Strain

CHINA_BAT_2008_NC_010438 (Region: China: Hong Kong;  Strain: Bat coronavirus HKU8, complete genome.;  Date: 2008)

Gene

spike protein

Description

Annotated in NCBI,  spike protein

Location

NC_010438(+):20956-25083

GenBank Accession

YP_001718612.1

Full name

Spike glycoprotein      

Alternative Name

E2
Peplomer protein

CDS

ATGAAATCTTTACTTGTCTTAAGCCTTTTGGCCTTGTTGGCCACATTGTCTGTCAATGCGCAGGTTACTGGTGAAGGCGGTGTGGCAGAAGGTAATTATTGGGTTAATGCCTCTTGTGCTGGTTGGAGCTATTTTTATGCTCTTAAGCTTGGCCTACCACCCAATGCCTCTGCCATAGTCACTGGTTATTTACCCAAACCTAAGGGTTGGATATGTCCTAGATTTAATGGTGCCGGTATCTATACACGTAATAATGCCAATGCTGTTTTTGTTATGTATAGAACCAAAGCCCTTGCCTTTGAGATTGGTGTTAGTTCTTCTGCTGGTGGTGAGCAGTATAGTGCTTACATGGCTCAGCAGAATGGCAAATACCTTGTGCTTCGTATATGCAAGTGGCAGAATGGCACTTTGGCTGCCCCCACTTTGCAGTCCACTTCTGGGAAGGATTGTATTGTCAATGTTAAAGTTGACAATCATATGTTCTATCATGCAGCTCATGATATAGTCGGCATGTCCTGGTCTGGTGACGCTGTACGTCTATATACCCAGACTGACACAAAAACTTATTACATCCCTAATTCTTGGGACAGAGTGTCTATTAGGTGCCCTGATAAGTTCTCGTGTTCCTCACAAATTGTCACTAAGGCTATTACTGTCAATGTCACCACTTTTGCTAATGGTACCATTGACAAGTATGCCATTTGTGACAATTGTAATGGATATCCGGCTCACATCTTTCCTGTATCTGAAGGTGGACTTATTCCAGCTGATTTTAATTTTTCTAACTGGTTCCTGCTTACTAATAGTTCTACTATTGTTGATGGCCGCATTGTTTCAGAACAGCCTGTGCTACTTATGTGTCTTTGGGCTGTACCTGGACTGATGTCAACTAATAGCTTTGTCTATTTCAATGGTACAGCCCCTAATAAGCAATGCAATGGCTATGCTACGGATAGTGCTTTTGAGGCATTACGGTTTTCCCTTAATTTTACCGATGAAAGAGTCTTTGCTGGCAGCGGCAGTGTTGTACTACTTGTGTCTGGTTTGCAGTACAAGTTTAGTTGCACTAATAATTCTGAGGCTGTGATCGATTCCGGAATTCCTTTTGGTAATGTTGTTGAGCCGTTTTATTGTTTTGTCTCTATTAATGGCACTTCTATTTTTGTTGGCATGCTCCCTGCTGTTTTACGTGAAATTGTTATCACTCGTTATGGCAGTATTTATCTCAATGGTTTCTCCATTTTTCAAGGCCCACCCATTCAGGGTGTTTTGTTCAATGTAACTAATAGAGGTGCAACTGATCTTTGGACCGTTGCACTCTCTAACTTTACGGAAGTCCTTGCTGAAGTTCAAAGTACTGCCATTAAAGCTCTGCTTTATTGTGATGACCCATTGTCTCAGCTTAAGTGTCAACAATTGCAATTTTCGCTGCCTGATGGGTTTTATGCAACTGCCTCACTTTTTCAACATGAGTTGCCACGTACTTTTGTCACTTTACCACGCCATTTTACGCATTCTTGGATTAACCTGCGTATTAAATGGAAGAATGGTGTTTGTTACAATTGTCCACCTGCTTCTTCTTGGATTGATTTTGTAACATTCAATTCTAATGGCACCGAGAATGTTCTTCCTGAACGCACTTTATGCGTTAACACCACTCAGTTTACTACCAATTTGACTCTTATTGAGGAGGCTTTTAGTTATTCCACTCCTGTTGTTGTTCGTGCTGATGATTGTCCTTTTGACTTCCAGTCCTTGAACAATTACCTAACTTTTGGTTCCATTTGTTTTTCTTTGAATGGCACCATTGGTAAGGGTTGCACACTTGGAATATATAAACGAGCCTCGTCTCAGTACATTCCTATTTGGAATGTTTGGGTGGCTTACACTAGTGGTGATAATATCCTCGGTGTCAGAGAGCCCAATGTTGGTGTTAGAGATCAGAGTGTAGTGCACCAGAATGTTTGTACATCATATACAATTTTTGGGCATTCAGGTCGCGGTATTATCAGACCTGCTAATATTTCATATATAGCAGGTGTGTATTATACTGCTGCTTCTGGTCAACTATTGGGCTTTAAGAATACCACCACTGGTGAAGTGTTTTCTGTTACACCATGTAACCCATCACAGCAGGCTGTTGTTGTGAAGGATCGTCTTGTTGGTGTTATGTCATCTACTAGCACTGTTTCGATTCCGTTTAATAATACGATTCCAACTCCTAGTTTTTACTATCATAGTAATGCCACTAGTAGTTGTGATGATCCATCTGTTGTTTATTCATCTATTGGTATTTGTGATGATGGCGGTATTACTTTTGTTAATAGTACTAGGGTTCGTGGTGAACCAGATCCTGCTATTTCAATGGGTAATATTTCTGTTCCATCAAATTTCACTGTTTCCATTCAGGTTGAGTACTTGCAGATGTCCATTAGGCCTGTTTCGATAGATTGTGCTATGTATGTCTGTAATGGCAATCCTCATTGTACTAGGTTGTTGCAGCAATATATTTCTGCTTGCCGAACCATTGAGGAGGCCTTACAGCTTAGCGCGCGCCTAGAGAGTTTTGAAGTTAATAGCATGCTGACTGTTTCTGAAACAGCGTTAGACCTAGTCAACATCAGCACATTTGGTGGCGATTACAATCTCACTGCTTTGTTGCCGCAAGGTGGTGGTAAACGCAGTGTTATTGAAGATATCTTGTTTGACAAGGTTGTCACCAGTGGGCTGGGCACTGTTGATGAGGATTACAAGCGTTGTACCAATGGTATTGGTATTGCTGATGTCCCATGTGCGCAGTATTATAATGGTATTATGGTACTGCCAGGTGTTGTTGATGAGGAGAAGATGTCCATCTATACTGCTTCCCTTCTTGGTGGCATGACTATGGGTGGTTTTACACCTGTCGCTGCTTTGCCTTTTGCTTTGTCGGTACAGTCCCGTCTTAATTATGTTGCACTCCAAACTGATGTTTTGCAGAAAAATCAACAGATTTTGGCAAATGCCTTTAATTCTGCAATTGGTAATATCACTGTTGCGTTTGATCAGGTAACAACTGCAGTGCAACAAACTTCTGATGCTATTAAAACTGTTGCCAGCGCTCTTAATAAGGTTCAGAGCGTTGTTAACTCTCAAGGTCAGGCCTTGCATCAACTTACTAAACAGCTTGCTTCCAATTTTCAAGCTATTTCTGCTTCTATTGAAGATATTTATAATAGGCTTGATGGGCTTGCTGCTGATGCTAATGTTGATCGCTTAATTACAGGACGCCTTGCTGCTTTGAATGCTTTTGTTACTCAGACTCTTACTAAGTACACAGAAGTTCGTGCTAGCAGGTTGTTGGCGCAGGAGAAGATTAATGAGTGTGTTAAGTCACAATCCACTCGTTATGGATTTTGTGGAAATGGCACTCATTTGTTCTCCATCCCTAATGCTGCACCTGAAGGTATTATGCTGTTTCATACAGTTCTTGTACCCACTGAATATGTCTCAGTTACTGCCTGGTCTGGCTATTGTCATAACGGTGTTGGTTATGCCGTGAAAGATGTAGGCAATTCGCTGTTTCAGTTTAATAATACATTTTACATCACACCTCGAAATATGTATCAGCCACGTACACCTACGTCCGCTGACTTTATTCGTATTTCAGGTTGTAATGTTGTCTATGTCAACATTACTGATGAACAGCTGCCACAAGTTCAGCCTGAGTTTATTGATGTCAACAAGACTCTTGAAGAGTTAATGTCCAGGTTGCCAAACAATACAGGGCCGAACTTGCCTCTTGATATTTTTAACCAGACATATCTTAATATCAGTGCTGAGATTGATGCTCTTGAAAATAAGTCATTGGAGCTTCAGGCTACTGCTGACAAATTACAGCTAACCATTGAGCAGCTCAATGCCACTCTCGTTGATCTTGAATGGCTTAATCGCTTTGAACAGTATGTTAAGTGGCCCTGGTGGGTATGGCTCACCATGATTATTGCCTTGGTCTTGTTGACTGGGCTTATGTTATGGTGTTGCCTTGCTACTGGATGCTGTGGTTGCTGTAGTTGTATGGCTAGTACTCTTGATTTTAGAGGCAGTAGGTTACAACAATACGAAGTTGAAAAAGTGCACATCCAGTAA

