Strain

UGANDA_BAT_2013_NC_034440 (Region: Uganda;  Strain: Bat coronavirus isolate PREDICT/PDF-2180, complete genome.;  Date: 2013)

Gene

spike glycoprotein

Description

Annotated in NCBI,  spike glycoprotein

Location

NC_034440(+):21232-25269

GenBank Accession

YP_009361857.1

Full name

Spike glycoprotein      

Alternative Name

E2
Peplomer protein

CDS

ATGACGTACTCAGTGTCTCTACTGATGTGCTTGTTAACTTTTATAGGGGCAAACGCTAAAATTGTGTCGATACCTGGTGGTGTCGGTACTGGAGCTTGTCCCCAGGTTGATATGCAGCCCAGTTATTTTATAAAGCATAACTGGCCTGAACCTATTGACATGAATAAGGCAGACGGTGTCATCTACCCAAATGGCCGCACTTATTCTAACATCACATTACAGACCACTAATCTGTTTCCTCGTAATGGTGATTTAGGCACTCAGTATGTCTATTCAGCATCTAATGAGAAAAGCCGCACTAGCAATGTGGCTTTTATTAGTAATTATTCATACTATGGCAATCCCTTTGGCGACGGCATTGTCATACGTATAGGTCAAAATTCTAATAAGACTGGTAGTGTCATTGTGGGCACAGCACAGACTACTATTAAAAAGATCTACCCAGCTCTTATGCTTGGTAGTTCTTTTGGCAATTTCTCTGTTAATAATAAGTCAGGTGCTTATTTTAATCACACCCTTCTTATCTTACCTAGCAAGTGTGGCACTGTATTTCAGGTGGCATACTGCCTTCTACAACCAAGGACTGACTCTTATTGTCCCGGTAATGCTAACTATGTTAGCTATGCACTCATTGATTCTCCTACGGATTGTACATCTGCGGATGAATCTAAACGTAGGAATGGTCTTGAGGACATTAAAAAGTACTTCAATTTGGTCAATTGTACCTATTTTGAAGAGTTTAATGTCACAGCTGACGAGCGTGCAGAGTGGTTTGGCATCACCCAAGATTCTCAGGGTGTGCACCTCTACACCTCTCGTAAAAATGGTTTCAATTCAAATAATCTCTTTTTATTTGCTTCTGTGCCCATTTATGATAAGATCAATTACTACACTGTAATTCCTCGCTCAATAATAACTCCTGCCAACCAGCGTTCTGCTTGGGCAGCATTTTATGTATATCCTTTACACCAACTTAGCTACTTGCTAAATTTTGATGTTAATGGTTATATTACGCAAGCAGCAGACTGTGGTTACAATGATTATACCCAGCTTGTCTGCTCGTATGGTGATTTTAATATGAAATCTGGTGTTTACTCTACTTCATATTATTCAGCCAAACCTGTAGGTGCGTACTATGAAGCTCATGTTTACCCAGATTGCAATTTTACTGATTTGTTCCGGGAAAATGCTCCCACAATCATGCAATATAAGCGTCAAGTTTTTACGCGTTGTAATTACAACCTCACACTACTGCTCTCTCTTGTGCAGGTGGATGAGTTTGTCTGCGATAAGATTACCCCTGAGGCTCTTGCAACAGGGTGTTATTCGTCTCTTACCGTCGATTGGTTTGCATTTCCGTATGCTTGGAAGTCATACCTAGCTATAGGTTCAGCAGATCGCATTGTGCGGTTTAATTATAACCAGGATTATAGCAATCCCTCTTGTAGAATTCACTCCAAGGTGAATTCTTCAGTTGGCATTTCTTACTCTGGTTTATATAGTTATATTACTAATTGTAATTACGGCGGCTTCAACAAGGATGACGTTGTTAAGCCTGGTGGTCGTGCCAGTCAACCCTGTGTTACTGGCGCACTCAATTCACCTACTAACGGTCAAGTCTGGTCTTTTAATTTTGGTGGCGTCCCTTACAGAACCTCCCGCCTCACCTACACTGACCATCTTAAAAACCCTCTAGATATGGTTTATGTCATCACTGTTAAGTATGAACCAGGCGCTGAAACTGTATGTCCCAAACAAGTGCGTCCTGATTATAGTACCAATATTACTGGCTTATTAGGCTCTTGTATCAGTTATGACATTTATGGTATAACTGGTACTGGTGTTTTCCAGCTGTGTAATGCAACTGGAATTCCTCAACAAAAGTTTGTCTATGACAAATTTGATAATATAATTGGCTTTCACTCTGATGACGGCAATTATTATTGTGTGGCACCTTGTGTCAGTGTGCCTGTTTCTGTTATATATGATGACAACACTAATCAATACGCCACATTGTTTGGCAGTGTTGCTTGTCAACATATATCTACAATGGCTGCTCAGTTTTCTCGTGAAACTCGTGCTTCCCTCGTTTCAAGAAATATGCAGAATCTTCTACAGACTTCTGTCGGTTGTGTCATGGGTTTCCATGAAACTAATGACACCGTTGAAGACTGCAATCTTTCTTTGGGACAATCACTCTGCGCAATCCCACCTAACACCAACTTGAGGGTTGGTCGCTCCACCTTTGGATTAGGTTCTTTAGCCTACAACAGTCCATTGCGTGTTGATGCACTTAACTCCTCTGAGTTTAAGGTCTCCTTGCCTCTCAATTTTACATTTGGTGTTACTCAGGAATATATTGAAACTAGCATACAGAAGATTACAGTTGACTGTAAACAGTACGTGTGCAATGGTTTTGCTAAGTGTGAAAAGCTGCTCGAACAATACGGTCAGTTTTGCTCTAAAATTAACCAGGCTCTCCATGGCGCGAATCTTCGCCAGGATGACTTTGTTCGTAATCTGTTTGAGAGTGTTAAAACACCACAGACAGTTCCTCTTACTACAGGTTTTGGAGGGGAGTTTAATCTTACTCTTCTAGAGCCGCTTTCTGTTTCTACAGGTTCTTCTAATGCGCGTAGTGCTTTGGAAGAGCTTTTGTTTGACAAAGTCACTATAGCTGATCCTGGCTACATGCAAGGTTATGATGACTGCATGCAACAGGGCCCTGCCTCAGCTCGTGATCTTATCTGTGCTCAATATGTTGCTGGCTACAAAGTGTTACCACCCCTTATGGATGTTAACATGGAAGCTGCATACACCTCTTCTTTGCTTGGTAGCATAGCTGGTGCTGGCTGGACTGCTGGTTTATCATCATTTGCTGCCATTCCATTTGCACAGAGTATATTTTACAGGTTAAATGGTGTTGGTATAACACAACAGGTTCTATCTGAGAATCAAAAGATTATTGCTAACAAGTTTAACCAAGCTCTTGGTGCCATGCAAACTGGTTTCACAACAACTAATGAAGCTTTTCAGAAAGTTCAAGATGCTGTGAACACTAATGCACAGGCTCTAGCTAAGTTGGCTAGTGAACTATCCAATACTTTTGGTGCTATTTCTTCTTCCATTGGTGACATCATTCAACGTCTTGATGTGCTTGAACAGGAAGTCCAAATAGACAGACTTATTAATGGCCGTCTGACTACACTCAACGCCTTTGTTGCTCAGCAGCTTGTTCGTTCTGAATCTGCTGCTCGTTCTGCACAATTGGCTAAGGATAAAGTCAATGAGTGTGTTAAATCACAATCCACTAGATCTGGATTTTGTGGTCAAGGCACTCATATAGTGTCCTTTGTTATTAACGCCCCTAATGGCCTCTACTTTATGCATGTTGGTTACCACCCTAGCCAACATATTGAGGTTGTTGCTGCCTATGGTCTTTGTGACGCGGCCAACCCCACTAATTGTATAGCCCCAGTTAATGGCTACTTTATTAAAAATCAAACTACTAGGGGTGTTGATGATTGGTCATATACAGGTTCTTCCTTTTATGCTCCAGAACCCATCACCACTCTTAATACTAGGTATGTCGCACCTCAAGTGACATTCCAAAACATTTCTACTAACCTTCCTCCTCCTCTGTTGGGCAATTCCACTGGAACTGACTTCAAAGATGAGTTGGATGAATTTTTCAAGAATGTTAGCACCAGTATACCAAATTTTGGTGCTCTAACACAAATTAATACTACTTTATTGGATCTTTCCGATGAAATGCTAGCTTTACAGCAAGTTGTCAAAGCGCTTAATGAGTCATATATTGACCTTAAAGAGCTCGGCAACTATACTTATTACAACAAATGGCCTTGGTACATTTGGTTGGGTTTCATTGCTGGACTTCTAGCCCTAGCCCTTTGTGTTTTCTTTATTCTTTGCTGCACTGGTTGCGGCACAAGTTGTTTAGGAAAACTTAAATGTAATCGTTGTTGTGACAAATATGAAGAATACGACCTTGAGCCGCATAAAATTCATATTCACTAA

