Strain

CHINA_AVIAN_2007_NC_016992 (Region: China: Hong Kong;  Strain: Sparrow coronavirus HKU17, complete genome.;  Date: 2007)

Gene

spike glycoprotein

Description

Annotated in NCBI,  spike glycoprotein

Location

NC_016992(+):19334-22954

GenBank Accession

YP_005352846.1

Full name

Spike glycoprotein      

Alternative Name

E2
Peplomer protein

CDS

ATGCAGGGAGCTCTACTGATCACATTTATCGCAGTGGTGACCTCGTCGCCGCTAGCTGATAAAATACTTGATTTTCTAACTTTTCCTGAAGCACATGCCTATCTATTTCCGCAGTCACGCATGGTCAGGAATATAGAGGGCGGTGCTACTGAACGGTGTATGTACGTCCAAGAGGGCGGTTTCATACCAGACAACTTTACATTCCCTCAGTGGTTTGTACTCACCAACGACTCTACATTGCTTCAAGGAGAGTTAACAACGTCGCAGCCGCTAATTGTCAATGGGCACCTTTGCTCATGGCAATCTAACCAACAATATCGAAAATATTCCTTTAACACCTCTTGCCCACTTCCGGCTGACGGTTGTAACCCCACCTGGGGTAGTGGCAATCTTAAGTTGTTTAAGGGATGGAACAACACGAAAGGTCTTACTGACAATATCAGAATTAATGTCAACATATCCCAGTCGGATTATAGGACTTCTGCTGGGTCTGTTGGACTTGAATTAGAAGGAGGTGGTACTGTTAATATTACTTGTACTAACAGTTCCACGCCAGTCACAACATACTCACTACTACCTTGGGCTCGTTCCAGTGGTGAACCAATCTATTGCTTTGCCAATGTTTCATCACCTAGTCAAAGCTATATTGATTTTATGGGCATTCTCCCGCCTTTTGTGTCAGAGATTGCCTTCGATAGGAGTGGCAGTATCTATATTAATGGTTATAGATACTTCAAAATTTCGCCACTACTCAATGTAGAGCTTCAGCTCAACTTCAATCTAACCAGTGACCACTTCTCAGTCACTTGGTCTAATTACACTGAGGTACATTTAAACACTACCAATGGTTATATACATCAGATTAAATACTGCTATGACCCACTTGACAAACTGGCGTGTGAAATGAACACATTCCAATTGCCTGATGGAGTCTATCCATACACGCCCGCTCAACAGCAGGCTTTACCTGAAACATTCGTTACTACACCTGTGTATGCTAATCATACGACTGTTGTAGTACGCACTCAATACACAGTGAGTTCAACCGGAATTAATGGACCACCTTCCTGGTCCACCGTTGAGCTTGATGGTGCCATTAATGACACCCTCTGTGTTAACTCTCGCCAGTTCACTGTACATCTTAACACTACAGTACACTATACCGCTGCACACTTGTTCGGCACGGAATTTGTTGCTGGCACGTGTCCATTCACATTACCAAACATTAACAATTACTTAACGTTTGGTTCCATATGTTTTTCCACTGTTAACAATGGTGGCTGCACTATACATGTTCAAAAAGTGTTGCGACACTATCGCTATACTTTTGGCACTATCTATGTTTCCTATCAACCAGGAAACCAAATAACAGCTATGCCAAAAGCCTCTTCAGGCACTACTGACATATCCACTGTTTATCTTAACGTGTGTACCAAGTATAATATCTATGGTAAAACTGGTACAGGCGTCATTACTAAAACAAATGAAACCCACATTGGAGGACTTTACTACTCCTCCCTTAGTGGTGACTTATTAGCATTTAAAAACTCAACTACACAAACAATTTACAGCATCACACCCTGTGAATTGTCTGCACAAGTTGCTGTATATAATGATTCTATTATTGCAGCATTCACTTCAACAGAGAATTTCACCTTCTCTGATTTCTCTTATAAGCTGAAAACTCCCATGTTCTATTACCACTCAATTGGTAATACGACATGTGAAGCACCAGCTATTACATTTGGTTCTATTGGTGTCTGCCCAGATGGTGGCCTAATTATTCAAAGTGCCACCACCAATGATGTAGACGCTGTAGTGCCTATTTCCACACAGAATATCTCAATACCTATCAACTTCACTGTATCTATTCAGACTGAGTACATACAGATTGAGCACCATCCTATTACGGTGGATTGCAGAAAATATGTTTGCAATGGCAACCCTCGTTGCCTGCAACTACTACTACAATATACTAGTGCGTGTTCAACAATTGAGCAGGCTCTAGCTTTAAATGCGCGACTTGAAGCAGCTAGCATCCAGTCAATGCTCACATACAACCCTCAGACAGTCAAGCTTGCAAACATTACAAACTTTCAGTCTGATGGTATCAAATATGACTTATCCTCCATACTACCTGTGTCAACTGGATCCAGGTCTGCTATTGAGGATTTACTCTTTGATAAAGTTGTCACAAATGGTCTAGGAACAGTAGACCAAGACTATAAAAAGTGTACCAACGGTTATTCCATTGCTGACCTTGTTTGTGCACAATATTATAATGGTATTATGGTACTTCCAGGCGTCGCTGACCCTGAGAAACTAGCCCAGTACACCGCTTCACTTACAGGTGCTATGGTCTTCGGTGGACTCACATCTGCCGCAGCCATACCATTTTCTCTAGCAGTCCAATCGCGTTTGAATTATGTTGCTCTTCAAACGGATGTGCTGCAACGCAACCAACAAATCTTGGCTACATCATTCAATAATGCTATGGGCAATATTACCCAGGCATTCCATGATGTCAACCAAGGACTTTCACAAGTTGCAGGTGCTGTCACCACGATAGCCAATGCATTCACAAAAATTCAGGATGTTGTCAATGCACAGGGCACTGCTCTCTCAACTCTGACAACACAGTTAACAAACAACTTTCAGGCTATCTCAGCCTCTATTGCTGACATTTATAATCGTCTCAACCAAATTGAGGCAGATGCACAAGTAGACAGACTCATTACAGGCAGGTTAGCTGCTCTCAATGCGTTTGTCACACAAACATTAGCTAAACTTGCTGAGGTTAGACAATCTCGCCAGTTAGCTCTTGACAAAGTTAATGAGTGTGTTAAATCGCAATCCGCTCGTTACGGATTTTGCGGCAACGGAACTCATCTTTTCTCATTTTCAAATGCAGCACCGTATGGACTGATGTTTTTCCACACTGTTCTGCTTCCCACACAATACGCCACAGTGCAAGCCTATTCAGGTATTTGCCACCAGAATAGAGCACTTACACTGAGAGACCCATCACTTGCACTCTTCCAGAAAGATGACAAGTATTTAATCACACCACGCAATATGTACCAACCCCGAACTGCCACCAAGGCGGACTTCGTGTACATACAGTCGTGTGACATCACATTCCTCAATCTAACTGACACTACTATTGAAGCCGTCATACCTGATTATGTCGACGTCAATAAAACAATTGAGGAGTTTCTCAACAACTTACCTAACTATACACTGCCAGATCTTTCGATCGACAGGTATAACAACACAATATTAAATCTCACCACTGAGATTGCTGATTTAAATGGTAAAGCTGCCAACCTCTCTCAAATTGTTGAGGAACTTGAGCAGTACATCAAAAACATTAACAGCACACTAGTTGACCTCGAATGGCTCAACCGTGTTGAAACCTACATCAAATGGCCATGGTATATATGGCTTGCCATAGCCCTGGCATTTACTGCATTTGTCGCAATCCTCATAACAATCTTTCTTTGCACTGGTTGCTGTGGAGGGTGCTTTGGTTGTTGCGGAGGTTGTTTTGGCCTTTTCTCAAAGAAGAAAAGGTATACAGACGACCATCCAACACCGTCCTTCAAATTTAAGGAATGGTAG

