Strain

AMERICA_WHALE_2007_NC_010646 (Region: North America;  Strain: Beluga Whale coronavirus SW1, complete genome.;  Date: 2007)

Gene

small membrane protein

Description

Annotated in NCBI,  small membrane protein

Location

NC_010646(+):24874-25161

GenBank Accession

YP_001876438.1

Full name

Envelope small membrane protein      

CDS

ATGTCAGCTATTAGTGATTGGTTTTATGCAAATGGCATGTTTTTCTCATGCCTTTACATATTACTAGGTTTGATTGCTATTTATATTGTTGGTAAGGTACTTACAGTCTTTGTTCAAGCCATTGACGTGTGCCTATTATTTTGTAAGGGCTGGGCGGTTGATCCCTCAGTTAGATTAGTTAGTTATGCTTATGGAGTACTCCCGAAACAACCCAAATTAAACTTTGAGGATATTGAAAGAGTGCCTTTGAGTTTTCCAAGAAATAGCAAAGATGGTGAATATGTATGA

Protein

MSAISDWFYANGMFFSCLYILLGLIAIYIVGKVLTVFVQAIDVCLLFCKGWAVDPSVRLVSYAYGVLPKQPKLNFEDIERVPLSFPRNSKDGEYV

Function

Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.

Subunit

Homooligomer. Interacts with the M membrane protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. The cytoplasmic tails of both proteins are important for this function. Interacts with Nucleoprotein.

Similarity

Belongs to the gammacoronaviruses E protein family.

Uniprot

B2BW34   V5TGY8   A0A068LJX6   A0A068LM75   J7I0S6   A0A516UWC5   + More
I1YZI0   A0A1L4BI86   A0A5J6RCP8   A0A1L1XHJ6   A5Z164   A0A1L1XGZ6   A5Z180   A5Z1C8   A0A1L1XH17   A0A1L1XGU6   A0A1L1XLB2   A0A1P8NTQ0   A0A516UWI9   A5Z172   A0A140HEW8   Q5MCW8   A5Z156   A0A0A1G2J1   A0A1P8SSX7   A0A1X9Y2N4   A0A1U9WSL6   A0A1P8VF97   Q5MCW9   C1KEW7   A0A023PN94   A0A1X9Y2P2   A0A5J6RC15   A0A1L1XH23   A0A1L1XH60   A0A1P8Z8B5   A0A1P8VEY3   K9LVL6   X2JBE2   A0A1P8SMU4   A0A291B5Z3   D0R6Q9   A0A1V0G389   A0A1L2FT83   A0A1U9WYH7   A5Z117   A5Z196   A0A0D4CFP4   A4ZCL2   A0A1L1XGZ7   A0A1L1XH06   A0A1L1XH05   D7SCB0   A0A1P8NTN8   K9LVJ1   A0A1L1XH00   A0A1X9Y2R6   K9LVF6   K9N1B2   A0A1U9WSI0   A0A023PLV6   A5Z125   A0A1L1XHH6   A0A1L1XIW1   S4SCA7   A0A1L1XL50   A5Z0T7   A0A291B658   Q9J4A7   A0A1W6AWJ5   A5Z0Y5   A0A0K0WRR8   G0ZGK4   A0A023PMY8   A0A386A2E7   A0A1P8SSQ0   A0A221J5Q1   A0A1P8SSM1   A0A1B0Z558   A0A1V0G381   A0A1L1XL42   A4ZCK5   A0A1P8SMV8   A5Z148   Q5MCX0   E5D092   Q5MCX3  

Pubmed

18353961    24227844    23202499    22421962    28923510    31561498    + More
18295413    28116527    19523910    26482289    28917538    19625463    18045937    23182435    11087096    15019237    19100792    20652731    21994806    21909766    23178317    28495648    28646651    28705717    27938680   

