Strain

CHINA_AVIAN_2008_NC_016995 (Region: China: Hong Kong;  Strain: Wigeon coronavirus HKU20, complete genome.;  Date: 2008)

Gene

membrane protein

Description

Annotated in NCBI,  membrane protein

Location

NC_016995(+):22708-23358

GenBank Accession

YP_005352873.1

Full name

Membrane protein      

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

CDS

ATGTCTGACTACTCTGAGTGGCAGCTTATTGTTTTTATTGTTATTATTTGGGCTCTTGGTATCATACTCCAGGGCGGGTATGCCACCAGGTTCCGTTTCACTTACATTCTTAAACTTATACTACTATGGGTACTTCAACCATTCACCCTGGTGGTTACCATCTGGACTGCTGTTGATAAGGGATCGGAACCTACTTCTGCTCTTTTCATCATTGCTGTCATATTTTCTGTGCTGACCTTTGTTTCATGGGCCAAGTATTGGTATGATTCCATTCGCTTGGCCATTAAAACAAAATCTGCATGGGCCCTATCTCCTGAGTCTAGGCTGCTAGCCTGTATGCTGGATAATTCTGGCATTATGCATGCAGTACCACTAGACTACCTTCCCACAGCGCTGTGCCCAGTCCTTGTTAGAGGCAAATTTATGTTGCATGGACAGTGTGTTGCGAAGCAGATGACTTTGTCATCTGTTCCACGTGCATTTTATGTGGCAACACCAAGCCACACATATCATTATTCGCTCCGTAAAACATTCCAAGACCCGGAGCTGCCTGACACAGCCACCTACATTTATTTGGTGGAGAAAATTAGCAAGGCTGATCTAAGCTCAGTCACAACAGGTAATAACGCTGCTTTTTATAAGCAGTTTTAA

Protein

MSDYSEWQLIVFIVIIWALGIILQGGYATRFRFTYILKLILLWVLQPFTLVVTIWTAVDKGSEPTSALFIIAVIFSVLTFVSWAKYWYDSIRLAIKTKSAWALSPESRLLACMLDNSGIMHAVPLDYLPTALCPVLVRGKFMLHGQCVAKQMTLSSVPRAFYVATPSHTYHYSLRKTFQDPELPDTATYIYLVEKISKADLSSVTTGNNAAFYKQF

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the gammacoronaviruses M protein family.

Keywords

Glycoprotein   Host Golgi apparatus   Host membrane   Membrane   Transmembrane   Transmembrane helix   Viral envelope protein   Viral matrix protein   Virion   Reference proteome  

Feature

chain  Membrane protein

Uniprot

H9BR27   A0A2U9I694   H9BR19   A0A2Z5XXU6   A0A2H4NFS0   A0A0U3BGC8   + More
A0A2Z4EVY0   A0A1Z4F680   X2EZT4   A0A075X0D1   A6N254   A0A075E3D6   A0A075E3P1   A0A075E3D0   A0A097EU50   W8R479   A0A075E3L3   H9BQY0   A0A0E3U220   A0A286NGL7   A0A140ES76   A0A1C9C4I5   A0A1Z4F693   A0A145YPB1   H9BQY7   A0A140ESG7   A0A514C923   A0A5J6NBG5   B6VDY0   A0A2Z4G602   A0A4Y6ER58   A0A2Z4G622   A0A2Z4G609   H9BQZ4   B6VDY9   A0A2Z5XXS3   H9BR10   A0A5B8JML2   A0A2Z5XXR4   A0A2Z5XXT2   A0A2Z4EVU8   A0A2Z4EVV0   H9BR02   B6VDW2   A0A346IMW4   B6VDX1   H9BR37   C9DST0   F6M7B9   A5Z126   K4FZE0   F4MIS0   M4I8Z0   A0A2K8GJ51   C5IZI9   A0A1X9Y2R8   Q9J3N8   C6KCX6   G4RJ99   A4ZCM1   F4MIR0   A0A286LPM1   A0A1X9Y2L9   A0A2N9QPI3   A0A1W6AWK4   Q0ZB50   A0A1P8SSQ9   A0A1P8VF79   A5Z0X0   A0A1L7H982   A4ZCM9   C9E9N8   A0A0U1WK55   A0A1V0G398   A0A1B2CWH4   E9LUF4   Q7TEH1   Q91SA1   A5Z173   C7S863   Q9J0X1   G4RJA1   Q91S97   A0A346M350   A0A4V6MBA0   Q6W9D6   P69604   P69603   P69605   A0A1W6AWL0   Q6VUR2   P69606   P69607   B3VN11   F4MIY0   A0A023VV51   C9DSU1   A0A2K8GJE1   C5IZI7   A4ZCV6  