Protein

MKSLLVLSLLALLATLSVNAQVTGEGGVAEGNYWVNASCAGWSYFYALKLGLPPNASAIVTGYLPKPKGWICPRFNGAGIYTRNNANAVFVMYRTKALAFEIGVSSSAGGEQYSAYMAQQNGKYLVLRICKWQNGTLAAPTLQSTSGKDCIVNVKVDNHMFYHAAHDIVGMSWSGDAVRLYTQTDTKTYYIPNSWDRVSIRCPDKFSCSSQIVTKAITVNVTTFANGTIDKYAICDNCNGYPAHIFPVSEGGLIPADFNFSNWFLLTNSSTIVDGRIVSEQPVLLMCLWAVPGLMSTNSFVYFNGTAPNKQCNGYATDSAFEALRFSLNFTDERVFAGSGSVVLLVSGLQYKFSCTNNSEAVIDSGIPFGNVVEPFYCFVSINGTSIFVGMLPAVLREIVITRYGSIYLNGFSIFQGPPIQGVLFNVTNRGATDLWTVALSNFTEVLAEVQSTAIKALLYCDDPLSQLKCQQLQFSLPDGFYATASLFQHELPRTFVTLPRHFTHSWINLRIKWKNGVCYNCPPASSWIDFVTFNSNGTENVLPERTLCVNTTQFTTNLTLIEEAFSYSTPVVVRADDCPFDFQSLNNYLTFGSICFSLNGTIGKGCTLGIYKRASSQYIPIWNVWVAYTSGDNILGVREPNVGVRDQSVVHQNVCTSYTIFGHSGRGIIRPANISYIAGVYYTAASGQLLGFKNTTTGEVFSVTPCNPSQQAVVVKDRLVGVMSSTSTVSIPFNNTIPTPSFYYHSNATSSCDDPSVVYSSIGICDDGGITFVNSTRVRGEPDPAISMGNISVPSNFTVSIQVEYLQMSIRPVSIDCAMYVCNGNPHCTRLLQQYISACRTIEEALQLSARLESFEVNSMLTVSETALDLVNISTFGGDYNLTALLPQGGGKRSVIEDILFDKVVTSGLGTVDEDYKRCTNGIGIADVPCAQYYNGIMVLPGVVDEEKMSIYTASLLGGMTMGGFTPVAALPFALSVQSRLNYVALQTDVLQKNQQILANAFNSAIGNITVAFDQVTTAVQQTSDAIKTVASALNKVQSVVNSQGQALHQLTKQLASNFQAISASIEDIYNRLDGLAADANVDRLITGRLAALNAFVTQTLTKYTEVRASRLLAQEKINECVKSQSTRYGFCGNGTHLFSIPNAAPEGIMLFHTVLVPTEYVSVTAWSGYCHNGVGYAVKDVGNSLFQFNNTFYITPRNMYQPRTPTSADFIRISGCNVVYVNITDEQLPQVQPEFIDVNKTLEELMSRLPNNTGPNLPLDIFNQTYLNISAEIDALENKSLELQATADKLQLTIEQLNATLVDLEWLNRFEQYVKWPWWVWLTMIIALVLLTGLMLWCCLATGCCGCCSCMASTLDFRGSRLQQYEVEKVHIQ

Function

S1 region attaches the virion to the cell membrane by interacting with host ANPEP/aminopeptidase N, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.

Subunit

Homotrimer. During virus morphogenesis, found in a complex with M and HE proteins. Interacts with host ANPEP.

Similarity

Belongs to the alphacoronaviruses spike protein family.

