Strain

USA_MURINE_1998_NC_023760 (Region: USA: Wisconsin;  Strain: Mink coronavirus strain WD1127, complete genome.;  Date: 1998)

Gene

envelope protein

Description

Annotated in NCBI,  envelope protein

Location

NC_023760(+):25368-25616

GenBank Accession

YP_009019184.1

Full name

Envelope small membrane protein      

CDS

ATGAGATTCCCGAACGTCTTGACTGTGATTGATGACAATGGAATTGTAATCAACTCCATATTTTGGCTACTGTTGATAATTGTAATTATATTATTTTCTATAGCACTACTTAACGTTGTTAAGTTGTGCATGGTTTGTTGTAGATTAAGCAATGTTGTTATCATTGCGCCTGCTCGACAAGCCTATAATGCCTATAAAGATTTCATGAACATACCAAAAGCACCAGACAGTGTTTGTATTGTTGTTTAA

Protein

MRFPNVLTVIDDNGIVINSIFWLLLIIVIILFSIALLNVVKLCMVCCRLSNVVIIAPARQAYNAYKDFMNIPKAPDSVCIVV

Function

Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.

Subunit

Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.

Similarity

Belongs to the alphacoronaviruses E protein family.

Keywords

Apoptosis   Host Golgi apparatus   Host membrane   Membrane   Transmembrane   Transmembrane helix   Reference proteome  

Feature

chain  Envelope small membrane protein

Uniprot

D9J1Z6   A0A2R4QL30   D9J205   A0A222UCB7   A0A1B4X969   D3XGJ6   + More
A0A172B5K4   A0A224ANV7   A0A222UC56   D3XGI8   A0A0K2SFA3   Q6Q2E0   P36696   S6BPG0   S6BUM6   I0B0R4   G8J7G8   A0A088ND87   C6GHG0   W0U135   A0A386YL30   W0U130   A0A088NBY1   A0A088NCW5   W0U1A4   Q6Q2D9   C6GHJ3   C6GHI2   A0A125R5H5   A0A2U8Z8V4   C5IJ75   A0A515KYV6   A0A088NFR3   A3DT39   O39435   A0A2H5BX06   C6GH88   E0AGZ0   E0AGV9   A0A088NBY7   T1SR97   E3W5G1   E3W5J3   A0A088NS11   C5IGF2   E0AH01   E3W5I3   A0A088NFY5   C6GHC9   D3KDL8   C6GHB0   E3W5H2   D3KDK7   Q3Y4E7   C6GHH1   A0A2H4KI33   C6GHD9   G1FEZ0   A0A1Z2WR54   A1DS44   A0A088NBU4   A0A088NC56   G1FEX9   C6GHB9   E0AGX9   A0A077JGD3   K7YHT2   V9PIT6   Q52PA5   B7T075   C5IG90   A0A088NRV6   D6RTP3   E0AGU8   C5IJ37   C6GHK4   C5IGA8   I0B0S3   C6K2T9   O12296   Q0ZVX2   E0AGW9   C5IGE3   K7Y4N5   A0A3Q8BZD0   A0A088NBX6  

Pubmed

21346029    20079778    1431811    25180686    22438554    22609354    + More
25667330    26822958    9654687    23996606    18077720    18306032    16033972    19036814    22718568    20603153    16704791    17275120    21481551    22002680    22542271    25953186   

