Strain

BULGARIA_BAT_2008_NC_014470 (Region: Bulgaria;  Strain: Bat coronavirus BM48-31/BGR/2008, complete genome.;  Date: 2008)

Gene

envelope protein

Description

Annotated in NCBI,  envelope protein

Location

NC_014470(+):26018-26248

GenBank Accession

YP_003858586.1

Full name

Envelope small membrane protein      

CDS

ATGTACTCATTCGTTTCAGAAGAAACCGGTACGTTAATAGTTAATAGCGTACTTCTTTTTCTAGCTTTTGTGGTATTCTTGCTAGTCACCCTAGCCATCCTTACTGCGCTTCGATTGTGTGCATACTGCTGCAATATTGTTAACGTGAGTTTAGTAAAACCGACTTTTTACGTTTACTCACGTGTAAAAAGCTTGAATTCCTCTCAGGAGGTTCCTGAATTTCTGGTCTAA

Protein

MYSFVSEETGTLIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPTFYVYSRVKSLNSSQEVPEFLV

Function

Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis (By similarity). Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction.

Subunit

Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.
Homopentamer (PubMed:22819936). Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex (PubMed:19322648). Interacts with Nucleoprotein (PubMed:24766657). Interacts with the accessory proteins 3a and 7a. Interacts (via C-terminus) with human MPP5 (via PDZ domain); this inhibits the interaction between human MPP5 and human CRB3, and causes delayed tight junction formation and defective cell polarity (PubMed:20861307).

Miscellaneous

Bat coronavirus rp3 is highly similar to SARS-CoV (SARS-like).
Bat coronavirus HKU3 is highly similar to SARS-CoV (SARS-like).

Similarity

Belongs to the betacoronaviruses E protein family.

Keywords

3D-structure   Apoptosis   Host Golgi apparatus   Host membrane   Membrane   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Envelope small membrane protein

Uniprot

E0XIZ5   A0A3Q8AHU5   A0A2D1PX27   U5WI28   A0A4Y6GLD0   A0A0K1Z002   + More
D5HJS5   D5HJW0   Q6RD17   D5HJR4   Q6TPE5   Q692E1   Q1T6X3   Q6SRI1   Q6T1D9   Q6RD61   Q6VA97   Q6SRN3   D5HJX1   Q6VA75   Q6GYQ8   Q6SRK1   B8Q8V1   Q6RCY4   B8Q8Q6   C4P6R0   A0A4Y6GM94   Q1EFP2   A0A0U1WHJ9   Q6RD28   Q6RD06   A0A0K1Z029   Q6SRK5   Q5DIC2   D5HJQ3   Q19QW7   R9QTR5   Q1EFM9   Q3ZTC2   Q6RCX3   Q4JDQ1   Q4JDR4   Q3S2C2   D5HJZ3   Q6SRL7   Q3ZTD7   Q6SRM9   D5HJY2   D2DJW7   Q6RD39   Q6SRJ7   Q6SRM5   Q6R7Y3   Q6VA86   Q6SRP5   A0A0U1WHK6   Q3LZU0   Q6SRK9   U5WLL8   Q6SRI9   Q5Y184   A0A4Y6GLE0   Q6SRI5   B8Q8R7   Q5Y298   D5HK04   Q6SRP1   Q6S8D4   A0A4Y6GM98   A0A0U2PTJ4   Q6SRJ3   Q6RCW2   Q6RCZ5   Q3ZTF0   Q6SRN7   Q6SRP9   Q3LZV1   U5WI54   A0A4Y6GLE3   Q6RD50   B8Q8S9   Q6WGP2   Q6SRL3   B8Q8U0   J9TE86   A0A3G5BJ03   A0A2D1PX21   D2E1F0   D2E224   D2E268   D2E1D5   A0A1W5YKU0   D3KDM8   P59637   Q3I5J3   Q3LZW9   D5HJT6   A0A0U1WHI5   D5HJU7   D2E2M8  

