Strain

ARABIA_CAMEL_2015_NC_028752 (Region: Saudi Arabia;  Strain: Camel alphacoronavirus isolate camel/Riyadh/Ry141/2015, complete genome.;  Date: 2015)

Gene

membrane protein

Description

Annotated in NCBI,  membrane protein

Location

NC_028752(+):24997-25677

GenBank Accession

YP_009194642.1

Full name

Membrane protein      

Alternative Name

E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein

CDS

ATGACTGAAGCTAATATTACTCAGGAGGAGTTGGTAACTCACCTGAAAAATTGGAATTTTAGTTGGAATATTATTCTAACTATTTTCATTGTCATTCTTCAGTTTGGCCATTATAAATACTCAAGAATCTTTTATGGTCTGAAGATGCTAGTTTTGTGGCTTTTGTGGCCACTTGTACTTGCACTTTCAATCTTTGACACTTGGGCAAACTGGGGATCCAACTGGGCCTTTGTCGCATTCAGCCTTTTTATGGCCGTATCAACACTCATTATGTGGGTGATGTATTTCGTAAATAGTTTCAGACTTTTCCGACGTGCTCGAACTTTTTGGGCATGGAATCCGGAAGTGAATGCAATCACAGTCACAACCGTGCTGGGACAGACGTACTACCAACCCATTCAACAAGCTCCAACAGGCATTACGGTGACCTTGTTGAGCGGCGTGCTTTACGTGGACGGACATAGATTGGCTTCAGGTGTTCAGGTTCATAACCTACCTGAACACATGACAGTTGCCGTGCCGAGCACTACTATAATTTATAGTAGAGTCGGAAGGTCCGTAAATTCACGAAACAGCACAGGCTGGGTTTTCTACGTACGAGTAAAACACGGTGACTTTTCTGCAGTGAGCTCTCCTACGAGCAATATGACAGAAAACGAAAGATTGCTTCATTTGATCTAA

Protein

MTEANITQEELVTHLKNWNFSWNIILTIFIVILQFGHYKYSRIFYGLKMLVLWLLWPLVLALSIFDTWANWGSNWAFVAFSLFMAVSTLIMWVMYFVNSFRLFRRARTFWAWNPEVNAITVTTVLGQTYYQPIQQAPTGITVTLLSGVLYVDGHRLASGVQVHNLPEHMTVAVPSTTIIYSRVGRSVNSRNSTGWVFYVRVKHGDFSAVSSPTSNMTENERLLHLI

Function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Similarity

Belongs to the alphacoronaviruses M protein family.

Keywords

Glycoprotein   Host Golgi apparatus   Host membrane   Membrane   Reference proteome   Transmembrane   Transmembrane helix   Viral envelope protein   Viral matrix protein   Virion  

