Strain

KENYA_BAT_2010_NC_032107 (Region: Kenya;  Strain: NL63-related bat coronavirus strain BtKYNL63-9a, complete genome.;  Date: 2010)

Gene

N protein

Description

Annotated in NCBI,  N protein

Location

NC_032107(+):26241-27464

GenBank Accession

YP_009328939.1

Full name

Nucleoprotein      

Alternative Name

Nucleocapsid protein

CDS

ATGGCTACTGTAAATTGGGCCGATGACAAACGTGGGAAAAGGAAGTACCCACCCCCATCATTTTATTTGCCCCTCGTGGTTAAGTCTGACAAGCAACCCTATAAGGTTATCCCTCGTAACCTTGTTCCTAAAGGTAAAGGTAACAAGGATCAACAAATCGGCTACTGGAATGTGCAACGTCGTTGGCGTATGCGTAAAGGCCAGAGAGTTGACATTGATCCAAAAGTTCATTTCTACTACCTTGGAACTGGACCACGAGCTGACCTTAAATTTAGGGAAAGAGCTGAAGATGTCGTTTGGGTCGCTATGCAGGGTTCAAAAACTGAACCTACCAACTTGGGCAACCGCAAACGCAATCAAAAGCCAATTCAACCTGAGTTTGACATCCAGCTCCCTAACGAGCTTGAGGTTGTTGAATTTGAAGACCGCTCTAATAGTTCCTCAAGAGCTAGCAGTAGGGCTTCTTCAAGGGGTAACTCTCGTGAAACCTCAAGGTCAAACTCAAGACAGCAGTCGCGCGACAACTCTAGATCCCCATCTAGGTCAAGATCCAACAGTACATCTGAGTCTTCCCAGAATTCTGCACAAGATCTTGTTGCCGCTGTTACGGCTGCTTTGAAAAATCTTGGTTTTGAACCACCTAAGTCAGACAAAAGCGGCAATGCTTCTGGCACTTCTACCCCCAAAGGTAAGAAAAAGCCAAAGCAGGCTAAATCCAATGAACAAGGTTCACCAAATAATGTTCCTTCTGACAAGAGTCAAATGAACAAACCTAAATGGAAACGTGTCCCTAATGCTAGTGAAAATGTAATCAAGTGCTTCGGCCCTAGGGATTTTGATCACAACATGGGTGACGCAGACCTTGTTCAGAATGGTGTTGAAGCCAAAAACTTCCCACAAATTGCTGAATTAATTCCAACTCAGGCTGCTATGTTCTTTGACAGTGAAGTCTCTACTAAAGAGATGGGCAACAAAGTGCAGATTATCTACACCTACAAAATGCTTGTGGATAAAGATAACAAACACCTTCCAAAATTTTTGGAACAGGTGAGTGCATTTACTAAACCCAGTGTTGTCAAAGAAACGCAAAGTCACCCTTTGCAAAATACCATGCCTGAACCTGCTCAGCTGAATGTGGCTGCCGCTGAATTTAAACCACCTGTTACAACAGCCAGTGATGGTTCCAATGCTGAAATTGAAATTGTCGATGAGGTTCTGCATTAA

Protein

MATVNWADDKRGKRKYPPPSFYLPLVVKSDKQPYKVIPRNLVPKGKGNKDQQIGYWNVQRRWRMRKGQRVDIDPKVHFYYLGTGPRADLKFRERAEDVVWVAMQGSKTEPTNLGNRKRNQKPIQPEFDIQLPNELEVVEFEDRSNSSSRASSRASSRGNSRETSRSNSRQQSRDNSRSPSRSRSNSTSESSQNSAQDLVAAVTAALKNLGFEPPKSDKSGNASGTSTPKGKKKPKQAKSNEQGSPNNVPSDKSQMNKPKWKRVPNASENVIKCFGPRDFDHNMGDADLVQNGVEAKNFPQIAELIPTQAAMFFDSEVSTKEMGNKVQIIYTYKMLVDKDNKHLPKFLEQVSAFTKPSVVKETQSHPLQNTMPEPAQLNVAAAEFKPPVTTASDGSNAEIEIVDEVLH

Function

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.

