Strain

CHINA_MURINE_2012_NC_026011 (Region: China;  Strain: Betacoronavirus HKU24 strain HKU24-R05005I, complete genome.;  Date: 2012)

Gene

hemagglutinin-esterase protein

Description

Annotated in NCBI,  hemagglutinin-esterase protein

Location

NC_026011(+):22484-23761

GenBank Accession

YP_009113024.1

Full name

Hemagglutinin-esterase      

Alternative Name

E3 glycoprotein

CDS

ATGGCCACCGCAGTCCTAACCATAGGCCTGCTTTGCCTCCTCGTCGGTGTTACAGGTTTTGAAAATCCTCCCACCAACGTGGTTTCTCACATTAATGACGATTGGTTTTTGTTTGGCGACAGTCGTAGTGACTGTAACCATATCAATAATATCAATCCTAAAAACTATTCTTATATGGACCTCGATCCCTCGTTGTGCAATTCAGGAAAAATATCTTCTAAGGCTGGCAATTCCATCTTTAGGAGCTTTCATTTCACTGACTTCTACAACTATCAGGGTGAAGGGAACCAAATAATATTCTATGAAGGCGTTAATTTTTCACCGAGTCATGCGTTTAAATGTACCTCGTCCGGTGATAATGGTATTTGGATAAATAATAAAGGTAAGTTTTATGAGCAAGTGTATAAGAAGATGTCCGTTTATCGAGGCCTCTCCATAATAACTGTTCCCTATGTGTACACTGGAGCGGCAGCTGCAACCTCAATTTGTAAGAGGGGCAGTCTGACCTTAAATAATCCAGCGTCTATACAGAGGGAAACTGGTGTTAATACTTATTTTTACACCGCTGAGGCTAATTTTACTCTCACGGGTTGTGATGAGTACATAGTCCCATTGTGTATTTATACTGGTATGTTCCTGGCTTCAGGTACTTACTACAATGACAGCCAGTATTATTATAGTTATAGTACTGGAGAATTCTATGGCCGTAACAACACAGTTGATAAAGCTACTGTAGTTGATTACGAGTGCCAATATCTTACCTTGCCTTCAGGAATTTATAAATCTGTTTCTAATGAGTTGCTTCTCACAGTTCCGACGAAGGCTATCTGTCTGACAAAGCCGAAGAGCTTTACGCCAGTACAGGTTGTCGATTCTCGTTGGAACCATGCCAGGACCTCTGATAATAAAACAGCAGAGGCATGTCAATTGCCTTATTGCTATTTTCGTAATTCTACCACAGATTATGTTGGTAGCTATGATATTAACCATGGCGATGTTGGATTTTCTAACATCCTCAAGGGTTTAATTTATAATGCCCCTTGCTTTGCTAAGCAAGGTGTGTTTATGTATAATAATGTTAGTAGTGTTTGGCCCGTCTATGCCTATGGCGAGTGCCCCACTGCTGCCAATATAAATATAAATGGAATTCCCATTTGTAATTATGATCCGCTACCTGTCATTTTGCTTGGCATTCTTCTTGGAATAGCGGTTATAACCATTGTGGTTTTGCTTTTATATTTCCTTGTAGATAATGGTACTAGGCTTCATGATGCGTAG

Protein

MATAVLTIGLLCLLVGVTGFENPPTNVVSHINDDWFLFGDSRSDCNHINNINPKNYSYMDLDPSLCNSGKISSKAGNSIFRSFHFTDFYNYQGEGNQIIFYEGVNFSPSHAFKCTSSGDNGIWINNKGKFYEQVYKKMSVYRGLSIITVPYVYTGAAAATSICKRGSLTLNNPASIQRETGVNTYFYTAEANFTLTGCDEYIVPLCIYTGMFLASGTYYNDSQYYYSYSTGEFYGRNNTVDKATVVDYECQYLTLPSGIYKSVSNELLLTVPTKAICLTKPKSFTPVQVVDSRWNHARTSDNKTAEACQLPYCYFRNSTTDYVGSYDINHGDVGFSNILKGLIYNAPCFAKQGVFMYNNVSSVWPVYAYGECPTAANININGIPICNYDPLPVILLGILLGIAVITIVVLLLYFLVDNGTRLHDA