Pubmed

20686038    29190287    24172901    20071579    14983045    15757562    + More
16269264    15809907    14709660    14654320    18987164    23739658    16625834    16485471    16140765    14527350    14733771    16112670    20016037    16169905    26719272    17222058    19370068    30393776    14569023    20463816    28384506    22412934    12730500    12730501    12853594    12958366    12876307    12781537    12917450    15194747    15763150    16580632    19322648    20861307    21450821    22819936    24788150    24766657    26331680    16195424   

EMBL

GU190215    ADK66843.1    KY352407    APO40581.1    KY417144    ATO98135.1    + More
KC881005    AGZ48809.1    MK211374    QDF43816.1    KP886809    AKZ19089.1    GQ153541    ADE34746.1    GQ153544    ADE34781.1    AY502927    AAR87548.1    GQ153540    ADE34735.1    AY390556    AAS00006.1    AY654624    AAT76151.1    AB257344    BAE93404.1    AY451891    AAS44758.1    AH013657    AAS01067.1    AY502923    AAR87504.1    AY345986    AAP94740.1    AY451878    AAS44706.1    GQ153545    ADE34792.1    AY345988    AAP94762.1    AY595412    AAT52333.1    AY451886    AAS44738.1    EU371563    ACB69896.1    AY502930    AAR87581.1    EU371559    ACB69852.1    FJ882963    ACQ82728.1    MK211375    QDF43821.1    AY864805    AAY60783.1    KJ473815    AIA62322.1    AY502926    AAR87537.1    AY502928    AAR87559.1    KP886808    AKZ19078.1    AY451885    AAS44734.1    AY772062    AAX16196.1    GQ153539    ADE34724.1    KU973692    ARO76384.1    JX993988    AGC74173.1    AY864806    AAY60796.1    AY572038    AAU04667.1    AY502931    AAR87592.1    AY686864    AAV49733.1    AY686863    AAV91634.1    DQ182595    ABA02270.1    GQ153547    ADE34814.1    AY451882    AAS44722.1    AY572035    AAU04652.1    AY451879    AAS44710.1    GQ153546    ADE34803.1    FJ588686    ACU31035.1    AY502925    AAR87526.1    AY451887    AAS44742.1    AY451880    AAS44714.1    AY508724    AAR91589.1    AY345987    AAP94751.1    AY451875    AAS44694.1    KJ473816    AIA62332.1    DQ084200    AAZ41342.1    AY451884    AAS44730.1    KC881006    AGZ48821.1    AY451889    AAS44750.1    AY714217    AAU81609.1    MK211376    QDF43826.1    AY451890    AAS44754.1    EU371560    ACB69863.1    AY707854    AAU88243.1    GQ153548    ADE34825.1    AY451876    AAS44698.1    AY463060    AAR86778.1    MK211377    QDF43831.1    KT444582    ALK02460.1    AY451888    AAS44746.1    AY502932    AAR87603.1    AY502929    AAR87570.1    AY572034    AAU04637.1    AY451877    AAS44702.1    AY451874    AAS44690.1    DQ084199    AAZ41331.1    KF367457    AGZ48834.1    MK211378    QDF43836.1    AY502924    AAR87515.1    EU371561    ACB69875.1    AY286320    AAR33051.1    AY451883    AAS44726.1    EU371562    ACB69886.1    DQ497008    DQ898174    JX163923    JX163924    JX163925    JX163926    JX163927    JX163928    ABF65839.1    ABI96961.1    AFR58675.1    AFR58689.1    AFR58703.1    MK062179    