTCTTACAGAGGTTGTTTTAGCAATACTGTCTGGTACGACATCTACTTTTGAAGAGTTGCGTGACTTGTGTCATAATGCGAGTTATGAAAAGGTGCGTGACCATTTAGTAAACCATGGCTTTGTGGTCACAATTGGTGATTATATTAGAGATGCAATTAATATAGGTGCAAATGGTGTTTGCAATGCTACTATTAACGCTCCTTTTATCGCCTTCACTGGTCTTGGTGAGTCATTTAAAAAAGTTTCTGCAATACCATGGAAAATTTGCAGTAATCTTAAAAGTGCCTTAGACTACTATAGTTCTAATATTATGTTTAGGGTTTTTCCTTATGACATACCTTGCGATGTCAGTAATTTTGTAGAGCTGCTGTTAGATTGTGGTAAACTTACAGTGGCTACTAGTTACTTCGTACTCCGTTATTTGGATGAGAAGTTTGATACAGTTCTTGGCACTGTTAGTAGTGCATGTCAAACTGCCCTGAGTAGTTTTCTTAATGCCTGTGTAGCAGCGTCGCGTGCTACTGCAGGCTTTATTAATGACATGTTCAAATTGTTTAAAGTGCTCATGCATAAGCTATATGTCTACACTAGTTGTGGCTATGTAGCTGTTGCTGAACATTCTTCTAAAATTGTACAACAAGTGCTCGACATTATGTCTAAGGCAATGAAGTTGTTGCACACTAATGTTTCCTGGGCAGGTACTAAATTATCTGCCATTATTTATGAAGGCCGTGAAGCCCTTTTGTTTAATAGTGGAACATATTTTTGTCTTTCCACTAAAGCCAAAACATTACAGGGTCAAATGAATCTTGTTTTGCCAGGCGATTATAACAAGAAGACTTTAGGTATTCTTGACCCTGTTCCCAATGCAGACACTATTGACGTTAATGCCAATAGTACAGTTGTAGATGTTGTGCATGGTCAATTAGAACCAACTAATGAGCATGGTCCCAGCATGATTGTAGGGAACTATGTACTCGTTAGCGACAAATTGTTTGTTCGCACTGAGGACGAAGAATTTTATCCTCTTTGCACTAATGGTAAAGTTGTGTCTACCTTGTTTAGACTTAAGGGTGGCATGCCTTCTAAAAAAGTTACATTCGGTGATGTTAATACCGTTGAAGTAACTGCTTATCGTAGTGTATCGATTACATATGATATTCATCCAGTTCTTGATGCATTACTTAGTAGCTCAAAGTTAGCTACTTTTACAGTTGAGAAAGATCTTCTAGTTGAAGATTTTGTTGATGTCATCAAGGATGAGGTATTAACATTGCTTACACCTTTGCTCCGTGGTTATGATATCGATGGTTTTGATGTAGAAGATTTTATTGATGTACCATGCTATGTTTATAACCAAGATGGTGACTGTGCATGGAGTTCTAATATGACCTTTTCTATTAACCCTGTTGAGGATGTAGAGGAGGTTGAAGAATTTATAGAAGATGATTATCTTTCTGATGAGCTGCCTATTGCTGATGATGAAGAAGCTTGGGCTCGCGCTGTAGAAGAAGTCATGCCTTTGGATGACATTCTAGTAGCTGAAATTGAGTTGGAAGAAGACCCACCACTGGAAACCGCCTTGGAAAGTGTGGAAGCTGAAGTAGTTGAAACAGCCGAAGCACAAGAACCAAGTGTAGAGTCAATAGACTCTACCCCTAGCACTTCTACAGTAGTAGGTGAAAATGACTTGAGCGTTAAGCCCATGTCACGTGTAGCTGAAACTGACGATGTGCTAGAATTGGAAACGGCCGTAGTAGGTGGACCTGTGTCAGATGTCACGGCTATTGTGACAAATGACATAGTGTCTGTTGAACAGGCTCAACAATGTGGTGTTTCTTCATTACCTATTCAAGATGAAGCTAGTGAAAATCAGGTGCATCAAGTGTCTGATTTACAAGGTAATGAATTACTTTGTTCAGAAACTAAGGTTGAAATAGTACAACCTAGACAAGATTTGAAGCCAAGACGCTCACGTAAGTCTAAGGTTGATTTAAGTAAATATAAGCATACTGTTATTAATAATAGTGTGACTTTAGTATTAGGTGATGCTATACAAATAGCCTCATTACTGCCTAAGTGTATTCTTGTAAATGCTGCTAACCGCCATCTTAAACATGGTGGTGGTATAGCTGGCGTTATAAATAAGGCATCTGGTGGTGATGTTCAGGAAGAATCAGATGAATATATAAGTAATAATGGACCACTTCATGTAGGTGATTCCGTATTACTTAAGGGCCATGGCTTAGCAGATGCAATTTTGCATGTTGTTGGTCCTGATGCTCGTAATAATGAAGATGCTGCTTTACTTAAACGCTGTTATAAGGCGTTTAATAAGCATACTATTGTAGTAACACCGTTAATATCAGCTGGTATTTTTAGTGTAGACCCTAAAGTGTCTTTTGAGTATCTCCTGGCTAATGTTACTACAACTACTTATGTTGTTGTTAACAATGAAGATATTTATAATACACTTGCAACACCATCAAAACCAGATGGTCTTGTTTATTCATTTGAAGGATGGCGTGGTACTGTTCGTACTGCTAAGAACTATGGTTTTACATGCTTCATTTGTACTGAGTATTCAGCCAATGTTAAATTTTTACGTACCAAAGGTGTGGATACTACTAAGAAAATTCAAACAGTTGATGGTGTTAGCTATTATTTATATAGTGCTAGAGATGCCTTGACTGATGTTATTGCAGCTGCTAATGGCTGCTCAGGTATTTGTGCCATGCCTTTTGGCTACGTTACGCATGGACTTGATTTGGCTCAATCTGGCAACTATGTACGTCAAGTAAAAGTGCCGTATGTTTGTTTATTAGCTTCTAAAGAACAGATTCCTATAATGAACTCAGATGTTGCTATTCAAACACCTGAGACAGCATTTATAAACAATGTTACTTCCAATGGGGGTTATCACAGTTGGCATTTAGTTAGCGGTGACCTCATTGTTAAGGATGTGTGTTATAAAAAGTTATTGCATTGGTCAGGTCAAACCATTTGCTATGCAGATAATAAATTCTATGTGGTAAAGAATGATGTAGCTTTACCCTTTAGTGATTTAGAAGCGTGTAGGGCTTATCTGACTTCTAGGGCCGCACAGCAAGTTAATATCGAAGTGCTTGTTACAATCGATGGTGTTAATTTCAGAACTGTTATTCTGAATGATACTACCACTTTTAGAAAACAGCTTGGTGCTACTTTCTATAAAGGTGTAGATATCTCAGATGCTTTTCCTACTGTGAAAATGGGAGGTGAGTCTCTATTTGTGGCTGATAATTTATCAGAATCGGAGAAAGTTGTACTGAAAGAATATTACGGTACATCTGATGTTACATTTTTGCAACGATATTATTCACTGCAGCCATTGGTTCAGCAGTGGAAATTTGTTGTACATGATGGTGTTAAGTCTTTGAAGCTTAGCAATTATAATTGTTACATTAATGCAACAATTATGATGATAGATATGCTACATGACATAAAATTTGTAGTGCCTGCGTTGCAGAATGCCTACTTAAGATATAAGGGCGGAGATCCTTATGATTTTCTTGCCCTAATTATGGCTTATGGTGATTGTACATTTGACAATCCTGATGACGAAGCCAAACTTTTACATACTCTCCTTGCTAAAGCAGAATTAACTGTTTCAGCTAAAATGGTATGGAGAGAATGGTGCACTGTTTGTGGTATTCGCGATATTGAATATACAGGCATGCGTGCATGCGTTTATGCTGGTGTTAATTCGATGGAAGAATTACAATCAGTTTTTAATGAAACTTGTGTGTGTGGTAGTGTAAAACACCGTCAATTGGTGGAACACTCGGCACCATGGTTATTGGTATCTGGTTTAAATGAAGTGAAAGTGTCTACTTCCACTGATCCAATTTACCGTGCCTTTAATGTCTTTCAGGGTGTGGAAACAAGTGTTGGTCACTATGTCCATATTCGAGTGAAGGATGGTTTGTTTTATAAGTATGACTCTGGTAGCTTAACTAAAACTTCTGATATGAAGTGTAAGATGACCAGTGTGTGGTATCCCACAGTTCGTTATACAGCAGACTGTAATGTCGTTGTATATGATCTTGATGGTGTTACTAAAGTTGAAGTCAATCCAGACTTATCTAACTATTATATGAAGGATGGTAAGTATTATACTAGTAAACCTACCATTAAATATTCACCTGCTACCATATTACCTGGTAGTGTTTATTCTAATAGTTGCCTTGTAGGTGTAGATGGAACTCCTGGCAGTGATACTATTAGTAAATTCTTTAATGATCTGTTAGGTTTTGATGAAACAAAGCCTATTTCTAAGAAACTCACTTATTCTCTGTTGCCTAATGAAGATGGCGATGTTTTATTATCTGAGTTTAGTAATTATAACCCAGTTTATAAGAAAGGCGTTATGCTTAAAGGCAAGCCTATCTTGTGGGTTAATAATGGGGTCTGTGACAGTGCGCTTAATAAGCCGAATAGAGCCAGCCTTCGTCAATTATACGATGTGGCACCTATTGTTCTTGATAATAAGTACACTGTCTTACAAGATAATACATCTCAACTAGTAGAACATAATGTTCCGGTTGTTGATGATGTTCCAATTACTACTAGAAAGTTAATTGAAGTTAAATGTAAAGGTTTAAATAAGCCTTTTGTAAAGGGTAACTTCAGTTTTGTTAATGATCCCAATGGTGTTACTGTTGTAGACACATTAGGTTTGACTGAACTACGTGCCTTGTACGTGGATATTAATACTAGATATATTGTCCTTAGGGATAATAATTGGTCTAGTTTATTTAAGTTACATACTGTTGAATCTGGAGACTTACAGATTGTAGCGGCTGGTGGATCTGTTACAAGAAGAGCGCGTGTTCTTCTTGGTGCATCATCACTTTTTGCAAGTTTTGCAAAAATTACAGTTACTGCAACGACAGCAGCATGTAAGACTGCTGGTCGCGGTTTCTGTAAATTTGTTGTTAATTATGGTGTTTTGCAGAATATGTTTGTATTTTTAAAAATGCTATTTTTCTTACCATTTAATTATTTATGGCCTAAGAAACAACCAACTGTTGACATCGGTGTTAGCGGTTTAAGAACTGCTGGCATTGTTACGACTAATATAGTAAAACAATGTGGTACAGCAGCCTATTATATGTTATTAGGAAAATTTAAGCGTGTAGACTGGAAAGCTACATTACGTTTGTTTTTACTATTATGCACAACAATTTTGTTGTTGTCATCAATATATCATTTGGTATTATTTAATCAAGTATTATCGAGTGATGTTATGTTAGAAGATGCTACTGGCATTTTAGCCATTTATAAAGAGGTGCGATCTTACCTCGGCATCCGTACGTTGTGTGATGGTTTAGTTGTAGAATACCGCAATACATCGTTTGATGTAATGGAGTTCTGTTCTAACCGCTCAGTTTTATGTCAATGGTGTCTTATTGGTCAAGACTCATTGACACGTTATTCAGCTCTTCAAATGCTTCAAACCCATATAACCAGCTATGTTTTGAACATAGATTGGATTTGGTTTGCACTTGAGTTCTTTTTAGCATATGTGTTGTATACGTCTAGCTTTAACGTATTATTGTTAGTTGTTACAGCACAATATTTCTTTGCTTACACTAGTGCATTTGTAAATTGGCGTGCTTACAATTACATAGTGTCAGGTCTCTTTTTCTTAGTAACACACATACCGTTACATGGTTTAGTGCGTGTTTATAATTTTCTTGCATGTTTGTGGTTTCTGAGGAAATTTTATAGCCATGTTATTAATGGTTGTAAAGACACAGCATGTCTTTTATGTTATAAAAGGAATCGTCTTACACGTGTTGAAGCTTCCACCATTGTCTGTGGTACTAAACGTACGTTTTATATCGCAGCTAATGGAGGCACGTCTTACTGTTGTAAACATAATTGGAATTGTGTTGAATGCGACACTGCAGGTGTAGGGAATACCTTTATCTGTACAGAAGTCGCTAATGACCTCACTACCACTTTACGCAGACTTATTAAACCCACTGATCAGTCACATTATTATGTAGATTCAGTTGTGGTTAAAGATGCAGTTGTTGAACTACATTACAATAGAGATGGTTCTTCATGTTATGAGCGTTACCCTCTCTGTTATTTTACTAATTTAGAAAAATTGAAGTTCAAAGAGGTTTGTAAAACTCCTACAGGTATACCTGAACACAATTTTCTAATTTATGACACTAATGATCGTGGCCAGGAAAATTTAGCTAGGTCAGCTTGTGTTTATTATTCCCAAGTCTTATGCAAGCCTATGCTGCTTGTTGATGTTAATTTGGTTACCACTGTTGGTGATAGTAGAGAAATCGCCATCAAAATGTTGGATTCCTTTATAAATAGTTTCATCTCTCTCTTTAGTGTAAGTCGTGATAAGCTTGAGAAGCTTATTAACACTGCACGTGATTGTGTTAGAAGAGGAGATGATTTCCAAAATGTTTTAAAGACTTTTACTGATGCTGCCCGTGGACATGCTGGTGTGGAGTCTGATGTTGAGACAACTATGGTTGTTGATGCATTACAGTATGCACATAAGAATGATATTCAGTTGACAACTGAATGTTATAATAATTATGTGCCTGGTTATATTAAACCAGATAGCATAAATACATTAGATTTAGGTTGTTTGATTGACCTTAAAGCTGCTTCTGTTAACCAAACTAGTATGCGAAATGCAAATGGTGCATGTGTTTGGAATAGTGGTGATTATATGAAGCTTTCTGATAGTTTCAAGCGTCAGATTAGAATTGCTTGCAGAAAGTGTAATATTCCGTTTAGACTTACTACGTCTAAACTTCGTGCAGCTGACAATATTTTGTCTGTAAAATTTAGCGCCACTAAAATTGTTGGTGGCGCTCCTAGTTGGCTTTTAAGAGTGCGTGATTTAACTGTTAAAGGTTACTGCATTCTTACGCTTTTTGTGTTTACAGTAGCTGTGCTATCCTGGTTTTGTTTACCTAGTTATAGTATTGCGACTGTTAATTTTAATGATGACCGCATTCTTACATATAAAGTTATTGAGAATGGTATTGTTAGAGACATAGCACCTAACGATGTATGCTTTGCCAATAAATATGGTCATTTTTCGAAATGGTTTAATGAGAACCACGGAGGCGTTTATCGTAACTCCATGGATTGTCCCATTACTATAGCTGTAATAGCTGGTGTAGCAGGTGCTCGTGTGGCAAATGTTCCAGCAAATTTAGCTTGGGTTGGTAAACAAATAGTGTTGTTTGTCTCCCGTGTCTTTGCTAATACTAATGTGTGTTTTACACCTATTAATGAAATTCCTTATGATACATTCTCTGATAGTGGCTGTGTGCTTTCTTCAGAGTGTACGTTGTTTAGGGATGCAGAAGGTAATTTAAATCCATTTTGCTATGACCCTACTGTACTACCTGGTGCTTCAAGCTATGCTGATATGAAACCTCATGTACGTTATGACATGTATGATTCTGACATGTATATTAAATTTCCTGAGGTTATAGTTGAAAGTACTCTCAGAATTACTAAAACTTTAGCAACTCAATACTGCCGTTTTGGTAGTTGTGAAGAGTCAGCTGCTGGTGTATGCATTAGCACCAATGGATCTTGGGCCTTGTATAATCAAAATTATAGTACTCGTCCTGGAATCTATTGTGGTGATGATTATTTTGATATAGTACGACGGTTGGCCATATCTTTATTTCAACCAGTTACGTATTTTCAACTTAGCACATCTTTAGCTATGGGTTTAGTACTTTGTGTGTTTCTTACAGCCGCTTTTTACTATATTAATAAAGTTAAGCGTGCTCTTGCCGATTACACACAATGTGCTGTTGTAGCTGTAGTTGCAGCGTTGTTAAACAGCTTATGTTTATGCTTTATAGTTGCCAACCCATTGTTGGTTGCTCCCTATACAGCTATGTATTACTATGCCACATTTTATCTTACTGGTGAACCGGCATTTATCATGCATATTTCCTGGTATGTAATGTTTGGTGCTGTAGTTCCTATTTGGATGTTAGCATCTTACACCGTTGGTGTAATGTTGCGTCATCTGTTTTGGGTGTTAGCTTATTTTAGTAAGAAGCATGTTGATGTTTTTACTGATGGTAAGCTTAATTGTAGCTTTCAGGATGCTGCTAGTAACATCTTTGTTATAGGTAAGGATACATATGTCGCTTTACGTAATGCTATAACACAAGATTCCTTTGTTAGGTATTTGTCATTATTTAACAAGTACAAGTATTATTCAGGTGCTATGGACACGGCTTCTTATAGAGAGGCTTGTGCCGCACATTTGTGTAAAGCCTTACAGACATACAGTGAAACTGGTAGTGACATCTTGTACCAACCACCTAATTGTAGTGTCACGTCTAGTGTGCTGCAAAGTGGTTTGGTTAAGATGTCAGCTCCTAGTGGTGCTGTAGAGAACTGTATTGTGCAAGTTACATGTGGGTCTATGACATTGAATGGTCTTTGGCTTGATAACACTGTATGGTGTCCTCGCCATATTATGTGTCCTGCTGACCAGTTAACTGACCCAAATTATGATGCTTTGTTAATTTCAAAAACTAATCATAGTTTTATTGTGCAAAAACACATAGGAGCTCAGGCTAATCTGCGTGTTGTTGCTCATTCTATGGTTGGTGTCTTACTTAAGTTAACTGTTGATGTTGCTAATCCTAGTACACCAGCATATACTTTTAGTACTGTTAAACCTGGCGCCTCGTTTAGCGTTTTAGCTTGTTATAATGGCAAGCCTACAGGTGTCTTTACAGTTAATTTACGCCACAATTCTACCATTAAAGGCAGTTTCCTTTGTGGTTCTTGTGGTAGTGTTGGTTACACTGAAAATGGAGGTGTAATCAACTTTGTTTATATGCATCAGATGGAATTATCAAATGGTACACATACTGGTAGTTCCTTTGATGGTGTTATGTATGGTGCTTTTGAAGATAAACAAACACACCAGTTACAGTTAACAGACAAATACTGCACTATTAATGTAGTAGCTTGGCTCTATGCAGCAGTTCTAAATGGTTGTAAGTGGTTTGTAAAACCCACCAGAGTTGGAATTGTAACTTATAATGAATGGGCTTTGAGTAATCAGTTTACAGAATTTGTAGGCACACAGTCCATTGATATGCTTGCTCACCGAACTGGTGTTTCTGTTGAACAAATGCTTGCTGCTATCCAGAGTCTGCATGCTGGTTTTCAGGGTAAAACTATTCTGGGCCAGTCTACTTTGGAGGATGAGTTCACTCCTGATGATGTTAATATGCAAGTCATGGGTGTTGTAATGCAGAGTGGTGTTAAACGTATATCATATGGCTTTATACACTGGTTGATTTCAACCTTTGTATTGGCATATGTTAGCGTTATGCAACTCACTAAGTTTACTATGTGGACTTATTTGTTTGAGACTATTCCCACACAAATGACTCCTCTCTTATTGGGTTTTATGGCATGCGTTATGTTTACTGTTAAACATAAACATACCTTCATGTCACTCTTCCTATTACCTGTGGCACTTTGTTTGACATATGCAAATATTGTATATGAACCACAGACTTTAATATCAAGCACATTGATTGCTGTAGCTAATTGGTTGACTCCTACTAGTGTGTATATGCGCACTACACATTTTGACTTTGGCTTATATATTAGCCTTAGTTTTGTATTAGCGATTATTGTTAGGCGGTTGTATCGTCCTTCAATGTCGAATTTAGCTCTAGCTTTATGTAGTGGTGTGATGTGGTTTTACACTTATGTTATAGGGGACCACAGTAGTCCCATAACCTATCTTATGTTTATAACTACGTTGACTAGTGATTACACAATTACTGTTTTTGCTACCGTTAACTTAGCTAAGTTTATTTCTGGCTTGGTGTTCTTTTATGCTCCGCATTTGGGATTCATATTGCCAGAAGTTAAACTTGTGTTATTAATATACCTGGGTTTAGGGTATATGTGTACAATGTATTTTGGTGTCTTTTCATTATTGAACCTGAAATTGCGTGTACCATTGGGTGTGTATGACTATTCAGTTTCAACTCAAGAATTTCGCTTCCTTACAGGTAATGGCCTTCATGCGCCACGTAACTCATGGGAAGCTCTAATACTTAATTTTAAATTGCTTGGTATTGGCGGTACACCTTGTATTAAGGTTGCAACAGTCCAATCCAAGCTTACAGATTTGAAATGCACATCTGTTGTTTTACTTACGGTGTTGCAACAATTACACCTTGAGTCTAATAGTAAGGCGTGGTCATATTGTGTTAAGTTACACAATGAAATTTTGGCTGCGGTTGATCCTACAGAAGCTTTTGAAAGATTTGTTTGTCTTTTTGCAACGCTAATGTCTTTTTCTGCTAATGTTGATTTAGATGCTTTAGCCAATGATCTCTTTGAGAATTCATCAGTCTTACAAGCTACTCTTACTGAGTTCTCTCATTTAGCTACTTATGCTGAATTAGAGACAGCTCAGTCATCTTACCAAAAAGCTTTGAACTCTGGTGATGCGTCACCACAGGTTCTTAAAGCGTTACAAAAAGCTGTTAACGTTGCTAAGAATGCCTATGAAAAAGATAAGGCTGTAGCACGTAAGTTAGAGCGTATGGCTGAACAAGCTATGACATCTATGTATAAGCAAGCACGTGCCGAGGATAAGAAGGCAAAAATTGTAAGTGCTATGCAAACTATGTTATTTGGCATGATTAAGAAGTTAGATAATGATGTTCTTAATGGTGTTATAGCAAATGCTAGAAATGGTTGTGTGCCTCTTAGCATTGTTCCTCTTTGTGCATCTAATAAGTTGAGGGTCGTAATACCTGATATTTCTGTTTGGAATAAAGTTGTTAATTGGCCTAGTGTTTCCTATGCTGGGTCTTTGTGGGATATTACAGTTATAAACAATGTGGATAATGAAGTTGTCAAACCTACAGATGTTGTAGAAACTAATGAAAGTTTGACATGGCCACTTGTTATTGAATGTAGCCGATCTTCTAGTTCTGCTGTGAAGCTACAGAATAATGAGATCCATCCTAAGGGTTTGAAGACTATGGTCATAACAGCTGGTGTAGATCAAGTTAATTGTAATAGTAGTGCCGTAGCTTACTATGAGCCTGTTCAAGGCCATAGGATGGTTATGGGTTTGTTATCAGAGAATGCTCACCTTAAATGGGCTAAAGTTGAGGGTAAAGATGGTTTTATTAACATAGAGTTACAACCACCTTGCAAATTTTTAATTGCAGGTCCTAAGGGCCCTGAAATTAGATATCTTTACTTTGTAAAGAATCTTAATAATTTACATAGAGGCCAACTCTTGGGGCATATAGCTGCAACTGTACGTTTGCAAGCTGGTGCTAATACAGAGTTTGCTAGTAATTCAACTGTTCTTACTCTTGTGGCATTTGCAGTTGATCCAGCTAAAGCATACTTGGACTATGTTGGTTCTGGTGGAACACCATTGTCCAATTATGTTAAGATGCTTGCACCTAAAACAGGTACTGGCGTGGCTATTTCAGTTAAGCCAGAAGCAACTGCAGACCAAGAAACATATGGTGGTGCGTCTGTGTGTCTCTATTGTAGAGCACATATAGAACATCCTGATGTTTCAGGTGTCTGTAAATATAAAACGCGTTTTGTACAAATCCCAGCGCACGTACGTGATCCTGTGGGATTTTTACTTAAAAACGTTCCGTGTAATGTCTGTCAGTATTGGGTTGGGTATGGTTGTAATTGTGACGCATTACGTAACAATACAGTCCCCCAATCCAAAGATACTAATTTTTTAAACGAGTCCGGGGTTCTAGTGTAAATGCCCGACTAGAACCCTGTTCAAGTGGTCTAACCACTGATGTCGTTTATAGGGCATTCGACATCTGCAATTTTAAAGCTAGAGTTGCAGGTATAGGAAAGTATTATAAAACTAATACTTGTAGATTTGTACAGGTTGATGATGAAGGTCATAAACTTGATTCTTATTTTATCGTTAAACGTCATACTATGAGTAATTATGAGTTAGAGAAGCGCTGCTATGATCTTCTTAAAGATTGTGATGCAGTGGCTATTCATGATTTCTTCATATTTGACGTTGATAAAACTAAAACTCCACACATAGTACGTCAGAGTTTGACTGAGTATACTATGATGGATTTAGTATATGCTTTGCGCCACTTTGACCAGAATAATTGTGAAGTGTTAAAGAGCATATTAGTTAAATATGGTTGCTGTGAACAGTCATATTTTGATAATAAATTATGGTTTGATTTTGTGGAAAACCCTAGTGTAATAGGTGTTTATCATAAACTTGGTGAAAGAATTCGCCAAGCTATGTTAAACACTGTAAAAATGTGTGACCACATGGTTAAAAGTGGCCTTGTGGGTGTTTTAACACTTGATAACCAAGACCTTAATGGTAAGTGGTATGATTTTGGTGATTTTGTTATTACCCAACCAGGTGCTGGAGTAGCTATTGTTGATAGCTATTATTCTTACCTTATGCCTGTGCTCTCAATGACCAATTGTTTGGCAGCAGAGACACATAAGGATTGTGATTTTAATAAGCCTCTTATAGAGTGGCCTTTATTGGAGTATGATTATACAGACTATAAAATTGGTCTGTTTAATAAATACTTTAAATATTGGGATCAAACATACCACCCTAATTGTGTTAATTGTAGTGATGATCGTTGTATTTTACATTGTGCTAATTTCAATGTACTCTTTTCAATGGTACTACCTAACACATCTTTCGGGCCTATCGTTCGTAAGATTTTTGTTGATGGCGTACCGTTTATAGTATCTTGTGGTTATCACTACAAGGAGTTAGGGTTAGTCATGAATATGGATTTTAACATCCATAGGCATAGGCTTGCACTTAAGGAATTGATGATGTATGCAGCAGATCCTGCTATGCATATAGCATCTGCATCAGCCCTTTGGGATTTGAGGACACCATGTTTTAGTGTTGCAGCTCTTACAACTGGTTTGACATTTCAAACCGTTAGACCTGGCAATTTTAATAAAGATTTTTATGACTTTGTAGTATCTAGAGGCTTTTTCAAGGAAGGGTCTTCAGTTACATTAAAACATTTCTTCTTTGCACAAGATGGTCATGCTGCTATTACAGATTATAGCTATTATGCTTATAATCTACCTACTATGGTTGACATCAAGCAGATGTTGTTCTGCATGGAAGTTGTCGACAAATATTTTGATATCTATGACGGTGGGTGCCTTAACGCTTCTGAAGTTATAGTTAATAATTTAGATAAGAGTGCTGGCCATCCTTTTAATAAGTTTGGCAAAGCACGTGTTTATTATGAAAGTATGAGTTATCAAGAGCAAGATGAATTGTTTGCTGTAACTAAGCGCAACGTTTTGCCTACTATAACTCAAATGAATTTGAAGTATGCTATTAGTGCTAAGAATAGAGCACGTACTGTAGCAGGCGTGTCTATACTTAGCACAATGACTAATCGTCAATATCACCAGAAGATGTTGAAGTCTATGGCTGCAACGCGTGGAGCCACGTGTGTCATAGGCACAACTAAATTTTATGGTGGTTGGGACTTTATGTTAAAAACCTTATATAAGGATGTTGAGAGTCCACATTTAATGGGTTGGGATTACCCTAAGTGTGATCGTGCTATGCCTAATATGTGTCGCATTTTAGCGTCATTGATTTTGGCACGTAAGCATAGTACTTGTTGTACTAATTCTGATAGGTTCTACCGCTTAGCCAATGAGTGTGCTCAAGTGTTAAGTGAGTATGTCCTATGCGGAGGAGGTTATTATGTTAAACCAGGTGGTACGAGTAGTGGTGATGCAACTACTGCTTATGCCAATAGTGTTTTTAACATATTACAAGCCACCACCGCTAATGTTAGTGCACTTATGAGTGCTAATGGTAATACTATCATAGATCGTGAAATAAAGGATATGCAATTTGACTTGTATATCAATGTATATAGAAAAGTAGTGCCTGATCCTAAATTTGTTGACAAGTACTACGCATTTCTTAATAAACACTTTTCTATGATGATCTTATCGGATGATGGTGTTGTGTGTTATAATAGCGACTATGCCGCTAAAGGTTATGTCGCCTCCATCCAAAATTTTAAAGAGACGCTTTATTATCAAAATAATGTCTTTATGTCAGAAGCTAAGTGCTGGGTGGAAACCAATTTGGAAAAGGGTCCACATGAATTTTGTTCACAGCATACGCTCTATATTAAAGATGGGGACGATGGCTACTTCTTACCTTATCCAGACCCTTCTAGGATTTTGTCTGCCGGTTGCTTTGTTGATGATATCGTTAAGACTGACGGTACTGTCATGATGGAGCGGTATGTGTCATTGGCTATAGATGCGTATCCTCTAACAAAGCATGATGATACTGAATATCAAAATGTATTCTGGGTCTATTTACAGTATATTGAAAAGCTTTATAAGGACCTAACTGGACACATGCTTGACAGTTATTCTGTTATGTTATGTGGTGATGATTCAGCCAAATTTTGGGAAGAGGGGTTCTATAGAGATCTCTATAGTTCGCCTACCACATTACAGGCTGTAGGTTCTTGTGTTGTGTGTCACTCACAAACATCTTTGAGGTGTGGTACATGTATACGAAGACCTTTCTTATGTTGCAAGTGTTGTTATGATCATGTAATTGCAACACCTCATAAAATGGTTCTGTCAGTTTCACCTTATGTCTGTAATGCACCTGGTTGTGATGTTTCAGATGTTACTAAATTATATCTGGGAGGTATGAGTTATTATTGTAATGACCATCGCCCAGTATGTAGTTTTCCTCTTTGTGCCAATGGCTTAGTCTTTGGTTTATATAAAAATATGTGCACCGGTAGTTCGTCTATTATGGAATTTAATAGACTTGCTACTTGTGATTGGAGTGATAGCGGTGACTACACTCTTGCTAATACAACTACAGAACCTCTTAAATTATTTGCGGCTGAGACACTTAGAGCTACAGAAGAAGCTTCTAAACAGTCGTATGCTATAGCCACTATCAAAGAAATAGTCGGTGAACGTGAATTAATACTTGTGTGGGAGGTTGGTAAATCCAAACCACCACTCAACCGTAATTATGTTTTTACTGGTTATCATTTAACCAAGAATAGTAAAGTACAGCTCGGTGAGTATGTCTTCGAGCGTATAGATTATAGTGATGCTGTCTCTTATAAATCTAGTACTACGTATAAGCTAGCAGTAGGAGACATCTTTGTGCTTACCTCTCATTCAGTGGCGACATTGTCAGCGCCAACAATAGTGAATCAAGAGAGGTATTTAAAAATAACTGGTATATATCCAACTATTACTGTGCCTGAGGAGTTTGCAAATCATGTAGTGAACTTTCAAAAAGCAGGCTTTAGTAAGTATGTTACCGTGCAAGGTCCTCCTGGTACAGGTAAGAGTCATTTTGCTATAGGGTTGGCAATATACTACCCTACAGCACGCATTGTTTATACAGCATGCTCACATGCGGCAGTTGATGCATTGTGTGAGAAGGCTTTTAAGTATTTGAACATTGCTAAATGTTCTCGTATTATTCCTGCTAAAGCGCGTGTAGAGTGTTATGACAGGTTTAAAGTCAATGATACAAATTCTCAATATTTATTCAGTACTGTTAATGCATTACCAGAAATATCAGTCGATATACTGGTAGTGGATGAAGTTAGCATGTGTACTAATTATGATTTGTCAATCATAAATTCACGTGTTAAAGCTAAACATATAGTGTATGTAGGTGATCCTGCTCAGTTACCAGCACCACGCACTTTGTTGATACGAGGCACTTTGGAGCCTGAAAATTTCAATAGTGTTACTCGTTTAATGTGTAACTTGGGACCTGACATATTTCTTAGTGTATGTTACCGGTGTCCTAAGGAAATTGTGAGCACTGTAAGCGCATTAGTTTACAACAATAAATTGTCAGCTAAGAAAGATGCTTCTGGCCAGTGCTTTAAGATACTATTTAAAGGCAGTGTGACGCATGATGCGAGCTCTGCCATTAATAGACCTCAATTGAATTTTGTAAAAACTTTTATAGCTGCTAACCCAAATTGGAGTAAAGCAGTATTTATTTCACCTTATAACAGTCAAAATGCTGTAGCTAGATCCATGTTAGGACTAACTACGCAGACTGTTGATTCTTCACAGGGCTCTGAATACCCGTATGTGATTTTCTGTCAAACAGCAGACACTGCACATGCTAATAACTTAAATAGGTTTAATGTGGCAGTGACTAGAGCACAGAAGGGTATATTATGTGTTATGACATCTCAAGTTTTATTCGATTCTCTCGAATTTGCTGAATTGTCTCTTAATAATTACAAATTGCAGTCTCAGATTGTGACTGGTTTGTTTAAAGATTGTTCTAGAGAGGACACTGGTCTTCCTCCTGCTTATGCACCTACTTATTTAAGTGTAGATGCTAAATATAAAACTACAGATGAGTTGTGTGTGAATTTGAATATAACACCTAACGTTACATATTCTAGAGTTATATCACGTATGGGATTTAAGCTTGATGCGACAATCCCAGGTTATCCTAAGTTATTCATCACGCGTGATGAAGCTATAAGGCAAGTTCGAAGCTGGGTAGGTTTCGATGTTGAGGGTGCACATGCTTCTCGTAATGCATGTGGCACCAATGTGCCTTTACAGTTAGGATTTTCTACAGGTGTGAACTTTGTTGTTCAACCCGTTGGAGTTGTAGACACTGAGTGGGGTAGTATGCTGACGACTATTTCAGCACGACCACCACCTGGTGAACAATTTAAACACCTCGTGCCACTAATGAATAAGGGTGCGACTTGGCCTATTGTACGAAGACGTATAGTTCAAATGTTATCTGATACTTTGGATAAGTTGTCAGATTACTGTACGTTTGTTTGTTGGGCTCATGGTTTTGAGCTCACGTCTGCGTCTTACTTTTGTAAGATTGGTAAAGAACAGCGGTGTAGCATGTGTAGTAGACGTGCATCTACTTTCTCCTCACCGTTGCAATCTTATGCCTGCTGGAGTCATTCCAGTGGATATGATTATGTTTACAACCCATTTTTTGTTGATGTTCAGCAGTGGGGGTATGTAGGCAATTTAGCTACCAACCACGACCGGTATTGTGGCATCCATGCTGGTGCTCATGTAGCATCCAGTGATGCCATAATGACTAGGTGTTTGGCAATTTATGATTGTTTTATAGAACGTGTTGATTGGGATGTTACGTATCCTTATATATCACATGAACAAAAACTTAATTCTTGCTGTCGTACAGTAGAGCGTAACGTTGTTCGCTCCGCTGTGCTCTCAGGCAAGTTTGAAAAAATTTATGATATTGGTAATCCTAAGGGTATTGCCATTATTTCTGAACCTGTGGAGTGGCATTTCTATGATGCACAGCCTCTTAGTAATAAAGTTAAGAAATTGTTTTACACAGATGATGTGTCTAAGCAATTTGAAGATGGGCTGTGTTTGTTTTGGAACTGTAATGTTTCAAAATACCCTAGTAATGCTGTTGTTTGTCGGTTTGATACTAGAGTGCATTCAGAGTTTAATTTGCCTGGTTGTAATGGTGGCAGTTTGTATGTTAACAAACATGCCTTTCATACACCTGCATATGACATTAATGCATTTAGAGATCTTAAACCGTTACCTTTCTTTTACTATTCTACTACTCCATGTGAAGTTCATGGTAGTGGTAATATGTTAGAAGATATAGACTATGTGCCACTTAAATCTGCTGTTTGTATAACAGCTTGTAATTTAGGTGGAGCTGTTTGTCGTAAGCATGCAGCAGAATACCGTGATTATATGGAAGCATATAACATTGTATCAGCTGCAGGTTTTCGTCTATGGGTATATAAGACCTTTGATATCTATAATCTTTGGTCTACTTTTGTTAAAGTTCAAGGTTTAGAAAACATTGCTTTTAATGTTATTAAACAAGGCCATTTTACAGGTGTTGATGGTGAGTTGCCTGTTGCTGTAGTCAACGACAAGATCTTCACTAAAAATGGTACTGATGATGTGTGCATTTTTAAGAATGAAACTGCACTTCCTACAAATGTAGCATTTGAATTGTATGCTAAGAGAGCTGTTCGCTCTCATCCTGATTTGAATTTGCTACGTAATTTAGAGGTGGATGTTTGTTACAACTTTGTTCTTTGGGACTATGATCGTAACAACATCTATGGTACAACTACAATCGGTGTGTGTAAATACACTGATATTGATGTCAATCCAAATTTGAATATGTGTTTTGACATACGTGACAAAGGGTCATTGGAAAGGTTTATGTCAATGCCCAATGGTGTTTTGATATCAGATCGCAAGATAAAGAATTATCCTTGCATTTCTGGTCCTAAGCATGCTTACTTTAATGGTGCTATTCTACGCAACATTGATGCCAAACAACCTGTTATTTTTTATTTGTATAAGAAAGTCAATAATGAATTCGTTTCATTTTCTGACACGTTTTATACGTGTGGCAGGACTGTTGGCGACTTTACTGTTTTAACTCCTATGGAGGAAGACTTTCTTGTGCTGGATAGCGATGTTTTTATTAAGAAGTATGGCTTGGAAGACTATGCTTTTGAACACGTAGTTTATGGTGATTTTTCACATACTACGTTAGGTGGCTTACATCTTCTTATAGGTTTATATAAGAAGATGCGTGAGGGTCACATATTAATGGAAGAAATGCTCAAGGATAGAGCTACTGTCCATAATTATTTTATAACAGATTCTAATACAGCTTCTTATAAGGCTGTTTGTTCTGTTATTGATTTAAGACTTGATGACTTTGTCACCATCATTAAGGAAATGGACCTTGATGTTGTGTCAAAAGTTGTTAAAGTTCCTATTGATTTAACTATGATTGAATTTATGTTGTGGTGTAGAGATGGAAAGGTTCAAACCTTCTATCCTAGACTTCAGGCTACCAATGATTGGAAACCTGGTCTAACTATGCCATCTTTGTTTAAAGTTCAGCAAATGAACCTTGAACCATGTTTATTAGCTAATTATAAGCAATCCATACCAATGCCAAACGGCGTTCATATGAATGTTGCTAAATATATGCAATTGTGTCAGTATTTGAATACTTGCACTCTAGCTGTTCCCGCCAATATGAGAGTCATTCATTTTGGTGCTGGTTGTGAAAAAGGTGTTGCCCCTGGTACATCTGTTTTACGGCAGTGGCTGCCTTTAGATGCAGTCCTGATAGATAATGATCTTAATGAGTTTGTATCAGATGCTGATATAACCATTTTTGGTGATTGCGTAACAGTACATGTCGGTCAGCAAGTGGATTTACTTATTTCTGACATGTATGACCCTTGTACTAAAGCTGTAGGAGAAGTTAATCAAACGAAGGCTTTGTTCTTCGTATACCTCTGCAACTTTATAAAGAATAATCTTGCATTAGGTGGCTCCGTTGCGATTAAAATAACTGAGCATTCATGGAGTGCAGATTTGTATAAAATTATGGGAAGATTTGCATATTGGACAGTTTTCTGTACTAATGCAAATGCATCCTCTTCAGAAGGGTTTCTCATTGGTATAAATTTCTTAGGCGAGTTAAAAGAAGAAATTGATGGCAATGTTATGCATGCCAATTATATATTTTGGAGAAATTCAACTCCAATGAATTTGAGTACATACTCACTTTTTGATTTATCTCGCTTTCCTCTTAAATTAAAAGGTACACCAGTACTTCAATTAAAGGAGAGTCAAATTAACGAACTTGTAATTTCTCTCTTGTCACAAGGAAAGTTGCTTATACGCGACAATGACACTCTTAATGTGTCTACTGATGTCCTTGTTAATTTTCGTAAGAGGCTGTGA