Protein

MQGALLITFIAVVTSSPLADKILDFLTFPEAHAYLFPQSRMVRNIEGGATERCMYVQEGGFIPDNFTFPQWFVLTNDSTLLQGELTTSQPLIVNGHLCSWQSNQQYRKYSFNTSCPLPADGCNPTWGSGNLKLFKGWNNTKGLTDNIRINVNISQSDYRTSAGSVGLELEGGGTVNITCTNSSTPVTTYSLLPWARSSGEPIYCFANVSSPSQSYIDFMGILPPFVSEIAFDRSGSIYINGYRYFKISPLLNVELQLNFNLTSDHFSVTWSNYTEVHLNTTNGYIHQIKYCYDPLDKLACEMNTFQLPDGVYPYTPAQQQALPETFVTTPVYANHTTVVVRTQYTVSSTGINGPPSWSTVELDGAINDTLCVNSRQFTVHLNTTVHYTAAHLFGTEFVAGTCPFTLPNINNYLTFGSICFSTVNNGGCTIHVQKVLRHYRYTFGTIYVSYQPGNQITAMPKASSGTTDISTVYLNVCTKYNIYGKTGTGVITKTNETHIGGLYYSSLSGDLLAFKNSTTQTIYSITPCELSAQVAVYNDSIIAAFTSTENFTFSDFSYKLKTPMFYYHSIGNTTCEAPAITFGSIGVCPDGGLIIQSATTNDVDAVVPISTQNISIPINFTVSIQTEYIQIEHHPITVDCRKYVCNGNPRCLQLLLQYTSACSTIEQALALNARLEAASIQSMLTYNPQTVKLANITNFQSDGIKYDLSSILPVSTGSRSAIEDLLFDKVVTNGLGTVDQDYKKCTNGYSIADLVCAQYYNGIMVLPGVADPEKLAQYTASLTGAMVFGGLTSAAAIPFSLAVQSRLNYVALQTDVLQRNQQILATSFNNAMGNITQAFHDVNQGLSQVAGAVTTIANAFTKIQDVVNAQGTALSTLTTQLTNNFQAISASIADIYNRLNQIEADAQVDRLITGRLAALNAFVTQTLAKLAEVRQSRQLALDKVNECVKSQSARYGFCGNGTHLFSFSNAAPYGLMFFHTVLLPTQYATVQAYSGICHQNRALTLRDPSLALFQKDDKYLITPRNMYQPRTATKADFVYIQSCDITFLNLTDTTIEAVIPDYVDVNKTIEEFLNNLPNYTLPDLSIDRYNNTILNLTTEIADLNGKAANLSQIVEELEQYIKNINSTLVDLEWLNRVETYIKWPWYIWLAIALAFTAFVAILITIFLCTGCCGGCFGCCGGCFGLFSKKKRYTDDHPTPSFKFKEW

Function

S1 region attaches the virion to the cell membrane by interacting with host ANPEP/aminopeptidase N, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.

Subunit

Homotrimer. During virus morphogenesis, found in a complex with M and HE proteins. Interacts with host ANPEP.

Miscellaneous

Bat coronavirus 512/2005 is highly similar to porcine epidemic diarrhea virus (PEDV).

Similarity

Belongs to the alphacoronaviruses spike protein family.

Keywords

Coiled coil   Glycoprotein   Host membrane   Host-virus interaction   Membrane   Reference proteome   Signal   Transmembrane   Transmembrane helix   Viral attachment to host cell   Viral envelope protein   Virion   Virulence   Virus entry into host cell   3D-structure  

Feature

chain  Spike glycoprotein

Uniprot

H9BR00   H9BR08   A0A2Z5XXS4   A0A2Z5XXT6   A0A2Z5XXR5   A0A1L2KGB2   + More
A0A0U1WJW2   A0A1L2KGD3   A0A1L2KGD0   F1DB14   A0A482K0W7   A0A1W5YKS6   A0A0U1UZ37   A0A3G3NGX8   A0A0P0KR98   A0A3G3NHH0   A0A3G3NGW9   A0A3G3NHL7   A0A0P0KBC5   A4ULL1   A0A482JZK4   K4JZU5   A0A0N7J128   A0A0P0K0X5   K4KCP3   A0A0P0KXK6   A0A0P0KI80   A0A4Y6GL52   A0A3G3NGT9   A0A0N7J129   A0A3G3NGQ0   A0A3G3NGS7   A0A1B3TNA4   A0A4Y6GL65   A0A3G3NGQ4   A0A4Y6GL57   A0A1L2KGE4   A0A3G3NGM2   A0A3G3NGM9   A0A3G3NGG7   A0A3G3NHH9   A0A1L2KGF1   A0A1W5YKT3   A0A219TUS3   A0A3G3NH05   A0A3G3NHI3   A0A4Y5QL66   A0A4Y6GL18   Q0Q466   Q0Q4F5   I1VWF5   A0A3G3NGN7   A0A3G3NGV3   Q0Q4F6   A0A0U2GQ76   A0A0U2GN50   A0A0U2GNG3   A0A0U2GMQ4   A0A0U2GRL6   A0A0U2GRB2   A0A3G3NGK2   A0A482JX42   A0A0U2GME6   A0A0U2GMN8   A0A3G3NHJ0   Q1HVM3   Q1HVL9   A0A0U2GMG2   A0A1C8YZ37   Q1HVM0   Q1HVM5   A0A1C8YZ26   A0A0U2GQI5   A0A059SGA9   Q1HVM1   A0A482JZV2   A0A0P0KRB3   A0A0P0KWD4   A0A3G3NGX2   A0A1C8YZ34   A0A0U2GN82   Q1HVL7   A0A0P0KH07   A0A3G3NGU0   Q1HVL8   P15423   A0A0U1WHD9   A0A1L7B934   A0A3G3NGU7   A0A384RJX8   A0A1V0BZ86   A0A0P0K6L9   A0A3G3NGJ7   S5YNL7   A0A0P0KR90   A0A384R9G0   H1AG30   Q1HVM6   H1AG29   A0A1L7B908  

