Strain

CHINA_BAT_2014_NC_030886 (Region: China;  Strain: Rousettus bat coronavirus isolate GCCDC1 356, complete genome.;  Date: 2014)

Gene

spike protein

Description

Annotated in NCBI,  spike protein

Location

NC_030886(+):21121-24993

GenBank Accession

YP_009273005.1

Full name

Spike glycoprotein      

Alternative Name

E2
Peplomer protein

CDS

ATGTTTCGGACGTTGCTCTTAGCGGCGTTGTTTAACGCCTGCTGGTGTGCGCGTCCGACTTGTATTAAGCCTACTGAAACATGGGGCACGCCTTCATTTACGGGTGTGGAGTATGTACCACATAACACTACCTATGTCTCAGTACCGCTTAACAAGCTATCATGCTTATTACCAGACCCTTATATGGCACACTCAGGACAGACTGTGAGACAAAAGTTATACATGGGCAATACCTCCAATACGCTTGTATACCCAGTCACACCACCAATGTTCAACCTTACATATGGCAATGTGACACCTGGTGTGTACAACACGTCTTTTCTACCAGTCTTTGACGGGCTCCTTGTGCATACCTACATGAATCGGTTTGCACACTTGGATAACCCTAATAGGACATGTCAAGAGCCATTTGGCGTTGTGTTTGGCACTACCTTTGAGCAAGACCGTATTGCTATGGTCATAATTGCTCCAGGTGAGTTTGGTATGTGGGGTCAGGTTAACCGGCCTAACACTACTTTTGTTCATGTAGTGGCATGTAGTAATGCTACCATTTGTGCCTACCCTATGTTCAATAGGTGGGGACCAGCTGGTAGCATACATGCCGAAAACTCCTTTGTTGAGCACAACTCCTCGTGCTTTTTGAATGACACTTTTGAGATTCCAATGGGTACATCTCGTGTCAATTTAGCTTTTAGGTTTCAAGACGGCAACCTTTTACTGTACCATACAGCTTGGCTGCCGACTGAAAACTATACTTTAAGTGGTGACTACCCCCTACGTTACGCACGTAGTGTTGGTGTAGGCTCCAATTTACCGTTTGCTCAATTCTTTCAGTCTGTCGCTCGTGCACGTGATAGTGCATGCGCTTTCCTACATAATAATTTGTACATAGCCCCTGTACAGCCTAAAGAGCTGCTTGTTAAGTACAATGACCAAGGCATGCCTGTAGAAATTGCAGACTGCTCTGCTGATTCTACACAAGAGCTATATTGTATTACTGGCACCTTCACACCAAGTGTCGGTGTTTATCAATTAAGTCGCTATCGCGCTGAAGCCAAAAAGCTTGTGCAAGTTACACAGCAAGAAGACTCCTGCGCGATACCGTATACTACTATTCTAGAACCACCCTCACCGGCTGCGTGGGTGCGTGCTACCATTTCTAATTGTACTTTCGACTTTGAATCGCTACTGCGGACATTGCCGACATACAATTTGAAGTGCTATGGCATCTCACCTGCTCGACTTAGTACTATGTGCTATGCTGGGGTGACGCTAGATATTTTTAAACTAAACACCACCCACTTGTCCAACATGCTTGGATCTGTGCCGGATGCTGTTAGTATTTACAATTATGCCTTGCCTAGCAACTTTTATGGTTGCGTGCATGCTTATCATCTTAATAGTACTACTCCATATGCAGTGGCTGTACCACCTGGCGCTTACCCAATTAAACCAGGTGGCAGACAGTTGTTTAACAGCTTTGTGTCTCAAGTCTTAGACTCACCAACGTCACAGTGCACCCCTGCTAATTGCATGGGTGTTGTTGTTATAGGGTTAACACCAGCTTCTGGTTCTAACCTCGTGTGTCCAAAGGCTAACGATACACAAGTTATCGAAGGTCAGTGTGTGAAGTACAACTTTTATGGCTATGCAGGCACCGGTGTTATAAACCAGAGTGACCTTGCCATACCCAACAACAAGTTGTTTGTTACTAGCAAATCAGGAGCTGTCCTTGCCGTACGTGCAGGTGACAAAGTTTACAGCATCACACCTTGTGTGTCAGTGCCCATTTCAGTTGGTTATGACCCTGGACATCAGCGTGCGCTTGTGTTCAACGGTCTCGACTGTAGTGCGCGCGCGAATGCTGTAAGCATGCCAGCTTCCGAATATTGGACCGCAGCCGCTAGCACTACTGCTCGCGGTTCTGAGCCTGTATTAGACACACCGTCTGGTTGCGTCTACAATGTTAATAACTGCACTACACACACAGTTAGTGTTTGTGAAATGCCTATTGGTAACAGCCTTTGCCTCGTCAGCAACTTTACGTGTTCTGACGTGGCAACAGCTAGCCTTAGTCCAAATTTGTTAAGCTTGGTTGTATACGACCCCACTGATGCGGGACTTAAAGTTCTAACACCGGTGTACTGGGTCAGTATACCCACCAACTTTACACTAGCTGCAACAACTGAGTACATTCAAACCACTGCACCCAAAGTCAATGTTGACTGTGTTAAGTACCTATGTGGCGACTCTGAGCGCTGCATAGATGTGCTGTCACAATATGGGGCTTTCTGTGAAGACGTCAACAAGGCTCTTGCCGACGTCAGTGCTATTATTGATTCATCTATGGTGACTATGGTTTCAGAGCTTACTGCCGGTGTGATGTGGAGTGAAACACCTCAAGCTAATGTCGGCTCATATAACTTTTCCGGTCTTATGGGCTGTCTAGGTTCCAACTGTCAGGAGAAGCAGTATCGTTCTGCTATCTCAGACTTGTTGTATAATAAAGTTAAGGTAGCAGACCCAGGGTTTATGGGTGCTTACCAGAAATGTATTGATGAGCAGTGGGGTGGCAGTGTGAGAGACCTTATTTGCACTCAGACATTTAATGGCATCTCAGTGTTACCGCCCATTGTCTCTCCTGGCATGCAAGCCTTGTATACATCTTTATTAGTAGGTGCTGTTGCTTCATCTGGCTACACCTTTGGCATTACGTCCGTTGGTGTCATACCATTTGCCACACAGCTCCAATTTAGACTTAATGGCCTTGGTGTTACCACCAATGTGCTCATGGAAAACCAAAAACTCATTGCCAACGCATTCAACAATGCCCTCACAGGCATACAGAAGGGTTTTGACGCTACCAACATGGCTTTAGCCAAAATGCAGAGTGTCATCAACCAGCATGCGCAGCAATTGAGTACTTTAGTTGACCAATTGGGCAACTCTTTTGGTGCTATCTCCTCATCCATCAATGAAATCTTTAGTCGGCTAGATGAATTAGAAGCCAATGCACAAGTAGATCGCCTTATCAATGGGCGTATGGTTGTCTTGAACACCTACGTCACTCAGCTGCTCATTAGAGCTTCTGAGGTTAAGGCACAAGCTGCGTTGGCTAGTCAAAAGATAAGTGAGTGTGTCAAAGCACAATCCCAGCGTAATGACTTTTGCGGTAATGGCACACATGTGTTGTCCATACCTCAAATGGCACCAAATGGTGTGTTGTTCTTGCACTACTCCTATCAACCTACAGCTTACAATTTAGTGCGTACTGCCGCTGGCCTTTGTTTTAATGACACTGGCTATGCACCTCTAGGAGGTTTGTTTGTGTTGCCTAACAACACAGACAGGTGGCTATTCACTAAAATGAGCTTTTACGATCCCGTAAACATCTCAGTTTCTAATACGCAGGTCCTTGCGGCTTGTGGTCTTAATTATTCTAGTGTCAACTACACCGTCCTTGAGCCGGCGGTTGACACTAGCTCCTTTAATTTTACAGAAGAGTTTGAAAAGTGGTACGTCAACCAGAGTCATATTTTTAACAACACCTTTAACGCCAGCGCCTTTAACTTTTCCCTTGTGGACGTTAATGAGCAGCTTGCGATTCTTACAGATGTTGTCAACCAGTTAAACCAGTCTTACATAGACCTCAAGCAGTTGGGCACCTATGAGTACACGGTCAAATGGCCGTGGTACGTATGGCTGGGTATGATTGCAGGACTAGTAGGCCTTGTGCTAGCGGTAGTTCTGCTGCTTTGTATGACTAATTGCTGCTCGTGTGCTCGCGGTGTTTGCTCTTGCAAGTCGTGTGCTTATGAGGAGCATGAGGATGTGTATCCTGCTGTTCGTGTGCATGGAAAACGAACGGCATGA

Protein

MFRTLLLAALFNACWCARPTCIKPTETWGTPSFTGVEYVPHNTTYVSVPLNKLSCLLPDPYMAHSGQTVRQKLYMGNTSNTLVYPVTPPMFNLTYGNVTPGVYNTSFLPVFDGLLVHTYMNRFAHLDNPNRTCQEPFGVVFGTTFEQDRIAMVIIAPGEFGMWGQVNRPNTTFVHVVACSNATICAYPMFNRWGPAGSIHAENSFVEHNSSCFLNDTFEIPMGTSRVNLAFRFQDGNLLLYHTAWLPTENYTLSGDYPLRYARSVGVGSNLPFAQFFQSVARARDSACAFLHNNLYIAPVQPKELLVKYNDQGMPVEIADCSADSTQELYCITGTFTPSVGVYQLSRYRAEAKKLVQVTQQEDSCAIPYTTILEPPSPAAWVRATISNCTFDFESLLRTLPTYNLKCYGISPARLSTMCYAGVTLDIFKLNTTHLSNMLGSVPDAVSIYNYALPSNFYGCVHAYHLNSTTPYAVAVPPGAYPIKPGGRQLFNSFVSQVLDSPTSQCTPANCMGVVVIGLTPASGSNLVCPKANDTQVIEGQCVKYNFYGYAGTGVINQSDLAIPNNKLFVTSKSGAVLAVRAGDKVYSITPCVSVPISVGYDPGHQRALVFNGLDCSARANAVSMPASEYWTAAASTTARGSEPVLDTPSGCVYNVNNCTTHTVSVCEMPIGNSLCLVSNFTCSDVATASLSPNLLSLVVYDPTDAGLKVLTPVYWVSIPTNFTLAATTEYIQTTAPKVNVDCVKYLCGDSERCIDVLSQYGAFCEDVNKALADVSAIIDSSMVTMVSELTAGVMWSETPQANVGSYNFSGLMGCLGSNCQEKQYRSAISDLLYNKVKVADPGFMGAYQKCIDEQWGGSVRDLICTQTFNGISVLPPIVSPGMQALYTSLLVGAVASSGYTFGITSVGVIPFATQLQFRLNGLGVTTNVLMENQKLIANAFNNALTGIQKGFDATNMALAKMQSVINQHAQQLSTLVDQLGNSFGAISSSINEIFSRLDELEANAQVDRLINGRMVVLNTYVTQLLIRASEVKAQAALASQKISECVKAQSQRNDFCGNGTHVLSIPQMAPNGVLFLHYSYQPTAYNLVRTAAGLCFNDTGYAPLGGLFVLPNNTDRWLFTKMSFYDPVNISVSNTQVLAACGLNYSSVNYTVLEPAVDTSSFNFTEEFEKWYVNQSHIFNNTFNASAFNFSLVDVNEQLAILTDVVNQLNQSYIDLKQLGTYEYTVKWPWYVWLGMIAGLVGLVLAVVLLLCMTNCCSCARGVCSCKSCAYEEHEDVYPAVRVHGKRTA

Function

attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.
mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.
Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.
Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.
Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.

Subunit

Homotrimer; each monomer consists of a S1 and a S2 subunit. The resulting peplomers protrude from the virus surface as spikes.

Similarity

Belongs to the betacoronaviruses spike protein family.