Feature

chain  Membrane protein

Uniprot

I1VWF8   A0A0U2GRI3   A0A1C8YZ14   A0A0U2GP28   A0A0U2GQ35   A0A1B3TNB8   + More
A0A0P0KH16   A0A0P0KI90   A0A1L2KJM1   A0A1L2KGD6   P15422   J9V9X2   A0A384KFG6   A0A1L7B920   A0A223FUI9   A0A0P0KXN3   A0A0P0KBF2   U3M6Q8   Q2EI24   U3M7U2   Q2HZW9   A0A4Y5QL73   K4P0W4   Q6Q1R9   J7JMA5   F1DB17   A0A1V0PKX6   A0A513ZT22   F1DB23   I7CC95   A0A2U8JDJ6   A0A5B9BHV3   A0A482K1V6   K4KCT7   A0A482JXA6   A0A482K0E0   A0A0U1WHF0   K4JZP2   K4JZB1   A0A4Y6GME6   A0A410N739   A0A2D1BHB6   A0A2P1G6R8   K4K1Y9   A0A482K1Y2   A0A249JPV0   A0A5B9Y8P9   A0A0U1YFS8   A0A3G1II33   A0A346LQ18   A0A2P1G6J7   A8JP03   A8JNZ5   A0A2P1G6J1   A0A2P1G6K5   A0A2P1G6H6   B1PHK5   A0A1P8NPR6   A0A0U1YIU9   P59771   A0A166ZM26   I6YQD5   A0A0F7L0A6   G8GN34   A0A2S1WCF2   A0A2K8IYQ4   A0A1Y0DD49   A0A5K1KB33   A0A1L2KGC0   A0A4Y6A782   A0A219TUC8   A0A0U1UZC6   A0A1L2KGC5   A0A4P8YSI7   B2CQ43   A0A0U1YGU7   G9HVU2   J9ZZ62   L0BDB1   F5CHU5   A0A2R4H2B7   A0A2H4WQM2   A0A0C5KQQ2   G8G0W9   G8G0X6   A0A1U9XPM0   W8GTY3   A0A1X9Q8A5   A0A2R4H2G5   A0A4Y6GN26   A0A068JHT0   A0A1Y0DDD3   A0A075EBH8   A0A068BCA0   A0A4Y6GN38   A0A482F7I7   A0A482FA87   A0A1L2KGD7   Q52QS3   G9HVU3  

Pubmed

26678874    27528677    26378164    2818210    2305554    11369870    + More
28893443    22926811    29167251    15073334    27799635    17054987    22837419    31067830    15034574    19239771    22561208    22879617    29741740    22933277    29618817    30171801    31207129    30103259    31419711    28654418    17617433    18420807    28284624    8291230    9782358    11724265    8397280    26847648    23599287    26611909    26112783    29704627    29540176    28534849    23269482    22585338    25694517    22528639    25272273    25279722   

