Strain

USA_MURINE_1998_NC_023760 (Region: USA: Wisconsin;  Strain: Mink coronavirus strain WD1127, complete genome.;  Date: 1998)

Gene

nucleocapsid protein

Description

Annotated in NCBI,  nucleocapsid protein

Location

NC_023760(+):26454-27584

GenBank Accession

YP_009019186.1

Full name

Nucleoprotein      

Alternative Name

Nucleocapsid protein

CDS

ATGGCTGGAAACGGCAACCGCGTGAACTGGGGAGATGAGCCTTCACCTTCTCAAAATCGTGGTAGATCTCGTTCCCGTAGTCGTAAAAATGAAAATATACCTCTGTCGTTTTTCAACCCTATAACTCATACAGGTAACAAGAAGTTTTGGAATGTTGCACCAAAAGACTTAGTACCTAAAGGTAAGGGTAACAGAGATCAGCAAGTTGGCTATTGGAATCGTCAGGAACGTTGGCGCATGCAGAAAGGTCAGAAAATCCAGTTACCATCGAGATGGTTCTTTTACTATCTAGGAACTGGACCTCATCAGAATGCCAAATTCCAAGAACGCATTGACGGCGTTTATTGGGTTGGCAAGAATGGTTCTAAAACTGTACCTACAGGACTAGGTACGAGAGGTTCTAACCAAGAATCTCTTGACCTACAATTTGATTGCGCAGTTCCTTCTGAATTTAAATTAGAACAAAATGTTAACTCTAGAAGCAACTCTAGGTCTAGGTCTAGAGGACGGTCTAGGTCTAACACAAGGTCTAATGACAACCAATCTTCAAGTCAAGATATAGCCACTGCTGTTGCTGCTGCTCTAGCTCAAATGGGTTTTGCTCCAAAAGAAACACAGAAGAATAAGTCTCGCTCTAAATCTAGAGATAGGGCTAAGTCTAGTGAAAGACCTGTTCCTAAGAATGAAAACAAGCACTCATGGAAGAAAACGCCTGGCAAAGGAGATGTTGAAACCATGTTTGGAAAACGCAGTGCCAACTCAAACTTTGGTGATGCAGAATTAGTGAAGGACGGTAGTTCGCATAAAAACTACCCTCAGTTGGCTGAAATGGTTCCTTCCACAGGTGCACTAGTGTTTGGTGGAAAGTGGGAAGCTACTGAGTCTGGTGATGATGTTATTGTTACTGTTAACTACAGTTACAAACTACCAAAGAATGACCCCAAAACTACCGCTTTTGTCGGTCAAATCGGTGCATATACCAAACCTTCACAAGTGGCTAAAGAACAAAGATCTCGTTCTAAATCTCGTGAGAGAGCAGCCACACCTGTGCCAACACCTGTGAGTGCTACAGCTGAGAATTACACTGATGTTTTTGATGAGAATGTTGAAATTATTGATGAACTAAACTAA

Protein

MAGNGNRVNWGDEPSPSQNRGRSRSRSRKNENIPLSFFNPITHTGNKKFWNVAPKDLVPKGKGNRDQQVGYWNRQERWRMQKGQKIQLPSRWFFYYLGTGPHQNAKFQERIDGVYWVGKNGSKTVPTGLGTRGSNQESLDLQFDCAVPSEFKLEQNVNSRSNSRSRSRGRSRSNTRSNDNQSSSQDIATAVAAALAQMGFAPKETQKNKSRSKSRDRAKSSERPVPKNENKHSWKKTPGKGDVETMFGKRSANSNFGDAELVKDGSSHKNYPQLAEMVPSTGALVFGGKWEATESGDDVIVTVNYSYKLPKNDPKTTAFVGQIGAYTKPSQVAKEQRSRSKSRERAATPVPTPVSATAENYTDVFDENVEIIDELN

Function

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.

Subunit

Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.

Similarity

Belongs to the alphacoronavirus nucleocapsid protein family.

Keywords

ADP-ribosylation   Host Golgi apparatus   Phosphoprotein   Reference proteome   Ribonucleoprotein   RNA-binding   Transcription   Transcription regulation   Viral nucleoprotein   Virion   Host nucleus  