Keywords

3D-structure   Coiled coil   Disulfide bond   Fusion of virus membrane with host endosomal membrane   Fusion of virus membrane with host membrane   Glycoprotein   Host cell membrane   Host membrane   Host-virus interaction   Lipoprotein   Membrane   Palmitate   Reference proteome   Signal   Transmembrane   Transmembrane helix   Viral attachment to host cell   Viral envelope protein   Viral penetration into host cytoplasm   Virion   Virulence   Virus entry into host cell  

Feature

chain  Spike glycoprotein

Uniprot

A0A1B3Q5W5   A0A1B3Q5V4   A0A5B9Y142   A0A4Y6GL90   E0ZN52   A3EXI2   + More
E0ZN36   A3EXH4   E0ZN60   E0ZN44   A0A2P1M5J5   A3EXJ0   A0A2Z4EVM5   A3EXG6   F1DAZ9   A0A2Z4EVN5   F1DAZ1   A0A2Z4EVK1   A0A2Z4EVN2   A0A2Z4EVR7   A0A0U1WHI2   A0A0U1WJY8   A0A4Y6GL43   A0A1W5YKT9   R9QTA0   A0A0P0INJ4   Q5GDB4   A0A2D1PX97   Q4JDP2   Q4JDM4   Q4JDN1   Q4JDN4   Q6TPE8   Q3ZTC8   Q4JDN2   Q3ZTC5   Q4JDM7   Q5GDB6   Q5GDJ7   Q4JDM9   Q4JDN0   Q4JDN3   Q5GDB5   Q5GDJ6   Q5GDB7   A0A3Q8AKM0   Q5GDB3   Q4JDM5   A0A0U2IWM2   C4P6Q7   Q4JDP1   D2E2D8   Q692E4   Q202H8   D3KDM5   Q3ZTC7   Q6JH46   Q202F2   D2E1Z1   A4ZF29   Q6RD20   Q6RD64   Q6VAA0   Q6T7X5   Q6UZF4   Q6VA78   Q6UZF0   Q6RCY7   Q6RD31   Q6RD09   Q5DIC5   Q202F9   Q19QX0   Q202H5   Q202G5   Q202G3   Q6DSU4   Q6JH38   Q6RCX6   Q3S2D2   D2E206   Q6RD42   Q6VA89   Q6RCZ8   Q6RCW5   Q6RD53   Q6WGP3   Q6V585   Q202E9   J9SFL2   Q202E5   A7J8L4   Q309G9   A0A3G5BJ32   A0A3G5BJ39   D2E2F2   D2E1E7   D2E235   F2YCW3  

Pubmed

20702646    17121802    29500692    19239771    22561208    28384506    + More
23739658    15695582    29190287    16140765    16485471    26719272    14569023    20463816    15757562    17112780    16269206    14983045    14654320    18987164    17222058    14527350    14733771    16112670    19370068    17184168    30393776   

