Strain

BULGARIA_BAT_2008_NC_014470 (Region: Bulgaria;  Strain: Bat coronavirus BM48-31/BGR/2008, complete genome.;  Date: 2008)

Gene

nucleocapsid

Description

Annotated in NCBI,  nucleocapsid

Location

NC_014470(+):27665-28918

GenBank Accession

YP_003858591.1

Full name

Nucleoprotein      

Alternative Name

Nucleocapsid protein

CDS

ATGACTGATAATGGACAATCAAACTCGCGTAATGCGCCTCGCATTACGTTTGGTGTCTCAGATACCTCAGACAATAATCAGAATGCAGAACGTGCTGGAGCGCGGCCAAAGCAAAGAAGACCGCAAGGCCCTCCTAACAACACAGCATCCTGGTTCACAGCTCTCACTCAGCATGGTAAAGAAGGTCTCTCCTTTCCGCGAGGACAGGGAGTGCCCGTTAATACCAATAGTACCAGGGACGACCAAATTGGCTACTATCGCAGAGCTACCCGACGAGTTCGTGGTGGTGATGGTAAGATGAAAGAACTCAGCCCGCGCTGGTACTTCTACTATCTAGGAACTGGACCAGAGGCCGCATTACCTTATGGTGCTAACAAAGATGGCATAGTTTGGGTCGCTACAGAAGGAGCCCTAAACACGCCTAAAGATCACATTGGCACGCGCAATCCCAACAACAATGCTGCCATTGTCATACAGTTACCACAAGGTACTACCTTGCCAAAAGGCTTCTACGCTGAAGGAAGTCGTGGTGGCAGTCAAGCCTCCTCGCGTTCTAACTCACGTAGCCGTGGTAATTCCAGAAATTCAACACCTAGCAGCAGCAGAGGTTCATCACCTGCACGCATGGCTGCCGGAGGAGATACGGCACTTGCATTATTGCTGTTAGACAGGCTGAACCAGCTTGAGAGCAAAGTTTCAGGTAAGACACCACAACAATCACAGGTTGTCACAAAGAAAACAGCTGCTGAGGCTTCTAAAAAGCCCAGACAGAAAAGAACAGCTACCAAAGCCTATAATGTTACTCAGGCTTTTGGTAGGCGAGGTCCCGAACCTACACAGGGAAATTTCGGTGACCAGGAATTAATCAGATTAGGTACTGATTACAAAAATTGGCCACAGATTGCACAGTTTGCACCCAGTGCTTCTGCATTCTTTGGCATGTCCCGTATAGGAATGGAAGTCACACCTACAGGGACTTGGTTAACCTATAATGGTGCCATAAAATTGGATGATAAAGACCCAAATTTCAAAGACCAAGTTATTCTGCTTAATAAGCACATTGATGCTTATAAGACATTTCCACCTACAGAACCTAAAAAGGACAAGAAGAAAAAGGCTGATGAAGTACAGTCACTGCCGCAGCGTCAGAAGAAACAGGCAACTGTGACTCTGTTACCTGCAGCAGATTTGGATGATTTTTCCAAACAACTTCAGAATTCCATGAATGCTTCACCTGATTCTACTCAGGCCTAA

Protein

MTDNGQSNSRNAPRITFGVSDTSDNNQNAERAGARPKQRRPQGPPNNTASWFTALTQHGKEGLSFPRGQGVPVNTNSTRDDQIGYYRRATRRVRGGDGKMKELSPRWYFYYLGTGPEAALPYGANKDGIVWVATEGALNTPKDHIGTRNPNNNAAIVIQLPQGTTLPKGFYAEGSRGGSQASSRSNSRSRGNSRNSTPSSSRGSSPARMAAGGDTALALLLLDRLNQLESKVSGKTPQQSQVVTKKTAAEASKKPRQKRTATKAYNVTQAFGRRGPEPTQGNFGDQELIRLGTDYKNWPQIAQFAPSASAFFGMSRIGMEVTPTGTWLTYNGAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADEVQSLPQRQKKQATVTLLPAADLDDFSKQLQNSMNASPDSTQA

Function

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.