EMBL

JQ410000    AFI49434.1    KT368892    KT368893    KT368895    KT368896    + More
KT368897    KT368898    KT368899    KT368900    KT368902    KT368903    KT368904    KT368905    KT368906    KT368907    KT368908    KT368909    KT368910    KT368911    KT368912    KT368913    KT368914    KT368915    KT368916    MF593473    ALA50091.1    ALA50098.1    ALA50112.1    ALA50119.1    ALA50126.1    ALA50133.1    ALA50140.1    ALA50147.1    ALA50161.1    ALA50168.1    ALA50175.1    ALA50182.1    ALA50189.1    ALA50196.1    ALA50203.1    ALA50210.1    ALA50217.1    ALA50224.1    ALA50231.1    ALA50238.1    ALA50245.1    ALA50252.1    ALA50259.1    ATI09440.1    KT253324    KT253325    KT253326    KT253327    KT253328    AOI28261.1    AOI28270.1    AOI28278.1    AOI28286.1    AOI28293.1    KT368901    ALA50154.1    KT368894    ALA50105.1    KU291449    AOG74792.1    KT253269    ALK28778.1    KT253270    ALK28784.1    KY073748    APD51510.1    KY073747    APD51502.1    X15498    M33560    AF304460    KF514429    KF514431    KF293664    KF293665    KF293666    KU291448    KY369908    KY369909    KY369912    KY369913    KY369914    KY684760    KY674914    KY674919    KY621348    KY967357    KY983587    KY996417    MN306046    MN369046    AGT21341.1    AGT21356.1    AGW80944.1    AOG74786.1    APT69852.1    APT69859.1    APT69879.1    APT69886.1    APT69892.1    ARA15432.1    ARB07395.1    ARB07428.1    ARK08623.1    ARK08645.1    ARU07604.1    ARX11399.1    QEG03788.1    QEO75988.1    JX503060    JX503061    KF514430    KF514432    KF514433    AFR79253.1    AFR79260.1    AGT21348.1    AGT21363.1    AGT21370.1    KY369910    KY369911    APT69865.1    APT69872.1    MF542265    AST12967.1    KT253271    ALK28790.1    KT253272    ALK28796.1    AY518894    KF530106    KT381875    KU521535    KX179500    AAS89770.1    AGT51341.1    ALJ53434.1    ANU06087.1    APF29074.1    DQ377336    MG772808    ABD34826.1    AVA26876.1    KF530110    AGT51369.1    DQ357629    DQ445912    DQ445911    JQ765563    JQ765564    JQ765565    JQ765566    JQ765567    JQ765568    JQ765569    JQ765570    JQ765571    JQ765572    JQ765573    JQ765574    JQ765575    KF530104    KF530105    KF530107    KF530108    KF530109    KF530111    KF530112    KF530113    KF530114    KY674915    KY674916    KY554967    KY554969    KY554971    KY829118    KY983586    ABC87313.1    ABE97133.1    ABE97140.1    AFD98753.1    AFD98760.1    AFD98767.1    AFD98774.1    AFD98781.1    AFD98788.1    AFD98795.1    AFD98802.1    AFD98809.1    AFD98816.1    AFD98823.1    AFD98830.1    AFD98837.1    AGT51327.1    AGT51334.1    AGT51348.1    AGT51355.1    AGT51362.1    AGT51376.1    AGT51383.1    AGT51390.1    AGT51397.1    ARB07402.1    ARB07409.1    ARE29959.1    ARE29971.1    ARE29983.1    ARK08630.1    ARU07597.1    MK720945    MK720946    QCX35173.1    QCX35184.1    JX504050    AFV53151.1    AY567487    JX524171    KX179499    MK334043    MK334044    MK334045    MK334046    MN306018    MN306040    AFQ55887.1    APF29068.1    QED88015.1    QED88022.1    QED88029.1    QED88036.1    QEG03734.1    QEG03751.1    HQ728485    ADX59491.1    KY554968    KY554970    ARE29965.1    ARE29977.1    MN026166    QDH43733.1    HQ728486    ADX59498.1    JX104161    KT266906    KX179497    KX179498    AFO70499.1    AKT07955.1    APF29064.1    APF29066.1    MG428699    MG428700    MG428701    MG428702    MG428703    MG428704    MG428705    MG428706    MG428707    AWK59934.1    AWK59940.1    AWK59946.1    AWK59952.1    AWK59958.1    AWK59964.1    AWK59970.1    AWK59976.1    AWK59982.1    MK334047    QED88043.1    MG916902    QBP43273.1    JQ989272    JQ989273    AFU92125.1    AFU92134.1    MG916903    QBP43284.1    MG916901    QBP43262.1    KJ473808    AIA62262.1    JQ989266    JQ989267    JQ989268    JQ989269    AFU92073.1    AFU92081.1    AFU92089.1    AFU92098.1    JQ989271    AFU92116.1    MK211373    QDF43812.1    MH539766    QAS69031.1    MF370205    ATN23892.1    MG557844    MF094681    MF094682    MF094683    MF094684    MF769416    MF769417    MF769418    MF769419    MF769420    MF769421    MF769422    MF769423    MF769424    MF769425    MF769426    MF769427    MF769428    MF769429    MF769430    MF769431    MF769432    MF769433    MF769434    MF769435    MF769436    MF769437    MF769438    MF769439    MF769440    MF769441    MF769442    MF769443    MF769444    MG605090    MG605091    MK651076    AVM41573.1    AVM80442.1    AVM80451.1    AVM80460.1    AVM80469.1    AVM80527.1    AVM80536.1    AVM80545.1    AVM80554.1    AVM80563.1    AVM80572.1    AVM80581.1    AVM80590.1    AVM80599.1    AVM80608.1    AVM80617.1    AVM80626.1    AVM80635.1    AVM80644.1    AVM80653.1    AVM80662.1    AVM80671.1    AVM80680.1    AVM80689.1    AVM80698.1    AVM80707.1    AVM80716.1    AVM80725.1    AVM80734.1    AVM80743.1    AVM80752.1    AVM80761.1    AVM80770.1    AVM80779.1    AXY04086.1    AXY04095.1    QDE12100.1    JQ989270    AFU92107.1    MH697599    QBP43303.1    MF462814    ASY04646.1    MK977618    QEH62672.1    KJ857395    AJD09518.1    MF167434    ASK51720.1    MH615810    AXP98442.1    MF094688    AVM80503.1    EF203065    EF203066    EF203067    ABQ57219.1    ABQ57227.1    ABQ57235.1    EF203064    ABQ57211.1    MF094686    AVM80487.1    MF094687    AVM80495.1    MF094685    AVM80478.1    EU420139    ACA52174.1    KU893873    APX42140.1    KJ857390    AJD09513.1    Z24733    AF353511    Z14976    KU182966    ANA96051.1    JX002685    JX002693    KC109141    KC210146    KP162057    KT323979    AFN66538.1    AFN66546.1    AGD98688.1    AGG55743.1    AJW67221.1    ALS35471.1    KR610991    KR610992    AKH45335.1    JN173344    AET71243.1    MG742313    AWJ64266.1    KY619828    ATJ03683.1    KY929405    ART85702.1    MH726382    QCQ19921.1    KY073744    APD51478.1    MG923574    QDE55568.1    KT346372    ANV78633.1    KJ473807    AIA62255.1    KY073745    APD51486.1    MK138353    QCT24240.1    EU542418    ACA81419.1    KJ857381    AJD09504.1    JN400901    AEW24879.1    JX512906    AFS63728.1    KC294275    AFZ85195.1    JF690777    JN400910    AEE38480.1    AEQ29503.1    MH004413    MH004414    AVU05350.1    AVU05357.1    MG373543    AUD08950.1    KM609208    AJP67429.1    JN089730    KJ001737    AER39411.1    AHK25075.1    JN089737    JN173338    AER39418.1    AET71237.1    KY010201    KX852351    AQZ26212.1    ASK39757.1    KJ001727    AHK25065.1    KX532183    ARQ18626.1    MH004416    MH004421    MH243319    AVU05371.1    AVU05406.1    QBA57561.1    MK211370    QDF43797.1    KF840543    AIE15968.1    KY929406    MH726379    ART85709.1    QCQ19903.1    KJ645674    AID56904.1    KJ646606    AIC82413.1    MK211372    QDF43807.1    MK032691    QBO24666.1    MK032690    QBO24660.1    KY073746    APD51494.1    AY974335    AAX84831.1    JN400902    AEW24880.1   

