Strain

UK_HS_2012_NC_038294 (Region: UK;  Strain: Betacoronavirus England 1, complete genome.;  Date: 2012)

Gene

S protein

Description

Annotated in NCBI,  S protein

Location

NC_038294(+):21455-25516

GenBank Accession

YP_007188579.1

Full name

Spike glycoprotein      

Alternative Name

E2
Peplomer protein

CDS

ATGATACACTCAGTGTTTCTACTGATGTTCTTGTTAACACCTACAGAAAGTTACGTTGATGTAGGGCCAGATTCTGTTAAGTCTGCTTGTATTGAGGTTGATATACAACAGACTTTCTTTGATAAAACTTGGCCTAGGCCAATTGATGTTTCTAAGGCTGACGGTATTATATACCCTCAAGGCCGTACATATTCTAACATAACTATCACTTATCAAGGTCTTTTTCCCTATCAGGGAGACCATGGTGATATGTATGTTTACTCTGCAGGACATGCTACAGGCACAACTCCACAAAAGTTGTTTGTAGCTAACTATTCTCAGGACGTCAAACAGTTTGCTAATGGGTTTGTCGTCCGTATAGGAGCAGCTGCCAATTCCACTGGCACTGTTATTATTAGCCCATCTACCAGCGCTACTATACGAAAAATTTACCCTGCTTTTATGCTGGGTTCTTCAGTTGGTAATTTCTCAGATGGTAAAATGGGCCGCTTCTTCAATCATACTCTAGTTCTTTTGCCCGATGGATGTGGCACTTTACTTAGAGCTTTTTATTGTATTCTAGAGCCTCGCTCTGGAAATCATTGTCCTGCTGGCAATTCCTATACTTCTTTTGCCACTTATCACACTCCTGCAACAGATTGTTCTGATGGCAATTACAATCGTAATGCCAGTCTGAACTCTTTTAAGGAGTATTTTAATTTACGTAACTGCACCTTTATGTACACTTATAACATTACCGAAGATGAGATTTTAGAGTGGTTTGGCATTACACAAACTGCTCAAGGTGTTCACCTCTTCTCATCTCGGTATGTTGATTTGTACGGCGGCAATATGTTTCAATTTGCCACCTTGCCTGTTTATGATACTATTAAGTATTATTCTATCATTCCTCACAGTATTCGTTCTATCCAAAGTGATAGAAAAGCTTGGGCTGCCTTCTACGTATATAAACTTCAACCGTTAACTTTCCTGTTGGATTTTTCTGTTGATGGTTATATACGCAGAGCTATAGACTGTGGTTTTAATGATTTGTCACAACTCCACTGCTCATATGAATCCTTCGATGTTGAATCTGGAGTTTATTCAGTTTCGTCTTTCGAAGCAAAACCTTCTGGCTCAGTTGTGGAACAGGCTGAAGGTGTTGAATGTGATTTTTCACCTCTTCTGTCTGGCACACCTCCTCAGGTTTATAATTTCAAGCGTTTGGTTTTTACCAATTGCAATTATAATCTTACCAAATTGCTTTCACTTTTTTCTGTGAATGATTTTACTTGTAGTCAAATATCTCCAGCAGCAATTGCTAGTAACTGTTATTCTTCACTGATTTTGGATTATTTTTCATACCCACTTAGTATGAAATCCGATCTCAGTGTTAGTTCTGCTGGTCCAATATCCCAGTTTAATTATAAACAGTCCTTTTCTAATCCCACATGTTTGATTTTAGCGACTGTTCCTCATAACCTTACTACTATTACTAAGCCTCTTAAGTACAGCTATATTAACAAGTGCTCTCGTTTTCTTTCTGATGATCGTACTGAAGTACCTCAGTTAGTGAACGCTAATCAATACTCACCCTGTGTATCCATTGTCCCATCCACTGTGTGGGAAGACGGTGATTATTATAGGAAACAACTATCTCCACTTGAAGGTGGTGGCTGGCTTGTTGCTAGTGGCTCAACTGTTGCCATGACTGAGCAATTACAGATGGGCTTTGGTATTACAGTTCAATATGGTACAGACACCAATAGTGTTTGCCCCAAGCTTGAATTTGCTAATGACACAAAAATTGCCTCTCAATTAGGCAATTGCGTGGAATATTCCCTCTATGGTGTTTCGGGCCGTGGTGTTTTTCAGAATTGCACAGCTGTAGGTGTTCGACAGCAGCGCTTTGTTTATGATGCGTACCAGAATTTAGTTGGCTATTATTCTGATGATGGCAACTACTACTGTTTGCGTGCTTGTGTTAGTGTTCCTGTTTCTGTCATCTATGATAAAGAAACTAAAACCCACGCTACTCTATTTGGTAGTGTTGCATGTGAACACATTTCCTCTACCATGTCTCAATACTCCCGTTCTACGCGATCAATGCTTAAACGGCGAGATTCTACATATGGCCCCCTTCAGACACCTGTTGGTTGTGTCCTAGGACTTGTTAATTCCTCTTTGTTCGTAGAGGACTGCAAGTTGCCTCTTGGTCAATCTCTCTGTGCTCTTCCTGACACACCTAGTACTCTCACACCTCGCAGTGTGCGCTCTGTTCCAGGTGAAATGCGCTTGGCATCCATTGCTTTTAATCATCCTATTCAGGTTGATCAACTTAATAGTAGTTATTTTAAATTAAGTATACCCACTAATTTTTCCTTTGGTGTGACTCAGGAGTACATTCAGACAACCATTCAGAAAGTTACTGTTGATTGTAAACAGTACGTTTGCAATGGTTTCCAGAAGTGTGAGCAATTACTGCGCGAGTATGGCCAGTTTTGTTCCAAAATAAACCAGGCTCTCCATGGTGCCAATTTACGCCAGGATGATTCTGTACGTAATTTGTTTGCGAGCGTGAAAAGCTCTCAATCATCTCCTATCATACCAGGTTTTGGAGGTGACTTTAATTTGACACTTCTAGAACCTGTTTCTATATCTACTGGCAGTCGTAGTGCACGTAGTGCTATTGAGGATTTGCTATTTGACAAAGTCACTATAGCTGATCCTGGTTATATGCAAGGTTACGATGATTGCATGCAGCAAGGTCCAGCATCAGCTCGTGATCTTATTTGTGCTCAATATGTGGCTGGTTACAAAGTATTACCTCCTCTTATGGATGTTAATATGGAAGCCGCGTATACCTCATCTTTGCTTGGCAGCATAGCAGGTGTTGGCTGGACTGCTGGCTTATCCTCCTTTGCTGCTATTCCATTTGCACAGAGTATCTTTTATAGGTTAAACGGTGTTGGCATTACTCAACAGGTTCTTTCAGAGAACCAAAAGCTTATTGCCAATAAGTTTAATCAGGCTCTGGGAGCTATGCAAACAGGCTTCACTACAACTAATGAAGCTTTTCACAAGGTTCAGGATGCTGTGAACAACAATGCACAGGCTCTATCCAAATTAGCTAGCGAGCTATCTAATACTTTTGGTGCTATTTCCGCCTCTATTGGAGACATCATACAACGTCTTGATGTTCTCGAACAGGACGCCCAAATAGACAGACTTATTAATGGCCGTTTGACAACACTAAATGCTTTTGTTGCACAGCAGCTTGTTCGTTCCGAATCAGCTGCTCTTTCGGCTCAATTGGCTAAAGATAAAGTCAATGAGTGTGTCAAGGCACAATCCAAGCGTTCTGGATTTTGCGGTCAAGGCACACATATAGTGTCCTTTGTTGTAAATGCCCCTAATGGCCTTTACTTCATGCATGTTGGTTATTACCCTAGCAACCACATTGAGGTTGTTTCTGCTTATGGTCTTTGCGATGCAGCTAACCCTACTAATTGTATAGCCCCTGTTAATGGCTACTTTATTAAAACTAATAACACTAGGATTGTTGATGAGTGGTCATATACTGGCTCGTCCTTCTATGCACCTGAGCCCATCACCTCTCTTAATACTAAGTATGTTGCACCACAGGTGACATACCAAAACATTTCTACTAACCTCCCTCCTCCTCTTCTCGGCAATTCCACCGGGATTGACTTCCAAGATGAGTTGGATGAGTTTTTCAAAAATGTTAGCACCAGTATACCTAATTTTGGTTCTCTAACACAGATTAATACTACATTACTCGATCTTACCTACGAGATGTTGTCTCTTCAACAAGTTGTTAAAGCCCTTAATGAGTCTTACATAGACCTTAAAGAGCTTGGCAATTATACTTATTACAACAAATGGCCGTGGTACATTTGGCTTGGTTTCATTGCTGGGCTTGTTGCCTTAGCTCTATGCGTCTTCTTCATACTGTGCTGCACTGGTTGTGGCACAAACTGTATGGGAAAACTTAAGTGTAATCGTTGTTGTGATAGATACGAGGAATACGACCTCGAGCCGCATAAGGTTCATGTTCACTAA