Protein

MTYSVSLLMCLLTFIGANAKIVSIPGGVGTGACPQVDMQPSYFIKHNWPEPIDMNKADGVIYPNGRTYSNITLQTTNLFPRNGDLGTQYVYSASNEKSRTSNVAFISNYSYYGNPFGDGIVIRIGQNSNKTGSVIVGTAQTTIKKIYPALMLGSSFGNFSVNNKSGAYFNHTLLILPSKCGTVFQVAYCLLQPRTDSYCPGNANYVSYALIDSPTDCTSADESKRRNGLEDIKKYFNLVNCTYFEEFNVTADERAEWFGITQDSQGVHLYTSRKNGFNSNNLFLFASVPIYDKINYYTVIPRSIITPANQRSAWAAFYVYPLHQLSYLLNFDVNGYITQAADCGYNDYTQLVCSYGDFNMKSGVYSTSYYSAKPVGAYYEAHVYPDCNFTDLFRENAPTIMQYKRQVFTRCNYNLTLLLSLVQVDEFVCDKITPEALATGCYSSLTVDWFAFPYAWKSYLAIGSADRIVRFNYNQDYSNPSCRIHSKVNSSVGISYSGLYSYITNCNYGGFNKDDVVKPGGRASQPCVTGALNSPTNGQVWSFNFGGVPYRTSRLTYTDHLKNPLDMVYVITVKYEPGAETVCPKQVRPDYSTNITGLLGSCISYDIYGITGTGVFQLCNATGIPQQKFVYDKFDNIIGFHSDDGNYYCVAPCVSVPVSVIYDDNTNQYATLFGSVACQHISTMAAQFSRETRASLVSRNMQNLLQTSVGCVMGFHETNDTVEDCNLSLGQSLCAIPPNTNLRVGRSTFGLGSLAYNSPLRVDALNSSEFKVSLPLNFTFGVTQEYIETSIQKITVDCKQYVCNGFAKCEKLLEQYGQFCSKINQALHGANLRQDDFVRNLFESVKTPQTVPLTTGFGGEFNLTLLEPLSVSTGSSNARSALEELLFDKVTIADPGYMQGYDDCMQQGPASARDLICAQYVAGYKVLPPLMDVNMEAAYTSSLLGSIAGAGWTAGLSSFAAIPFAQSIFYRLNGVGITQQVLSENQKIIANKFNQALGAMQTGFTTTNEAFQKVQDAVNTNAQALAKLASELSNTFGAISSSIGDIIQRLDVLEQEVQIDRLINGRLTTLNAFVAQQLVRSESAARSAQLAKDKVNECVKSQSTRSGFCGQGTHIVSFVINAPNGLYFMHVGYHPSQHIEVVAAYGLCDAANPTNCIAPVNGYFIKNQTTRGVDDWSYTGSSFYAPEPITTLNTRYVAPQVTFQNISTNLPPPLLGNSTGTDFKDELDEFFKNVSTSIPNFGALTQINTTLLDLSDEMLALQQVVKALNESYIDLKELGNYTYYNKWPWYIWLGFIAGLLALALCVFFILCCTGCGTSCLGKLKCNRCCDKYEEYDLEPHKIHIH

Function

Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.
Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.
Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Interacts with host DPP4 to mediate virla entry.
mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.

Subunit

Homotrimer; each monomer consists of a S1 and a S2 subunit. The resulting peplomers protrude from the virus surface as spikes.
Homotrimer; each monomer consists of a S1 and a S2 subunit. The resulting peplomers protrude from the virus surface as spikes. S1 interacts with murine DPP4.

Similarity

Belongs to the betacoronaviruses spike protein family.

