Strain

CHINA_RABBIT_2006_NC_017083 (Region: China;  Strain: Rabbit coronavirus HKU14, complete genome.;  Date: 2006)

Gene

nucleocapsid protein

Description

Annotated in NCBI,  nucleocapsid protein

Location

NC_017083(+):29462-30796

GenBank Accession

YP_005454249.1

Full name

Nucleoprotein      

Alternative Name

Nucleocapsid protein

CDS

ATGTCCTTTACTCCTGGTAAGCAACCCAGCAGTAGAGCGTCCTCTGGAAATCGTGCTGGTAATGGCATCCTTAAGTGGGCCGATCAGTCCGAACAGTCTAGAAATATTCAAACCAGGGGTAGAAGAGCTCAACCCAAGCAAACTGTTACTTCTCAGCAACCAACGGGAGGGAACGTTGTACCCTACTATTCTTGGTTCTCTGGAATTACTCAGTTTCAAAAGGGAAAGGAGTTTGAATTTGCAGAAGGACAAGGTGTGCCTATTGCACCAGGAGTCCCAGCTACTGAAGCTAAGGGGTATTGGTACAGACACAGCAGACGTTCTTTTAAAACAGCCGACGGCAATCAGCGTCAATTGCTGCCACGATGGTATTTCTACTATCTGGGAACAGGACCGCATGCTAAAGACCAGTATGGCACCGACATTGACGGAGTCTTCTGGGTCGCTAGCAACCAGGCTGATGTTAATACCCCGGCTGACATTCTCGATCGGGACCCAAGTAGCGATGAGGCTATTCCGACTAGGTTTCCGCCTGGCACGGTACTCCCTCAAGGCTACTATATTGAAGGCTCAGGAAGGTCTGCTCCTAATTCCAGATCTACTTCTCGCGCATCCAGCAGAGCCTCTAGTGCAGGATCGCGTAGTAGAGCCAATTCAGGTACTAGAACCCCTACCTCTGGTGTAACACCTGACATGGCTGATCAAATTGCTAGTCTTGTTCTGGCAAAGCTTGGCAAGGATGCCACAAAGCCTCAACAAGTAACTAAGCAGACAGCCAAAGAAGTCAGACAGAAAATTTTGAACAAACCCCGCCAAAAGAGGAGCCCCAATAAACAATGCACTGTTCAGCAGTGTTTTGGGAAGAGAGGCCCCAATCAGAATTTTGGTGGTGGAGAAATGTTAAAACTTGGAACTAGTGATCCACAGTTCCCCATTCTTGCAGAACTCGCACCCACAGCAGGTGCGTTTTTCTTTGGATCAAGATTAGAGTTGGCCAAAGTGCAGAATTTGTCTGGGAATGCTGATGAACCCCAGAAGGATGTTTATGAATTGCGCTATAGTGGCGCGATTAGATTTGATAGTACACTTTCAGGTTTTGAAACTATAATGAAGGTGTTAAATGAGAATTTGAATGCCTATCAGCAACAGGATGATGGGATGAGTCCTAAACCACAGCGTCAGCGTGGTCAAAGGAAGGGAGAAAATGATAATATAAGTGTTGCAGTGCCCAAAAGCCGCGTGCAGCAAAATAAGAGCAGAGAGTTGACAGCAGAGGACATCAGCCTTCTTAAGAAGATGGATGAGCCTTATACTGAAGACACCTCAGAAATATAA

Protein

MSFTPGKQPSSRASSGNRAGNGILKWADQSEQSRNIQTRGRRAQPKQTVTSQQPTGGNVVPYYSWFSGITQFQKGKEFEFAEGQGVPIAPGVPATEAKGYWYRHSRRSFKTADGNQRQLLPRWYFYYLGTGPHAKDQYGTDIDGVFWVASNQADVNTPADILDRDPSSDEAIPTRFPPGTVLPQGYYIEGSGRSAPNSRSTSRASSRASSAGSRSRANSGTRTPTSGVTPDMADQIASLVLAKLGKDATKPQQVTKQTAKEVRQKILNKPRQKRSPNKQCTVQQCFGKRGPNQNFGGGEMLKLGTSDPQFPILAELAPTAGAFFFGSRLELAKVQNLSGNADEPQKDVYELRYSGAIRFDSTLSGFETIMKVLNENLNAYQQQDDGMSPKPQRQRGQRKGENDNISVAVPKSRVQQNKSRELTAEDISLLKKMDEPYTEDTSEI

Function

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.