Protein

MIHSVFLLMFLLTPTESYVDVGPDSVKSACIEVDIQQTFFDKTWPRPIDVSKADGIIYPQGRTYSNITITYQGLFPYQGDHGDMYVYSAGHATGTTPQKLFVANYSQDVKQFANGFVVRIGAAANSTGTVIISPSTSATIRKIYPAFMLGSSVGNFSDGKMGRFFNHTLVLLPDGCGTLLRAFYCILEPRSGNHCPAGNSYTSFATYHTPATDCSDGNYNRNASLNSFKEYFNLRNCTFMYTYNITEDEILEWFGITQTAQGVHLFSSRYVDLYGGNMFQFATLPVYDTIKYYSIIPHSIRSIQSDRKAWAAFYVYKLQPLTFLLDFSVDGYIRRAIDCGFNDLSQLHCSYESFDVESGVYSVSSFEAKPSGSVVEQAEGVECDFSPLLSGTPPQVYNFKRLVFTNCNYNLTKLLSLFSVNDFTCSQISPAAIASNCYSSLILDYFSYPLSMKSDLSVSSAGPISQFNYKQSFSNPTCLILATVPHNLTTITKPLKYSYINKCSRFLSDDRTEVPQLVNANQYSPCVSIVPSTVWEDGDYYRKQLSPLEGGGWLVASGSTVAMTEQLQMGFGITVQYGTDTNSVCPKLEFANDTKIASQLGNCVEYSLYGVSGRGVFQNCTAVGVRQQRFVYDAYQNLVGYYSDDGNYYCLRACVSVPVSVIYDKETKTHATLFGSVACEHISSTMSQYSRSTRSMLKRRDSTYGPLQTPVGCVLGLVNSSLFVEDCKLPLGQSLCALPDTPSTLTPRSVRSVPGEMRLASIAFNHPIQVDQLNSSYFKLSIPTNFSFGVTQEYIQTTIQKVTVDCKQYVCNGFQKCEQLLREYGQFCSKINQALHGANLRQDDSVRNLFASVKSSQSSPIIPGFGGDFNLTLLEPVSISTGSRSARSAIEDLLFDKVTIADPGYMQGYDDCMQQGPASARDLICAQYVAGYKVLPPLMDVNMEAAYTSSLLGSIAGVGWTAGLSSFAAIPFAQSIFYRLNGVGITQQVLSENQKLIANKFNQALGAMQTGFTTTNEAFHKVQDAVNNNAQALSKLASELSNTFGAISASIGDIIQRLDVLEQDAQIDRLINGRLTTLNAFVAQQLVRSESAALSAQLAKDKVNECVKAQSKRSGFCGQGTHIVSFVVNAPNGLYFMHVGYYPSNHIEVVSAYGLCDAANPTNCIAPVNGYFIKTNNTRIVDEWSYTGSSFYAPEPITSLNTKYVAPQVTYQNISTNLPPPLLGNSTGIDFQDELDEFFKNVSTSIPNFGSLTQINTTLLDLTYEMLSLQQVVKALNESYIDLKELGNYTYYNKWPWYIWLGFIAGLVALALCVFFILCCTGCGTNCMGKLKCNRCCDRYEEYDLEPHKVHVH