EMBL

KU762338    AOG30822.1    KU762337    AOG30812.1    MK492263    QEH60463.1    + More
MK211379    QDF43840.1    HM211100    ADM33574.1    EF065515    ABN10927.1    HM211098    ADM33558.1    EF065514    ABN10919.1    HM211101    ADM33582.1    HM211099    ADM33566.1    MG762674    AVP25406.1    EF065516    ABN10935.1    MG693170    AWV67056.1    EF065513    HQ728483    ADX59474.1    MG693169    AWV67048.1    HQ728482    ADX59466.1    MG693168    AWV67040.1    MG693171    AWV67064.1    MG693172    AWV67072.1    KJ473814    AIA62310.1    KJ473816    AIA62330.1    MK211374    QDF43815.1    KY770858    KY770859    ARI44799.1    ARI44804.1    JX993987    AGC74165.1    KR559017    ALJ94036.1    AY627047    AAV49722.1    KY417150    ATO98205.1    AY687354    AAV97984.1    AY687372    AAV98002.1    AY687365    AAV97995.1    AY687362    AAV97992.1    AY390556    AAS00003.1    AY572036    AAU04661.1    AY687364    AAV97994.1    AY572038    AAU04664.1    AY687369    AAV97999.1    AY627045    AAV49720.1    AY613951    AAU93318.1    AY687367    AAV97997.1    AY687366    AAV97996.1    AY686864    AY687363    AAV49730.1    AAV97993.1    AY627046    AAV49721.1    AY613952    AAU93319.1    AY627044    AAV49719.1    KY352407    APO40579.1    AY627048    AAV49723.1    AY687371    AAV98001.1    KT444582    ALK02457.1    FJ882963    ACQ82725.1    AY687355    AAV97985.1    FJ882950    ACZ72108.1    AY654624    AAT76147.1    DQ412575    ABD72969.1    GU553363    GU553364    ADC35483.1    AY572037    AAU04662.1    AY485277    AAR23250.1    DQ412617    ABD72995.1    FJ882940    ACZ71961.1    DQ514531    ABF68958.1    AY502927    AAR87545.1    AY502923    AAR87501.1    AY345986    AAP94737.1    AY429078    AAR07630.1    AY357075    AAR14807.1    AY345988    AAP94759.1    AY357076    AAR14811.1    AY502930    AAR87578.1    AY502926    AAR87534.1    AY502928    AAR87556.1    AY772062    AAX16192.1    DQ412609    ABD72988.1    DQ497008    ABF65836.1    DQ412578    ABD72972.1    DQ412594    ABD72982.1    DQ412596    ABD72984.1    AY648300    AAT74874.1    AY485278    AAR23258.1    AY502931    AAR87589.1    DQ182595    ABA02260.1    FJ882941    ACZ71976.1    AY502925    AAR87523.1    AY345987    AAP94748.1    AY502929    AAR87567.1    AY502932    AAR87600.1    AY502924    AAR87512.1    AY286320    AAR33050.1    AY350750    AAR14803.1    DQ412574    DQ412581    DQ412587    DQ412589    DQ412590    DQ412595    DQ412605    DQ412611    DQ412613    DQ412616    DQ412618    DQ412624    ABD72968.1    ABD72975.1    ABD72978.1    ABD72980.1    ABD72981.1    ABD72983.1    ABD72987.1    ABD72989.1    ABD72991.1    ABD72994.1    ABD72996.1    ABD72998.1    JX163923    JX163925    JX163927    AFR58672.1    AFR58700.1    AFR58728.1    DQ412576    DQ412577    DQ412579    DQ412580    DQ412582    DQ412621    DQ412625    DQ412626    DQ412629    ABD72970.1    ABD72971.1    ABD72973.1    ABD72974.1    ABD72976.1    ABD72997.1    ABD72999.1    ABD73000.1    ABD73002.1    DQ898174    JX163924    JX163928    ABI96958.1    AFR58686.1    AFR58742.1    DQ231462    EU371559    ABB29898.2    ACB69849.1    MK062180    MK062182    MK062184    AYV99789.1    MK062179    MK062181    MK062183    AYV99803.1    FJ882951    FJ882959    FJ882962    ACZ72122.1    FJ882927    FJ882932    FJ882933    FJ882934    FJ882935    FJ882936    FJ882937    FJ882938    FJ882939    FJ882946    FJ882947    JF292921    KF514388    KF514392    KF514394    KF514396    KF514397    KF514398    KF514399    KF514400    KF514404    KF514408    KF514409    KF514413    KF514415    KF514418    KF514419    KF514421    KF514422    KF514423    ACZ71767.1    ACZ71841.1    AEA10998.1    AGT20793.1    AGT20853.1    AGT20883.1    AGT20913.1    AGT20928.1    AGT20943.1    AGT20958.1    AGT20973.1    AGT21033.1    AGT21093.1    AGT21108.1    AGT21168.1    AGT21198.1    AGT21243.1    AGT21258.1    AGT21288.1    AGT21303.1    AGT21318.1    FJ882943    FJ882953    HQ890526    HQ890527    HQ890528    HQ890530    HQ890532    HQ890533    HQ890535    HQ890537    JF292902    ACZ72005.1    AEA10398.1    HQ890531    HQ890538    HQ890539    HQ890540    JF292903    JF292904    JF292905    JF292906    AEA10473.1   

