Strain

CHINA_RABBIT_2006_NC_017083 (Region: China;  Strain: Rabbit coronavirus HKU14, complete genome.;  Date: 2006)

Gene

hemagglutinin-esterase protein

Description

Annotated in NCBI,  hemagglutinin-esterase protein

Location

NC_017083(+):22504-23778

GenBank Accession

YP_005454244.1

Full name

Hemagglutinin-esterase      

Alternative Name

E3 glycoprotein

CDS

ATGTTTTTGCTTCCTAGATATATTCTAGTTAGCTGCATAATTGGTAGCTTAGGTTTTGATAACCCTCCTACCAATGTTGTTTCGCATGTAAATGGAGATTGGTTTTTATTTGGTGACAGTCGTTCAGATTGTAATCATGTTGTTAATACTAATCCTCGTAATTATTCTTATATGGACCTTAACCCAGCCCTATGTGATTCAGGTAAAATCTCTTCGAAAGCTGGTAACTCTTTGTTTAGGAGTTTCCACTTCACGGATTTTTATAATTACACAGGTGAAGGTCAACAAATTATATTCTATGAGGGTGTTAATTTTAATCCTTATCACGCCTTTAAATGCACCAGTTTTGGTAGTAATGATATTTGGATGCAGAATAAAGGCTTGTTTTATACTCAGGTTTATAAGAATATGGCTGTGTATCGCAGCCTTACTTTTGTTAATGTACCATATGTTTACAATGGTTCTGCACAAGCCACAGCTCTTTGTAAATCTGGTAGTTTAGTCCTTAATAATCCTGCCTATATAGCTCGTGAAGCTAATTTGGGGGATTATTACTATAAGGTTGAAGCTGACTTTCATTTGTCAGGTTGTGACGAGTATATCGTACCACTTTGTATTTTTAATGGTAAGTTTTTGTCGAATACAAAGTATTATGATGATAGTCAATATTATTTTAATAAAGACACTGGTGTTATTTATGGTCTTAATTCTACTGAGACTATTACCACTGGTTTTGATTTTAATTGTCATTATTTAGTTTTACCCTCTGGTAATTATTTAGCCATTTCAAATGAGCTATTATTAACTGTTCCCACGAAAGCAATCTGTCTTAGTAAGCGTAAGGATTTTACGCCTGTACAAGTGGTAGATTCTCGTTGGAACAATGCCAGGCCTTCTGATAACATGACGGCGGTTGCTTGTCAACCCCCGTACTGTTATTTTCGTAATTCTACTACCAACTATGTTGGTGTTTATGATATCAATCATGGGGATGCTGGTTTTACTAGCATACTCAGTGGTTTGTTATATGATTCACCTTGTTTTTCACAGCAAGGTGTTTTTAGGTATGATAATGTTAGCAGTGTCTGGCCTCTTTACCCTTACGGTAGATGTCCTACTGCTGCTGATATTAATACTCCTGATGTACCTATTTGTGTGTATGATCCGCTACCACTTATTTTGCTTGGCATTCTTTTGTGTGTTGCGGTCATAATTATTGTAGTTTTGTTGTTATATTTTATGGTGGATAATGGTACTAGGCTGCATGATGCTTAG

Protein

MFLLPRYILVSCIIGSLGFDNPPTNVVSHVNGDWFLFGDSRSDCNHVVNTNPRNYSYMDLNPALCDSGKISSKAGNSLFRSFHFTDFYNYTGEGQQIIFYEGVNFNPYHAFKCTSFGSNDIWMQNKGLFYTQVYKNMAVYRSLTFVNVPYVYNGSAQATALCKSGSLVLNNPAYIAREANLGDYYYKVEADFHLSGCDEYIVPLCIFNGKFLSNTKYYDDSQYYFNKDTGVIYGLNSTETITTGFDFNCHYLVLPSGNYLAISNELLLTVPTKAICLSKRKDFTPVQVVDSRWNNARPSDNMTAVACQPPYCYFRNSTTNYVGVYDINHGDAGFTSILSGLLYDSPCFSQQGVFRYDNVSSVWPLYPYGRCPTAADINTPDVPICVYDPLPLILLGILLCVAVIIIVVLLLYFMVDNGTRLHDA