MK062180    MK062181    MK062182    MK062183    MK062184    AYV99764.1    KY417142    KY417143    KY417145    KY417147    KY417149    KY417150    KY417151    ATO98111.1    ATO98123.1    ATO98148.1    ATO98172.1    ATO98196.1    ATO98208.1    ATO98221.1    FJ882927    FJ882932    FJ882933    FJ882934    FJ882935    FJ882936    FJ882937    FJ882938    FJ882939    FJ882946    FJ882947    FJ882949    JF292921    KF514388    KF514392    KF514394    KF514396    KF514397    KF514398    KF514399    KF514400    KF514404    KF514408    KF514409    KF514413    KF514415    KF514418    KF514419    KF514421    KF514422    KF514423    ACZ71770.1    ACZ71844.1    AEA11001.1    AGT20796.1    AGT20856.1    AGT20886.1    AGT20916.1    AGT20931.1    AGT20946.1    AGT20961.1    AGT20976.1    AGT21036.1    AGT21096.1    AGT21111.1    AGT21171.1    AGT21201.1    AGT21246.1    AGT21261.1    AGT21291.1    AGT21306.1    AGT21321.1    FJ882942    FJ882943    FJ882951    FJ882953    FJ882962    HQ890526    HQ890527    HQ890528    HQ890529    HQ890530    HQ890531    HQ890532    HQ890533    HQ890534    HQ890535    HQ890536    HQ890537    HQ890538    HQ890539    HQ890540    JF292902    JF292903    JF292904    JF292905    JF292906    ACZ71994.1    AEA10401.1    FJ882945    FJ882948    FJ882952    FJ882957    FJ882958    FJ882961    HQ890541    HQ890542    HQ890543    HQ890544    HQ890545    HQ890546    JF292907    JF292908    JF292909    JF292910    JF292911    JF292912    JF292913    JF292914    JF292915    JF292916    JF292917    JF292918    JF292919    JF292920    ACZ72038.1    AEA10626.1    FJ882926    FJ882928    FJ882929    FJ882930    FJ882931    FJ882940    FJ882941    FJ882950    FJ882955    JF292922    KF514389    KF514390    KF514391    KF514393    KF514395    KF514401    KF514402    KF514403    KF514405    KF514406    KF514410    KF514411    KF514412    KF514414    KF514416    KF514417    KF514420    ACZ71755.1    ACZ71799.1    ACZ71964.1    AEA11016.1    AGT20811.1    AGT20826.1    AGT20841.1    AGT20871.1    AGT20901.1    AGT20991.1    AGT21006.1    AGT21021.1    AGT21051.1    AGT21066.1    AGT21126.1    AGT21141.1    AGT21156.1    AGT21186.1    AGT21216.1    AGT21231.1    AGT21276.1    KY770858    KY770859    ARI44800.1    ARI44805.1    GU553363    GU553364    JQ316196    JN854286    ADC35486.1    AFD56976.1    AFK10257.1    AY278741    AY274119    AY304492    AY282752    AY278554    AY278491    AY283794    AY283795    AY283796    AY283797    AY283798    AY278487    AY278488    AY278489    AY278490    AY279354    AY291451    AY310120    AY291315    AY297028    AY323975    AY321118    AY463059    AY338174    AY338175    AY348314    AP006557    AP006558    AP006559    AP006560    AP006561    AY323977    AY362698    AY362699    AY427439    DQ071615    DQ022305    GQ153542    ADE34757.1    KJ473814    AIA62312.1    GQ153543    ADE34768.1    FJ882956    JX162087    KF514407    ACZ72198.1    AFM43870.1    AGT21081.1   