Subunit

Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.

Similarity

Belongs to the betacoronavirus nucleocapsid protein family.

Keywords

ADP-ribosylation   Host Golgi apparatus   Phosphoprotein   Ribonucleoprotein   RNA-binding   Transcription   Transcription regulation   Viral nucleoprotein   Virion   Reference proteome  

Feature

chain  Nucleoprotein

Uniprot

H9AA59   H9AA48   A0A142D7Z3   A0A142D800   A0A142D7Z2   A0A142D801   + More
A8HB22   C6GHR6   B7TYH5   P26020   A0A3S7H0D9   B8YPE5   A0A142D7Z9   Q9QAR8   A0A0U2GMC1   A0A142D803   B7U2S1   C6GHL9   Q0PL33   A7BKC8   B7U2R0   A0A191URZ1   A0A3S7GYG0   A0A5J6NRW3   B8RIR3   B7U2N9   B7U2M8   B7U2L7   A0A2R4STY7   X2JHN2   A0A5J6NUA1   Q6W358   A0A2R4STX2   Q9QAR1   P19902   C6GHN1   A0A2P1IQ86   A4ZU80   C6GHP3   A4ZU69   A4ZTY1   A4ZU47   A4ZU36   A4ZU58   A0A1S6KXS1   A0A142D7Z1   A0A142D7Z4   A0A2R4STY0   B9TXU3   A0A3Q9K420   A0A5J6NU34   D0EY99   B9TXU6   A0A291L0T4   A2ICF6   A0A5J6NRS1   B7U2P9   A4ZTZ2   Q06BD4   A0A481SB66   A0A451EU00   P59712   P10527   A0A451ETZ8   A0A191URC9   B9TXU8   U3M7K1   Q696P4   C6GHQ4   A0A3T0IBL9   A3E2F7   A2ICF7   A0A5J6NS08   U3M7Z6   A4ZU25   A4ZU14   A0A166IK31   D0EY79   A4ZU03   B9TXU7   A0A0G2RC83   A0A3Q9JZV8   Q91A22   A0A5J6NUQ9   A0A5J6NRV2   U3M820   D0EY89   Q2QKM8   A0A2R4STW5   U3M7Z8   A0A0C5AYI0   U3M822   Q8V432   A0A5J6NRR9   A0A0B4Q8L7   U3M6V7   A0A166MX98   A0A0G2RCY1   Q8BB23   A0A0G2RC64  

Pubmed

22398294    26969241    17916374    1856695    9778786    26678874    + More
18842722    17374765    31534035    19162098    24655427    3207501    29508550    17344285    17434558    17459444    11774548    3029965    27274850    15280490    17092595    27084706    26008694    11714968    23405345    16809333    25530469    12237422   

EMBL

JN874559    JN874561    AFE48799.1    AFE48821.1    JN874560    AFE48809.1    + More
KT318086    KT318088    AMQ23462.1    AMQ23464.1    KT318093    AMQ23469.1    KT318085    AMQ23461.1    KT318089    KT318090    KT318091    KT318094    KT318095    KX982264    MG757140    MG757141    MG757142    AMQ23465.1    AMQ23466.1    AMQ23467.1    AMQ23470.1    AMQ23471.1    ARD06005.1    AVI15028.1    AVI15039.1    AVI15050.1    EU019216    ABV74060.1    FJ938067    ACT11036.1    FJ415324    ACJ35489.1    AF058944    MG757139    AVI15017.1    FJ556872    ACL80212.1    KT318092    AMQ23468.1    AF058942    KT368891    ALA50084.1    KT318096    AMQ23472.1    FJ425189    ACJ67006.1    FJ938063    ACT10989.1    DQ811784    ABG89284.1    AB354579    BAF75637.1    FJ425188    FJ425190    ACJ66985.1    KU886219    ANJ04980.1    MG757138    AVI15006.1    MN514962    QEY10629.1    EU999954    ACL13001.1    FJ425186    ACJ66964.1    FJ425185    ACJ66963.1    FJ425184    ACJ66950.1    MH043955    AVZ61135.1    KF906249    KF906250    KF906251    AHN64778.1    AHN64787.1    AHN64796.1    MN514975    QEY10677.1    AY316299    AAQ67202.1    MH043953    AVZ61115.1    AF058943    M36656    FJ938064    ACT11001.1    MG518518    AVN88326.1    EF424624    ABP38330.1    FJ938065    ACT11013.1    EF424623    ABP38321.1    EF424615    ABP38232.1    EF424621    ABP38302.1    EF424620    ABP38294.1    EF424622    ABP38310.1    KX432213    AQT26504.1    KT318084    AMQ23460.1    KT318087    AMQ23463.1    MH043954    AVZ61125.1    EU401980    EU401981    EU401982    ACB30189.1    ACB30190.1    ACB30191.1    MK095163    MK095167    MK095168    MK095169    MK095170    AZS64210.1    AZS64214.1    AZS64215.1    AZS64216.1    AZS64217.1    MN514963    QEY10637.1    GQ918143    ACX46866.1    EU401983    ACB30192.1    MF593476    ATI09453.1    EF193073    ABM66808.1    MN514972    QEY10674.1    FJ425187    ACJ66983.1    EF424616    ABP38247.1    DQ915164    ABI94003.2    MH475915    QBH22433.1    MK095166    AZS64213.1    AF220295    U00735    MK095161    MK095162    AZS64208.1    AZS64209.1    KU558922    KU558923    ANJ04723.1    ANJ04734.1    EU401985    ACB30194.1    KF530071    AGT51525.1    AY585229    AAT84366.1    FJ938066    ACT11024.1    MH810163    AZU96330.1    DQ682406    ABG78753.1    EF193074    ABM66809.1    MN514964    MN514965    MN514967    QEY10645.1    QEY10653.1    QEY10669.1    KF530067    KF530076    KF530079    KF530082    KF530088    KF530089    KF530091    AGT51485.1    AGT51574.1    AGT51604.1    AGT51634.1    AGT51694.1    AGT51704.1    AGT51724.1    EF424619    ABP38276.1    EF424618    ABP38273.1    KT852998    ANA11064.1    GQ918141    ACX46846.1    EF424617    ABP38259.1    EU401984    ACB30193.1    KF963197    AIX10716.1    MK095164    MK095165    MK095171    MK095172    MK095173    AZS64211.1    AZS64212.1    AZS64218.1    AZS64219.1    AZS64220.1    AF391541    MN514973    QEY10675.1    MN514966    QEY10661.1    KF530094    AGT51754.1    GQ918142    JX860640    ACX46856.1    AFW97366.1    DQ011855    AAY68302.1    MH043952    AVZ61105.1    KF530077    KF530083    KF530087    KF530093    AGT51584.1    AGT51644.1    AGT51684.1    AGT51744.1    KM985634    AJL33725.1    KF530095    KF530096    AGT51764.1    AGT51774.1    AF391542    MN514974    QEY10676.1    KF572746    KF572747    KF923896    AIL49426.1    AIL49427.1    AIV41838.1    KF530059    KF530061    KF530062    KF530064    KF530065    KF530066    KF530072    KF530073    KF530074    KF530075    KF530078    KF530080    KF530085    KF530090    AGT51406.1    AGT51426.1    AGT51435.1    AGT51455.1    AGT51465.1    AGT51475.1    AGT51535.1    AGT51545.1    AGT51555.1    AGT51565.1    AGT51594.1    AGT51614.1    AGT51664.1    AGT51714.1    KU127229    KY994645    MF083115    ANA52021.1    AUF40280.1    AVV64339.1    KF963201    KY014281    AIX10720.1    ATP16761.1    AY078417    KF963204    AIX10723.1   