Keywords

3D-structure   Coiled coil   Disulfide bond   Fusion of virus membrane with host endosomal membrane   Fusion of virus membrane with host membrane   Glycoprotein   Host cell membrane   Host membrane   Host-virus interaction   Lipoprotein   Membrane   Palmitate   Reference proteome   Signal   Transmembrane   Transmembrane helix   Viral attachment to host cell   Viral envelope protein   Viral penetration into host cytoplasm   Virion   Virulence   Virus entry into host cell  

Feature

chain  Spike protein S2

Uniprot

A0A1W6ASU7   U5NJG5   A0A2R2YRG8   A0A2P1IT43   A0A2P1IT40   A0A140HF74   + More
M4SVE7   A0A0U2P155   A0A0U2GL10   K0BRG7   A0A2D0YGK8   A0A384YDY2   A0A023VYK5   A0A2D0YNJ0   A0A482DX17   A0A1L2DZI5   A0A0U2MGJ8   A0A2D0YIQ0   A0A482DX85   A0A2P1IT75   A0A0S3IUB8   A0A1W5LIC4   A0A2H1YPP7   A0A2D0YDA3   A0A0U2NTX5   A0A4P8L6Q6   A0A0A0Q4U2   W6A0A7   A0A2D0Y380   A0A0U2NY03   A0A0U2NVR1   R9UCW7   A0A0U2P188   A0A291I6B7   A0A0H4JBS8   W5ZZF5   A0A384VXU1   W6A028   A0A411PBL8   A0A2D0YGA8   A0A0A0Q7F8   A0A2D0YAP4   A0A0U3SQE0   A0A0G3U597   A0A2D0YCE0   A0A0A0Q7G4   A0A0B5A1M3   A0A168DLI3   A0A411PBH5   A0A140AZ15   A0A140AYZ5   A0A0U2MS90   A0A410SR78   A0A140AZ05   A0A5C0PYB9   A0A2D0YPZ8   A0A516IIX0   A0A291I5Y3   A0A0U2J5U2   A0A0U2NY17   A0A0U4AGH8   T2B9T0   T2B999   A0A1W5LGN6   A0A3T0I8D8   A0A2H4GWK9   A0A0R9USA1   A0A411PBG2   A0A2D0Y9L1   A0A1W5LGL0   A0A1W5LGE4   M1RNL5   A0A0B5KTJ9   R9UQ53   T2BB24   A0A0U2GKS5   A0A291I632   A0A141BR51   K9N5Q8   A0A2H4KGX9   W6A8L9   T2BAV6   A0A411PBG4   A0A2P1IT84   A0A140AQ46   A0A0U2NE92   A0A2D0YLD5   A0A2D0YJ37   A0A024BSJ1   A0A3S7R2I2   A0A2D0YCT4   A0A2D0YM48   A0A126G7T9   A0A411PBD4   A0A0A0Q7F3   A0A3B8DUP5   A0A2D0YXA8   A0A2D0YUG7   A0A0U2P9D9   A0A2D0Y7Z5  

Pubmed

28377531    24050621    25031349    29579103    29507189    27125484    + More
23903833    26678874    23170002    26391698    29116217    24874668    27999424    26632876    25323704    24549846    26281793    23782859    26079346    24857749    24896817    31553909    24781747    26584223    26272560    26691200    26981770    26839489    26933050    30753126    26272558    26814649    30482895    24055451    31022948    23693015    23835475    24473083    23078800    23486063    29239118    24786258    30294617   