Subunit

Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.

Similarity

Belongs to the alphacoronavirus nucleocapsid protein family.

Keywords

3D-structure   ADP-ribosylation   Host Golgi apparatus   Phosphoprotein   Ribonucleoprotein   RNA-binding   Transcription   Transcription regulation   Viral nucleoprotein   Virion   Reference proteome  

Feature

chain  Nucleoprotein

Uniprot

A0A1L2KGB9   Q06Y06   U3M7G3   A0A384RBU9   A0A2U8JDM2   A0A2P1E959   + More
H9EJ69   A0A2P1E945   A0A2P1E971   A0A1Y0EV18   A0A5B9MVD7   A0A384RBV1   A0A5B9BGU8   A0A2P1E948   Q0GMF2   A0A384R2N5   A0A127ATS5   H9EJA4   Q6Q1R8   A0A127AV50   A0A127ATV7   A0A127AX00   A0A127AU27   A0A127ATQ0   A0A127AX58   A0A127ATT3   A0A127ATP0   A0A127AV25   A0A127ATS9   A0A127ATT5   A0A127AU18   A0A127ATQ1   I7DJE7   A0A2P1E938   A0A127ATY8   Q06Y12   A0A127ATR0   A0A2L0WQF7   H9EJ20   A0A127AU68   U3M6A0   H9EJ76   A0A127ATR3   A0A127ATW4   A0A127ATU8   A0A127AUA1   A0A127ATQ8   A0A127ATS0   A0A127AV68   A0A127AV38   A0A127AU90   A0A127ATX3   A0A127ATR7   A0A127ATQ4   A0A127ATS6   A0A127ATV6   A0A127AU23   A0A127ATQ7   A0A127ATR6   A0A127ATY7   A0A127AU79   A0A127ATT9   A0A127AX15   A0A127ATX8   A0A127ATW2   A0T2T5   A0A127ATS3   A0A5B9BJR5   A0A127AX50   A0A127ATY1   C0LI68   A0A0P0KXM1   A0A0P0KBE2   A0A0N7J131   A0A0P0KMP3   A0A1L2KGF4   Q1HVP2   A0A059SGB0   A0A0U1WHF4   Q1HVQ0   P15130   I1VWF9   A0A0U1UZD2   Q1HVP1   Q1HVP0   A0A1C8YZ39   A0A0U2GMT2   S5YAG2   A0A0U2GR32   A0A0U2GRD7  

Pubmed

17054987    29741740    22837419    27799635    26928836    15073334    + More
15034574    25700263    22879617    17889596    19788804    26378164    16603522    2922924    2167350    11369870    15890900    27528677    26678874   