Subunit

Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.

Similarity

Belongs to the betacoronavirus nucleocapsid protein family.

Keywords

ADP-ribosylation   Host Golgi apparatus   Phosphoprotein   Ribonucleoprotein   RNA-binding   Transcription   Transcription regulation   Viral nucleoprotein   Virion   3D-structure   Host cytoplasm   Reference proteome  

Feature

chain  Nucleoprotein

Uniprot

E0XJ00   D2DJX7   A0A023PSY2   D5HJT1   D5HJS0   D5HJQ9   + More
D5HJW6   D5HJX7   D5HJY8   D5HK10   Q3I5K3   A0A096XNN7   A0A4Y6GNJ2   D5HJZ9   Q3I5K0   Q3I5I7   A0A4Y6GL41   A0A1W6S781   A0A1W5YKU3   A0A2D1PX79   A0A4Y6GL44   R9QTA2   A0A0U1WHI7   A0A1W5YKT7   A0A0U1WJZ1   B8Q8W6   B8Q8V5   D2DJX3   B8Q8S2   B8Q8T3   B8Q8U4   Q6RD13   Q6TPE0   Q6RD57   Q6VA93   Q6UZF2   Q6VA71   Q6GYQ2   Q6JH41   Q6UZE8   Q6RCY0   B8Q8R0   C4P6R7   Q1EFN5   Q6RD24   Q6RD02   Q1EFM2   Q6UUW1   Q6JH33   Q6RCW9   Q3S2B5   D2E216   Q6RD35   Q6R7X9   D5HJV5   Q6VA82   D5HJU2   U5WIP0   Q5Y179   A2TGS3   Q6S8C7   Q6RCV8   Q6RCZ1   Q6V583   Q6S8E1   A0A3G5BJ14   D2E1F7   D2E230   D2E1E2   D2E275   D3KDN4   P59595   Q5DIB8   Q3ZTD1   Q6RD46   R9QTB4   U5WLN3   Q692D7   D2E2N5   A0A2D1PXA5   A0A4Y6GNK2   Q1T6X0   A0A0U1WHK2   Q4JDP5   D2E2E7   A0A2D1PXD1   Q3I5K6   A0A4Y6GL48   A0A2D1PXH1   Q6QJ37   A0A2D1PX69   A0A2D1PX74   Q3ZTB6   A0A2D1PXA6   A0A0U2NR12   Q3ZTE4   U5WLA2   A0A2D1PX42   Q4JDQ8   Q0Q468  

Pubmed

20686038    20016037    24719429    20071579    16195424    28384506    + More
29190287    23739658    14983045    14654320    16269206    16625834    14527350    14733771    16112670    14569023    20463816    24172901    17222058    19370068    30393776    22412934    12730500    12730501    12853594    12958366    12876307    12781537    12917450    15351485    15862300    17210170    19106108    24766657    15147189    16041067    16627473    17379242    17229691    18561946    20844028    18987164    16485471    15757562    16269264    26719272    16140765    16840328   