Function

Structural protein that makes short spikes at the surface of the virus. Contains receptor binding and receptor-destroying activities. Mediates de-O-acetylation of N-acetyl-4-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells. This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell. May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one. May become a target for both the humoral and the cellular branches of the immune system.

Catalytic Activity

H2O + N-acetyl-4-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate
H2O + N-acetyl-9-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate

Subunit

Homodimer; disulfide-linked. Forms a complex with the M protein in the pre-Golgi. Associates then with S-M complex to form a ternary complex S-M-HE.

Miscellaneous

The sequence shown is that of Quebec reference strain.

Similarity

Belongs to the influenza type C/coronaviruses hemagglutinin-esterase family.

Keywords

Disulfide bond   Glycoprotein   Hemagglutinin   Host cell membrane   Host membrane   Hydrolase   Membrane   Signal   Transmembrane   Transmembrane helix   Viral envelope protein   Virion   3D-structure   Direct protein sequencing  

Feature

chain  Hemagglutinin-esterase

Uniprot

H9AA33   H9AA54   H9AA43   H9AA64   C6GHL2   Q0PL40   + More
Q9DR81   A0A3S7GY11   P31613   C6GHQ9   B7TYG8   Q66165   A0A3S9Y2A6   A6YD39   B7U2R4   B7U2N2   B7U2M1   B7U2L0   B7U2S6   A4ZU73   A4ZU62   B7U2P3   A4ZU40   A4ZU51   Q2EEZ0   P59711   A0A291L0R5   Q9QAQ9   A0A346I7H1   A0A481SAP1   A0A451ETZ3   A4ZTX4   A0A2R4STW8   A0A1J3   Q9QAR6   A0A2P1IQB6   A4ZU07   Q2EEZ2   A0A1V0JAY6   A4ZTZ6   Q4U3S3   P15776   A4ZU18   Q06BD8   B7U2Q3   A0A3S9Y2S0   A0A1J2   X2JFB2   A0A191URB1   A0A2R4STV0   A0A3Q9K3J1   P59709   Q8V437   P59710   A8HB15   A0A3S9Y2C0   A0A3Q9K3J3   Q2EEZ7   C6GHM4   C6GHN6   A4ZU29   A0A481S1W3   A0A346I7H2   A0A5J6NRK9   A4ZTY5   A0A481S2D5   A0A451ETZ0   X2JHM7   A0A0U2GN17   Q4U3S2   A0A493R5L6   A0A481S1B0   A0A191URZ4   A0A346I7H4   Q4U3S0   A0A5J6NRQ9   B9TXU2   A0A481S1A3   Q2EEZ4   A0A3S7GXV6   A0A3S7H0W0   C6GHP8   Q4U3S5   Q2EEZ3   Q4U3S6   D0EY82   D0EY92   A0A191URC1   P33468   Q2EEZ1   A7BKC1   Q2EEZ9   Q2EEZ5   Q4U3S4   B8RIQ6   A0A0C5AY37   D0EY72   A0A411D561   A0A5J6NRI4   A3E2F1  

EC Number

3.1.1.53

Pubmed

22398294    11376845    11774537    1962455    9778786    1727608    + More
17669602    18842722    17344285    17803510    20880639    30771080    11714968    17434558    16954245    29508550    16604443    2319653    2103108    2732694    15507445    18550812    17459444    24655427    27274850    2732684    7730812    11504427    11774548    17916374    31534035    26678874    23405345    1715665    17374765    19162098    17092595   