EMBL

KY073744    APD51479.1    DQ445912    ABE97134.1    KF530105    AGT51335.1    + More
KM055598    AIW52795.1    MG428705    AWK59971.1    KY862064    AVL25602.1    JQ765564    JQ765565    JQ765566    JQ765567    JQ765569    JQ765570    KF530112    KM055591    KM055592    KM055593    KM055595    KM055597    KM055602    KT381875    KU521535    KX179500    KY674915    KY674916    KY554967    KY554968    KY554970    KY862055    KY862058    KY862060    KY862061    KY862062    KY862065    KY862067    KY862068    KY862069    KY862070    KY862072    AFD98761.1    AFD98768.1    AFD98775.1    AFD98782.1    AFD98796.1    AFD98803.1    AGT51384.1    AIW52788.1    AIW52789.1    AIW52790.1    AIW52792.1    AIW52794.1    AIW52799.1    ALJ53435.1    ANU06088.1    APF29075.1    ARB07403.1    ARB07410.1    ARE29963.1    ARE29969.1    ARE29981.1    AVL25593.1    AVL25596.1    AVL25598.1    AVL25599.1    AVL25600.1    AVL25603.1    AVL25605.1    AVL25606.1    AVL25607.1    AVL25608.1    AVL25610.1    KY862057    AVL25595.1    KY862071    AVL25609.1    KY983586    ARU07598.1    MN306040    QEG03752.1    KM055608    AIW52805.1    MK334046    QED88037.1    KY862066    AVL25604.1    DQ846901    KM055611    ABI20791.1    AIW52808.1    KM055594    KM055596    AIW52791.1    AIW52793.1    KT359854    AMM42613.1    AY518894    JQ765568    JQ765572    JQ765573    JQ765574    JQ765575    JX504050    KF530104    KF530107    KF530108    KF530109    KF530111    KF530113    KF530114    KY554969    KY554971    KY829118    KY862073    KY862074    AAS89771.1    AFD98789.1    AFD98817.1    AFD98824.1    AFD98831.1    AFD98838.1    AFV53152.1    AGT51328.1    AGT51349.1    AGT51356.1    AGT51363.1    AGT51377.1    AGT51391.1    AGT51398.1    ARE29975.1    ARE29987.1    ARK08631.1    AVL25611.1    AVL25612.1    AY567487    KT359858    AMM42617.1    KT359853    AMM42612.1    KT359835    AMM42594.1    KT359871    AMM42630.1    KT359839    AMM42598.1    KT359865    AMM42624.1    KT359864    AMM42623.1    KT359829    AMM42588.1    KT359838    AMM42597.1    KT359866    AMM42625.1    KT359862    AMM42621.1    KT359851    AMM42610.1    KT359836    AMM42595.1    JX104161    JX524171    KM055599    KM055600    KM055601    KM055603    KM055604    KM055605    KM055606    KM055607    KM055609    KM055610    KT266906    KX179497    KX179498    KX179499    KY862059    KY862063    MG428699    MG428700    MG428701    MG428702    MG428703    MG428704    MG428706    MG428707    MK334043    MK334044    MK334045    MN306018    AFO70495.1    AFQ55888.1    AIW52796.1    AIW52797.1    AIW52798.1    AIW52800.1    AIW52801.1    AIW52802.1    AIW52803.1    AIW52804.1    AIW52806.1    AIW52807.1    AKT07956.1    APF29065.1    APF29067.1    APF29069.1    AVL25597.1    AVL25601.1    AWK59935.1    AWK59941.1    AWK59947.1    AWK59953.1    AWK59959.1    AWK59965.1    AWK59977.1    AWK59983.1    QED88016.1    QED88023.1    QED88030.1    QEG03735.1    KY862056    AVL25594.1    KT359870    AMM42629.1    DQ445911    ABE97141.1    KT359846    AMM42605.1    MG772808    AVA26877.1    JQ765563    AFD98754.1    KT359837    AMM42596.1    KF530106    KF530110    AGT51342.1    AGT51370.1    JQ765571    AFD98810.1    KT359844    AMM42603.1    KT359863    AMM42622.1    KT359843    AMM42602.1    KT359867    AMM42626.1    KT359849    AMM42608.1    KT359856    AMM42615.1    KT359868    AMM42627.1    KT359848    AMM42607.1    KT359857    AMM42616.1    KT359850    AMM42609.1    KT359842    AMM42601.1    KT359834    AMM42593.1    KT359852    AMM42611.1    KT359830    AMM42589.1    KT359861    AMM42620.1    KT359832    AMM42591.1    KT359859    AMM42618.1    KT359841    AMM42600.1    KT359847    AMM42606.1    KT359833    AMM42592.1    KT359845    AMM42604.1    KT359831    AMM42590.1    KT359840    AMM42599.1    EF081296    ABK63972.1    KT359869    AMM42628.1    MK334047    QED88044.1    KT359855    AMM42614.1    KT359860    AMM42619.1    FJ710055    ACN78943.1    KT253269    ALK28779.1    KT253270    ALK28785.1    KT253271    ALK28791.1    KT253272    ALK28797.1    KY073747    APD51503.1    DQ243947    ABB90490.1    KF293666    AGW80953.1    KJ473807    AIA62256.1    DQ243939    KF293664    KF293665    ABB90482.1    AGW80937.1    J04419    X51325    AF304460    JQ410000    AFI49435.1    KJ473810    AIA62275.1    DQ243948    ABB90491.1    DQ243949    ABB90492.1    KT253327    AOI28287.1    KT368900    KT368904    KT368905    KT368908    KT368916    ALA50148.1    ALA50176.1    ALA50183.1    ALA50204.1    ALA50260.1    KF514429    AGT21342.1    KT368892    KT368893    KT368894    ALA50092.1    ALA50099.1    ALA50106.1    KT368911    ALA50225.1   