Pubmed

22278237    29875375    29872066    28634353    24723718    25759498    + More
17459938    24723704    24964136    25153521    24744332    26584185    26337879    26514769    26250097    25817405    26982324    27718337    28758347    29621617    29695146    29569144    27424024    27231358    18971277    29363281    31239538    30758768    20022075    20574643    27938680    18295413    21539870    23203570    29337625    28116527    11087096    18045937    17364511    21049275    22542436    25721384    21909766    19100792    20652731    21994806    23178317    26482289    31561498    28495648    28646651    30526618    16934878   

EMBL

JQ065048    AFD29236.1    MH013338    AWR88317.1    JQ065047    AFD29228.1    + More
LC364345    LC364346    BBC54854.1    BBC54863.1    KY363867    ATV90796.1    KT313678    KT313680    ALT00614.1    ALT00616.1    MG812377    AWV67127.1    LC216914    BAY00725.1    KJ567050    AHM88402.1    KJ769231    AIH06859.1    EF584908    ABQ39960.1    KJ601779    AIB07802.1    KJ601778    AIB07795.1    KJ601777    AIB07787.1    KM820765    AIT11902.1    KJ481931    AHL45009.1    KJ601780    AIB07809.1    JQ065042    KJ462462    KJ569769    KJ584355    KJ584356    KJ584357    KJ584358    KJ584359    KJ584360    KJ620016    KM012168    KT381613    AFD29189.1    AHN16222.1    AHN16229.1    AIA60975.1    AIA60982.1    AIA60989.1    AIA60996.1    AIA61003.1    AIA61009.1    AIA99520.1    AIP90488.1    ALJ32187.1    KP981395    KP757890    KP757891    KP757892    KT266822    KR131621    KT021234    KT336560    KT313675    KT313676    KT313677    KT313679    KT313681    KT313682    KT313683    KT313684    KT313685    KT313686    KR150443    KR265847    KR265848    KR265849    KR265850    KR265852    KR265853    KR265854    KR265855    KR265856    KR265857    KR265858    KR265859    KR265860    KR265861    KR265862    KR265863    KR265865    KU665558    KU051641    KU051642    KU051643    KU051644    KU051645    KU051646    KU051647    KU051648    KU051649    KU051650    KU051651    KU051652    KU051653    KU051654    KU051655    KU051656    KU517165    KU981059    KU981060    KU981061    KU981062    KX022602    KX022603    KX022604    KX022605    KU870483    KU870484    KY065120    KY129985    KX834351    KX834352    KX443143    KY354363    KY354364    KY364365    KY293677    KY293678    MF431742    MF431743    KY926512    MF948005    KY363868    KY513724    KY513725    MF041982    MF280390    MG242062    MG837130    MG837131    MG837132    MG837133    MH708123    MH708124    MH708125    MG832584    MH715491    LC260045    LC260038    LC260039    LC260040    LC260041    LC260042    LC260043    LC260044    MK005882    MK330605    AKA97940.1    AKC54430.1    AKC54437.1    AKC54444.1    AKQ63085.1    ALA13747.1    ALD83758.1    ALS54088.1    ALT00611.1    ALT00612.1    ALT00613.1    ALT00615.1    ALT00617.1    ALT00618.1    ALT00619.1    ALT00620.1    ALT00621.1    ALT00622.1    AML40606.1    AML40778.1    