Strain

CHINA_MURINE_2015_NC_035191 (Region: China;  Strain: Wencheng Sm shrew coronavirus isolate Xingguo-101 ORF1ab polyprotein, spike glycoprotein, envelope protein, membrane protein, and nucleocapsid protein genes, complete cds.;  Date: 2015)

Gene

nucleocapsid protein

Description

Annotated in NCBI,  nucleocapsid protein

Location

NC_035191(+):24239-25339

GenBank Accession

YP_009389428.1

Full name

Nucleoprotein      

Alternative Name

Nucleocapsid protein

CDS

ATGTCTGCCGAAAAAGTAAGCTGGAGCAGTAGTCTCCCTACTAAGGCTGATACTAAAAATGGATCTAAGGTAGAAGTTGAATTGTCTGCATGGGACCCAATAATTATACAGAATAATAAAAATATTCAAGATGTTTTGCCCAGGACTTCAGTTCCAAAAGGATTGCCGTCTGGACATGAAATTGGCTATTGGTACAAAGGACCTGAAAGATACCGCTTTACTAGGGGTGAAAAAGTGCCTCTAGATCCTAAATGGTATTTTTATCCTTTAGGCCATGGACCTGCTGCTAATAAAAAATGGAATTCTAAAGTAGAAGGTGTATTCTGGGTTGCAAGAGATGGAGCATCCATTGAAAAAGTTCCAGATTTTGAACCAAGAAAGAAAGGTGCCGAAGCAAAGCGTGTGCGTTTGCCTGGAAAAGCCCCTGCTAATGTGTATTTCACTACTACCTCTGCCTCAAGAAGTCAGAGTAGAGATAATTCAAGGGCTGCAAGCAGAAGTGGGAGTAAGAGTCGGATTCAATCTAGATCTCCTTCTGCTGAGCGAGGCCACGTAGATATAAAGCTAGCTGTACTTGAAGCTCTCAAGGATCTTGGCATTGGTCAAGATACTAAGAAGAAGAGTTCAAAAAGTGCTGCTGCTTCTGGTAATAATACACCAAAGCAAGAAAGCTCTCCAAAAGTTCAACGTAAGCAAATAGAACGGCTCAGACACAAAAGAGTGCCCACTGGTAAAGAAAATATTACAGTTTGTTTTGGACCAAGAGGACCAGAACAAAATTTTGGTAGTGATGAAATAGTAAATGGTGGGGCACAAGGAAAGAAAGTGGCTCAATTGCTTGAAAATGTTCCAGGTCCTTCTGCCCTCCTTTTTGGAGGAAAAGTAGAACAAATTGGAAAAGCCAATGGAAAAGTTGCTGTTCAGTACACTTATGTGGCTGAGTTGGATGATAATGAAGAGGTGAAAAGGTTTTTAGATCTGATTGATGCATATAAAAAACCAACGACTGCAAATTCAATTAATTCTGTGTTGAATCCTCAAGCTACTGCTTTTGCACCACCTAGTGGAGTAATTGAAGAGCTTCAGGATGACCTTAATTAA

Protein

MSAEKVSWSSSLPTKADTKNGSKVEVELSAWDPIIIQNNKNIQDVLPRTSVPKGLPSGHEIGYWYKGPERYRFTRGEKVPLDPKWYFYPLGHGPAANKKWNSKVEGVFWVARDGASIEKVPDFEPRKKGAEAKRVRLPGKAPANVYFTTTSASRSQSRDNSRAASRSGSKSRIQSRSPSAERGHVDIKLAVLEALKDLGIGQDTKKKSSKSAAASGNNTPKQESSPKVQRKQIERLRHKRVPTGKENITVCFGPRGPEQNFGSDEIVNGGAQGKKVAQLLENVPGPSALLFGGKVEQIGKANGKVAVQYTYVAELDDNEEVKRFLDLIDAYKKPTTANSINSVLNPQATAFAPPSGVIEELQDDLN

Function

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.