EMBL

KX574227    ARJ34226.1    KC869678    AGY29650.2    MF593268    ATQ39390.1    + More
MG923466    MG923467    AVN89291.1    AVN89302.1    MG923468    AVN89313.1    KU740200    AMO03401.1    KC776174    AGH58717.1    KT805973    ALJ54453.1    KT368834    ALA49451.1    JX869059    AFS88936.1    MF598608    MF598650    MF598700    ASU90076.1    ASU90538.1    ASU91087.1    MG912607    AVK87450.1    KJ614529    AHY21469.1    MF598600    MF598678    ASU89988.1    ASU90846.1    MK564475    QBM11748.1    KX108943    ANI69889.1    KT806016    ALJ54496.1    MF598711    ASU91208.1    MK564474    QBM11737.1    MG923470    MG923471    AVN89334.1    AVN89344.1    KT805981    KT751244    MF598596    MF598599    MF598601    MF598605    MF598609    MF598610    MF598626    MF598630    MF598653    MF598655    MF598659    MF598671    MF598683    MF598690    MF598699    MF598702    MF598703    MF598704    MF598705    MF598706    MF598707    MF598708    MF598709    MF598710    MF598712    MF598713    MF598714    MF598715    MF598716    MF598717    MF598719    MF598720    MF598721    MF598722    ALJ54461.1    ALR69641.1    ASU89944.1    ASU89977.1    ASU89999.1    ASU90043.1    ASU90087.1    ASU90098.1    ASU90274.1    ASU90318.1    ASU90571.1    ASU90593.1    ASU90637.1    ASU90769.1    ASU90901.1    ASU90978.1    ASU91076.1    ASU91109.1    ASU91120.1    ASU91131.1    ASU91142.1    ASU91153.1    ASU91164.1    ASU91175.1    ASU91186.1    ASU91197.1    ASU91219.1    ASU91230.1    ASU91241.1    ASU91252.1    ASU91262.1    ASU91273.1    ASU91295.1    ASU91305.1    ASU91315.1    ASU91325.1    KX154689    MG757604    ANF29217.1    AXN73514.1    MF598597    ASU89955.1    MF598651    ASU90549.1    KT806028    ALJ54508.1    MK858160    MK858161    MK858162    QCQ28832.1    QCQ28833.1    QCQ28834.1    KM027279    KT368824    AID55090.1    ALA49341.1    KJ156905    AHI48692.1    MF598623    ASU90241.1    KT806020    ALJ54500.1    KT806011    ALJ54491.1    KF192507    AGN52936.1    KT806021    ALJ54501.1    MG011354    ATG84833.1    KP405225    KP405227    KT805988    MF598616    MG011341    MH822886    MK462250    AKO69634.1    AKO69636.1    ALJ54468.1    ASU90164.1    ATG84690.1    AYM48030.1    QBF80532.1    KF917527    KF958702    KJ156949    KJ156952    KJ556336    AHE78097.1    AHE78108.1    AHI48594.1    AHI48605.1    AHN10812.1    MF741827    MF741832    ASY99811.1    ASY99864.1    KJ156934    KJ156873    KJ713295    KJ713296    KM015348    KM027281    KM210278    KP966104    KT006149    KT026453    KT026454    KT026455    KT026456    KT036372    KT036373    KT036374    KT182953    KT275306    KT275307    KT275308    KT368833    KT368868    KT368870    KT368871    KT368872    KT368873    KT368874    KT368876    KT368877    KT368878    KT368882    KT368883    KT368884    KT368885    KT368886    KT368889    KT805964    KT805965    KT805967    KT805969    KT805974    KT805977    KT805979    KT805980    KT805982    KT805984    KT805989    KT805990    KT805993    KT805996    KT806002    KT806005    KT806007    KT806009    KT806012    KT806014    KT806018    KT806019    KT806023    KT806024    KT806025    KT806026    KT806027    KT806029    KT806030    KT806031    KT806033    KT806034    KT806035    KT806039    KT868870    KU233362    KU233363    KU233364    KT806044    KT806045    KT806046    KT806047    KT806048    KT806050    KT806051    KT806052    KT806053    KU851859    KU851860    KU851861    KU851862    KU851863    KU851864    KX154684    KX108945    KY688118    KY688120    KY688121    KY688122    KY688123    KY688124    MF598594    MF598595    MF598603    MF598604    MF598606    MF598607    MF598611    MF598612    MF598613    MF598615    MF598620    MF598625    MF598627    