Strain

CHINA_BAT_2008_NC_010437 (Region: Hong Kong;  Strain: Bat coronavirus 1A, complete genome.;  Date: 2008)

Gene

nucleocapsid protein

Description

Annotated in NCBI,  nucleocapsid protein

Location

NC_010437(+):26870-28039

GenBank Accession

YP_001718609.1

Full name

Nucleoprotein      

Alternative Name

Nucleocapsid protein

CDS

ATGGCTTCTGTTCAGTTTGAAGATACCAACTCTCGTGGTCGTTCTGGTAGAATACCACTATCCTATTATGCTCCTCTGCGTGTTGCTGATGACAAGCTTTTCCTTAAGTCTATGCCTGGTAATGGTGTACCAAAGGGTATGGGCGGAAAGGCCGAGCAAATCGGATATTGGACAGAACAACGACGCTGGCGCATGAATAAAGGTCAGAGAAAGGATCTGCCTTCTAATTGGCATTTCTATTATCTCGGTACTGGACCTCATGCAGATTTGAAATTCCGCGAACGCCAAGTTGGAGTTTTCTGGGTTGCCAAGCAAGGTTCTAAGACTGAGCCTACTAATCTTGGTACACGTAATCGCAATCAGCAATTGCGTATTCCTGAATTTGACTTTACACTGCCTGACAGTCTTGAGGTTGTTAACTCTGACAGCAGACCTGCTTCACGCTCTGACTCTCGTAGTCAGAGCAAGAGTAATAATCAATCTCGGTCTAATTCAAAGGCACGTGATCAGTCTGGAACCAGAACTCCAAAGAATGCTTCTCAGAATCAAAAACCTAAGAAGAACCAGCAAGAAGATCTTGTTGCTGCAGTTCGCGAAGCACTGAAAGGTCTTGGCATTCAACAAAGCAGATCTTCTAGTGGCAAATCTACTCCAGCTCGTTCAAAATCTCCAGCTAGACCATCCAATAAGAAACAACTTGACAAGCCTGAATGGAAACGTGTTCCTAACAGAACTGAAAATGCAACCACTTGTTTTGGTCAGCGTTCTGTTGAGAGAAACTGTGGATCAGCTTCTGTAGTTGCAATGGGTGTTGAAGCACCTAATTTTCCTCAGATTGCTGAATTGATTCCTACTCAGGCTGCTTTGTTCTTTGGTTCGAGAGTCTCTACTAAAGAAGTTGGTGATACTGTTGAAATCAAGTATCACTACAAAATGTCTGTACCTAAAACTAATCCTAACCTTCCTTACTTTCTTCAGCAGGTAAATGCTTATCTTGATCCAAACTCTGATCAGCCTATACCTAAAAAGCCTAAGGCTAAATCTGAAGAAGTTCCTCAACTGAATCCTGCTGCCCCTGTGTTTACACCTCCTGCTCAGGAACCTGCTGTTGAGCTTGAAATGGTCGATGAAGTCTTCGACATCGATCCTCTTGGTGACTCTGTTGCTTGA

Protein

MASVQFEDTNSRGRSGRIPLSYYAPLRVADDKLFLKSMPGNGVPKGMGGKAEQIGYWTEQRRWRMNKGQRKDLPSNWHFYYLGTGPHADLKFRERQVGVFWVAKQGSKTEPTNLGTRNRNQQLRIPEFDFTLPDSLEVVNSDSRPASRSDSRSQSKSNNQSRSNSKARDQSGTRTPKNASQNQKPKKNQQEDLVAAVREALKGLGIQQSRSSSGKSTPARSKSPARPSNKKQLDKPEWKRVPNRTENATTCFGQRSVERNCGSASVVAMGVEAPNFPQIAELIPTQAALFFGSRVSTKEVGDTVEIKYHYKMSVPKTNPNLPYFLQQVNAYLDPNSDQPIPKKPKAKSEEVPQLNPAAPVFTPPAQEPAVELEMVDEVFDIDPLGDSVA

Function

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.