AML40785.1    AML40792.1    AML40799.1    AML40813.1    AML40820.1    AML40827.1    AML40834.1    AML40841.1    AML40848.1    AML40855.1    AML40862.1    AML40869.1    AML40876.1    AML40883.1    AML40890.1    AML40904.1    AML83918.1    AMN91623.1    AMN91629.1    AMN91635.1    AMN91641.1    AMN91647.1    AMN91653.1    AMN91659.1    AMN91665.1    AMN91672.1    AMN91678.1    AMN91684.1    AMN91690.1    AMN91696.1    AMN91702.1    AMN91708.1    AMN91714.1    ANA78298.1    ANA78445.1    ANI85827.1    ANI85834.1    ANI85841.1    ANI85848.1    APC23097.1    APC23098.1    APG38200.1    APW35736.1    APZ76692.1    APZ76700.1    AQS99155.1    AQT34132.1    AQT34138.1    ARJ31776.1    ASK86336.1    ASK86343.1    ASR75141.1    ASR75152.1    ASS83088.1    ATJ00131.1    ATV90800.1    AUG59158.1    AUG59166.1    AUH28252.1    AVR48521.1    AVZ61084.1    AWG96867.1    AWG96874.1    AWG96880.1    AWG96886.1    AXP32218.1    AXP32225.1    AXP32232.1    AYP31080.1    AYU65234.1    BAZ95611.1    BBA66307.1    BBA66314.1    BBA66321.1    BBA66328.1    BBA66335.1    BBA66342.1    BBA66349.1    QCO76965.1    QDP14520.1    MF095123    KY398011    MK572803    MK330604    ASY98689.1    ATU88975.1    QDH76196.1    QDP14513.1    KR265851    AML40806.1    KX118627    AOM53029.1    LC216915    BAY00732.1    KU984334    KU870479    KU870480    KU870481    KU870482    AMW88199.1    APC23093.1    APC23094.1    APC23095.1    APC23096.1    JQ065043    AFD29196.1    KR265864    AML40897.1    MK355396    QDH76190.1    MK673766    QEX51275.1    FJ376621    ACJ12055.1    MF642322    AWV96561.1    MK211169    QDF21513.1    MF642325    AWV96582.1    MF642323    MF642324    AWV96568.1    AWV96575.1    JQ065044    AFD29203.1    FJ376622    ACJ12064.1    LC364343    BBC54834.1    JQ065046    AFD29219.1    MK204388    QDY92323.1    LC364342    BBC54824.1    LC364344    BBC54844.1    MG812378    AWV67136.1    MG812375    MG812376    AWV67109.1    AWV67118.1    JQ065045    AFD29211.1    FJ376619    ACJ12037.1    MH532440    AXP20283.1    FJ376620    ACJ12046.1    JQ065049    AFD29246.1    GQ427173    ACV87238.1    JF732918    KU556806    AEF98434.1    APP92746.1    EF602448    ABQ84834.1    JN176213    KU556807    AFK30969.1    APP92759.1    FJ904715    ADA83491.1    JQ693042    JQ693044    AFZ88837.1    AFZ88839.1    KU949740    KU949741    KU949742    KU949743    KU949744    KU949745    MG738155    ARI46248.1    ARI46256.1    ARI46264.1    ARI46272.1    ARI46280.1    ARI46288.1    QAA92391.1    FJ976464    ACR16065.1    KU900744    ARS22464.1    AF202999    AF206266    AF206267    AF206268    AF206269    AF206270    AF206271    GQ174479    ACS45211.1    FJ849824    ACZ67646.1    DQ490209    ABF61498.1    FJ904714    ADA83481.1    MF462335    ASU92400.1    KU900739    ARS22414.1    KU949737    KU949738    KU949739    MG738154    ARI46224.1    ARI46232.1    ARI46240.1    QAA92381.1    KY626044    ARJ35785.1    DQ646405    ABG36791.1    KX236007    APY26802.1    KX302867    