MF598628    MF598633    MF598643    MF598644    MF598645    MF598646    MF598652    MF598654    MF598657    MF598660    MF598661    MF598662    MF598664    MF598665    MF598666    MF598668    MF598670    MF598677    MF598680    MF598682    MF598684    MF598685    MF598686    MF598687    MF598688    MF598691    MF598692    MF598694    MF598695    MF598697    MF598698    MF598701    MF741837    MF741825    MF741826    MF741828    MF741829    MF741831    MF741833    MF741834    MF741835    MF741836    MG011343    MG011352    MG011353    MG011355    MF679172    MG366880    MG912608    MH306207    MH371127    MH432120    MG757593    MG757594    MG757595    MG757596    MG757598    MG757599    MG757600    MG757601    MG757602    MG757603    MH029552    MK129253    MH978888    MK462248    MH259486    MK858156    MK858158    MK858163    AHI48572.1    AHI48662.1    AHY22525.1    AHY22535.1    AID50418.1    AID55092.1    AJD81451.1    AKA63509.1    AKJ80137.2    AKK52582.1    AKK52592.1    AKK52602.1    AKK52612.1    AKL80593.1    AKL80604.1    AKL80615.1    AKN11071.1    AKQ21055.1    AKQ21064.1    AKQ21073.1    ALA49440.1    ALA49825.1    ALA49847.1    ALA49858.1    ALA49869.1    ALA49880.1    ALA49891.1    ALA49913.1    ALA49924.1    ALA49935.1    ALA49979.1    ALA49990.1    ALA50001.1    ALA50012.1    ALA50023.1    ALA50056.1    ALJ54444.1    ALJ54445.1    ALJ54447.1    ALJ54449.1    ALJ54454.1    ALJ54457.1    ALJ54459.1    ALJ54460.1    ALJ54462.1    ALJ54464.1    ALJ54469.1    ALJ54470.1    ALJ54473.1    ALJ54476.1    ALJ54482.1    ALJ54485.1    ALJ54487.1    ALJ54489.1    ALJ54492.1    ALJ54494.1    ALJ54498.1    ALJ54499.1    ALJ54503.1    ALJ54504.1    ALJ54505.1    ALJ54506.1    ALJ54507.1    ALJ54509.1    ALJ54510.1    ALJ54511.1    ALJ54513.1    ALJ54514.1    ALJ54515.1    ALJ54519.1    ALK80242.1    ALT66802.1    ALT66813.1    ALT66824.1    ALW82636.1    ALW82647.1    ALW82658.1    ALW82669.1    ALW82680.1    ALW82702.1    ALW82709.1    ALW82720.1    ALW82731.1    AMQ49015.1    AMQ49026.1    AMQ49037.1    AMQ49048.1    AMQ49059.1    AMQ49070.1    ANF29162.1    ANI69911.1    AQZ41311.1    AQZ41332.1    AQZ41343.1    AQZ41354.1    AQZ41365.1    AQZ41376.1    ASU89921.1    ASU89933.1    ASU90021.1    ASU90032.1    ASU90054.1    ASU90065.1    ASU90109.1    ASU90120.1    ASU90131.1    ASU90153.1    ASU90208.1    ASU90263.1    ASU90285.1    ASU90295.1    ASU90351.1    ASU90461.1    ASU90472.1    ASU90483.1    ASU90494.1    ASU90560.1    ASU90582.1    ASU90615.1    ASU90648.1    ASU90659.1    ASU90670.1    ASU90692.1    ASU90703.1    ASU90714.1    ASU90736.1    ASU90758.1    ASU90835.1    ASU90868.1    ASU90890.1    ASU90912.1    ASU90923.1    ASU90934.1    ASU90945.1    ASU90956.1    ASU90988.1    ASU90999.1    ASU91021.1    ASU91032.1    ASU91054.1    ASU91065.1    ASU91098.1    ASY99778.1    ASY99789.1    ASY99800.1    ASY99820.1    ASY99831.1    ASY99853.1    ASY99873.1    ASY99884.1    ASY99895.1    ASY99906.1    ATG84712.1    ATG84811.1    ATG84822.1    ATG84844.1    ATW75478.1    ATY74381.1    AVK87461.1    AWM99582.1    AXG21643.1    AXG21665.1    AXN73393.1    AXN73404.1    AXN73415.1    AXN73426.1    AXN73448.1    AXN73459.1    AXN73470.1    AXN73481.1    AXN73492.1    AXN73503.1    AYO86699.1    AZK15900.1    QBF44115.1    QBF80510.1    QCI31480.1    QCQ28828.1    QCQ28830.1    QCQ28835.1    MK462253    MK462254    MK462255    QBF80565.1    QBF80576.1    QBF80587.1    MF598629    MF598640    MF598658    MF598689    ASU90307.1    ASU90428.1    ASU90626.1    ASU90966.1    KM027273    AID55084.1    MF598679    ASU90857.1    KT806054    ALW82742.1    KT029139    AKL59401.1    MF598631    ASU90329.1    KM027288    AID55099.1    KM210277    AJD81440.1    