Subunit

Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.

Miscellaneous

Bat coronavirus 512/2005 is highly similar to porcine epidemic diarrhea virus (PEDV).

Similarity

Belongs to the alphacoronavirus nucleocapsid protein family.

Keywords

ADP-ribosylation   Host Golgi apparatus   Phosphoprotein   Reference proteome   Ribonucleoprotein   RNA-binding   Transcription   Transcription regulation   Viral nucleoprotein   Virion  

Feature

chain  Nucleoprotein

Uniprot

A0A240FW20   A0A240FW15   A0A240FW34   A0A240FW29   A0A240FW43   A0A240FW57   + More
A0A240FW53   A0A482JZN4   A0A0U1WHF4   K4K2Q3   A0A4Y5QL74   K4KCK5   K4K1V4   A0A0U1UZD2   K4JZT7   K4KCN8   K4K203   F1DAY0   K4K2W1   A0A482JX97   A0A482K014   A0A4Y6GNF9   A0A3G3NH92   A0A4Y6GL32   A0A4Y6GL31   Q0Q462   A0A4Y6GNG7   A0A3G3NHI7   A0A3G3NGV1   A0A3G3NGN9   A0A3G3NGH7   A0A3G3NHJ5   A0A3G3NGJ4   A0A3G3NGR8   A0A3G3NGW5   A0A3G3NGJ1   A0A1X9JRR1   A0A3G3NHM0   A0A3G3NGY6   A0A3G3NHH2   A0A3G3NGS4   A0A3G3NGS1   A0A219TUM0   A0A3G3NGQ8   A0A3G3NGP5   A0A3G3NHI8   A0A3G3NGR2   A0A3G3NGV8   A0A3G3NH65   Q8JVR2   A0A2H4MWX9   A0A1L7HJ39   A0A2H4MZ50   A0A493R5F6   A0A2H4MX13   A0A2R3NG38   A0A2P1G6H8   A0A4Y5WWA6   A0A2P1G6J5   A0A0U1WHF9   I1VWF9   A0A5B9Y683   A0A3G1II26   A0A2P1G739   A0A410N738   Q88515   A0A2P1G6K4   A0A2S1WCF9   A0A2D1BNM3   A0A384VGQ5   A0A0K1RLP0   A0A0U2GR32   A0A1C8YZ39   A0A0U2GMT2   A0A384RBS7   A0A0U2GRD7   A0A1C8YZ17   A0A0P0KBE2   Q1HVN9   A0A2P1G6P9   A0A0U2GN51   A0A0U2GMD8   A0A384R2K5   A0A0U2GNG7   A0A1B1IJL4   C8CAL5   A0A0U2GMI4   C8CAL4   C8CAL6  

Pubmed

28637760    22933277    31067830    19239771    22561208    16840328    + More
28549438    8839428    30285857    25463600    30704076    29618817    31207129    31419711    28654418    30171801    30103259    8546012    29704627    26250391    26678874    27528677    26378164    16603522    20414714   