EMBL

HM245925    ADI80515.1    MF113046    AVY53337.1    HM245926    ADI80524.1    + More
KX512809    ASR18940.1    LC119077    BAV31351.1    GU338457    ADD49360.1    KM347965    AKG92642.1    LC215871    BBA21170.1    KX512810    ASR18948.1    GU338456    ADD49351.1    LC029419    BAS25712.1    AY566160    AAS68509.1    D13096    AB781788    BAN67904.1    AB781790    BAN67922.1    JQ408980    AFH55115.1    JN856008    AEQ61971.1    KJ879390    AIN55906.1    FJ938058    ACT10930.1    HE860490    CCI69283.1    MH817484    AYF53097.1    KP143507    KP143508    KP143509    KP143510    KP143511    KP143512    HE598741    HE598742    HE598743    HE598744    HE598745    HE598746    HE598747    HE860479    HE860480    HE860481    HE860482    HE860483    HE860484    HE860485    HE860487    HE860488    HE860489    HE860491    AJO26977.1    AJO26987.1    AJO26997.1    AJO27007.1    AJO27017.1    AJO27027.1    CCD41999.1    CCI69261.1    CCI69263.1    CCI69265.1    CCI69267.1    CCI69269.1    CCI69271.1    CCI69273.1    CCI69277.1    CCI69279.1    CCI69281.1    CCI69285.1    KJ879347    KJ879387    KJ879388    AIN55788.1    AIN55893.1    AIN55899.1    KJ879340    KJ879341    KJ879342    KJ879352    KJ879391    KJ879392    KJ879393    AIN55771.1    AIN55775.1    AIN55776.1    AIN55797.1    AIN55910.1    AIN55913.1    AIN55914.1    HE860486    CCI69275.1    AY566161    JQ404409    KC175340    AAS68510.1    AFG19731.1    AFX81101.1    FJ938061    ACT10963.1    FJ938060    ACT10952.1    KU215419    KU215420    KU215421    KU215422    KU215423    KU215424    KU215425    KU215426    KU215427    KU215428    AMD11134.1    AMD11146.1    AMD11157.1    AMD11168.1    AMD11179.1    AMD11190.1    AMD11201.1    AMD11212.1    AMD11223.1    AMD11234.1    MF457591    AWN93245.1    FJ943771    ACR46151.1    MN165107    QDM36990.1    KJ879375    KJ879376    KJ879378    AIN55844.1    AIN55849.1    AIN55857.1    DQ286389    ABD33843.1    AF033000    KC461235    AAB87471.1    AGZ84520.1    KY566209    KY566210    KY566211    AUG98123.1    AUG98134.1    AUG98145.1    FJ938051    ACT10858.1    HQ012371    ADL71490.1    HQ012368    ADL71459.1    KJ879348    KJ879349    KJ879350    KJ879385    AIN55789.1    AIN55792.1    AIN55793.1    AIN55885.1    KF530123    AGT52084.1    HQ392469    ADO39821.1    HQ392472    ADO39853.1    KJ879386    AIN55889.1    FJ917526    FJ943762    ACR10345.1    ACR46121.1    HQ012372    ADL71501.1    HQ392471    ADO39843.1    KJ879389    AIN55902.1    FJ938055    ACT10899.1    GU553362    ADC35476.1    FJ938053    ACT10880.1    HQ392470    ADO39832.1    GU553361    ADC35465.1    DQ160294    EU186072    KJ879335    KJ879336    KJ879337    KJ879338    KJ879339    KJ879351    KY292377    KX722529    AAZ86081.1    ABX60146.1    AIN55757.1    AIN55761.1    AIN55762.1    AIN55767.1    AIN55770.1    AIN55795.1    ASB16891.1    ASU62492.1    FJ938059    ACT10941.1    KX722530    KX722531    ASU62503.1    ASU62513.1    FJ938056    ACT10909.1    JN183883    AEK25525.1    KY063616    KY063617    KY063618    ASB15742.1    ASB15752.1    ASB15760.1    EF056487    ABK79900.1    KJ879334    AIN55753.1    KJ879377    AIN55853.1    JN183882    AEK25514.1    FJ938054    ACT10889.1    HQ012370    ADL71479.1    AB907624    BAP19070.1    KC175339    AFX81094.1    KC461236    KC461237    AGZ84530.1    AGZ84540.1    DQ010921    AY994055    EU856362    ACJ63246.1    FJ917519    FJ917520    FJ917530    FJ917531    FJ917532    FJ917533    FJ917534    FJ917535    ACR10283.1    ACR10292.1    ACR10381.1    ACR10390.1    ACR10399.1    ACR10408.1    ACR10417.1    ACR10425.1    KJ879343    KJ879344    KJ879346    KJ879379    KJ879380    KJ879381    KJ879382    KJ879383    KJ879384    AIN55779.1    AIN55781.1    AIN55785.1    AIN55860.1    AIN55865.1    AIN55869.1    AIN55873.1    AIN55876.1    AIN55881.1    AB535528    BAJ08259.1    HQ012367    ADL71448.1    FJ943761    ACR46113.1    FJ938062    ACT10974.1    FJ917521    FJ917522    FJ917524    FJ943763    ACR10301.1    ACR10310.1    ACR10328.1    ACR46124.1    JQ408981    AFH55124.1    GQ152141    ACS44221.1    Y13921    CAA74228.1    DQ112226    EU856361    EU924791    GU146061    GQ477367    HQ450376    JF682842    KP981644    AAZ91440.1    ACJ63235.1    ACJ64188.1    ADB10853.1    ADB28911.1    ADU17729.1    AEE69326.1    AKA65833.1    HQ012369    ADL71469.1    FJ917525    ACR10336.1    KC175341    AFX81111.1    KY406735    ASV45151.1    KJ879345    AIN55783.1   