APZ73719.1    EF602441    ABQ84778.1    KX348115    APU51851.1    DQ490210    DQ490211    DQ490213    DQ490218    JN983807    KF460437    KF931628    ABF61506.1    ABF61514.1    ABF61527.1    ABF61567.1    AFK30957.1    AIG54287.1    AIG54299.1    GQ476990    ACV85618.1    KF975405    KR265092    AIB54162.1    ART35353.1    KX364296    ARB66166.1    KX258195    ANY58998.1    HQ141058    ADW77296.1    AY302747    AAP68695.1    AF363600    GQ504722    AAK50027.1    ADP06477.1    EF602454    EF602459    EF602460    EU826084    FJ976463    KX185057    ABQ84881.1    ABQ84921.1    ABQ84929.1    ACE95720.1    ACR16064.1    APX44051.1    EU817497    ACJ12838.1    AF221667    AAF35863.1    FJ849796    FJ849805    FJ849807    FJ849826    JQ801377    ACZ67618.1    ACZ67627.1    ACZ67629.1    ACZ67648.1    AFJ24941.1    AF363606    AAK50033.1    MG913342    AXQ05194.1    MK071267    QCS40644.1    AY302742    AY302743    AY325732    AY846835    AY856347    EF602437    EF602438    EF602439    EF602443    EU714028    EU822341    FJ807652    FJ888351    FJ919614    FJ849808    GU393335    JF330899    JF828981    JX273198    KF188434    KJ425486    KJ425487    KJ425488    KJ425490    KJ425491    KJ425492    KJ425493    KJ425494    KJ425495    KJ425497    KJ425498    KJ425499    KJ425500    KJ425501    KJ425502    KJ425503    KJ425505    KJ425506    KJ425507    KJ425509    KJ425510    KJ425511    KJ425512    KJ435284    KT203557    MG763935    MK937829    MK887093    MK887097    MK887099    MK887106    AAP68690.1    AAP68691.1    AAP86207.1    AAW56626.1    AAW83033.1    ABQ84746.1    ABQ84754.1    ABQ84762.1    ABQ84794.1    ACH72797.1    ACJ50203.1    ACO37570.1    ACQ55234.1    ACQ91088.1    ACZ67630.1    ADV71781.1    ADY62556.1    AEP84750.1    AFS18118.1    AGW24531.1    AHX25906.1    AHX25915.1    AHX25924.1    AHX25942.1    AHX25951.1    AHX25960.1    AHX25969.1    AHX25978.1    AHX25987.1    AHX26005.1    AHX26014.1    AHX26023.1    AHX26032.1    AHX26041.1    AHX26050.1    AHX26059.1    AHX26077.1    AHX26086.1    AHX26095.1    AHX26113.1    AHX26122.1    AHX26131.1    AHX26140.1    AHX26158.1    ALE71335.1    AVX27616.1    QDA76304.1    QEY95698.1    QEY95702.1    QEY95704.1    QEY95711.1    AY028295    AF203004    AF322367    KY626045    ARJ35795.1    AY325728    AY325729    GQ174486    FJ904720    FJ904723    GQ504724    GQ504725    JQ693036    KJ425504    KJ425508    KY805845    KY273667    MH539771    MH539772    MK728875    MK937830    MK937833    AAP86204.1    ACS45218.1    ADA83541.1    ADA83571.1    ADP06501.1    ADP06511.1    AFZ88831.1    AHX26068.1    AHX26104.1    ARS23143.1    ASF20084.1    AZP23934.1    AZP23944.1    QCE31537.1    QDA76313.1    QDA76340.1    AF363609    AF343343    AF286184    DQ834384    AY851295    AY044184    AF286185    EU780078    ACE88707.2    FJ904721    ADA83551.1    KJ469748    AHY19802.1    GQ427174    ACV87250.1    KU949746    ARI46296.1    FJ976462    ACR16063.1    DQ490221    ABF61583.1   