Proteomes

UP000146121    UP000100137    UP000101679    UP000103248    UP000103783    UP000104585    + More
UP000108758    UP000110675    UP000115199    UP000116691    UP000120649    UP000124352    UP000128900    UP000136940    UP000136947    UP000147133    UP000151210    UP000152663    UP000152773    UP000153580    UP000153625    UP000169049    UP000171347    UP000173795    UP000173458    UP000115399    UP000118770    UP000122373    UP000006716    UP000105041    UP000110267    UP000137891    UP000139984    UP000143565    UP000096398    UP000130985    UP000145724    UP000146557    UP000161757    UP000143818    UP000100468    UP000105969    UP000106901    UP000108941    UP000110792    UP000115484    UP000125140    UP000129674    UP000130385    UP000134798    UP000136929    UP000138462    UP000140530    UP000141321    UP000144638    UP000151180    UP000151840    UP000153644    UP000162862    UP000167796    UP000168590    UP000171901    UP000173136    UP000174240    UP000103541    UP000008573    UP000158277    UP000098690    UP000141634    UP000112496    UP000126962    UP000104963    UP000119818    UP000123997    UP000126615    UP000132096    UP000162430    UP000155419    UP000096660    UP000130662    UP000152921    UP000166619    UP000143524    UP000008159    UP000096075    UP000134644    UP000180353    UP000180354    UP000156820    UP000171486    UP000204102    UP000106394    UP000277178    UP000124473    UP000112678   