Protein

MLSKASVTTQGARGKYRAELYNEKRSDHVACTVPLCDTDDMACKLTPWFEDGETAFNQVSSILKEKGKILFVPMHMQRAMKFLPGPRVYLVERLTGGMLSKHFLVNQLAYKDQVGAAMMRTTLNAKPLGMFFPYDSSLETGEYTFLLRKNGLGGQLFRERPWDRKETPYVEILDDLEADPTGKYSQNLLKKLIGGDCIPIDQYMCGKNGKPIADYAKIVAKEGLTTLADIEVDVKSRMDSDRFIVLNKKLYRVVWNVTRRNVPYPKQTAFTIVSVVQCDDKDSVPEHTFTIGSQILMVSPLKATNNKNFNLKQRLLYTFYGKDAVQQPGYIYHSAYVDCNACGRGTWCTGNAIQGFACDCGANYSANDVDLQSSGLVPRNALFLANCPCANNGACSHSAAQVYNILDGKACVEVGGKSFTLTFGGVVYAYMGCCDGTMYFVPRAKSCVSRIGDAIFTGCTGTWDKVVETANLFLEKAQRSLNFCQQFALTEVVLAILSGTTSTFEELRDLCHNASYEKVRDHLVNHGFVVTIGDYIRDAINIGANGVCNATINAPFIAFTGLGESFKKVSAIPWKICSNLKSALDYYSSNIMFRVFPYDIPCDVSNFVELLLDCGKLTVATSYFVLRYLDEKFDTVLGTVSSACQTALSSFLNACVAASRATAGFINDMFKLFKVLMHKLYVYTSCGYVAVAEHSSKIVQQVLDIMSKAMKLLHTNVSWAGTKLSAIIYEGREALLFNSGTYFCLSTKAKTLQGQMNLVLPGDYNKKTLGILDPVPNADTIDVNANSTVVDVVHGQLEPTNEHGPSMIVGNYVLVSDKLFVRTEDEEFYPLCTNGKVVSTLFRLKGGMPSKKVTFGDVNTVEVTAYRSVSITYDIHPVLDALLSSSKLATFTVEKDLLVEDFVDVIKDEVLTLLTPLLRGYDIDGFDVEDFIDVPCYVYNQDGDCAWSSNMTFSINPVEDVEEVEEFIEDDYLSDELPIADDEEAWARAVEEVMPLDDILVAEIELEEDPPLETALESVEAEVVETAEAQEPSVESIDSTPSTSTVVGENDLSVKPMSRVAETDDVLELETAVVGGPVSDVTAIVTNDIVSVEQAQQCGVSSLPIQDEASENQVHQVSDLQGNELLCSETKVEIVQPRQDLKPRRSRKSKVDLSKYKHTVINNSVTLVLGDAIQIASLLPKCILVNAANRHLKHGGGIAGVINKASGGDVQEESDEYISNNGPLHVGDSVLLKGHGLADAILHVVGPDARNNEDAALLKRCYKAFNKHTIVVTPLISAGIFSVDPKVSFEYLLANVTTTTYVVVNNEDIYNTLATPSKPDGLVYSFEGWRGTVRTAKNYGFTCFICTEYSANVKFLRTKGVDTTKKIQTVDGVSYYLYSARDALTDVIAAANGCSGICAMPFGYVTHGLDLAQSGNYVRQVKVPYVCLLASKEQIPIMNSDVAIQTPETAFINNVTSNGGYHSWHLVSGDLIVKDVCYKKLLHWSGQTICYADNKFYVVKNDVALPFSDLEACRAYLTSRAAQQVNIEVLVTIDGVNFRTVILNDTTTFRKQLGATFYKGVDISDAFPTVKMGGESLFVADNLSESEKVVLKEYYGTSDVTFLQRYYSLQPLVQQWKFVVHDGVKSLKLSNYNCYINATIMMIDMLHDIKFVVPALQNAYLRYKGGDPYDFLALIMAYGDCTFDNPDDEAKLLHTLLAKAELTVSAKMVWREWCTVCGIRDIEYTGMRACVYAGVNSMEELQSVFNETCVCGSVKHRQLVEHSAPWLLVSGLNEVKVSTSTDPIYRAFNVFQGVETSVGHYVHIRVKDGLFYKYDSGSLTKTSDMKCKMTSVWYPTVRYTADCNVVVYDLDGVTKVEVNPDLSNYYMKDGKYYTSKPTIKYSPATILPGSVYSNSCLVGVDGTPGSDTISKFFNDLLGFDETKPISKKLTYSLLPNEDGDVLLSEFSNYNPVYKKGVMLKGKPILWVNNGVCDSALNKPNRASLRQLYDVAPIVLDNKYTVLQDNTSQLVEHNVPVVDDVPITTRKLIEVKCKGLNKPFVKGNFSFVNDPNGVTVVDTLGLTELRALYVDINTRYIVLRDNNWSSLFKLHTVESGDLQIVAAGGSVTRRARVLLGASSLFASFAKITVTATTAACKTAGRGFCKFVVNYGVLQNMFVFLKMLFFLPFNYLWPKKQPTVDIGVSGLRTAGIVTTNIVKQCGTAAYYMLLGKFKRVDWKATLRLFLLLCTTILLLSSIYHLVLFNQVLSSDVMLEDATGILAIYKEVRSYLGIRTLCDGLVVEYRNTSFDVMEFCSNRSVLCQWCLIGQDSLTRYSALQMLQTHITSYVLNIDWIWFALEFFLAYVLYTSSFNVLLLVVTAQYFFAYTSAFVNWRAYNYIVSGLFFLVTHIPLHGLVRVYNFLACLWFLRKFYSHVINGCKDTACLLCYKRNRLTRVEASTIVCGTKRTFYIAANGGTSYCCKHNWNCVECDTAGVGNTFICTEVANDLTTTLRRLIKPTDQSHYYVDSVVVKDAVVELHYNRDGSSCYERYPLCYFTNLEKLKFKEVCKTPTGIPEHNFLIYDTNDRGQENLARSACVYYSQVLCKPMLLVDVNLVTTVGDSREIAIKMLDSFINSFISLFSVSRDKLEKLINTARDCVRRGDDFQNVLKTFTDAARGHAGVESDVETTMVVDALQYAHKNDIQLTTECYNNYVPGYIKPDSINTLDLGCLIDLKAASVNQTSMRNANGACVWNSGDYMKLSDSFKRQIRIACRKCNIPFRLTTSKLRAADNILSVKFSATKIVGGAPSWLLRVRDLTVKGYCILTLFVFTVAVLSWFCLPSYSIATVNFNDDRILTYKVIENGIVRDIAPNDVCFANKYGHFSKWFNENHGGVYRNSMDCPITIAVIAGVAGARVANVPANLAWVGKQIVLFVSRVFANTNVCFTPINEIPYDTFSDSGCVLSSECTLFRDAEGNLNPFCYDPTVLPGASSYADMKPHVRYDMYDSDMYIKFPEVIVESTLRITKTLATQYCRFGSCEESAAGVCISTNGSWALYNQNYSTRPGIYCGDDYFDIVRRLAISLFQPVTYFQLSTSLAMGLVLCVFLTAAFYYINKVKRALADYTQCAVVAVVAALLNSLCLCFIVANPLLVAPYTAMYYYATFYLTGEPAFIMHISWYVMFGAVVPIWMLASYTVGVMLRHLFWVLAYFSKKHVDVFTDGKLNCSFQDAASNIFVIGKDTYVALRNAITQDSFVRYLSLFNKYKYYSGAMDTASYREACAAHLCKALQTYSETGSDILYQPPNCSVTSSVLQSGLVKMSAPSGAVENCIVQVTCGSMTLNGLWLDNTVWCPRHIMCPADQLTDPNYDALLISKTNHSFIVQKHIGAQANLRVVAHSMVGVLLKLTVDVANPSTPAYTFSTVKPGASFSVLACYNGKPTGVFTVNLRHNSTIKGSFLCGSCGSVGYTENGGVINFVYMHQMELSNGTHTGSSFDGVMYGAFEDKQTHQLQLTDKYCTINVVAWLYAAVLNGCKWFVKPTRVGIVTYNEWALSNQFTEFVGTQSIDMLAHRTGVSVEQMLAAIQSLHAGFQGKTILGQSTLEDEFTPDDVNMQVMGVVMQSGVKRISYGFIHWLISTFVLAYVSVMQLTKFTMWTYLFETIPTQMTPLLLGFMACVMFTVKHKHTFMSLFLLPVALCLTYANIVYEPQTLISSTLIAVANWLTPTSVYMRTTHFDFGLYISLSFVLAIIVRRLYRPSMSNLALALCSGVMWFYTYVIGDHSSPITYLMFITTLTSDYTITVFATVNLAKFISGLVFFYAPHLGFILPEVKLVLLIYLGLGYMCTMYFGVFSLLNLKLRVPLGVYDYSVSTQEFRFLTGNGLHAPRNSWEALILNFKLLGIGGTPCIKVATVQSKLTDLKCTSVVLLTVLQQLHLESNSKAWSYCVKLHNEILAAVDPTEAFERFVCLFATLMSFSANVDLDALANDLFENSSVLQATLTEFSHLATYAELETAQSSYQKALNSGDASPQVLKALQKAVNVAKNAYEKDKAVARKLERMAEQAMTSMYKQARAEDKKAKIVSAMQTMLFGMIKKLDNDVLNGVIANARNGCVPLSIVPLCASNKLRVVIPDISVWNKVVNWPSVSYAGSLWDITVINNVDNEVVKPTDVVETNESLTWPLVIECSRSSSSAVKLQNNEIHPKGLKTMVITAGVDQVNCNSSAVAYYEPVQGHRMVMGLLSENAHLKWAKVEGKDGFINIELQPPCKFLIAGPKGPEIRYLYFVKNLNNLHRGQLLGHIAATVRLQAGANTEFASNSTVLTLVAFAVDPAKAYLDYVGSGGTPLSNYVKMLAPKTGTGVAISVKPEATADQETYGGASVCLYCRAHIEHPDVSGVCKYKTRFVQIPAHVRDPVGFLLKNVPCNVCQYWVGYGCNCDALRNNTVPQSKDTNFLNRVRGSSVNARLEPCSSGLTTDVVYRAFDICNFKARVAGIGKYYKTNTCRFVQVDDEGHKLDSYFIVKRHTMSNYELEKRCYDLLKDCDAVAIHDFFIFDVDKTKTPHIVRQSLTEYTMMDLVYALRHFDQNNCEVLKSILVKYGCCEQSYFDNKLWFDFVENPSVIGVYHKLGERIRQAMLNTVKMCDHMVKSGLVGVLTLDNQDLNGKWYDFGDFVITQPGAGVAIVDSYYSYLMPVLSMTNCLAAETHKDCDFNKPLIEWPLLEYDYTDYKIGLFNKYFKYWDQTYHPNCVNCSDDRCILHCANFNVLFSMVLPNTSFGPIVRKIFVDGVPFIVSCGYHYKELGLVMNMDFNIHRHRLALKELMMYAADPAMHIASASALWDLRTPCFSVAALTTGLTFQTVRPGNFNKDFYDFVVSRGFFKEGSSVTLKHFFFAQDGHAAITDYSYYAYNLPTMVDIKQMLFCMEVVDKYFDIYDGGCLNASEVIVNNLDKSAGHPFNKFGKARVYYESMSYQEQDELFAVTKRNVLPTITQMNLKYAISAKNRARTVAGVSILSTMTNRQYHQKMLKSMAATRGATCVIGTTKFYGGWDFMLKTLYKDVESPHLMGWDYPKCDRAMPNMCRILASLILARKHSTCCTNSDRFYRLANECAQVLSEYVLCGGGYYVKPGGTSSGDATTAYANSVFNILQATTANVSALMSANGNTIIDREIKDMQFDLYINVYRKVVPDPKFVDKYYAFLNKHFSMMILSDDGVVCYNSDYAAKGYVASIQNFKETLYYQNNVFMSEAKCWVETNLEKGPHEFCSQHTLYIKDGDDGYFLPYPDPSRILSAGCFVDDIVKTDGTVMMERYVSLAIDAYPLTKHDDTEYQNVFWVYLQYIEKLYKDLTGHMLDSYSVMLCGDDSAKFWEEGFYRDLYSSPTTLQAVGSCVVCHSQTSLRCGTCIRRPFLCCKCCYDHVIATPHKMVLSVSPYVCNAPGCDVSDVTKLYLGGMSYYCNDHRPVCSFPLCANGLVFGLYKNMCTGSSSIMEFNRLATCDWSDSGDYTLANTTTEPLKLFAAETLRATEEASKQSYAIATIKEIVGERELILVWEVGKSKPPLNRNYVFTGYHLTKNSKVQLGEYVFERIDYSDAVSYKSSTTYKLAVGDIFVLTSHSVATLSAPTIVNQERYLKITGIYPTITVPEEFANHVVNFQKAGFSKYVTVQGPPGTGKSHFAIGLAIYYPTARIVYTACSHAAVDALCEKAFKYLNIAKCSRIIPAKARVECYDRFKVNDTNSQYLFSTVNALPEISVDILVVDEVSMCTNYDLSIINSRVKAKHIVYVGDPAQLPAPRTLLIRGTLEPENFNSVTRLMCNLGPDIFLSVCYRCPKEIVSTVSALVYNNKLSAKKDASGQCFKILFKGSVTHDASSAINRPQLNFVKTFIAANPNWSKAVFISPYNSQNAVARSMLGLTTQTVDSSQGSEYPYVIFCQTADTAHANNLNRFNVAVTRAQKGILCVMTSQVLFDSLEFAELSLNNYKLQSQIVTGLFKDCSREDTGLPPAYAPTYLSVDAKYKTTDELCVNLNITPNVTYSRVISRMGFKLDATIPGYPKLFITRDEAIRQVRSWVGFDVEGAHASRNACGTNVPLQLGFSTGVNFVVQPVGVVDTEWGSMLTTISARPPPGEQFKHLVPLMNKGATWPIVRRRIVQMLSDTLDKLSDYCTFVCWAHGFELTSASYFCKIGKEQRCSMCSRRASTFSSPLQSYACWSHSSGYDYVYNPFFVDVQQWGYVGNLATNHDRYCGIHAGAHVASSDAIMTRCLAIYDCFIERVDWDVTYPYISHEQKLNSCCRTVERNVVRSAVLSGKFEKIYDIGNPKGIAIISEPVEWHFYDAQPLSNKVKKLFYTDDVSKQFEDGLCLFWNCNVSKYPSNAVVCRFDTRVHSEFNLPGCNGGSLYVNKHAFHTPAYDINAFRDLKPLPFFYYSTTPCEVHGSGNMLEDIDYVPLKSAVCITACNLGGAVCRKHAAEYRDYMEAYNIVSAAGFRLWVYKTFDIYNLWSTFVKVQGLENIAFNVIKQGHFTGVDGELPVAVVNDKIFTKNGTDDVCIFKNETALPTNVAFELYAKRAVRSHPDLNLLRNLEVDVCYNFVLWDYDRNNIYGTTTIGVCKYTDIDVNPNLNMCFDIRDKGSLERFMSMPNGVLISDRKIKNYPCISGPKHAYFNGAILRNIDAKQPVIFYLYKKVNNEFVSFSDTFYTCGRTVGDFTVLTPMEEDFLVLDSDVFIKKYGLEDYAFEHVVYGDFSHTTLGGLHLLIGLYKKMREGHILMEEMLKDRATVHNYFITDSNTASYKAVCSVIDLRLDDFVTIIKEMDLDVVSKVVKVPIDLTMIEFMLWCRDGKVQTFYPRLQATNDWKPGLTMPSLFKVQQMNLEPCLLANYKQSIPMPNGVHMNVAKYMQLCQYLNTCTLAVPANMRVIHFGAGCEKGVAPGTSVLRQWLPLDAVLIDNDLNEFVSDADITIFGDCVTVHVGQQVDLLISDMYDPCTKAVGEVNQTKALFFVYLCNFIKNNLALGGSVAIKITEHSWSADLYKIMGRFAYWTVFCTNANASSSEGFLIGINFLGELKEEIDGNVMHANYIFWRNSTPMNLSTYSLFDLSRFPLKLKGTPVLQLKESQINELVISLLSQGKLLIRDNDTLNVSTDVLVNFRKRL