EMBL

KY967717    ASF90453.1    KY967715    ASF90447.1    KY967724    ASF90468.1    + More
KY967723    ASF90463.1    KY967725    KY967726    ASF90473.1    ASF90478.1    KY967734    ASF90494.1    KY967733    KY967735    ASF90489.1    ASF90499.1    MG916904    QBP43296.1    KJ473807    AIA62256.1    JQ989268    AFU92090.1    MK720945    MK720946    QCX35174.1    QCX35185.1    JQ989266    AFU92074.1    JQ989267    AFU92082.1    KJ473810    AIA62275.1    JQ989270    AFU92108.1    JQ989269    AFU92099.1    JQ989271    AFU92117.1    HQ728480    ADX59455.1    JQ989272    JQ989273    AFU92126.1    AFU92135.1    MG916902    QBP43274.1    MG916903    QBP43285.1    MK211369    QDF43793.1    MH687963    MH687964    MH687967    AYR18571.1    AYR18577.1    AYR18595.1    MK211372    QDF43808.1    MK211370    QDF43798.1    DQ648858    MK211371    QDF43803.1    MH687938    AYR18428.1    MH687960    MH687961    AYR18553.1    AYR18559.1    MH687946    AYR18477.1    MH687937    AYR18422.1    MH687955    AYR18523.1    MH687943    AYR18459.1    MH687958    AYR18541.1    MH687941    AYR18446.1    MH687945    AYR18471.1    KX964649    AQW43028.1    MH687965    AYR18583.1    MH687948    AYR18485.1    MH687934    AYR18404.1    MH687954    AYR18517.1    MH687956    AYR18529.1    KT346372    ANV78634.1    MH687950    MH687951    AYR18497.1    AYR18503.1    MH687952    AYR18509.1    MH687936    MH687939    AYR18416.1    AYR18434.1    MH687940    AYR18440.1    MH687959    AYR18547.1    MH687935    MH687949    MH687962    AYR18410.1    AYR18491.1    AYR18565.1    AB086902    BAC01157.1    KY370045    ATP66741.1    KF294380    APU57648.1    KY370054    ATP66792.1    MK249068    QBG64642.1    KY370050    ATP66770.1    MF094702    AVM80791.1    MF094686    AVM80488.1    MK651076    QDE12101.1    MF094687    AVM80496.1    KJ473808    AIA62263.1    JQ410000    AFI49435.1    MK977618    QEH62673.1    MF167434    ASK51721.1    MG557844    MF094681    MF094682    MF094683    MF094684    MF769416    MF769417    MF769418    MF769419    MF769420    MF769421    MF769422    MF769423    MF769424    MF769425    MF769426    MF769427    MF769428    MF769429    MF769430    MF769431    MF769432    MF769433    MF769434    MF769435    MF769436    MF769437    MF769438    MF769439    MF769440    MF769441    MF769442    MF769443    MF769444    MH615810    MG605087    MG605088    MG605089    MG605090    MG605091    MG775251    MG775253    AVM41574.1    AVM80443.1    AVM80452.1    AVM80461.1    AVM80470.1    AVM80528.1    AVM80537.1    AVM80546.1    AVM80555.1    AVM80564.1    AVM80573.1    AVM80582.1    AVM80591.1    AVM80600.1    AVM80609.1    AVM80618.1    AVM80627.1    AVM80636.1    AVM80645.1    AVM80654.1    AVM80663.1    AVM80672.1    AVM80681.1    AVM80690.1    AVM80699.1    AVM80708.1    AVM80717.1    AVM80726.1    AVM80735.1    AVM80744.1    AVM80753.1    AVM80762.1    AVM80771.1    AVM80780.1    AXP98443.1    AXY04078.1    AXY04079.1    AXY04080.1    AXY04087.1    AXY04096.1    MH539766    MH697599    QAS69032.1    QBP43304.1    Z35758    CAA84811.1    MF094688    AVM80504.1    MG742313    AWJ64267.1    MF370205    ATN23893.1    KX900411    ASV64443.1    KR270796    AKV62760.1    KT368892    KT368893    KT368894    ALA50092.1    ALA50099.1    ALA50106.1    KT253327    AOI28287.1    KT368900    KT368904    KT368905    KT368908    KT368916    ALA50148.1    ALA50176.1    ALA50183.1    ALA50204.1    ALA50260.1    KM055518    AIW52715.1    KT368911    ALA50225.1    KT253325    KT253326    AOI28271.1    AOI28279.1    KT253270    ALK28785.1    DQ243950    ABB90493.1    MF094685    AVM80479.1    KT368895    KT368896    KT368897    KT368902    KT368906    KT368909    KT368910    KT368913    KT368914    MF593473    ALA50113.1    ALA50120.1    ALA50127.1    ALA50162.1    ALA50190.1    ALA50211.1    ALA50218.1    ALA50239.1    ALA50246.1    ATI09441.1    KT368898    KT368899    ALA50134.1    ALA50141.1    KM055516    AIW52713.1    KT368915    ALA50253.1    KU500159    ANR94930.1    GQ374556    GQ374560    GQ374563    GQ374564    ACU56723.1    ACU56727.1    ACU56730.1    ACU56731.1    KT368901    ALA50155.1    GQ374555    ACU56722.1    GQ374557    GQ374561    GQ374562    ACU56724.1    ACU56728.1    ACU56729.1   

