Strain

CHINA_MURINE_2015_NC_035191 (Region: China;  Strain: Wencheng Sm shrew coronavirus isolate Xingguo-101 ORF1ab polyprotein, spike glycoprotein, envelope protein, membrane protein, and nucleocapsid protein genes, complete cds.;  Date: 2015)

Gene

envelope protein

Description

Annotated in NCBI,  envelope protein

Location

NC_035191(+):23306-23533

GenBank Accession

YP_009389426.1

Full name

Envelope small membrane protein      

CDS

ATGTTGCCGTTGATTTATAATGATAATGGACTTGTAGTTTCTGTGTTTTTGTGGTTTTTAATTTTAATTGTGTTTTTGTTGTTTTTAATTGTGTTTATAAAGTGTTGTAAGTGTGTGTTTTTAACACACCGTGCCTTGAACGCTACTGTCTATAGGCCAGTGGCTAAATTTTATAGACAGTATCAAGAGTTTATGCATATTGAGCCTTTGTCTGAAGATATTGTCTAA

Protein

MLPLIYNDNGLVVSVFLWFLILIVFLLFLIVFIKCCKCVFLTHRALNATVYRPVAKFYRQYQEFMHIEPLSEDIV

Function

Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.

Subunit

Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.

Miscellaneous

Bat coronavirus 512/2005 is highly similar to porcine epidemic diarrhea virus (PEDV).

Similarity

Belongs to the alphacoronaviruses E protein family.

Keywords

Apoptosis   Host Golgi apparatus   Host membrane   Membrane   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Envelope small membrane protein

Uniprot

A0A220I8U1   A0A240FW13   A0A220I8X2   A0A240FW41   A0A240FW32   A0A240FW55   + More
A0A240FW51   A0A3G3NGT0   A0A219TV00   A0A4Y6GLB2   A0A4Y6GM71   A0A4Y6GLC2   A0A3G3NH15   Q0Q464   A0A3G3NGS8   A0A3G3NHM3   A0A4Y6GM80   A0A0P0TDN2   A0A3G3NHH7   A0A3G3NGF7   A0A3G3NGZ5   A0A3S8Z5K9   A0A0K0YGJ7   A0A1X9Q889   U6BPE0   A0A2U9EW62   A0A3G3NHG3   A0A286R3Q0   A0A0U1YFC9   A0A482F7H5   X5C414   A0A5B8YSJ0   L0HAG1   A0A0U1YFA6   A0A4Y6ACU9   A0A1L2KGB6   A0A3S8TLN4   A0A0N7EJQ5   A0A5J6DDR7   A0A0U2C7N6   M4PKF6  

Pubmed

28637760    16840328    26512689    26196056    25272273    24197882    + More
29789941    24818713    23469356    26743534    31503522    23462888   