Proteomes

UP000149701    UP000138593    UP000143681    UP000126363    UP000128919    UP000174857    + More
UP000159980    UP000166164    UP000101079    UP000113286    UP000148533    UP000133546    UP000102617    UP000115935    UP000158790    UP000144273    UP000125082    UP000099142    UP000112237    UP000133349    UP000129833    UP000148329    UP000124386    UP000174731    UP000156013    UP000157996    UP000127630    UP000149347    UP000153024    UP000132037    UP000126514    UP000115496    UP000163176    UP000144982    UP000141980    UP000172322    UP000122532    UP000139901    UP000117876    UP000129608    UP000128606    UP000143770    UP000157984    UP000171372    UP000105365    UP000128853    UP000133987    UP000100289    UP000110133    UP000099158    UP000127950    UP000164299    UP000110240    UP000166558    UP000171533    UP000129563    UP000105036    UP000116351    UP000135071    UP000148108    UP000166757    UP000180360    UP000180361    UP000180362    UP000097931    UP000121467    UP000125925    UP000128288    UP000150617    UP000151673    UP000151756    UP000153830    UP000155701    UP000157930    UP000160899    UP000161442    UP000161729    UP000162782    UP000164349    UP000169779    UP000173963    UP000174280    UP000180434    UP000180435    UP000180436    UP000180437    UP000180438    UP000180439    UP000180440    UP000180441    UP000180442    UP000180443    UP000180444    UP000180445    UP000180446    UP000120111    UP000180409    UP000180410    UP000180411    UP000180412    UP000180414    UP000180415    UP000180416    UP000180417    UP000180418    UP000180419    UP000180420    UP000180421    UP000180422    UP000180423    UP000180424    UP000180425    UP000180426    UP000180427    UP000180428    UP000180429    UP000180430    UP000180431    UP000180432    UP000180433    UP000145008    UP000180383    UP000180384    UP000180385    UP000180386    UP000180387    UP000180388    UP000180389    UP000180390    UP000180391    UP000180393    UP000180394    UP000180395    UP000180396    UP000180397    UP000180398    UP000180399    UP000180400    UP000180401    UP000180402    UP000180403    UP000180404    UP000180405    UP000180406    UP000180407    UP000180408    UP000097852    UP000106870    UP000117796    UP000119316    UP000119820    UP000124542    UP000125968    UP000130610    UP000133348    UP000141212    UP000143912    UP000145152    UP000149516    UP000166143    UP000171773    UP000180363    UP000180364    UP000180365    UP000180366    UP000180367    UP000180368    UP000180369    UP000180371    UP000180373    UP000180376    UP000180377    UP000180378    UP000112510    UP000152329    UP000180379    UP000180381    UP000000354    UP000103670    UP000109640    UP000116947    UP000121636    UP000131569    UP000131955    UP000137377    UP000138690    UP000143093    UP000145651    UP000146108    UP000146181    UP000146296    UP000148194    UP000153467    UP000160648    UP000164441    UP000172416    UP000006570    UP000007450    UP000131329    UP000140614    UP000118513    UP000114004    UP000159535    UP000180374   

PRIDE

P59637   

Pfam

PF02723   NS3_envE

Interpro

IPR003873   NS3/E

ProteinModelPortal

E0XIZ5   A0A3Q8AHU5   A0A2D1PX27   U5WI28   A0A4Y6GLD0   A0A0K1Z002   + More
D5HJS5   D5HJW0   Q6RD17   D5HJR4   Q6TPE5   Q692E1   Q1T6X3   Q6SRI1   Q6T1D9   Q6RD61   Q6VA97   Q6SRN3   D5HJX1   Q6VA75   Q6GYQ8   Q6SRK1   B8Q8V1   Q6RCY4   B8Q8Q6   C4P6R0   A0A4Y6GM94   Q1EFP2   A0A0U1WHJ9   Q6RD28   Q6RD06   A0A0K1Z029   Q6SRK5   Q5DIC2   D5HJQ3   Q19QW7   R9QTR5   Q1EFM9   Q3ZTC2   Q6RCX3   Q4JDQ1   Q4JDR4   Q3S2C2   D5HJZ3   Q6SRL7   Q3ZTD7   Q6SRM9   D5HJY2   D2DJW7   Q6RD39   Q6SRJ7   Q6SRM5   Q6R7Y3   Q6VA86   Q6SRP5   A0A0U1WHK6   Q3LZU0   Q6SRK9   U5WLL8   Q6SRI9   Q5Y184   A0A4Y6GLE0   Q6SRI5   B8Q8R7   Q5Y298   D5HK04   Q6SRP1   Q6S8D4   A0A4Y6GM98   A0A0U2PTJ4   Q6SRJ3   Q6RCW2   Q6RCZ5   Q3ZTF0   Q6SRN7   Q6SRP9   Q3LZV1   U5WI54   A0A4Y6GLE3   Q6RD50   B8Q8S9   Q6WGP2   Q6SRL3   B8Q8U0   J9TE86   A0A3G5BJ03   A0A2D1PX21   D2E1F0   D2E224   D2E268   D2E1D5   A0A1W5YKU0   D3KDM8   P59637   Q3I5J3   Q3LZW9   D5HJT6   A0A0U1WHI5   D5HJU7   D2E2M8  

PDB

5X29     E-value=5.33142e-07,     Score=122