EMBL

GU190215    ADK66848.1    FJ588688    ACU31047.1    KF569996    AHX37566.1    + More
GQ153541    ADE34752.1    GQ153540    ADE34741.1    GQ153539    ADE34730.1    GQ153544    ADE34787.1    GQ153545    ADE34798.1    GQ153546    ADE34809.1    GQ153548    ADE34831.1    DQ071613    AAZ67043.1    KF294457    AID16719.1    MK211375    QDF43823.1    GQ153547    ADE34820.1    DQ071614    AAZ67046.1    DQ071615    MK211374    QDF43818.1    KU973692    ARO76389.1    KY770858    ARI44802.1    KY417147    ATO98178.1    MK211376    QDF43828.1    JX993988    AGC74175.1    KJ473814    AIA62318.1    KY770859    ARI44807.1    KJ473816    AIA62338.1    EU371564    ACB69912.1    EU371563    ACB69901.1    FJ588686    ACU31039.1    EU371560    ACB69868.1    EU371561    ACB69879.1    EU371562    ACB69890.1    AY502927    AAR87551.1    AY390556    AAS00011.1    AY502923    AAR87507.1    AY345986    AAP94744.1    AY357075    AAR14809.1    AY345988    AAP94766.1    AY595412    AAT52334.1    AY485277    AAR23249.1    AY357076    AAR14813.1    AY502930    AAR87584.1    EU371559    ACB69856.1    FJ882963    ACQ82735.1    AY864805    AAY60790.1    AY502926    AAR87540.1    AY502928    AAR87562.1    AY864806    AAY60803.1    AY360146    AAQ63890.1    AY485278    AAR23257.1    AY502931    AAR87595.1    DQ182595    ABA02277.1    FJ882941    ACZ71986.1    AY502925    AAR87529.1    AY508724    AAR91593.1    GQ153543    ADE34776.1    AY345987    AAP94755.1    GQ153542    ADE34763.1    KC881006    AGZ48827.1    AY714217    AAU81611.1    EF199653    ABM92863.1    AY463060    AAR86785.1    AY502932    AAR87606.1    AY502929    AAR87573.1    AY350750    AAR14805.1    AY463059    DQ497008    DQ898174    JX163923    JX163924    JX163925    JX163926    JX163927    JX163928    AAR86795.1    ABF65846.1    ABI96968.1    AFR58681.1    AFR58695.1    AFR58709.1    MK062179    MK062180    MK062181    MK062182    MK062183    MK062184    AYV99771.1    FJ882927    FJ882932    FJ882933    FJ882934    FJ882935    FJ882936    FJ882937    FJ882938    FJ882939    FJ882946    FJ882947    FJ882949    JF292921    KF514388    KF514392    KF514394    KF514396    KF514397    KF514398    KF514399    KF514400    KF514404    KF514408    KF514409    KF514413    KF514415    KF514418    KF514419    KF514421    KF514422    KF514423    ACZ71777.1    ACZ71851.1    AEA11008.1    AGT20803.1    AGT20863.1    AGT20893.1    AGT20923.1    AGT20938.1    AGT20953.1    AGT20968.1    AGT20983.1    AGT21043.1    AGT21103.1    AGT21118.1    AGT21178.1    AGT21208.1    AGT21253.1    AGT21268.1    AGT21298.1    AGT21313.1    AGT21328.1    FJ882942    FJ882943    FJ882951    FJ882953    FJ882959    FJ882962    HQ890526    HQ890527    HQ890528    HQ890529    HQ890530    HQ890531    HQ890532    HQ890533    HQ890534    HQ890535    HQ890536    HQ890537    HQ890538    HQ890539    HQ890540    JF292902    JF292903    JF292904    JF292905    JF292906    ACZ72000.1    AEA10408.1    FJ882926    FJ882928    FJ882929    FJ882930    FJ882931    FJ882940    FJ882944    FJ882954    FJ882955    FJ882960    JF292922    JX162087    KF514389    KF514390    KF514391    KF514393    KF514395    KF514401    KF514402    KF514403    KF514405    KF514406    KF514407    KF514410    KF514411    KF514412    KF514414    KF514416    KF514417    KF514420    ACZ71762.1    ACZ71806.1    ACZ71971.1    AEA11023.1    AFM43876.1    AGT20818.1    AGT20833.1    AGT20848.1    AGT20878.1    AGT20908.1    AGT20998.1    AGT21013.1    AGT21028.1    AGT21058.1    AGT21073.1    AGT21088.1    AGT21133.1    AGT21148.1    AGT21163.1    AGT21193.1    AGT21223.1    AGT21238.1    AGT21283.1    FJ882945    FJ882948    FJ882952    FJ882957    FJ882958    FJ882961    HQ890541    HQ890542    HQ890543    HQ890544    HQ890545    HQ890546    JF292907    JF292908    JF292909    JF292910    JF292911    JF292912    JF292913    JF292914    JF292915    JF292916    JF292917    JF292918    JF292919    JF292920    ACZ72045.1    AEA10633.1    GU553363    GU553364    GU553365    JQ316196    JN854286    ADC35492.1    AFD56983.1    AFK10264.1    AY278741    AY274119    AY278554    AY282752    AY304492    AY304495    AY278491    AY283794    AY283795    AY283796    AY283797    AY278487    AY278488    AY278489    AY278490    AY279354    AY291451    AY310120    AY291315    AY307165    AY290752    AY321118    AY322208    AY338174    AY338175    AY348314    AP006557    AP006558    AP006559    AP006560    AP006561    AY323977    AY362698    AY362699    AY427439    AY772062    AAX16200.1    AY572035    AAU04658.1    AY502924    AAR87518.1    JX993987    AGC74169.1    KF367457    AGZ48841.1    AY654624    AAT76155.1    FJ882956    ACZ72205.1    KY417149    ATO98202.1    MK211377    QDF43833.1    AB257344    BAE93407.1    KJ473815    AIA62328.1    AY686864    AAV49739.1    FJ882950    ACZ72117.1    KY417151    ATO98228.1    DQ412043    AAZ67039.1    MK211378    QDF43838.1    KY417148    KY417152    ATO98190.1    ATO98240.1    AY536760    AAS48456.1    KY417146    ATO98166.1    KY417142    ATO98117.1    AY572038    AAU04673.1    KY417150    ATO98215.1    KT444582    ALK02467.1    AY572034    AAU04642.1    KC881005    AGZ48815.1    KY417144    ATO98142.1    AY686863    AAV91640.1    DQ648857   