EMBL

EU111742    ABW87821.1    KF793824    KF793825    KF793826    AHB63482.1    + More
AHB63496.1    AHB63509.1    KJ690949    KJ690950    AIE47675.1    AIE47679.1    KJ690948    AIE47671.1    JQ267589    JQ920388    JQ977697    AFN26096.1    AFP50241.1    AFQ31003.1    MK581202    QDQ69124.1    JQ088078    AFJ11179.1    KY047602    API80973.1    MK887090    QEY95695.1    KJ940535    AJP08787.1    EF602453    KX375808    ABQ84872.1    AQY55833.1    KJ940508    AJP08760.1    EF602455    KX185056    ABQ84888.1    APX44041.1    EF602461    ABQ84936.1    KJ940538    AJP08790.1    KJ940540    AJP08792.1    KM365468    KM279000    AJP08860.1    KX185059    APX44068.1    MK581207    MK581208    QDQ69189.1    QDQ69202.1    EF602454    EF602459    EF602460    ABQ84880.1    ABQ84920.1    ABQ84928.1    KT886454    AMO03295.1    AY835641    AAV88493.1    EF602452    KX302866    ABQ84864.1    APZ73709.1    KM213963    AIY51831.1    KX219796    KX236014    APV46142.1    APY26864.1    KU900740    ARS22423.1    KX400753    AQY55851.1    KX302875    APZ73790.1    AY835640    AAV88492.1    FJ821732    FJ821761    FJ821762    FJ821763    ACO58523.1    KJ425507    AHX26094.1    KU900741    ARS22433.1    MK887071    QEY95676.1    KM365466    KM278996    AJP08824.1    KM365467    KM365469    KM278997    KM278998    KM279007    KR265084    MK217372    AJP08832.1    AJP08858.1    AJP08867.1    QDA76222.1    KX259254    AQD20731.1    KX302861    KX259252    KX364290    APZ73664.1    AQD20713.1    ARB66111.1    JQ267605    JQ920390    AFN26112.1    AFP50249.1    KJ135013    AHN54761.1    KX252781    APY23563.1    KY933089    ATE90970.1    FN430414    CAZ86702.1    KX364297    ARB66174.1    KX266757    AOC59730.1    KY620116    AQY61372.1    EF602447    ABQ84825.1    EF602457    KX236001    ABQ84904.1    APY26748.1    KP118886    AJT47899.1    DQ490208    ABF61489.1    KJ940534    AJP08786.1    KJ940529    AJP08781.1    KJ940526    KJ940527    KJ940528    KJ940530    KJ940544    KJ940545    AJP08778.1    AJP08779.1    AJP08780.1    AJP08782.1    AJP08796.1    AJP08797.1    HM245924    ADI54958.1    KX185057    APX44050.1    JQ267595    JQ267601    JQ267606    JQ920380    JQ920386    AFN26102.1    AFN26108.1    AFN26113.1    AFP50209.1    AFP50233.1    KP085588    AJP08853.1    KU900743    ARS22453.1    JQ267613    JQ920397    AFN26120.1    AFP50277.1    KC013541    KC119407    AFY11701.1    AFY11710.1    KX375806    AQY55815.1    KJ425490    AHX25941.1    EF602448    ABQ84833.1    KJ940515    AJP08767.1    KJ940532    AJP08784.1    JQ267612    AFN26119.1    KJ940509    KJ940517    KJ940520    AJP08761.1    AJP08769.1    AJP08772.1    EF602437    EF602438    EF602439    ABQ84745.1    ABQ84753.1    ABQ84761.1    KY933090    ATE90983.1    AF203003    AF317210    EU714028    EU822341    FJ807652    FJ888351    GQ504725    GU393335    JF330899    JF828981    JQ231289    KF188435    KJ425486    KJ425488    KJ425491    KJ425492    KJ425493    KJ425494    KJ425495    KJ425498    KJ425499    KJ425500    KJ425501    KJ425502    KJ425505    KJ425506    KJ425508    KJ425509    KJ425510    KJ425511    KJ425512    KJ435284    KJ435285    KT203557    KT736031    KY588134    KY805845    KY273667    MG763935    MK937829    MK937833    MK887069    MK887070    MK887074    MK887076    MK887079    AAF69119.1    AAL26888.1    ACH72801.1    ACJ50202.1    ACO37569.1    ACQ55233.1    ADP06512.1    ADV71782.1    ADY62555.1    AEP84749.1    AEY99615.1    AGW24532.1    AHX25905.1    AHX25923.1    AHX25950.1    AHX25959.1    AHX25968.1    AHX25977.1    AHX25986.1    AHX26013.1    AHX26022.1    AHX26031.1    AHX26040.1    AHX26049.1    AHX26076.1    AHX26085.1    AHX26103.1    AHX26112.1    AHX26121.1    AHX26130.1    AHX26139.1    AHX26157.1    AHX26166.1    ALE71334.1    AMK51941.1    ARE67875.1    ARS23142.1    ASF20083.1    AVX27615.1    QDA76303.1    QDA76339.1    QEY95674.1    QEY95675.1    QEY95679.1    QEY95681.1    QEY95684.1    KY626045    MK071267    ARJ35794.1    QCS40643.1    EF602443    ABQ84793.1    KP790146    AKS25255.1    JF274479    AEL12224.1    KJ425487    KY588135    AHX25914.1    ARE67887.1    MH020185    AYC44185.1    KX236006    KX236009    APY26792.1    APY26819.1    MF421319    ASM61963.1    KX236003    APY26766.1    KU361188    ANO81457.1    KX364294    ARB66147.1    KJ940507    AJP08759.1    DQ490207    KU556804    ABF61482.1    APP92723.1    KX252785    APY23599.1    EF602451    KX252791    ABQ84856.1    APY26730.1    AY835639    AAV88491.1    GQ504722    ADP06478.1    AY835636    AAV88488.1   