Proteomes

UP000202100    UP000106394    UP000123997    UP000126615    UP000132096    UP000144177    + More
UP000155419    UP000119818    UP000162430    UP000112496    UP000126962    UP000113079    UP000203395    UP000204448    UP000104963    UP000146121    UP000129150    UP000108758    UP000110675    UP000115399    UP000103248    UP000104585    UP000120649    UP000136940    UP000152663    UP000100137    UP000122373    UP000101679    UP000115199    UP000124352    UP000128900    UP000147133    UP000152773    UP000169049    UP000171347    UP000173795    UP000116691    UP000136947    UP000153625    UP000173458   

PRIDE

Q0Q462   

Pfam

PF00937   Corona_nucleoca

Interpro

IPR037179   Nucleocapsid_C
IPR037195   Nucleocapsid_N
IPR001218   Corona_nucleocap
IPR042548   ALPHA_CORONA_NCAP

SUPFAM

SSF103068   SSF103068
SSF110304   SSF110304

ProteinModelPortal

A0A240FW20   A0A240FW15   A0A240FW34   A0A240FW29   A0A240FW43   A0A240FW57   + More
A0A240FW53   A0A482JZN4   A0A0U1WHF4   K4K2Q3   A0A4Y5QL74   K4KCK5   K4K1V4   A0A0U1UZD2   K4JZT7   K4KCN8   K4K203   F1DAY0   K4K2W1   A0A482JX97   A0A482K014   A0A4Y6GNF9   A0A3G3NH92   A0A4Y6GL32   A0A4Y6GL31   Q0Q462   A0A4Y6GNG7   A0A3G3NHI7   A0A3G3NGV1   A0A3G3NGN9   A0A3G3NGH7   A0A3G3NHJ5   A0A3G3NGJ4   A0A3G3NGR8   A0A3G3NGW5   A0A3G3NGJ1   A0A1X9JRR1   A0A3G3NHM0   A0A3G3NGY6   A0A3G3NHH2   A0A3G3NGS4   A0A3G3NGS1   A0A219TUM0   A0A3G3NGQ8   A0A3G3NGP5   A0A3G3NHI8   A0A3G3NGR2   A0A3G3NGV8   A0A3G3NH65   Q8JVR2   A0A2H4MWX9   A0A1L7HJ39   A0A2H4MZ50   A0A493R5F6   A0A2H4MX13   A0A2R3NG38   A0A2P1G6H8   A0A4Y5WWA6   A0A2P1G6J5   A0A0U1WHF9   I1VWF9   A0A5B9Y683   A0A3G1II26   A0A2P1G739   A0A410N738   Q88515   A0A2P1G6K4   A0A2S1WCF9   A0A2D1BNM3   A0A384VGQ5   A0A0K1RLP0   A0A0U2GR32   A0A1C8YZ39   A0A0U2GMT2   A0A384RBS7   A0A0U2GRD7   A0A1C8YZ17   A0A0P0KBE2   Q1HVN9   A0A2P1G6P9   A0A0U2GN51   A0A0U2GMD8   A0A384R2K5   A0A0U2GNG7   A0A1B1IJL4   C8CAL5   A0A0U2GMI4   C8CAL4   C8CAL6  

PDB

5EPW     E-value=1.93557e-11,     Score=166