Uniprot

B1PHK2   A0A0U1WHD0   F1DB20   A0A1L2KGD0   A0A482JX42   A0A482JZV2   + More
A0A0U1WJW2   A4ULL1   K4JZ69   K4JZP8   K4K2R0   A0A0U1WHD9   A0A0U1UZ37   A0A4Y5QL66   A0A0U1UYV9   K4JZD2   K4K211   A0A482K0W7   A0A4Y6GL65   F1DAX6   A0A482JZK4   A0A0U1WHB6   A0A1W5YKS6   A0A0U1WHD7   A0A1W5YKT3   F1DB14   K4JZU5   K4KCP3   A0A0U1WHE4   F1DB07   A0A126K9I9   A0A1L2KGB2   A0A126K9A8   A0A1Z1W238   A0A1L2KGD3   A0A0U1WHB3   A0A0U1UZ27   A0A126KBA9   A0A126K9U6   A0A126K9J8   B1PHJ5   A0A0U1WHB7   A0A126KBA2   A0A1Z1W245   A0A126KB98   A0A1Z1W240   A0A1Z1W228   A0A1Z1W250   A0A126KBA0   A0A0U1WHD6   A0A1Z1W243   A0A1Z1W231   A0A1L2KGF1   B1PHI8   A0A0N7J129   A0A3G8EWN4   A0A4Y5QL97   A0A0P0KI80   A0A0P0KR98   A0A0P0K0X5   A0A0N7J128   A0A0P0KXK6   A0A0P0KBC5   A0A1L2KGE4   A0A3G8EWC1   A0A3G8EWD5   A0A0P0KMM1   A0A0P0KR90   A0A0P0K6L9   A4ULL0   A0A0U1UZD0   A0A220YLM0   A0A0P0KRB3   A0A0P0KWD4   A0A0P0KH07   A0A286R3Q7   S5YNL4   A0A3G3NGQ9   A0A3G3NGQ6   A0A3G3NGX2   A0A3G3NGH9   A0A3G3NGU0   A0A3G3NH26   A0A3G3NGU7   A0A3G3NH85   A0A3G3NHI1   A0A3G3NH56   A0A1L3GVA2   A0A023ULP1   A0A0U2L0Z5   A0A3G3NHJ6   A0A3S8TLM6   A0A0U1YG53   A0A516KAN2   A0A222NUN9   A0A5A4M032   D1MJB7   I7BQC9   A0A1L3KJ30   A0A0U1YG21  

Pubmed

18420807    27125516    19239771    22561208    17267506    22933277    + More
31067830    28384506    26262818    26920708    28589292    26378164    30447246    28840816    31319854    28758349    20132850    27880757   

EMBL

EU420139    ACA52171.1    KJ473798    AIA62220.1    HQ728486    ADX59495.1    + More
KY073746    APD51491.1    MG916902    QBP43268.1    MG916903    QBP43279.1    KJ473807    AIA62252.1    EF434381    ABO88151.1    JQ989268    AFU92086.1    JQ989266    JQ989267    AFU92070.1    AFU92078.1    JQ989269    AFU92095.1    KJ473800    AIA62234.1    KJ473810    AIA62271.1    MK720945    MK720946    QCX35167.1    QCX35178.1    KJ473799    AIA62227.1    JQ989273    AFU92131.1    JQ989272    AFU92122.1    MG916904    QBP43290.1    MK211373    QDF43810.1    HQ728480    ADX59451.1    MG916901    QBP43256.1    KJ473797    AIA62212.1    KY770850    ARI44789.1    KJ473806    AIA62246.1    KY770851    ARI44794.1    HQ728485    ADX59488.1    JQ989271    AFU92113.1    JQ989270    AFU92104.1    KJ473803    AIA62242.1    HQ728484    ADX59482.1    KU343205    AMB43195.1    KY073744    APD51475.1    KU343208    AMB43198.1    KY783847    ARX80143.1    KY073745    APD51483.1    KJ473795    AIA62200.1    KJ473802    AIA62241.1    KU343206    AMB43196.1    KU343202    AMB43192.1    KU343207    AMB43197.1    EU420138    ACA52164.1    KJ473796    AIA62206.1    KU343204    AMB43194.1    KY783850    ARX80146.1    KU343203    AMB43193.1    KY783848    ARX80144.1    KY783845    ARX80141.1    KY783851    ARX80147.1    KU343201    AMB43191.1    KJ473801    AIA62240.1    KY783849    ARX80145.1    KY783846    ARX80142.1    KY073748    APD51507.1    EU420137    ACA52157.1    KT253269    ALK28775.1    MH938450    AZF86130.1    MK720944    QCX35160.1    KT253266    ALK28772.1    KT253270    ALK28781.1    KT253265    ALK28771.1    KT253261    KT253263    ALK28767.1    ALK28769.1    KT253262    ALK28768.1    KT253267    ALK28773.1    KY073747    APD51499.1    MH938448    AZF86118.1    MH938449    AZF86124.1    KT253268    ALK28774.1    KT253264    ALK28770.1    KT253271    ALK28787.1    EF434379    ABO88150.1    KJ473809    AIA62265.1    KY799179    ASL24654.1    KT253272    ALK28793.1    KT253259    ALK28765.1    KT253260    ALK28766.1    MF577027    ASV51733.1    KF430219    AGT21333.1    MH687955    AYR18519.1    MH687957    AYR18531.1    MH687965    AYR18579.1    MH687944    AYR18461.1    MH687960    AYR18549.1    MH687956    AYR18525.1    MH687958    AYR18537.1    MH687966    AYR18585.1    MH687937    AYR18418.1    MH687961    AYR18555.1    KY019624    APG31005.1    KJ451037    AHY04180.1    KR061459    ALR84915.1    MH687942    AYR18448.1    MH593141    AZL47242.1    KJ857476    AJD09599.1    MK410092    QDP38456.1    KX982564    ASQ43221.1    MG198634    AXS76458.1    GU180148    ACZ52971.1    JX018180    AFO42861.1    KX883635    APG77336.1    KJ857474    AJD09597.1   