Function

The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.
Inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.
May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses.
Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3. Prevents also host NF-kappa-B signaling.
Participates in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication.
Proteinase 3CL-PRO: Cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Also able to bind an ADP-ribose-1''-phosphate (ADRP).
Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes.
Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.
Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.
May participate in viral replication by acting as a ssRNA-binding protein.
Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation.
Responsible for replication and transcription of the viral RNA genome.
Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium.
Enzyme possessing two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity.
Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.
Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. N7-methyl guanosine cap is a prerequisite for binding of nsp16. Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system.

Catalytic Activity

a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)
ATP + H2O = ADP + H(+) + phosphate
TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position.
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit

Nsp2 interacts with host PHB and PHB2. 3CL-PRO exists as monomer and homodimer. Nsp4 interacts with PL-PRO and nsp6. Only the homodimer shows catalytic activity. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer dsRNA-encircling ring structure. Nsp9 is a dimer. Nsp10 forms a dodecamer and interacts with nsp14 and nsp16; these interactions enhance nsp14 and nsp16 enzymatic activities. Nsp14 interacts (via N-terminus) with DDX1.

Miscellaneous

Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.

Similarity

Belongs to the coronaviruses polyprotein 1ab family.

Keywords

3D-structure   Activation of host autophagy by virus   ATP-binding   Decay of host mRNAs by virus   Endonuclease   Eukaryotic host gene expression shutoff by virus   Eukaryotic host translation shutoff by virus   Exonuclease   Helicase   Host cytoplasm   Host gene expression shutoff by virus   Host membrane   Host mRNA suppression by virus   Host-virus interaction   Hydrolase   Inhibition of host innate immune response by virus   Inhibition of host interferon signaling pathway by virus   Inhibition of host ISG15 by virus   Inhibition of host NF-kappa-B by virus   Membrane   Metal-binding   Methyltransferase   Modulation of host ubiquitin pathway by viral deubiquitinase   Modulation of host ubiquitin pathway by virus   Nuclease   Nucleotide-binding   Nucleotidyltransferase   Protease   Reference proteome   Repeat   Ribosomal frameshifting   RNA-binding   RNA-directed RNA polymerase   Thiol protease   Transferase   Transmembrane   Transmembrane helix   Ubl conjugation pathway   Viral immunoevasion   Viral RNA replication   Zinc   Zinc-finger  

Feature

chain  Host translation inhibitor nsp1

Uniprot

P0C6W3  

Pubmed

17121802   

EMBL

EF065505   

Proteomes

UP000006574   

PRIDE

P0C6W3   

Pfam

PF09401   NSP10
PF08710   nsp9
PF00680   RdRP_1
PF08715   Viral_protease
PF16348   Corona_NSP4_C
PF11633   SUD-M
PF05409   Peptidase_C30
PF01661   Macro
PF06471   NSP11
PF08716   nsp7
PF13087   AAA_12
PF16251   NAR
PF08717   nsp8
PF06460   NSP16
PF06478   Corona_RPol_N

Interpro

IPR024375   Nsp3_coronavir
IPR009466   NSP11
IPR008740   Peptidase_C30
IPR029063   SAM-dependent_MTases
IPR032592   NAR_dom
IPR002589   Macro_dom
IPR036333   NSP10_sf
IPR041679   DNA2/NAM7-like_AAA
IPR027352   CV_ZBD
IPR014828   NSP7
IPR009461   Coronavirus_NSP16
IPR038123   NSP4_C_sf
IPR013016   Peptidase_C30/C16
IPR042515   Nsp15_N
IPR009003   Peptidase_S1_PA
IPR037204   NSP7_sf
IPR007094   RNA-dir_pol_PSvirus
IPR037227   EndoU-like
IPR014822   NSP9
IPR032505   Corona_NSP4_C
IPR038400   Nsp3_coronavir_sf
IPR038083   R1a/1ab
IPR018995   RNA_synth_NSP10_coronavirus
IPR009469   RNA_pol_N_coronovir
IPR037230   NSP8_sf
IPR036499   NSP9_sf
IPR027351   (+)RNA_virus_helicase_core_dom
IPR001205   RNA-dir_pol_C
IPR014827   Viral_protease
IPR027417   P-loop_NTPase
IPR042570   NAR_sf
IPR014829   NSP8

SUPFAM

SSF140367   SSF140367
SSF159936   SSF159936
SSF52540   SSF52540
SSF143076   SSF143076
SSF50494   SSF50494
SSF101816   SSF101816
SSF53335   SSF53335
SSF142877   SSF142877
SSF144246   SSF144246

Gene 3D

1.10.150.420     1.10.8.370     2.20.25.360     2.40.10.250     2.40.10.290     3.10.20.350     3.40.220.20     3.40.50.11020    

ProteinModelPortal

P0C6W3  

PDB

6NUS     E-value=0,     Score=3728