KX034097    ANC28678.1    MK462247    QBF80499.1    KT868872    KT868876    ALK80261.1    ALK80301.1    KT182954    KT182955    KT326819    KT374052    KT374053    KT374054    KT374055    KT868865    KT868866    KT868867    KT868868    KT868869    KT868873    KT868874    KU308549    KX034096    KX034098    KX034099    KX034100    AKN11072.1    AKN11073.1    AKS48062.1    ALB08267.1    ALB08278.1    ALB08289.1    ALB08300.1    ALK80192.1    ALK80202.1    ALK80212.1    ALK80222.1    ALK80232.1    ALK80271.1    ALK80281.1    AML60270.1    ANC28667.1    ANC28689.1    ANC28700.1    ANC28711.1    KT805978    KT806003    ALJ54458.1    ALJ54483.1    MK357908    MK357909    QAT98898.1    QAT98909.1    KT868875    KX034094    KX034095    ALK80291.1    ANC28645.1    ANC28656.1    MN365232    MN365233    QEJ82215.1    QEJ82226.1    MF598632    ASU90340.1    MN120514    QDP16206.1    MG011342    ATG84701.1    KT806038    ALJ54518.1    KT806036    ALJ54516.1    KT806049    ALW82691.1    KF600652    KT806040    AGV08584.1    ALJ54520.1    KF600612    KF600620    AGV08379.1    AGV08408.1    KX154685    KX154688    MG011346    ANF29173.1    ANF29206.1    ATG84745.1    MK280984    AZU90731.1    KY673149    AQZ41296.1    KT225476    ALD51904.1    MK462251    QBF80543.1    MF598649    ASU90527.1    KX154691    ANF29239.1    KX154687    ANF29195.1    KC667074    AGG22542.1    KP719931    KP719932    AJG44102.1    AJG44113.1    KF186564    KF186566    KF186567    KF186565    KF600623    KF600627    KF600632    KF600636    KF600644    KF600645    KF600647    KF600651    KJ156866    KJ156872    KJ156939    AGN70929.1    AGN70951.1    AGN70962.1    AGN70973.1    AGV08426.1    AGV08444.1    AGV08480.1    AGV08505.1    AGV08535.1    AGV08546.1    AGV08558.1    AGV08573.1    AHI48517.1    AHI48652.1    AHI48711.1    KF600628    KJ156874    KJ156910    KJ156942    KJ156901    KP405226    AGV08455.1    AHI48539.1    AHI48561.1    AHI48626.1    AHI48682.1    AKO69635.1    KT368825    KT805983    ALA49352.1    ALJ54463.1    MG011348    MG011349    MG011350    ATG84767.1    ATG84778.1    ATG84789.1    KT182956    KT182957    AKN11074.1    AKN11075.1    KC164505    KY581694    ASU45807.1    KJ156881    AHI48550.1    KF600613    AGV08390.1    MK462246    QBF80488.1    MG923473    AVN89365.1    KT374056    ALB08311.1    KT806010    ALJ54490.1    MF598618    ASU90186.1    MF598634    ASU90362.1    KJ782549    AHZ20790.1    MG757597    AXN73437.1    MF598641    ASU90439.1    MF598638    ASU90406.1    KT374050    KT374051    ALB08246.1    ALB08257.1    MK462243    MK462244    MK462245    QBF80455.1    QBF80466.1    QBF80477.1    KM027255    KM027256    KM027257    KM027258    KM027259    KM027260    KM027261    KM027263    KM027264    KM027265    KM027266    KM027267    KM027269    KM027270    KM027271    KM027272    KM027275    KM027291    KT861629    KT861630    KT861631    KT861633    KT861628    KY581693    MK052676    MK039552    MK039553    AID55066.1    AID55067.1    AID55068.1    AID55069.1    AID55070.1    AID55071.1    AID55072.1    AID55074.1    AID55075.1    AID55076.1    AID55077.1    AID55078.1    AID55080.1    AID55081.1    AID55082.1    AID55083.1    AID55086.1    AID55102.1    ALX27225.1    ALX27226.1    ALX27227.1    ALX27229.1    ALX27243.1    ASU45796.1    AYP10298.1    AYV64549.1    AYV64560.1    MG520075    MG520076    MG546331    AXN73370.1    AYJ71481.1    MF598648    MF598667    MF598696    ASU90516.1    ASU90725.1    ASU91043.1    MF598635    MF598637    ASU90373.1    ASU90395.1    KT806008    KT806017    ALJ54488.1    ALJ54497.1    MF598619    MF598621    MF598624    MF598672    MF598675    ASU90197.1    ASU90219.1    ASU90252.1    ASU90780.1    ASU90813.1   