Pubmed

22278237    19239771    22561208    28384506    26378164    17267506    + More
22933277    27528677    31067830    16840328    26678874    16603522    2345367    11369870    9870593    2701946    1350662    8970993    12551991    12634402    11162792    27125516    22673931   

EMBL

JQ065045    AFD29209.1    JQ065046    AFD29217.1    LC364343    BBC54832.1    + More
LC364344    BBC54842.1    LC364342    BBC54822.1    KY073744    APD51475.1    KJ473807    AIA62252.1    KY073745    APD51483.1    KY073746    APD51491.1    HQ728485    ADX59488.1    MG916904    QBP43290.1    KY770850    ARI44789.1    KJ473810    AIA62271.1    MH687963    AYR18567.1    KT253270    ALK28781.1    MH687946    AYR18473.1    MH687967    AYR18591.1    MH687964    AYR18573.1    KT253267    ALK28773.1    EF434381    ABO88151.1    MG916901    QBP43256.1    JQ989271    AFU92113.1    KT253261    KT253263    ALK28767.1    ALK28769.1    KT253265    ALK28771.1    JQ989270    AFU92104.1    KT253262    ALK28768.1    KT253266    ALK28772.1    MK211369    QDF43790.1    MH687962    AYR18561.1    KT253269    ALK28775.1    MH687949    AYR18487.1    MH687935    AYR18406.1    KU291449    AOG74789.1    MK211373    QDF43810.1    MH687939    AYR18430.1    MK211371    QDF43800.1    KY073747    APD51499.1    MH687934    AYR18400.1    MH687945    AYR18467.1    MH687936    MH687959    AYR18412.1    AYR18543.1    MH687950    AYR18493.1    KY073748    APD51507.1    KY770851    ARI44794.1    KT346372    ANV78630.1    MH687952    AYR18505.1    MH687938    AYR18424.1    MK720945    MK720946    QCX35167.1    QCX35178.1    MK211370    QDF43795.1    DQ648858    DQ648792    ABG11964.1    JQ410000    AFI49431.1    MH687951    AYR18499.1    MH687940    AYR18436.1    DQ648791    ABG11963.1    KT368899    ALA50137.1    KT368898    ALA50130.1    KT368916    ALA50256.1    KT368901    ALA50151.1    KT368903    ALA50165.1    KT368907    KT368908    ALA50193.1    ALA50200.1    MH687948    AYR18481.1    MG916902    QBP43268.1    KT368895    KT368896    MF593473    ALA50109.1    ALA50116.1    ATI09437.1    KT368892    KT368893    KT368894    KT368902    KT368904    KT368905    KT368906    KT368909    KT368910    KT368911    KT368912    KT368913    KT368914    ALA50088.1    ALA50095.1    ALA50102.1    ALA50158.1    ALA50172.1    ALA50179.1    ALA50186.1    ALA50207.1    ALA50214.1    ALA50221.1    ALA50228.1    ALA50235.1    ALA50242.1    MH687954    AYR18513.1    DQ243966    ABB90509.1    DQ243970    ABB90513.1    KT368897    ALA50123.1    KT253324    KT253326    KT253328    AOI28259.1    AOI28275.1    AOI28291.1    DQ243965    DQ243969    ABB90508.1    ABB90512.1    DQ243964    ABB90507.1    KT253325    AOI28267.1    KT368915    ALA50249.1    KF293664    KF293665    KF293666    AGW80948.1    DQ243967    DQ243968    ABB90510.1    ABB90511.1    MG916903    QBP43279.1    KT253272    ALK28793.1    KT253259    ALK28765.1    MH687965    AYR18579.1    KT253327    AOI28283.1    KT368900    ALA50144.1    DQ243972    ABB90515.1    KT253260    ALK28766.1    MH687960    AYR18549.1    DQ243971    ABB90514.1    X16816    AF304460    AF344186    AF344187    AF344188    AF344189    Y09923    Y10051    Y10052    X15654    KJ473800    AIA62234.1    KY369910    KY369911    APT69862.1    APT69869.1    MH687958    AYR18537.1    KM055532    KM055533    AIW52729.1    AIW52730.1    KY684760    ARA15429.1    KT253271    ALK28787.1    MH687941    AYR18442.1    KF514429    AGT21338.1    KT253264    ALK28770.1    KM055550    AIW52747.1    AB691764    BAL45638.1    DQ243963    ABB90506.1    AB691763    BAL45637.1    KY369909    KY674914    KY621348    APT69856.1    ARB07392.1    ARK08620.1   