Proteomes

UP000204102    UP000138462    UP000171901    UP000105969    UP000108941    UP000125140    + More
UP000130385    UP000136929    UP000145724    UP000151180    UP000151840    UP000100468    UP000103541    UP000106901    UP000110792    UP000129674    UP000134798    UP000140530    UP000144638    UP000153644    UP000161757    UP000162862    UP000167796    UP000168590    UP000174240    UP000008573    UP000098690    UP000141634    UP000158277    UP000115484    UP000173136    UP000143818    UP000146557    UP000141321    UP000118770    UP000122373    UP000096398    UP000130985    UP000106394    UP000006716    UP000146121    UP000144177    UP000103248    UP000104585    UP000120649    UP000136940    UP000152663    UP000108758    UP000110675    UP000115399    UP000100137   

PRIDE

Q6Q1R8    P15130   

Pfam

PF00937   Corona_nucleoca

Interpro

IPR037179   Nucleocapsid_C
IPR001218   Corona_nucleocap
IPR037195   Nucleocapsid_N
IPR042548   ALPHA_CORONA_NCAP

SUPFAM

SSF110304   SSF110304
SSF103068   SSF103068

ProteinModelPortal

A0A1L2KGB9   Q06Y06   U3M7G3   A0A384RBU9   A0A2U8JDM2   A0A2P1E959   + More
H9EJ69   A0A2P1E945   A0A2P1E971   A0A1Y0EV18   A0A5B9MVD7   A0A384RBV1   A0A5B9BGU8   A0A2P1E948   Q0GMF2   A0A384R2N5   A0A127ATS5   H9EJA4   Q6Q1R8   A0A127AV50   A0A127ATV7   A0A127AX00   A0A127AU27   A0A127ATQ0   A0A127AX58   A0A127ATT3   A0A127ATP0   A0A127AV25   A0A127ATS9   A0A127ATT5   A0A127AU18   A0A127ATQ1   I7DJE7   A0A2P1E938   A0A127ATY8   Q06Y12   A0A127ATR0   A0A2L0WQF7   H9EJ20   A0A127AU68   U3M6A0   H9EJ76   A0A127ATR3   A0A127ATW4   A0A127ATU8   A0A127AUA1   A0A127ATQ8   A0A127ATS0   A0A127AV68   A0A127AV38   A0A127AU90   A0A127ATX3   A0A127ATR7   A0A127ATQ4   A0A127ATS6   A0A127ATV6   A0A127AU23   A0A127ATQ7   A0A127ATR6   A0A127ATY7   A0A127AU79   A0A127ATT9   A0A127AX15   A0A127ATX8   A0A127ATW2   A0T2T5   A0A127ATS3   A0A5B9BJR5   A0A127AX50   A0A127ATY1   C0LI68   A0A0P0KXM1   A0A0P0KBE2   A0A0N7J131   A0A0P0KMP3   A0A1L2KGF4   Q1HVP2   A0A059SGB0   A0A0U1WHF4   Q1HVQ0   P15130   I1VWF9   A0A0U1UZD2   Q1HVP1   Q1HVP0   A0A1C8YZ39   A0A0U2GMT2   S5YAG2   A0A0U2GR32   A0A0U2GRD7  

PDB

5N4K     E-value=3.03809e-55,     Score=545