Feature

chain  Nucleoprotein

Uniprot

D9J1Z8   D9J207   A0A2R4QKX6   A0A1B4X966   A0A0K2SF49   A0A222UC65   + More
D3XGJ8   Q20D20   A0A224AV88   D3XGJ0   A0A222UCC3   A0A0K2SFU5   A0A172AZA9   A0A0K2SFV1   A0A166IHH5   G8J7H0   A0A0E3M3T7   M4I906   C8CAL7   Q0PKZ9   A0A1L6BQB7   A0A1B1IJL6   A0A1B1IJK8   F1CNZ2   P04134   B7T4B4   A0A384VI14   Q9YRA4   A0A1L7NS54   D3XKB3   K7WUV5   M4I828   Q0PL25   F6M1R5   Q9DY21   A0A1B1IJN1   A0A1B1IJL2   H9TEX7   P05991   B7T4C3   Q0PL16   A0A1I9UVL9   A0A384V9R5   C8CAL4   Q0ZVX0   A0A384VI73   A0A384V9J2   Q8JVB2   C8CAM4   E7E032   A0A384VGQ5   Q7T712   I3QKR2   Q0PKZ0   A0A1B1IJL5   Q1W2N6   A0A1B1IJL8   C8CAL6   C8CAL8   A1DS39   A4UIJ0   A0A1B1IJL3   Q88515   S6BPJ1   A0A1D8ELQ5   D2WXM3   A0A0U2UGH8   Q80IQ7   G8A506   A0A1B1IJL4   K7XKS8   Q6T523   A0A1B1IJL0   A0A1I9UVM4   E7E041   A0A1B1IJM5   Q6TPK8   Q6TPK9   S6BFL6   K7X1B6   S6CE41   Q7T6S8   C8CAL5   S6BPH9   A4UII9   A0A1I9UVM2   S6B921   A0A1B1IJN3   Q6PQ03   Q0PL08   O12298   S6CE38   A0A1B1IJL1   A0A1B1IJM2   S6BUP2   D3JBG9   S6BPJ6   C5IJ39  

Pubmed

21346029    20079778    16499943    27084706    22609354    20414714    + More
17023013    23043168    25890036    2825819    3008432    10805807    2841792    1645905    15507657    16033973    19036814    10365166    27840394    22002680    20229183    2835592    11533198    16704791    17275120    25953186    21481551    18306032    17267506    8546012    25180686    27619563    22542271    15177889    8839428    21213598   

EMBL

HM245925    ADI80517.1    HM245926    ADI80526.1    MF113046    AVY53339.1    + More
LC119077    BAV31353.1    LC029423    BAS25720.1    KX512809    ASR18942.1    GU338457    ADD49362.1    DQ340562    ABC70094.1    LC215871    BBA21172.1    GU338456    ADD49353.1    KX512810    ASR18950.1    LC029419    BAS25714.1    KM347965    AKG92644.1    LC029422    BAS25719.1    KT852997    ANA11063.1    JN856008    AEQ61973.1    KP202848    AKA60059.1    JQ693057    JQ693059    JQ693060    AFZ88852.1    AFZ88854.1    AFZ88855.1    GQ374558    ACU56725.1    DQ811788    ABG89327.1    KX083668    APQ31247.1    KU500157    KX900402    ANR94928.1    ASV64363.1    KU500153    ANR94924.1    HQ462571    HM776941    KC962433    KU729220    KU981075    KX499468    KX900394    ADY39745.1    AEM55571.1    AGM75131.1    AML22779.1    APA05106.1    AQT01354.1    ASV64291.1    X06371    M14878    AJ271965    M21627    EU924790    ACJ64181.1    KX900393    ASV64282.1    AF104420    AAC96008.1    LC190907    BAW32708.1    GU356398    ADC53234.1    JX827600    AFX69274.1    JQ693058    AFZ88853.1    DQ811785    ABG89293.1    JF682842    AEE69328.1    AF302264    EU074218    FJ755618    GQ374566    JX827601    JX827602    JX827603    JX827604    JX827605    JX827606    JX827607    KT696544    KU500154    KU500163    KU981076    KU981078    AAG30228.1    ABU49664.1    ACN71201.1    ACU56733.1    AFX69275.1    AFX69276.1    AFX69277.1    AFX69278.1    AFX69279.1    AFX69280.1    AFX69281.1    AMB66493.1    ANR94925.1    ANR94934.1    APA05107.1    APA05109.1    KU500166    KU500167    ANR94937.1    ANR94938.1    KU500156    ANR94927.1    JQ404410    KY063616    KY063617    KY063618    AFG19745.1    ASB15744.1    ASB15754.1    ASB15762.1    Y00542    EU924791    ACJ64190.1    DQ811786    ABG89310.1    KU981074    APA05105.1    KX900408    KX900409    KX900410    ASV64416.1    ASV64425.1    ASV64434.1    GQ374555    ACU56722.1    DQ112226    EU856361    KP981644    AAZ91442.1    ACJ63237.1    AKA65835.1    KX900403    ASV64372.1    KX900401    ASV64354.1    AF298213    AAM97563.1    GQ374565    KX900395    KX900396    KX900397    KX900398    KX900399    KX900400    KX900404    KX900405    KX900406    KX900407    ACU56732.1    ASV64300.1    ASV64309.1    ASV64318.1    ASV64327.1    ASV64336.1    ASV64344.1    ASV64380.1    ASV64389.1    ASV64398.1    ASV64407.1    HQ450376    ADU17731.1    KX900411    ASV64443.1    AY335549    DQ201447    AAQ02627.1    ABC72419.1    JQ700302    AFK10484.1    DQ811789    ABG89328.1    KU500161    ANR94932.1    DQ443743    ABD97840.1    KU500155    ANR94926.1    GQ374557    GQ374561    GQ374562    ACU56724.1    ACU56728.1    ACU56729.1    GQ374559    ACU56726.1    EF056485    ABK79895.1    EF192158    ABO88144.1    KU500160    ANR94931.1    Z35758    CAA84811.1    AB781797    AB781798    BAN67933.1    BAN67934.1    KX689261    AOT21924.1    GQ477367    ADB28913.1    KR061459    ALR84919.1    JQ404409    AB105373    AFG19729.1    BAC65328.1    GU146061    ADB10855.1    KU500159    ANR94930.1    KC175340    KC175341    AFX81103.1    AFX81113.1    AY436636    AAR11076.1    KU500152    ANR94923.1    KU981079    APA05110.1    HQ450377    ADU17740.1    KU500169    ANR94940.1    AY390346    AAQ96370.1    AY390345    AAQ96369.1    AB781800    BAN67936.1    JX827599    AFX69273.1    AB781804    BAN67940.1    AY342160    GQ374556    GQ374560    GQ374563    GQ374564    ACU56723.1    ACU56727.1    ACU56730.1    ACU56731.1    AB781790    BAN67924.1    EF192157    ABO88143.1    KU981077    APA05108.1    AB781802    BAN67938.1    KU500164    ANR94935.1    AY587884    AAT00647.1    DQ811787    ABG89315.1    AB086904    Y13921    BAC01161.1    CAA74230.1    AB781799    BAN67935.1    KU500158    ANR94929.1    KU500165    ANR94936.1    AB781801    BAN67937.1    GU017094    ADC34637.1    AB781803    BAN67939.1    FJ943761    ACR46115.1   