Function

Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.
Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.
Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Interacts with host DPP4 to mediate virla entry.
mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.

Subunit

Homotrimer; each monomer consists of a S1 and a S2 subunit. The resulting peplomers protrude from the virus surface as spikes.
Homotrimer; each monomer consists of a S1 and a S2 subunit. The resulting peplomers protrude from the virus surface as spikes. S1 interacts with murine DPP4.

Similarity

Belongs to the betacoronaviruses spike protein family.

Keywords

3D-structure   Coiled coil   Disulfide bond   Fusion of virus membrane with host endosomal membrane   Fusion of virus membrane with host membrane   Glycoprotein   Host cell membrane   Host membrane   Host-virus interaction   Lipoprotein   Membrane   Palmitate   Reference proteome   Signal   Transmembrane   Transmembrane helix   Viral attachment to host cell   Viral envelope protein   Viral penetration into host cytoplasm   Virion   Virulence   Virus entry into host cell  

Feature

chain  Spike protein S2

Uniprot

M1RNL5   K9N5Q8   W5ZZF5   R9UCW7   W6A8L9   A0A0U2GP35   + More
W5ZZM0   K0BRG7   A0A493R163   A0A024E0Q9   A0A291I6B7   A0A140AYZ5   A0A0U2GQI8   T2BAV6   W6A028   A0A2H1YPP7   A0A0U2P188   A0A1W5LGE4   A0A411PBL8   A0A291I635   A0A0U4AGH8   A0A0U2MGK9   T2B9T0   A0A0G2UN32   A0A2D0YXA8   A0A0U2HTD9   A0A2D0YPZ8   A0A0U2MS80   A0A023SFE5   A0A3T0I8D8   A0A0U2INY2   A0A0B5A1M3   A0A0R9USA1   A0A0U2J5U2   A0A0U2NY17   A0A384YDY2   W6A090   A0A291I632   A0A0A0Q4V1   A0A2D0Y7Z5   A0A0U2P155   A0A0U3SQE0   A0A2D0YCE0   A0A023VZC9   A0A2D0YCT4   A0A140AZ15   A0A126G7T9   A0A411PBD4   A0A384VXU1   A0A0P0HBE6   A0A0U2GKS5   A0A0A0Q7F3   A0A3B8DUP5   A0A023VZB8   A0A2D0YNS6   A0A0U2GL10   T2BBH7   A0A2D0YT69   A0A1C8EAZ2   A0A140AZ25   A0A2D0Y9L1   A0A1W5LGL0   A0A2D0Y305   A0A0H4JBS8   A0A0U2GPP3   R9UQ53   A0A0U2GP47   A0A1W5LGJ4   A0A0U2P9D9   A0A141BR51   A0A5J6EDL6   A0A2D0YKN0   A0A0P0GPV1   A0A0U2NE84   A0A0U2NY03   A0A0U2NVR1   A0A168DJZ9   A0A146AAQ5   A0A0U2GMX5   A0A291I6J3   A0A0U2MS90   A0A0A7E695   V9TWK2   A0A2H4KGM2   A0A0G3U597   A0A0U2NQQ0   A0A2H4GWK9   A0A0R7E3J6   A0A2D0YLD5   A0A2D0YPK3   A0A0S1TQ87   A0A0A0Q4T9   A0A4V1ES19   A0A2D0YGK8   T2BB24   A0A1W5LIC4   A0A384WFI4   A0A0A0Q7G4   A0A3B8DTZ0   A0A0U2GR08  