PRIDE

P15422   

Pfam

PF01635   Corona_M

Interpro

IPR002574   Corona_M
IPR042551   ALPHA_CORONA_M

ProteinModelPortal

I1VWF8   A0A0U2GRI3   A0A1C8YZ14   A0A0U2GP28   A0A0U2GQ35   A0A1B3TNB8   + More
A0A0P0KH16   A0A0P0KI90   A0A1L2KJM1   A0A1L2KGD6   P15422   J9V9X2   A0A384KFG6   A0A1L7B920   A0A223FUI9   A0A0P0KXN3   A0A0P0KBF2   U3M6Q8   Q2EI24   U3M7U2   Q2HZW9   A0A4Y5QL73   K4P0W4   Q6Q1R9   J7JMA5   F1DB17   A0A1V0PKX6   A0A513ZT22   F1DB23   I7CC95   A0A2U8JDJ6   A0A5B9BHV3   A0A482K1V6   K4KCT7   A0A482JXA6   A0A482K0E0   A0A0U1WHF0   K4JZP2   K4JZB1   A0A4Y6GME6   A0A410N739   A0A2D1BHB6   A0A2P1G6R8   K4K1Y9   A0A482K1Y2   A0A249JPV0   A0A5B9Y8P9   A0A0U1YFS8   A0A3G1II33   A0A346LQ18   A0A2P1G6J7   A8JP03   A8JNZ5   A0A2P1G6J1   A0A2P1G6K5   A0A2P1G6H6   B1PHK5   A0A1P8NPR6   A0A0U1YIU9   P59771   A0A166ZM26   I6YQD5   A0A0F7L0A6   G8GN34   A0A2S1WCF2   A0A2K8IYQ4   A0A1Y0DD49   A0A5K1KB33   A0A1L2KGC0   A0A4Y6A782   A0A219TUC8   A0A0U1UZC6   A0A1L2KGC5   A0A4P8YSI7   B2CQ43   A0A0U1YGU7   G9HVU2   J9ZZ62   L0BDB1   F5CHU5   A0A2R4H2B7   A0A2H4WQM2   A0A0C5KQQ2   G8G0W9   G8G0X6   A0A1U9XPM0   W8GTY3   A0A1X9Q8A5   A0A2R4H2G5   A0A4Y6GN26   A0A068JHT0   A0A1Y0DDD3   A0A075EBH8   A0A068BCA0   A0A4Y6GN38   A0A482F7I7   A0A482FA87   A0A1L2KGD7   Q52QS3   G9HVU3  

KEGG

vg:26613668     vg:918762     vg:2943503     vg:26628037     vg:13842719     vg:5741387     vg:6020266     vg:935182     vg:30522874     vg:26626968    

GO

GO:0039660  F:structural constituent of virion
GO:0055036  C:virion membrane
GO:0044178  C:host cell Golgi membrane
GO:0019031  C:viral envelope
GO:0019058  P:viral life cycle
GO:0016021  C:integral component of membrane

From MSLVP

Host nucleus. Host cytoplasm.

From Uniprot

Virion membrane   Largely embedded in the lipid bilayer.   With evidence from 1 publications.
Host Golgi apparatus membrane   Largely embedded in the lipid bilayer.   With evidence from 1 publications.

Length:

226

Number of predicted TMHs:

3

Exp number of AAs in TMHs:

66.16325

Exp number, first 60 AAs:

35.33191

Total prob of N-in:

0.11584

POSSIBLE N-term signal

sequence

outside

1  -  19

TMhelix

20  -  38

inside

39  -  42

TMhelix

43  -  65

outside

66  -  74

TMhelix

75  -  97

inside

98  -  226

 

 

Pi

0.221265

Theta

0.3037274

Tajima's D

-0.9539855

CLR

6.843359

Interpretation

No evidence of Selection