Proteomes

UP000156811    UP000132946    UP000272061    UP000150460    UP000153699    UP000098772    + More
UP000137024    UP000113525    UP000123026    UP000131894    UP000166047    UP000001440    UP000145148    UP000111647    UP000121388    UP000166023    UP000106470    UP000115330    UP000156732    UP000158285    UP000158504    UP000129066    UP000125818    UP000119169    UP000155481    UP000165378    UP000149523   

PRIDE

Q7T6S8   

Pfam

PF00937   Corona_nucleoca

Interpro

IPR037179   Nucleocapsid_C
IPR001218   Corona_nucleocap
IPR037195   Nucleocapsid_N
IPR042548   ALPHA_CORONA_NCAP

SUPFAM

SSF103068   SSF103068
SSF110304   SSF110304

ProteinModelPortal

D9J1Z8   D9J207   A0A2R4QKX6   A0A1B4X966   A0A0K2SF49   A0A222UC65   + More
D3XGJ8   Q20D20   A0A224AV88   D3XGJ0   A0A222UCC3   A0A0K2SFU5   A0A172AZA9   A0A0K2SFV1   A0A166IHH5   G8J7H0   A0A0E3M3T7   M4I906   C8CAL7   Q0PKZ9   A0A1L6BQB7   A0A1B1IJL6   A0A1B1IJK8   F1CNZ2   P04134   B7T4B4   A0A384VI14   Q9YRA4   A0A1L7NS54   D3XKB3   K7WUV5   M4I828   Q0PL25   F6M1R5   Q9DY21   A0A1B1IJN1   A0A1B1IJL2   H9TEX7   P05991   B7T4C3   Q0PL16   A0A1I9UVL9   A0A384V9R5   C8CAL4   Q0ZVX0   A0A384VI73   A0A384V9J2   Q8JVB2   C8CAM4   E7E032   A0A384VGQ5   Q7T712   I3QKR2   Q0PKZ0   A0A1B1IJL5   Q1W2N6   A0A1B1IJL8   C8CAL6   C8CAL8   A1DS39   A4UIJ0   A0A1B1IJL3   Q88515   S6BPJ1   A0A1D8ELQ5   D2WXM3   A0A0U2UGH8   Q80IQ7   G8A506   A0A1B1IJL4   K7XKS8   Q6T523   A0A1B1IJL0   A0A1I9UVM4   E7E041   A0A1B1IJM5   Q6TPK8   Q6TPK9   S6BFL6   K7X1B6   S6CE41   Q7T6S8   C8CAL5   S6BPH9   A4UII9   A0A1I9UVM2   S6B921   A0A1B1IJN3   Q6PQ03   Q0PL08   O12298   S6CE38   A0A1B1IJL1   A0A1B1IJM2   S6BUP2   D3JBG9   S6BPJ6   C5IJ39  

PDB

5N4K     E-value=3.64509e-32,     Score=345