EMBL

JN874559    AFE48794.1    JN874561    AFE48816.1    JN874560    AFE48804.1    + More
JN874562    AFE48826.1    FJ938063    ACT10982.1    DQ811784    ABG89283.1    AF239308    AF239309    MG757139    MG757141    AVI15010.1    AVI15032.1    M84486    AF058942    FJ938067    ACT11029.1    FJ415324    ACJ35485.1    M80842    MK095142    AZS64189.1    EF445634    ABP73655.1    FJ425189    ACJ66999.1    FJ425186    ACJ66968.1    FJ425185    ACJ66956.1    FJ425184    ACJ66944.1    FJ425190    ACJ67011.1    EF424624    ABP38338.1    EF424623    ABP38323.1    FJ425187    ACJ66975.1    EF424621    ABP38304.1    EF424622    ABP38312.1    DQ389651    EU401975    EU401976    HM573321    HM573322    HM573323    HM573324    HM573325    MH043953    MH043954    MK045992    MK045993    MK046000    MK046002    ABD18927.1    ACB30195.1    ACB30196.1    ADP21330.1    ADP21331.1    ADP21332.1    ADP21333.1    ADP21334.1    AVZ61108.1    AVZ61118.1    QBG67061.1    QBG67062.1    QBG67069.1    QBG67071.1    AF391541    MF593476    ATI09448.1    AF058944    MH203059    AXP11691.1    MH475914    QBH22432.1    MK095145    MK095146    AZS64192.1    AZS64193.1    EF424615    ABP38240.1    MH043955    AVZ61128.1    DQ994168    ABI98029.1    AF058943    MG518518    AVN88333.1    EF424618    ABP38271.1    DQ389649    ABD18925.1    KX982264    ARD05998.1    EF424617    ABP38257.1    AH014866    AH014870    AAY33928.1    AAY33940.1    U00735    S50936    EF424619    ABP38274.1    DQ915164    ABI94000.1    FJ425188    ACJ66986.1    MK095147    AZS64194.1    DQ994167    ABI98028.1    KF906250    KF906251    AHN64782.1    AHN64791.1    KU558922    ANJ04716.1    MH043952    AVZ61098.1    MK095141    MK095143    MK095144    AZS64188.1    AZS64190.1    AZS64191.1    L38962    L38963    U06093    AF239306    AF239307    AF230523    AF230524    AF230525    AF230526    AF230527    AF230528    AF339836    AF220295    AF391542    S69264    M76372    EU019216    ABV74053.1    MK095140    AZS64187.1    MK095138    MK095139    AZS64185.1    AZS64186.1    DQ389643    DQ389644    DQ389645    ABD18919.1    ABD18920.1    ABD18921.1    FJ938064    ACT10994.1    FJ938065    ACT11006.1    EF424620    ABP38286.1    MK045994    QBG67063.1    MH203060    MH203061    MH203063    AXP11692.1    AXP11693.1    AXP11695.1    MN514964    MN514965    QEY10640.1    QEY10648.1    EF424616    ABP38246.1    MK046001    QBG67070.1    MK095135    MK095136    MK095137    AZS64182.1    AZS64183.1    AZS64184.1    KF906249    AHN64773.1    KT368891    ALA50079.1    AH014871    AAY33943.1    MK045995    QBG67064.1    MK045996    MK045997    QBG67065.1    QBG67066.1    KU886219    ANJ04973.1    MH203062    AXP11694.1    AH014872    AH014873    AH014874    AH014875    DQ994162    DQ994163    DQ994164    DQ994165    DQ994166    DQ994169    DQ994170    AAY33946.1    AAY33949.1    AAY33952.1    AAY33955.1    ABI98023.1    ABI98024.1    ABI98025.1    ABI98026.1    ABI98027.1    ABI98030.1    ABI98031.1    MN514967    QEY10664.1    EU401979    ACB30199.1    MK045998    MK045999    QBG67067.1    QBG67068.1    DQ389647    ABD18923.1    MG757138    AVI14999.1    MG757140    MG757142    AVI15021.1    AVI15043.1    FJ938066    ACT11018.1    AH014868    AAY33934.1    DQ389648    ABD18924.1    AH014867    AAY33931.1    GQ918142    JX860640    ACX46849.1    AFW97359.1    GQ918143    ACX46859.1    KU558923    ANJ04727.1    DQ389650    ABD18926.1    EU401977    EU401978    AB354579    ACB30197.1    ACB30198.1    BAF75630.1    DQ389642    ABD18918.1    DQ389646    ABD18922.1    AH014869    AAY33937.1    EU999954    ACL12995.1    KM985632    AJL33727.1    GQ918141    ACX46839.1    MH249786    QAY30019.1    MN514962    QEY10624.1    DQ682406    ABG78747.1   