Subunit

Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.

Miscellaneous

Bat coronavirus 512/2005 is highly similar to porcine epidemic diarrhea virus (PEDV).

Similarity

Belongs to the alphacoronavirus nucleocapsid protein family.

Keywords

ADP-ribosylation   Host Golgi apparatus   Phosphoprotein   Reference proteome   Ribonucleoprotein   RNA-binding   Transcription   Transcription regulation   Viral nucleoprotein   Virion   3D-structure  

Feature

chain  Nucleoprotein

Uniprot

B1PHJ9   A0A0U1WHB5   A0A0U1WHB1   Q0Q0A2   F1DB11   Q0Q0A1   + More
B1PHJ2   F1DB18   A0A0U1UZ25   A0A0U1WHC2   A0A0U1WJV4   A0A0U1WJU3   Q0Q099   A0A0U1UZD2   A0A0U1WHF4   A0A2P1G6H8   A0A2R3NG38   A0A2P1G6P9   A0A2S1WCF9   A0A2P1G6J5   A0A2D1BNM3   A0A3G1II26   A0A2P1G739   A0A410N738   A0A5B9Y683   A0A2P1G6K4   A0A4Y5WWA6   A0A482JZN4   A0A0U1WHF9   A0A3G8EWJ3   Q0Q0A0   K4K2Q3   K4K203   K4K1V4   K4KCK5   K4JZT7   F1DAY0   K4K2W1   A0A4Y5QL74   K4KCN8   A0A482K1U9   A0A4Y6GNH9   Q0Q462   A0A3G3NH65   A0A1L2KGB9   A0A3G3NGR2   A0A3G3NGQ8   A0A3G3NH92   A0A4Y6GL32   A0A219TUM0   A0A4Y6GL31   A0A3G3NHI8   A0A3G3NGN9   A0A3G3NGV8   A0A4Y6GNG7   A0A3G3NGY6   A0A3G3NGJ4   A0A3G3NHH2   A0A4Y6GNF9   A0A3G3NHI7   A0A3G3NGR8   A0A3G3NGW5   A0A3G3NGV1   A0A3G3NHJ5   A0A3G3NHM0   A0A3G3NGS1   A0A3G3NGH7   A0A3G3NGS4   A0A3G3NGJ1   A0A3G3NH39   A0A3G3NHF3   A0A3G3NGY3   A0A3G3NGW3   A0A1L2KGD9   A0A1L2KGC8   U3M7G3   A0A384RBU9   Q06Y06   A0A2U8JDM2   H9EJA4   Q6Q1R8   A0A2P1E971   A0A2P1E959   Q06Y12   A0A384RBV1   H9EJ76   A0A127AV50   A0A127ATV7   A0A127AX00   A0A127AU27   A0A127ATQ0   A0A127AX58   A0A127ATT3   A0A127ATP0   A0A127AV25  

Pubmed

18420807    27125516    16894183    19239771    22561208    29618817    + More
29704627    28654418    30171801    30103259    31419711    31207129    30447246    22933277    31067830    16840328    17054987    29741740    15073334    22837419    15034574    25700263    26928836   