Proteomes

UP000167590    UP000132721    UP000126862    UP000139576    UP000104403    UP000129252    + More
UP000160089    UP000114014    UP000102644    UP000172095    UP000103266    UP000118543    UP000122701    UP000124223    UP000147537    UP000149778    UP000152486    UP000152859    UP000156755    UP000161942    UP000174689    UP000097413    UP000100106    UP000108307    UP000115701    UP000116882    UP000117737    UP000118503    UP000120336    UP000120804    UP000130144    UP000131750    UP000132517    UP000136494    UP000137853    UP000141273    UP000144892    UP000147360    UP000148151    UP000150502    UP000151351    UP000154045    UP000156468    UP000158884    UP000161041    UP000162784    UP000163421    UP000169372    UP000170248    UP000172024    UP000180351    UP000180352    UP000171091    UP000112854    UP000103330    UP000118624    UP000011786    UP000135406    UP000103579    UP000162232    UP000142997    UP000161619    UP000116644    UP000144236    UP000123786    UP000129334    UP000133571    UP000149405    UP000123393    UP000128029    UP000101527    UP000107830    UP000097868    UP000102121    UP000102163    UP000103149    UP000106511    UP000108224    UP000113245    UP000113896    UP000113939    UP000118008    UP000120286    UP000120642    UP000132365    UP000136241    UP000136440    UP000138146    UP000146865    UP000149404    UP000155572    UP000158124    UP000158949    UP000159206    UP000163887    UP000165788    UP000166253    UP000167410    UP000170189    UP000170844    UP000173109    UP000173215    UP000180343    UP000098752    UP000107291    UP000114242    UP000117985    UP000155946    UP000165485    UP000007642    UP000096468    UP000169726    UP000098674   

Pfam

PF01635   Corona_M

Interpro

IPR002574   Corona_M
IPR042550   GAMMA_CORONA_M

ProteinModelPortal

H9BR27   A0A2U9I694   H9BR19   A0A2Z5XXU6   A0A2H4NFS0   A0A0U3BGC8   + More
A0A2Z4EVY0   A0A1Z4F680   X2EZT4   A0A075X0D1   A6N254   A0A075E3D6   A0A075E3P1   A0A075E3D0   A0A097EU50   W8R479   A0A075E3L3   H9BQY0   A0A0E3U220   A0A286NGL7   A0A140ES76   A0A1C9C4I5   A0A1Z4F693   A0A145YPB1   H9BQY7   A0A140ESG7   A0A514C923   A0A5J6NBG5   B6VDY0   A0A2Z4G602   A0A4Y6ER58   A0A2Z4G622   A0A2Z4G609   H9BQZ4   B6VDY9   A0A2Z5XXS3   H9BR10   A0A5B8JML2   A0A2Z5XXR4   A0A2Z5XXT2   A0A2Z4EVU8   A0A2Z4EVV0   H9BR02   B6VDW2   A0A346IMW4   B6VDX1   H9BR37   C9DST0   F6M7B9   A5Z126   K4FZE0   F4MIS0   M4I8Z0   A0A2K8GJ51   C5IZI9   A0A1X9Y2R8   Q9J3N8   C6KCX6   G4RJ99   A4ZCM1   F4MIR0   A0A286LPM1   A0A1X9Y2L9   A0A2N9QPI3   A0A1W6AWK4   Q0ZB50   A0A1P8SSQ9   A0A1P8VF79   A5Z0X0   A0A1L7H982   A4ZCM9   C9E9N8   A0A0U1WK55   A0A1V0G398   A0A1B2CWH4   E9LUF4   Q7TEH1   Q91SA1   A5Z173   C7S863   Q9J0X1   G4RJA1   Q91S97   A0A346M350   A0A4V6MBA0   Q6W9D6   P69604   P69603   P69605   A0A1W6AWL0   Q6VUR2   P69606   P69607   B3VN11   F4MIY0   A0A023VV51   C9DSU1   A0A2K8GJE1   C5IZI7   A4ZCV6  

KEGG

vg:11945667     vg:11945656     vg:7040217     vg:11945624     vg:7040228     vg:11945645     vg:11945634     vg:11945679    

GO

GO:0044178  C:host cell Golgi membrane
GO:0019031  C:viral envelope
GO:0016021  C:integral component of membrane
GO:0019058  P:viral life cycle
GO:0039660  F:structural constituent of virion
GO:0055036  C:virion membrane

From MSLVP

Host nucleus > host nucleolus. Host cytoplasm. Secreted.

From Uniprot

Host Golgi apparatus membrane  
Virion membrane  

Length:

216

Number of predicted TMHs:

3

Exp number of AAs in TMHs:

63.8954900000001

Exp number, first 60 AAs:

42.54628

Total prob of N-in:

0.01037

POSSIBLE N-term signal

sequence

outside

1  -  4

TMhelix

5  -  27

inside

28  -  33

TMhelix

34  -  56

outside

57  -  65

TMhelix

66  -  88

inside

89  -  216