Proteomes

UP000107676    UP000125269    UP000124585    UP000145001    UP000172225    UP000147981    + More
UP000164707    UP000158296    UP000133443    UP000140344    UP000104294    UP000174569    UP000102696    UP000147178    UP000163913    UP000158327    UP000136116    UP000139235    UP000008570    UP000121953    UP000173415    UP000151273    UP000007554    UP000134650    UP000154814    UP000148210    UP000145507    UP000149260    UP000008572    UP000008571    UP000136745    UP000139966    UP000170940    UP000127099    UP000121258    UP000158231    UP000162935    UP000137675    UP000168103   

Pfam

PF02710   Hema_HEFG
PF03996   Hema_esterase

Interpro

IPR007142   Hemagglutn-estrase_core
IPR008980   Capsid_hemagglutn
IPR003860   Hemagglutn-estrase_hemagglutn
IPR042545   HEMA

SUPFAM

SSF49818   SSF49818

ProteinModelPortal

H9AA33   H9AA54   H9AA43   H9AA64   C6GHL2   Q0PL40   + More
Q9DR81   A0A3S7GY11   P31613   C6GHQ9   B7TYG8   Q66165   A0A3S9Y2A6   A6YD39   B7U2R4   B7U2N2   B7U2M1   B7U2L0   B7U2S6   A4ZU73   A4ZU62   B7U2P3   A4ZU40   A4ZU51   Q2EEZ0   P59711   A0A291L0R5   Q9QAQ9   A0A346I7H1   A0A481SAP1   A0A451ETZ3   A4ZTX4   A0A2R4STW8   A0A1J3   Q9QAR6   A0A2P1IQB6   A4ZU07   Q2EEZ2   A0A1V0JAY6   A4ZTZ6   Q4U3S3   P15776   A4ZU18   Q06BD8   B7U2Q3   A0A3S9Y2S0   A0A1J2   X2JFB2   A0A191URB1   A0A2R4STV0   A0A3Q9K3J1   P59709   Q8V437   P59710   A8HB15   A0A3S9Y2C0   A0A3Q9K3J3   Q2EEZ7   C6GHM4   C6GHN6   A4ZU29   A0A481S1W3   A0A346I7H2   A0A5J6NRK9   A4ZTY5   A0A481S2D5   A0A451ETZ0   X2JHM7   A0A0U2GN17   Q4U3S2   A0A493R5L6   A0A481S1B0   A0A191URZ4   A0A346I7H4   Q4U3S0   A0A5J6NRQ9   B9TXU2   A0A481S1A3   Q2EEZ4   A0A3S7GXV6   A0A3S7H0W0   C6GHP8   Q4U3S5   Q2EEZ3   Q4U3S6   D0EY82   D0EY92   A0A191URC1   P33468   Q2EEZ1   A7BKC1   Q2EEZ9   Q2EEZ5   Q4U3S4   B8RIQ6   A0A0C5AY37   D0EY72   A0A411D561   A0A5J6NRI4   A3E2F1  

PDB

3CL4     E-value=0,     Score=1849