EMBL

EU420138    ACA52168.1    KJ473796    AIA62210.1    KJ473795    AIA62204.1    + More
DQ666341    ABG75576.1    HQ728484    ADX59486.1    DQ666342    ABG75577.1    EU420137    ACA52161.1    HQ728485    ADX59492.1    KJ473799    AIA62231.1    KJ473798    AIA62224.1    KJ473800    AIA62238.1    KJ473797    AIA62216.1    DQ666344    EU420139    ABG75579.1    ACA52175.1    KJ473810    AIA62275.1    KJ473807    AIA62256.1    MF094686    AVM80488.1    MF094702    AVM80791.1    MF094685    AVM80479.1    MG742313    AWJ64267.1    MF094687    AVM80496.1    MF370205    ATN23893.1    MF167434    ASK51721.1    MG557844    MF094681    MF094682    MF094683    MF094684    MF769416    MF769417    MF769418    MF769419    MF769420    MF769421    MF769422    MF769423    MF769424    MF769425    MF769426    MF769427    MF769428    MF769429    MF769430    MF769431    MF769432    MF769433    MF769434    MF769435    MF769436    MF769437    MF769438    MF769439    MF769440    MF769441    MF769442    MF769443    MF769444    MH615810    MG605087    MG605088    MG605089    MG605090    MG605091    MG775251    MG775253    AVM41574.1    AVM80443.1    AVM80452.1    AVM80461.1    AVM80470.1    AVM80528.1    AVM80537.1    AVM80546.1    AVM80555.1    AVM80564.1    AVM80573.1    AVM80582.1    AVM80591.1    AVM80600.1    AVM80609.1    AVM80618.1    AVM80627.1    AVM80636.1    AVM80645.1    AVM80654.1    AVM80663.1    AVM80672.1    AVM80681.1    AVM80690.1    AVM80699.1    AVM80708.1    AVM80717.1    AVM80726.1    AVM80735.1    AVM80744.1    AVM80753.1    AVM80762.1    AVM80771.1    AVM80780.1    AXP98443.1    AXY04078.1    AXY04079.1    AXY04080.1    AXY04087.1    AXY04096.1    MH539766    MH697599    QAS69032.1    QBP43304.1    MK977618    QEH62673.1    MF094688    AVM80504.1    MK651076    QDE12101.1    MG916904    QBP43296.1    KJ473808    AIA62263.1    MH938450    AZF86134.1    DQ666343    ABG75578.1    JQ989268    AFU92090.1    JQ989271    AFU92117.1    JQ989267    AFU92082.1    JQ989266    AFU92074.1    JQ989270    AFU92108.1    HQ728480    ADX59455.1    JQ989272    JQ989273    AFU92126.1    AFU92135.1    MK720945    MK720946    QCX35174.1    QCX35185.1    JQ989269    AFU92099.1    MG916901    QBP43263.1    MK211373    QDF43813.1    DQ648858    MH687935    MH687949    MH687962    AYR18410.1    AYR18491.1    AYR18565.1    KY073744    APD51479.1    MH687940    AYR18440.1    MH687950    MH687951    AYR18497.1    AYR18503.1    MH687963    MH687964    MH687967    AYR18571.1    AYR18577.1    AYR18595.1    MK211372    QDF43808.1    KT346372    ANV78634.1    MK211370    QDF43798.1    MH687936    MH687939    AYR18416.1    AYR18434.1    MH687946    AYR18477.1    MH687959    AYR18547.1    MK211371    QDF43803.1    MH687948    AYR18485.1    MH687943    AYR18459.1    MH687934    AYR18404.1    MK211369    QDF43793.1    MH687938    AYR18428.1    MH687958    AYR18541.1    MH687941    AYR18446.1    MH687960    MH687961    AYR18553.1    AYR18559.1    MH687955    AYR18523.1    MH687965    AYR18583.1    MH687956    AYR18529.1    MH687937    AYR18422.1    MH687954    AYR18517.1    MH687945    AYR18471.1    MH687957    AYR18535.1    MH687942    AYR18453.1    MH687966    AYR18589.1    MH687944    AYR18465.1    KY073746    APD51495.1    KY073745    APD51487.1    KF530105    AGT51335.1    KM055598    AIW52795.1    DQ445912    ABE97134.1    MG428705    AWK59971.1    AY518894    JQ765568    JQ765572    JQ765573    JQ765574    JQ765575    JX504050    KF530104    KF530107    KF530108    KF530109    KF530111    KF530113    KF530114    KY554969    KY554971    KY829118    KY862073    KY862074    AAS89771.1    AFD98789.1    AFD98817.1    AFD98824.1    AFD98831.1    AFD98838.1    AFV53152.1    AGT51328.1    AGT51349.1    AGT51356.1    AGT51363.1    AGT51377.1    AGT51391.1    AGT51398.1    ARE29975.1    ARE29987.1    ARK08631.1    AVL25611.1    AVL25612.1    AY567487    KY862071    AVL25609.1    KY862064    AVL25602.1    DQ445911    ABE97141.1    KM055608    AIW52805.1    JQ765571    AFD98810.1    KT359858    AMM42617.1    KT359853    AMM42612.1    KT359835    AMM42594.1    KT359871    AMM42630.1    KT359839    AMM42598.1    KT359865    AMM42624.1    KT359864    AMM42623.1    KT359829    AMM42588.1    KT359838    AMM42597.1   