Proteomes

UP000107676    UP000125269    UP000124585    UP000164707    UP000158296    UP000158231    + More
UP000133443    UP000172225    UP000147981    UP000168103    UP000102696    UP000148210    UP000140344    UP000104294    UP000174569    UP000121258    UP000145507    UP000149260    UP000136745    UP000147178    UP000139966    UP000163913    UP000121953    UP000136116    UP000170940    UP000139235    UP000158327    UP000127099    UP000154814    UP000008572    UP000007554    UP000097333    UP000100580    UP000162935    UP000109543    UP000114034    UP000119922    UP000122365    UP000143194    UP000150595    UP000160021    UP000134650    UP000173415    UP000151273    UP000008570    UP000104124    UP000137675    UP000125924    UP000105266    UP000136788    UP000159503    UP000140040    UP000158566    UP000008571    UP000174077    UP000100971    UP000106834    UP000115705    UP000143333    UP000147052    UP000147585    UP000149702    UP000154668    UP000165173    UP000165185    UP000168172    UP000170317    UP000007546   

PRIDE

Q9QAR8    Q91A22   

Pfam

PF00937   Corona_nucleoca

Interpro

IPR037179   Nucleocapsid_C
IPR001218   Corona_nucleocap
IPR037195   Nucleocapsid_N

SUPFAM

SSF110304   SSF110304
SSF103068   SSF103068

ProteinModelPortal

H9AA59   H9AA48   A0A142D7Z3   A0A142D800   A0A142D7Z2   A0A142D801   + More
A8HB22   C6GHR6   B7TYH5   P26020   A0A3S7H0D9   B8YPE5   A0A142D7Z9   Q9QAR8   A0A0U2GMC1   A0A142D803   B7U2S1   C6GHL9   Q0PL33   A7BKC8   B7U2R0   A0A191URZ1   A0A3S7GYG0   A0A5J6NRW3   B8RIR3   B7U2N9   B7U2M8   B7U2L7   A0A2R4STY7   X2JHN2   A0A5J6NUA1   Q6W358   A0A2R4STX2   Q9QAR1   P19902   C6GHN1   A0A2P1IQ86   A4ZU80   C6GHP3   A4ZU69   A4ZTY1   A4ZU47   A4ZU36   A4ZU58   A0A1S6KXS1   A0A142D7Z1   A0A142D7Z4   A0A2R4STY0   B9TXU3   A0A3Q9K420   A0A5J6NU34   D0EY99   B9TXU6   A0A291L0T4   A2ICF6   A0A5J6NRS1   B7U2P9   A4ZTZ2   Q06BD4   A0A481SB66   A0A451EU00   P59712   P10527   A0A451ETZ8   A0A191URC9   B9TXU8   U3M7K1   Q696P4   C6GHQ4   A0A3T0IBL9   A3E2F7   A2ICF7   A0A5J6NS08   U3M7Z6   A4ZU25   A4ZU14   A0A166IK31   D0EY79   A4ZU03   B9TXU7   A0A0G2RC83   A0A3Q9JZV8   Q91A22   A0A5J6NUQ9   A0A5J6NRV2   U3M820   D0EY89   Q2QKM8   A0A2R4STW5   U3M7Z8   A0A0C5AYI0   U3M822   Q8V432   A0A5J6NRR9   A0A0B4Q8L7   U3M6V7   A0A166MX98   A0A0G2RCY1   Q8BB23   A0A0G2RC64  

PDB

4LMT     E-value=5.64821e-72,     Score=689