Function

Structural protein that makes short spikes at the surface of the virus. Contains receptor binding and receptor-destroying activities. Mediates de-O-acetylation of N-acetyl-4-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells. This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell. May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one. May become a target for both the humoral and the cellular branches of the immune system.

Catalytic Activity

H2O + N-acetyl-4-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate
H2O + N-acetyl-9-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate

Subunit

Homodimer; disulfide-linked. Forms a complex with the M protein in the pre-Golgi. Associates then with S-M complex to form a ternary complex S-M-HE.

Miscellaneous

The sequence shown is that of Quebec reference strain.

Similarity

Belongs to the influenza type C/coronaviruses hemagglutinin-esterase family.

Keywords

3D-structure   Direct protein sequencing   Disulfide bond   Glycoprotein   Hemagglutinin   Host cell membrane   Host membrane   Hydrolase   Membrane   Signal   Transmembrane   Transmembrane helix   Viral envelope protein   Virion  

Feature

chain  Hemagglutinin-esterase

Uniprot

A0A0A7UX90   A0A0A7V3Y4   A0A0A7V3Z7   A0A3G3NHC2   A0A3G3NH50   A0A3G3NHN3   + More
A0A2H4MXC4   A0A096XNF9   A0A3G3NHC5   A0A2H4MX16   A0A2H4MZ34   A0A5J6NRP2   A0A191URZ4   A0A5J6NUD6   A0A481SAP1   A0A5J6NRK9   A0A5J6NRQ9   C6GHQ9   B7TYG8   P15776   Q66165   Q2QKN4   A0A451ETZ3   D0EY82   B9TXU2   D0EY92   P59709   P59710   C6GHL2   Q0PL40   A0A451ETZ0   A0A493R5L6   A0A3S9Y2C0   B7U2R4   B7U2N2   B7U2M1   H9AA54   H9AA33   B7U2L0   B7U2S6   D0EY72   A0A3S9Y2S0   A0A2R4STV0   A7BKC1   A0A3Q9K3J3   A0A346I7H2   P31613   A0A1S6KXR2   A0A5J6NRI4   B7U2Q3   H9AA43   A0A3S9Y2A6   A0A3S7GXV6   Q2EEZ7   A0A0U2GN17   A0A291L0R5   B8RIQ6   A0A411D561   A0A3S7GY11   Q9QAQ9   A0A191URB1   C6GHM4   C6GHN6   H9AA64   A4ZU29   A0A1V0JAY6   A6YD39   X2JFB2   A8HB15   A0A2P1IQB6   A4ZU73   A4ZU62   B7U2P3   A4ZU40   A4ZU51   A0A2R4STW8   A0A1J3   Q2EEZ0   Q9DR81   P59711   A0A346I7H1   A4ZTX4   Q2EEZ3   A0A481S1W3   X2JHM7   A4ZU07   Q4U3S2   A4ZTZ6   A0A346I7H4   A4ZU18   A3E2F1   Q2EEZ4   A0A481S1A3   Q4U3S3   A4ZTY5   Q2EEZ2   A0A481S2D5   A0A1J2   Q8V437   Q06BD8  

EC Number

3.1.1.53

Pubmed

25552712    30285857    25463600    31534035    2319653    2103108    + More
2732694    15507445    18550812    1727608    16809333    23405345    2732684    7730812    11774537    11504427    11376845    11774548    1962455    30771080    18842722    22398294    17374765    9778786    17803510    26678874    19162098    27274850    17434558    17669602    24655427    17916374    29508550    17344285    16954245    20880639    11714968    16604443    17092595    17459444   