Proteomes

UP000149701    UP000150494    UP000126363    UP000159980    UP000157996    UP000128919    + More
UP000102617    UP000172322    UP000128853    UP000119208    UP000144982    UP000006570    UP000127630    UP000140614    UP000128606    UP000117687    UP000144273    UP000122532    UP000105365    UP000171533    UP000129563    UP000174857    UP000166164    UP000148533    UP000133546    UP000118579    UP000115935    UP000158790    UP000123303    UP000147828    UP000125082    UP000099142    UP000112237    UP000133349    UP000148329    UP000124386    UP000149347    UP000168969    UP000132037    UP000163176    UP000180369    UP000139901    UP000117876    UP000118513    UP000129608    UP000131329    UP000157984    UP000171372    UP000133987    UP000110133    UP000099158    UP000170944    UP000105036    UP000116351    UP000135071    UP000148108    UP000164441    UP000166757    UP000180360    UP000180361    UP000180362    UP000097931    UP000121467    UP000125925    UP000128288    UP000150617    UP000151673    UP000151756    UP000153830    UP000155701    UP000157930    UP000160899    UP000161442    UP000161729    UP000162782    UP000164349    UP000169779    UP000173963    UP000174280    UP000180434    UP000180435    UP000180436    UP000180437    UP000180438    UP000180439    UP000180440    UP000180441    UP000180442    UP000180443    UP000180444    UP000180445    UP000180446    UP000120111    UP000180409    UP000180410    UP000180411    UP000180412    UP000180413    UP000180414    UP000180415    UP000180416    UP000180417    UP000180418    UP000180419    UP000180420    UP000180421    UP000180422    UP000180423    UP000180424    UP000180425    UP000180426    UP000180427    UP000180428    UP000180429    UP000180430    UP000180431    UP000180432    UP000180433    UP000097852    UP000106870    UP000114004    UP000117796    UP000119316    UP000119820    UP000124542    UP000125968    UP000130610    UP000133348    UP000141212    UP000143912    UP000145152    UP000149516    UP000159535    UP000166143    UP000171773    UP000180363    UP000180364    UP000180365    UP000180366    UP000180367    UP000180368    UP000180370    UP000180372    UP000180373    UP000180375    UP000180376    UP000180377    UP000180378    UP000145008    UP000180383    UP000180384    UP000180385    UP000180386    UP000180387    UP000180388    UP000180389    UP000180390    UP000180391    UP000180393    UP000180394    UP000180395    UP000180396    UP000180397    UP000180398    UP000180399    UP000180400    UP000180401    UP000180402    UP000180403    UP000180404    UP000180405    UP000180406    UP000180407    UP000180408    UP000112510    UP000152329    UP000180379    UP000180381    UP000180382    UP000000354    UP000103670    UP000109640    UP000116947    UP000121636    UP000131569    UP000131955    UP000137377    UP000138690    UP000143093    UP000145651    UP000146108    UP000146181    UP000146296    UP000148194    UP000153467    UP000160648    UP000172416    UP000156013    UP000141980    UP000166558    UP000106179    UP000110240    UP000101079    UP000180374    UP000113286    UP000129833    UP000126514    UP000180371    UP000125672    UP000153024    UP000100289    UP000127950    UP000138593    UP000115496    UP000006573   