Proteomes

UP000143524    UP000110898    UP000106394    UP000123997    UP000126615    UP000132096    + More
UP000119818    UP000126502    UP000144177    UP000135768    UP000126962    UP000112496    UP000106776    UP000144778    UP000162430    UP000155419    UP000204102    UP000277178    UP000137012    UP000100808    UP000157060    UP000147155    UP000118770    UP000122373    UP000096398    UP000103794    UP000130985    UP000174423    UP000125818   

Pfam

PF01601   Corona_S2
PF01600   Corona_S1

Interpro

IPR002552   Corona_S2
IPR002551   Corona_S1
IPR042552   ALPHA_CORONA_SPIKE

ProteinModelPortal

B1PHK2   A0A0U1WHD0   F1DB20   A0A1L2KGD0   A0A482JX42   A0A482JZV2   + More
A0A0U1WJW2   A4ULL1   K4JZ69   K4JZP8   K4K2R0   A0A0U1WHD9   A0A0U1UZ37   A0A4Y5QL66   A0A0U1UYV9   K4JZD2   K4K211   A0A482K0W7   A0A4Y6GL65   F1DAX6   A0A482JZK4   A0A0U1WHB6   A0A1W5YKS6   A0A0U1WHD7   A0A1W5YKT3   F1DB14   K4JZU5   K4KCP3   A0A0U1WHE4   F1DB07   A0A126K9I9   A0A1L2KGB2   A0A126K9A8   A0A1Z1W238   A0A1L2KGD3   A0A0U1WHB3   A0A0U1UZ27   A0A126KBA9   A0A126K9U6   A0A126K9J8   B1PHJ5   A0A0U1WHB7   A0A126KBA2   A0A1Z1W245   A0A126KB98   A0A1Z1W240   A0A1Z1W228   A0A1Z1W250   A0A126KBA0   A0A0U1WHD6   A0A1Z1W243   A0A1Z1W231   A0A1L2KGF1   B1PHI8   A0A0N7J129   A0A3G8EWN4   A0A4Y5QL97   A0A0P0KI80   A0A0P0KR98   A0A0P0K0X5   A0A0N7J128   A0A0P0KXK6   A0A0P0KBC5   A0A1L2KGE4   A0A3G8EWC1   A0A3G8EWD5   A0A0P0KMM1   A0A0P0KR90   A0A0P0K6L9   A4ULL0   A0A0U1UZD0   A0A220YLM0   A0A0P0KRB3   A0A0P0KWD4   A0A0P0KH07   A0A286R3Q7   S5YNL4   A0A3G3NGQ9   A0A3G3NGQ6   A0A3G3NGX2   A0A3G3NGH9   A0A3G3NGU0   A0A3G3NH26   A0A3G3NGU7   A0A3G3NH85   A0A3G3NHI1   A0A3G3NH56   A0A1L3GVA2   A0A023ULP1   A0A0U2L0Z5   A0A3G3NHJ6   A0A3S8TLM6   A0A0U1YG53   A0A516KAN2   A0A222NUN9   A0A5A4M032   D1MJB7   I7BQC9   A0A1L3KJ30   A0A0U1YG21  

PDB

6U7K     E-value=0,     Score=2847