Proteomes

UP000203393    UP000152619    UP000115362    UP000098522    UP000111929    UP000147688    + More
UP000123432    UP000123364    UP000006576    UP000140614    UP000128606    UP000106179    UP000166164    UP000153024    UP000126514    UP000100289    UP000112237    UP000180371    UP000101079    UP000180379    UP000180381    UP000123303    UP000180368    UP000174857    UP000148533    UP000133546    UP000118579    UP000115935    UP000147828    UP000125082    UP000148329    UP000124386    UP000156013    UP000116351    UP000168969    UP000132037    UP000163176    UP000180369    UP000139901    UP000129608    UP000099158    UP000110133    UP000166558    UP000170944    UP000105036    UP000148108    UP000180360    UP000135071    UP000166757    UP000180361    UP000099142    UP000180411    UP000180413    UP000180414    UP000097931    UP000121467    UP000125925    UP000128288    UP000150617    UP000151673    UP000151756    UP000153830    UP000155701    UP000157930    UP000161442    UP000161729    UP000162782    UP000164349    UP000169779    UP000173963    UP000174280    UP000180434    UP000180435    UP000180436    UP000180437    UP000180438    UP000180439    UP000180440    UP000180441    UP000180442    UP000180443    UP000180444    UP000180445    UP000180446    UP000180410    UP000180412    UP000180415    UP000180416    UP000180417    UP000180419    UP000180421    UP000180422    UP000180424    UP000180426    UP000180430    UP000120111    UP000180420    UP000180427    UP000180428    UP000180429    UP000180431    UP000180432    UP000180433   

PRIDE

A3EXG6   

Pfam

PF01601   Corona_S2
PF09408   Spike_rec_bind
PF16451   Spike_NTD

Interpro

IPR036326   Spike_rcpt-bd_sf
IPR018548   Spike_rcpt-bd
IPR002552   Corona_S2
IPR027400   S_HR2
IPR042578   BETA_CORONA_SPIKE
IPR043002   Spike_N_sf
IPR032500   Spike_N

SUPFAM

SSF143587   SSF143587

Gene 3D

1.20.5.790     2.60.120.960    

ProteinModelPortal

A0A1B3Q5W5   A0A1B3Q5V4   A0A5B9Y142   A0A4Y6GL90   E0ZN52   A3EXI2   + More
E0ZN36   A3EXH4   E0ZN60   E0ZN44   A0A2P1M5J5   A3EXJ0   A0A2Z4EVM5   A3EXG6   F1DAZ9   A0A2Z4EVN5   F1DAZ1   A0A2Z4EVK1   A0A2Z4EVN2   A0A2Z4EVR7   A0A0U1WHI2   A0A0U1WJY8   A0A4Y6GL43   A0A1W5YKT9   R9QTA0   A0A0P0INJ4   Q5GDB4   A0A2D1PX97   Q4JDP2   Q4JDM4   Q4JDN1   Q4JDN4   Q6TPE8   Q3ZTC8   Q4JDN2   Q3ZTC5   Q4JDM7   Q5GDB6   Q5GDJ7   Q4JDM9   Q4JDN0   Q4JDN3   Q5GDB5   Q5GDJ6   Q5GDB7   A0A3Q8AKM0   Q5GDB3   Q4JDM5   A0A0U2IWM2   C4P6Q7   Q4JDP1   D2E2D8   Q692E4   Q202H8   D3KDM5   Q3ZTC7   Q6JH46   Q202F2   D2E1Z1   A4ZF29   Q6RD20   Q6RD64   Q6VAA0   Q6T7X5   Q6UZF4   Q6VA78   Q6UZF0   Q6RCY7   Q6RD31   Q6RD09   Q5DIC5   Q202F9   Q19QX0   Q202H5   Q202G5   Q202G3   Q6DSU4   Q6JH38   Q6RCX6   Q3S2D2   D2E206   Q6RD42   Q6VA89   Q6RCZ8   Q6RCW5   Q6RD53   Q6WGP3   Q6V585   Q202E9   J9SFL2   Q202E5   A7J8L4   Q309G9   A0A3G5BJ32   A0A3G5BJ39   D2E2F2   D2E1E7   D2E235   F2YCW3  

PDB

5XLR     E-value=4.55038e-155,     Score=1411