Proteomes

UP000202992    UP000145931    UP000108469    UP000168352    UP000112279    UP000180345    + More
UP000135646    UP000138672    UP000104220    UP000119765    UP000120438    UP000135014    UP000148657    UP000159930    UP000095864    UP000096875    UP000102966    UP000104540    UP000109666    UP000112022    UP000115322    UP000118563    UP000119223    UP000121965    UP000122049    UP000125198    UP000128184    UP000128186    UP000128651    UP000142239    UP000144056    UP000144472    UP000147538    UP000151795    UP000153269    UP000157492    UP000158935    UP000159306    UP000161565    UP000163035    UP000163895    UP000170921    UP000171516    UP000171892    UP000174054    UP000174558    UP000180347    UP000180348    UP000171389    UP000118772    UP000114773    UP000129370    UP000097149    UP000098933    UP000105311    UP000106595    UP000109122    UP000126763    UP000128076    UP000140611    UP000147342    UP000145271    UP000167218    UP000146591    UP000148810    UP000140430    UP000154518    UP000119183    UP000160415    UP000131416    UP000174176    UP000101567    UP000108647    UP000117251    UP000125629    UP000127508    UP000130711    UP000140498    UP000144449    UP000158466    UP000160534    UP000171868    UP000115754    UP000165701    UP000167295    UP000131256    UP000139997    UP000105272    UP000134122    UP000149108    UP000103178    UP000113724    UP000100765    UP000113762    UP000116785    UP000124216    UP000144709    UP000159190    UP000175153   

PRIDE

K9N5Q8   

Pfam

PF01601   Corona_S2
PF09408   Spike_rec_bind

Interpro

IPR036326   Spike_rcpt-bd_sf
IPR042578   BETA_CORONA_SPIKE
IPR027400   S_HR2
IPR018548   Spike_rcpt-bd
IPR002552   Corona_S2

SUPFAM

SSF143587   SSF143587

Gene 3D

1.20.5.790    

ProteinModelPortal

A0A1W6ASU7   U5NJG5   A0A2R2YRG8   A0A2P1IT43   A0A2P1IT40   A0A140HF74   + More
M4SVE7   A0A0U2P155   A0A0U2GL10   K0BRG7   A0A2D0YGK8   A0A384YDY2   A0A023VYK5   A0A2D0YNJ0   A0A482DX17   A0A1L2DZI5   A0A0U2MGJ8   A0A2D0YIQ0   A0A482DX85   A0A2P1IT75   A0A0S3IUB8   A0A1W5LIC4   A0A2H1YPP7   A0A2D0YDA3   A0A0U2NTX5   A0A4P8L6Q6   A0A0A0Q4U2   W6A0A7   A0A2D0Y380   A0A0U2NY03   A0A0U2NVR1   R9UCW7   A0A0U2P188   A0A291I6B7   A0A0H4JBS8   W5ZZF5   A0A384VXU1   W6A028   A0A411PBL8   A0A2D0YGA8   A0A0A0Q7F8   A0A2D0YAP4   A0A0U3SQE0   A0A0G3U597   A0A2D0YCE0   A0A0A0Q7G4   A0A0B5A1M3   A0A168DLI3   A0A411PBH5   A0A140AZ15   A0A140AYZ5   A0A0U2MS90   A0A410SR78   A0A140AZ05   A0A5C0PYB9   A0A2D0YPZ8   A0A516IIX0   A0A291I5Y3   A0A0U2J5U2   A0A0U2NY17   A0A0U4AGH8   T2B9T0   T2B999   A0A1W5LGN6   A0A3T0I8D8   A0A2H4GWK9   A0A0R9USA1   A0A411PBG2   A0A2D0Y9L1   A0A1W5LGL0   A0A1W5LGE4   M1RNL5   A0A0B5KTJ9   R9UQ53   T2BB24   A0A0U2GKS5   A0A291I632   A0A141BR51   K9N5Q8   A0A2H4KGX9   W6A8L9   T2BAV6   A0A411PBG4   A0A2P1IT84   A0A140AQ46   A0A0U2NE92   A0A2D0YLD5   A0A2D0YJ37   A0A024BSJ1   A0A3S7R2I2   A0A2D0YCT4   A0A2D0YM48   A0A126G7T9   A0A411PBD4   A0A0A0Q7F3   A0A3B8DUP5   A0A2D0YXA8   A0A2D0YUG7   A0A0U2P9D9   A0A2D0Y7Z5  

PDB

5X5F     E-value=0,     Score=4044