Proteomes

UP000142997    UP000162232    UP000204102    UP000106394    UP000277178    UP000144177    + More
UP000122373    UP000162430    UP000155419    UP000118770    UP000113079    UP000146121    UP000136947    UP000116691    UP000152663    UP000173458    UP000103783    UP000120649    UP000151210    UP000101679    UP000169049    UP000100137    UP000103248    UP000108758    UP000110675    UP000115199    UP000115399    UP000124352    UP000128900    UP000136940    UP000152773    UP000153580    UP000171347    UP000173795    UP000147133    UP000153625    UP000130985    UP000104585    UP000006716    UP000126502    UP000096398   

PRIDE

Q0Q466    P15423   

Pfam

PF01600   Corona_S1
PF01601   Corona_S2

Interpro

IPR002551   Corona_S1
IPR002552   Corona_S2
IPR042552   ALPHA_CORONA_SPIKE

ProteinModelPortal

H9BR00   H9BR08   A0A2Z5XXS4   A0A2Z5XXT6   A0A2Z5XXR5   A0A1L2KGB2   + More
A0A0U1WJW2   A0A1L2KGD3   A0A1L2KGD0   F1DB14   A0A482K0W7   A0A1W5YKS6   A0A0U1UZ37   A0A3G3NGX8   A0A0P0KR98   A0A3G3NHH0   A0A3G3NGW9   A0A3G3NHL7   A0A0P0KBC5   A4ULL1   A0A482JZK4   K4JZU5   A0A0N7J128   A0A0P0K0X5   K4KCP3   A0A0P0KXK6   A0A0P0KI80   A0A4Y6GL52   A0A3G3NGT9   A0A0N7J129   A0A3G3NGQ0   A0A3G3NGS7   A0A1B3TNA4   A0A4Y6GL65   A0A3G3NGQ4   A0A4Y6GL57   A0A1L2KGE4   A0A3G3NGM2   A0A3G3NGM9   A0A3G3NGG7   A0A3G3NHH9   A0A1L2KGF1   A0A1W5YKT3   A0A219TUS3   A0A3G3NH05   A0A3G3NHI3   A0A4Y5QL66   A0A4Y6GL18   Q0Q466   Q0Q4F5   I1VWF5   A0A3G3NGN7   A0A3G3NGV3   Q0Q4F6   A0A0U2GQ76   A0A0U2GN50   A0A0U2GNG3   A0A0U2GMQ4   A0A0U2GRL6   A0A0U2GRB2   A0A3G3NGK2   A0A482JX42   A0A0U2GME6   A0A0U2GMN8   A0A3G3NHJ0   Q1HVM3   Q1HVL9   A0A0U2GMG2   A0A1C8YZ37   Q1HVM0   Q1HVM5   A0A1C8YZ26   A0A0U2GQI5   A0A059SGA9   Q1HVM1   A0A482JZV2   A0A0P0KRB3   A0A0P0KWD4   A0A3G3NGX2   A0A1C8YZ34   A0A0U2GN82   Q1HVL7   A0A0P0KH07   A0A3G3NGU0   Q1HVL8   P15423   A0A0U1WHD9   A0A1L7B934   A0A3G3NGU7   A0A384RJX8   A0A1V0BZ86   A0A0P0K6L9   A0A3G3NGJ7   S5YNL7   A0A0P0KR90   A0A384R9G0   H1AG30   Q1HVM6   H1AG29   A0A1L7B908  

PDB

6U7H     E-value=0,     Score=2360