Proteomes

UP000100808    UP000157060    UP000137012    UP000147155    UP000135768    UP000110898    + More
UP000126502    UP000106776    UP000143524    UP000144177    UP000106394    UP000104963    UP000123997    UP000162430    UP000132096    UP000126615    UP000155419    UP000112496    UP000126962    UP000119818    UP000113079    UP000204102    UP000277178    UP000171901    UP000138462    UP000100468    UP000103541    UP000106901    UP000110792    UP000129674    UP000134798    UP000140530    UP000144638    UP000153644    UP000161757    UP000162862    UP000167796    UP000168590    UP000174240    UP000008573    UP000115484    UP000141321   

PRIDE

Q0Q462    Q6Q1R8   

Pfam

PF00937   Corona_nucleoca

Interpro

IPR037179   Nucleocapsid_C
IPR037195   Nucleocapsid_N
IPR001218   Corona_nucleocap
IPR042548   ALPHA_CORONA_NCAP

SUPFAM

SSF103068   SSF103068
SSF110304   SSF110304

ProteinModelPortal

B1PHJ9   A0A0U1WHB5   A0A0U1WHB1   Q0Q0A2   F1DB11   Q0Q0A1   + More
B1PHJ2   F1DB18   A0A0U1UZ25   A0A0U1WHC2   A0A0U1WJV4   A0A0U1WJU3   Q0Q099   A0A0U1UZD2   A0A0U1WHF4   A0A2P1G6H8   A0A2R3NG38   A0A2P1G6P9   A0A2S1WCF9   A0A2P1G6J5   A0A2D1BNM3   A0A3G1II26   A0A2P1G739   A0A410N738   A0A5B9Y683   A0A2P1G6K4   A0A4Y5WWA6   A0A482JZN4   A0A0U1WHF9   A0A3G8EWJ3   Q0Q0A0   K4K2Q3   K4K203   K4K1V4   K4KCK5   K4JZT7   F1DAY0   K4K2W1   A0A4Y5QL74   K4KCN8   A0A482K1U9   A0A4Y6GNH9   Q0Q462   A0A3G3NH65   A0A1L2KGB9   A0A3G3NGR2   A0A3G3NGQ8   A0A3G3NH92   A0A4Y6GL32   A0A219TUM0   A0A4Y6GL31   A0A3G3NHI8   A0A3G3NGN9   A0A3G3NGV8   A0A4Y6GNG7   A0A3G3NGY6   A0A3G3NGJ4   A0A3G3NHH2   A0A4Y6GNF9   A0A3G3NHI7   A0A3G3NGR8   A0A3G3NGW5   A0A3G3NGV1   A0A3G3NHJ5   A0A3G3NHM0   A0A3G3NGS1   A0A3G3NGH7   A0A3G3NGS4   A0A3G3NGJ1   A0A3G3NH39   A0A3G3NHF3   A0A3G3NGY3   A0A3G3NGW3   A0A1L2KGD9   A0A1L2KGC8   U3M7G3   A0A384RBU9   Q06Y06   A0A2U8JDM2   H9EJA4   Q6Q1R8   A0A2P1E971   A0A2P1E959   Q06Y12   A0A384RBV1   H9EJ76   A0A127AV50   A0A127ATV7   A0A127AX00   A0A127AU27   A0A127ATQ0   A0A127AX58   A0A127ATT3   A0A127ATP0   A0A127AV25  

PDB

5N4K     E-value=1.68447e-31,     Score=340