Proteomes

UP000125413    UP000101112    UP000126730    UP000134696    UP000096390    UP000139891    + More
UP000133437    UP000174764    UP000113245    UP000138100    UP000159366    UP000166017    UP000124698    UP000119449    UP000165290    UP000120642    UP000097868    UP000102121    UP000102163    UP000103149    UP000106511    UP000107224    UP000108224    UP000113896    UP000113939    UP000114242    UP000118008    UP000120286    UP000132365    UP000136241    UP000136440    UP000138146    UP000149404    UP000155572    UP000155946    UP000158949    UP000159206    UP000163887    UP000165788    UP000166253    UP000167410    UP000170189    UP000173109    UP000173215    UP000174151    UP000180343    UP000101166    UP000159542    UP000146865    UP000101527   

Pfam

PF03620   IBV_3C

Interpro

IPR005296   IBV_3C

ProteinModelPortal

B2BW34   V5TGY8   A0A068LJX6   A0A068LM75   J7I0S6   A0A516UWC5   + More
I1YZI0   A0A1L4BI86   A0A5J6RCP8   A0A1L1XHJ6   A5Z164   A0A1L1XGZ6   A5Z180   A5Z1C8   A0A1L1XH17   A0A1L1XGU6   A0A1L1XLB2   A0A1P8NTQ0   A0A516UWI9   A5Z172   A0A140HEW8   Q5MCW8   A5Z156   A0A0A1G2J1   A0A1P8SSX7   A0A1X9Y2N4   A0A1U9WSL6   A0A1P8VF97   Q5MCW9   C1KEW7   A0A023PN94   A0A1X9Y2P2   A0A5J6RC15   A0A1L1XH23   A0A1L1XH60   A0A1P8Z8B5   A0A1P8VEY3   K9LVL6   X2JBE2   A0A1P8SMU4   A0A291B5Z3   D0R6Q9   A0A1V0G389   A0A1L2FT83   A0A1U9WYH7   A5Z117   A5Z196   A0A0D4CFP4   A4ZCL2   A0A1L1XGZ7   A0A1L1XH06   A0A1L1XH05   D7SCB0   A0A1P8NTN8   K9LVJ1   A0A1L1XH00   A0A1X9Y2R6   K9LVF6   K9N1B2   A0A1U9WSI0   A0A023PLV6   A5Z125   A0A1L1XHH6   A0A1L1XIW1   S4SCA7   A0A1L1XL50   A5Z0T7   A0A291B658   Q9J4A7   A0A1W6AWJ5   A5Z0Y5   A0A0K0WRR8   G0ZGK4   A0A023PMY8   A0A386A2E7   A0A1P8SSQ0   A0A221J5Q1   A0A1P8SSM1   A0A1B0Z558   A0A1V0G381   A0A1L1XL42   A4ZCK5   A0A1P8SMV8   A5Z148   Q5MCX0   E5D092   Q5MCX3  

KEGG

vg:6264434    

GO

GO:0016021  C:integral component of membrane
GO:0019031  C:viral envelope
GO:0044662  P:disruption by virus of host cell membrane
GO:0046760  P:viral budding from Golgi membrane
GO:0044178  C:host cell Golgi membrane

From MSLVP

Host nucleus. Host cytoplasm.

From Uniprot

Host Golgi apparatus membrane   The cytoplasmic tail functions as a Golgi complex-targeting signal.   With evidence from 1 publications.

Length:

95

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

26.64655

Exp number, first 60 AAs:

26.62889

Total prob of N-in:

0.90684

POSSIBLE N-term signal

sequence

inside

1  -  6

TMhelix

7  -  29

outside

30  -  95