PRIDE

Q3I5I7    P59595    Q0Q468   

Pfam

PF00937   Corona_nucleoca

Interpro

IPR037195   Nucleocapsid_N
IPR037179   Nucleocapsid_C
IPR001218   Corona_nucleocap

SUPFAM

SSF103068   SSF103068
SSF110304   SSF110304

ProteinModelPortal

E0XJ00   D2DJX7   A0A023PSY2   D5HJT1   D5HJS0   D5HJQ9   + More
D5HJW6   D5HJX7   D5HJY8   D5HK10   Q3I5K3   A0A096XNN7   A0A4Y6GNJ2   D5HJZ9   Q3I5K0   Q3I5I7   A0A4Y6GL41   A0A1W6S781   A0A1W5YKU3   A0A2D1PX79   A0A4Y6GL44   R9QTA2   A0A0U1WHI7   A0A1W5YKT7   A0A0U1WJZ1   B8Q8W6   B8Q8V5   D2DJX3   B8Q8S2   B8Q8T3   B8Q8U4   Q6RD13   Q6TPE0   Q6RD57   Q6VA93   Q6UZF2   Q6VA71   Q6GYQ2   Q6JH41   Q6UZE8   Q6RCY0   B8Q8R0   C4P6R7   Q1EFN5   Q6RD24   Q6RD02   Q1EFM2   Q6UUW1   Q6JH33   Q6RCW9   Q3S2B5   D2E216   Q6RD35   Q6R7X9   D5HJV5   Q6VA82   D5HJU2   U5WIP0   Q5Y179   A2TGS3   Q6S8C7   Q6RCV8   Q6RCZ1   Q6V583   Q6S8E1   A0A3G5BJ14   D2E1F7   D2E230   D2E1E2   D2E275   D3KDN4   P59595   Q5DIB8   Q3ZTD1   Q6RD46   R9QTB4   U5WLN3   Q692D7   D2E2N5   A0A2D1PXA5   A0A4Y6GNK2   Q1T6X0   A0A0U1WHK2   Q4JDP5   D2E2E7   A0A2D1PXD1   Q3I5K6   A0A4Y6GL48   A0A2D1PXH1   Q6QJ37   A0A2D1PX69   A0A2D1PX74   Q3ZTB6   A0A2D1PXA6   A0A0U2NR12   Q3ZTE4   U5WLA2   A0A2D1PX42   Q4JDQ8   Q0Q468  

PDB

1SSK     E-value=1.02101e-66,     Score=644