EMBL

KY967717    ASF90451.1    KY967715    ASF90445.1    KY967723    ASF90461.1    + More
KY967725    KY967726    ASF90471.1    ASF90476.1    KY967724    ASF90466.1    KY967734    ASF90492.1    KY967733    KY967735    ASF90487.1    ASF90497.1    MH687958    AYR18539.1    KT346372    ANV78632.1    MK211370    QDF43796.1    MK211369    QDF43791.1    MK211372    QDF43806.1    MH687941    MH687943    MH687945    MH687946    MH687948    MH687954    MH687956    MH687963    MH687964    AYR18444.1    AYR18457.1    AYR18469.1    AYR18475.1    AYR18483.1    AYR18515.1    AYR18527.1    AYR18569.1    AYR18575.1    DQ648858    MH687937    MH687938    MH687955    MH687960    MH687961    MH687965    AYR18420.1    AYR18426.1    AYR18521.1    AYR18551.1    AYR18557.1    AYR18581.1    MH687967    AYR18593.1    MK211371    QDF43801.1    KT021231    KT021232    KT021233    ALM09384.1    ALM09390.1    ALM09396.1    MH687935    MH687936    MH687939    MH687940    MH687949    MH687950    MH687951    MH687952    MH687959    MH687962    AYR18408.1    AYR18414.1    AYR18432.1    AYR18438.1    AYR18489.1    AYR18495.1    AYR18501.1    AYR18507.1    AYR18545.1    AYR18563.1    MH687934    AYR18402.1    MH687942    MH687966    AYR18450.1    AYR18587.1    MH056657    AZN28589.1    KR873436    KR873437    KT021230    KU558701    KY825240    KY825241    KY825242    KY825243    MH056658    MN037494    AKS50251.1    AKS50256.1    ALM09378.1    ANY27033.1    ASA40093.1    ASA40099.1    ASA40105.1    ASA40111.1    AZN28595.1    QED58403.1    KX532182    ARQ18620.1    KF650375    KF840541    KF840542    MH726382    MH726396    MH726397    AHA38155.1    AIE15957.1    AIE15962.1    QCQ19920.1    QCQ20004.1    QCQ20010.1    MG837058    AWQ28490.1    MH687944    MH687957    AYR18463.1    AYR18533.1    MF577027    ASV51731.1    KJ857353    AJD09476.1    MK032690    QBO24659.1    KJ196348    AHW40032.1    MH726377    MH726378    MH726379    MK841494    MK841495    QCQ19890.1    QCQ19896.1    QCQ19902.1    QED40657.1    QED40663.1    KC196276    AGA94622.1    KJ857371    AJD09494.1    MG923574    QDE55567.1    KY073744    APD51477.1    MH061341    MK644605    AZL47224.1    QFG01714.1    KR095279    ALF39591.1    MN065811    QER90706.1    KR265817    KR265840    AKJ22051.1    AKJ22177.1    KC189828    AGH06453.1   

Proteomes

UP000202100    UP000113079    UP000109730    UP000141943    UP000167996    UP000109960    + More
UP000168944    UP000129155    UP000170972    UP000204102    UP000153801    UP000111048    UP000170995   

Pfam

PF02723   NS3_envE

Interpro

IPR003873   NS3/E

ProteinModelPortal

A0A220I8U1   A0A240FW13   A0A220I8X2   A0A240FW41   A0A240FW32   A0A240FW55   + More
A0A240FW51   A0A3G3NGT0   A0A219TV00   A0A4Y6GLB2   A0A4Y6GM71   A0A4Y6GLC2   A0A3G3NH15   Q0Q464   A0A3G3NGS8   A0A3G3NHM3   A0A4Y6GM80   A0A0P0TDN2   A0A3G3NHH7   A0A3G3NGF7   A0A3G3NGZ5   A0A3S8Z5K9   A0A0K0YGJ7   A0A1X9Q889   U6BPE0   A0A2U9EW62   A0A3G3NHG3   A0A286R3Q0   A0A0U1YFC9   A0A482F7H5   X5C414   A0A5B8YSJ0   L0HAG1   A0A0U1YFA6   A0A4Y6ACU9   A0A1L2KGB6   A0A3S8TLN4   A0A0N7EJQ5   A0A5J6DDR7   A0A0U2C7N6   M4PKF6  

KEGG

vg:11266520     vg:30522873    

GO

GO:0016021  C:integral component of membrane
GO:0019031  C:viral envelope
GO:0044662  P:disruption by virus of host cell membrane
GO:0046760  P:viral budding from Golgi membrane
GO:0044178  C:host cell Golgi membrane

From MSLVP

Host nucleus. Host cytoplasm.

From Uniprot

Host Golgi apparatus membrane   The cytoplasmic tail functions as a Golgi complex-targeting signal.   With evidence from 1 publications.

Length:

75

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

22.43367

Exp number, first 60 AAs:

22.43354

Total prob of N-in:

0.02250

POSSIBLE N-term signal

sequence

outside

1  -  9

TMhelix

10  -  32

inside

33  -  75

 

 

Pi

0.2322802

Theta

0.3715951

Tajima's D

-1.1775781

CLR

13.212302

Interpretation

No evidence of Selection