EMBL

KM349742    AJA91195.1    KM349743    AJA91206.1    KM349744    AJA91216.1    + More
MH687969    AYR18606.1    MH687973    MH687974    MH687977    MH687978    AYR18642.1    AYR18651.1    AYR18678.1    AYR18687.1    MH687971    MH687972    AYR18624.1    AYR18633.1    KY370047    ATP66749.1    KF294357    AID16630.1    MH687975    AYR18660.1    KY370052    ATP66778.1    KY370046    ATP66743.1    MN514966    QEY10656.1    KU886219    ANJ04973.1    MN514963    QEY10632.1    MH475914    QBH22432.1    MN514964    MN514965    QEY10640.1    QEY10648.1    MN514967    QEY10664.1    FJ938067    ACT11029.1    FJ415324    ACJ35485.1    U00735    S50936    M80842    DQ011855    AAY68296.1    MK095145    MK095146    AZS64192.1    AZS64193.1    GQ918142    JX860640    ACX46849.1    AFW97359.1    EU401979    ACB30199.1    GQ918143    ACX46859.1    L38962    L38963    U06093    AF239306    AF239307    AF230523    AF230524    AF230525    AF230526    AF230527    AF230528    AF339836    AF220295    S69264    M76372    FJ938063    ACT10982.1    DQ811784    ABG89283.1    MK095135    MK095136    MK095137    AZS64182.1    AZS64183.1    AZS64184.1    MK045995    QBG67064.1    MK095140    AZS64187.1    FJ425189    ACJ66999.1    FJ425186    ACJ66968.1    FJ425185    ACJ66956.1    JN874561    AFE48816.1    JN874559    AFE48794.1    FJ425184    ACJ66944.1    FJ425190    ACJ67011.1    GQ918141    ACX46839.1    MK095147    AZS64194.1    MH043952    AVZ61098.1    EU401977    EU401978    AB354579    ACB30197.1    ACB30198.1    BAF75630.1    MK095138    MK095139    AZS64185.1    AZS64186.1    MH203060    MH203061    MH203063    AXP11692.1    AXP11693.1    AXP11695.1    M84486    AF058942    KX432213    AQT26497.1    MN514962    QEY10624.1    FJ425188    ACJ66986.1    JN874560    AFE48804.1    MK095142    AZS64189.1    MG757138    AVI14999.1    DQ389643    DQ389644    DQ389645    ABD18919.1    ABD18920.1    ABD18921.1    KT368891    ALA50079.1    MF593476    ATI09448.1    EU999954    ACL12995.1    MH249786    QAY30019.1    MG757139    MG757141    AVI15010.1    AVI15032.1    AF058944    KU558922    ANJ04716.1    FJ938064    ACT10994.1    FJ938065    ACT11006.1    JN874562    AFE48826.1    EF424620    ABP38286.1    KX982264    ARD05998.1    EF445634    ABP73655.1    KF906250    KF906251    AHN64782.1    AHN64791.1    EU019216    ABV74053.1    MG518518    AVN88333.1    EF424624    ABP38338.1    EF424623    ABP38323.1    FJ425187    ACJ66975.1    EF424621    ABP38304.1    EF424622    ABP38312.1    MH043955    AVZ61128.1    DQ994168    ABI98029.1    DQ389651    EU401975    EU401976    HM573321    HM573322    HM573323    HM573324    HM573325    MH043953    MH043954    MK045992    MK045993    MK046000    MK046002    ABD18927.1    ACB30195.1    ACB30196.1    ADP21330.1    ADP21331.1    ADP21332.1    ADP21333.1    ADP21334.1    AVZ61108.1    AVZ61118.1    QBG67061.1    QBG67062.1    QBG67069.1    QBG67071.1    AF239308    AF239309    AF391541    MH203059    AXP11691.1    EF424615    ABP38240.1    DQ389648    ABD18924.1    MK045994    QBG67063.1    KF906249    AHN64773.1    EF424618    ABP38271.1    AH014871    AAY33943.1    EF424617    ABP38257.1    MH203062    AXP11694.1    EF424619    ABP38274.1    DQ682406    ABG78747.1    DQ389647    ABD18923.1    MK045998    MK045999    QBG67067.1    QBG67068.1    AH014866    AH014870    AAY33928.1    AAY33940.1    EF424616    ABP38246.1    DQ389649    ABD18925.1    MK046001    QBG67070.1    DQ994167    ABI98028.1    AF391542    DQ915164    ABI94000.1   