Proteomes

UP000156811    UP000132946    UP000272061    UP000150460    UP000096172    UP000153699    + More
UP000122558    UP000100168    UP000105943    UP000115718    UP000140032    UP000149467    UP000170923    UP000119169    UP000155481    UP000147290    UP000118118    UP000102801    UP000113596    UP000117806    UP000125896    UP000126919    UP000135072    UP000135717    UP000143834    UP000158395    UP000161862    UP000144800    UP000169693    UP000117062    UP000169984    UP000141579    UP000113324    UP000113038    UP000153548    UP000110620    UP000145457    UP000162682    UP000138585    UP000123646    UP000165438    UP000137357    UP000141821    UP000153160    UP000140550    UP000173564    UP000144443    UP000155736    UP000128709    UP000119918    UP000131699    UP000156095    UP000000835    UP000140386    UP000171330    UP000173643    UP000180339    UP000164750    UP000115330    UP000129066    UP000161789    UP000165378   

PRIDE

Q52PA5   

Pfam

PF02723   NS3_envE

Interpro

IPR003873   NS3/E

ProteinModelPortal

D9J1Z6   A0A2R4QL30   D9J205   A0A222UCB7   A0A1B4X969   D3XGJ6   + More
A0A172B5K4   A0A224ANV7   A0A222UC56   D3XGI8   A0A0K2SFA3   Q6Q2E0   P36696   S6BPG0   S6BUM6   I0B0R4   G8J7G8   A0A088ND87   C6GHG0   W0U135   A0A386YL30   W0U130   A0A088NBY1   A0A088NCW5   W0U1A4   Q6Q2D9   C6GHJ3   C6GHI2   A0A125R5H5   A0A2U8Z8V4   C5IJ75   A0A515KYV6   A0A088NFR3   A3DT39   O39435   A0A2H5BX06   C6GH88   E0AGZ0   E0AGV9   A0A088NBY7   T1SR97   E3W5G1   E3W5J3   A0A088NS11   C5IGF2   E0AH01   E3W5I3   A0A088NFY5   C6GHC9   D3KDL8   C6GHB0   E3W5H2   D3KDK7   Q3Y4E7   C6GHH1   A0A2H4KI33   C6GHD9   G1FEZ0   A0A1Z2WR54   A1DS44   A0A088NBU4   A0A088NC56   G1FEX9   C6GHB9   E0AGX9   A0A077JGD3   K7YHT2   V9PIT6   Q52PA5   B7T075   C5IG90   A0A088NRV6   D6RTP3   E0AGU8   C5IJ37   C6GHK4   C5IGA8   I0B0S3   C6K2T9   O12296   Q0ZVX2   E0AGW9   C5IGE3   K7Y4N5   A0A3Q8BZD0   A0A088NBX6  

KEGG

vg:18585631     vg:27963646     vg:10040184    

GO

GO:0044178  C:host cell Golgi membrane
GO:0044662  P:disruption by virus of host cell membrane
GO:0019031  C:viral envelope
GO:0016021  C:integral component of membrane
GO:0046760  P:viral budding from Golgi membrane

From MSLVP

Host nucleus. Host cytoplasm.

From Uniprot

Host Golgi apparatus membrane   The cytoplasmic tail functions as a Golgi complex-targeting signal.   With evidence from 1 publications.

Length:

82

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

23.34608

Exp number, first 60 AAs:

23.28789

Total prob of N-in:

0.03775

POSSIBLE N-term signal

sequence

outside

1  -  14

TMhelix

15  -  37

inside

38  -  82