Proteomes

UP000153628    UP000174571    UP000144342    UP000164707    UP000158296    UP000007554    + More
UP000125924    UP000137675    UP000008572    UP000172225    UP000147981    UP000133443    UP000140344    UP000104294    UP000125269    UP000107676    UP000174569    UP000102696    UP000168103    UP000148210    UP000124585    UP000158231    UP000136745    UP000139966    UP000145001    UP000170940    UP000145507    UP000149260    UP000147178    UP000163913    UP000158327    UP000136116    UP000139235    UP000008570    UP000121953    UP000121258    UP000173415    UP000151273    UP000134650    UP000127099    UP000008571    UP000154814   

Pfam

PF02710   Hema_HEFG
PF03996   Hema_esterase

Interpro

IPR008980   Capsid_hemagglutn
IPR007142   Hemagglutn-estrase_core
IPR042545   HEMA
IPR003860   Hemagglutn-estrase_hemagglutn

SUPFAM

SSF49818   SSF49818

ProteinModelPortal

A0A0A7UX90   A0A0A7V3Y4   A0A0A7V3Z7   A0A3G3NHC2   A0A3G3NH50   A0A3G3NHN3   + More
A0A2H4MXC4   A0A096XNF9   A0A3G3NHC5   A0A2H4MX16   A0A2H4MZ34   A0A5J6NRP2   A0A191URZ4   A0A5J6NUD6   A0A481SAP1   A0A5J6NRK9   A0A5J6NRQ9   C6GHQ9   B7TYG8   P15776   Q66165   Q2QKN4   A0A451ETZ3   D0EY82   B9TXU2   D0EY92   P59709   P59710   C6GHL2   Q0PL40   A0A451ETZ0   A0A493R5L6   A0A3S9Y2C0   B7U2R4   B7U2N2   B7U2M1   H9AA54   H9AA33   B7U2L0   B7U2S6   D0EY72   A0A3S9Y2S0   A0A2R4STV0   A7BKC1   A0A3Q9K3J3   A0A346I7H2   P31613   A0A1S6KXR2   A0A5J6NRI4   B7U2Q3   H9AA43   A0A3S9Y2A6   A0A3S7GXV6   Q2EEZ7   A0A0U2GN17   A0A291L0R5   B8RIQ6   A0A411D561   A0A3S7GY11   Q9QAQ9   A0A191URB1   C6GHM4   C6GHN6   H9AA64   A4ZU29   A0A1V0JAY6   A6YD39   X2JFB2   A8HB15   A0A2P1IQB6   A4ZU73   A4ZU62   B7U2P3   A4ZU40   A4ZU51   A0A2R4STW8   A0A1J3   Q2EEZ0   Q9DR81   P59711   A0A346I7H1   A4ZTX4   Q2EEZ3   A0A481S1W3   X2JHM7   A4ZU07   Q4U3S2   A4ZTZ6   A0A346I7H4   A4ZU18   A3E2F1   Q2EEZ4   A0A481S1A3   Q4U3S3   A4ZTY5   Q2EEZ2   A0A481S2D5   A0A1J2   Q8V437   Q06BD8  

PDB

3CL4     E-value=2.90633e-146,     Score=1330