Pubmed

23693015    23078800    23486063    24857749    24549846    24896817    + More
31553909    23782859    26678874    23170002    26391698    30753126    25100864    25323704    26484549    26565003    26691200    26814649    26839489    26933050    24055451    24781747    26079346    26584223    26272560    26981770    27999424    29116217    25075761    31022948    25989145    29239118    30294617    23835475    24473083    26981708    26272558    31296843   

EMBL

KC667074    AGG22542.1    KC164505    KF917527    KF958702    KJ156949    + More
KJ156952    KJ556336    AHE78097.1    AHE78108.1    AHI48594.1    AHI48605.1    AHN10812.1    KF192507    AGN52936.1    KJ156881    AHI48550.1    KT368826    ALA49363.1    KJ156944    AHI48583.1    JX869059    AFS88936.1    MH978886    MH978887    QBF44113.1    QBF44114.1    KJ813439    KM027262    KM027278    KM027280    KM027282    KM027283    KM027287    KM027289    KM027290    KM027292    KT121572    KT121573    KT121574    KT121575    KT121576    KT121577    KT121580    KT357803    KT357804    KT357805    KT357806    KT357807    KT357808    KT357809    KT357812    AHZ58501.1    AID55073.1    AID55089.1    AID55091.1    AID55093.1    AID55094.1    AID55098.1    AID55100.1    AID55101.1    AID55103.1    AKN24749.1    AKN24758.1    AKN24767.1    AKN24776.1    AKN24785.1    AKN24794.1    AKN24821.1    AMW90845.1    AMW90846.1    AMW90847.1    AMW90848.1    AMW90849.1    AMW90850.1    AMW90851.1    AMW90854.1    MG011354    ATG84833.1    KT182954    KT182955    KT326819    KT374052    KT374053    KT374054    KT374055    KT868865    KT868866    KT868867    KT868868    KT868869    KT868873    KT868874    KU308549    KX034096    KX034098    KX034099    KX034100    AKN11072.1    AKN11073.1    AKS48062.1    ALB08267.1    ALB08278.1    ALB08289.1    ALB08300.1    ALK80192.1    ALK80202.1    ALK80212.1    ALK80222.1    ALK80232.1    ALK80271.1    ALK80281.1    AML60270.1    ANC28667.1    ANC28689.1    ANC28700.1    ANC28711.1    KT368869    KT368875    KT368879    MH259485    ALA49836.1    ALA49902.1    ALA49946.1    QCI31469.1    KF600613    AGV08390.1    KJ156934    KJ156873    KJ713295    KJ713296    KM015348    KM027281    KM210278    KP966104    KT006149    KT026453    KT026454    KT026455    KT026456    KT036372    KT036373    KT036374    KT182953    KT275306    KT275307    KT275308    KT368833    KT368868    KT368870    KT368871    KT368872    KT368873    KT368874    KT368876    KT368877    KT368878    KT368882    KT368883    KT368884    KT368885    KT368886    KT368889    KT805964    KT805965    KT805967    KT805969    KT805974    KT805977    KT805979    KT805980    KT805982    KT805984    KT805989    KT805990    KT805993    KT805996    KT806002    KT806005    KT806007    KT806009    KT806012    KT806014    KT806018    KT806019    KT806023    KT806024    KT806025    KT806026    KT806027    KT806029    KT806030    KT806031    KT806033    KT806034    KT806035    KT806039    KT868870    KU233362    KU233363    KU233364    KT806044    KT806045    KT806046    KT806047    KT806048    KT806050    KT806051    KT806052    KT806053    KU851859    KU851860    KU851861    KU851862    KU851863    KU851864    KX154684    KX108945    KY688118    KY688120    KY688121    KY688122    KY688123    KY688124    MF598594    MF598595    MF598603    MF598604    MF598606    MF598607    MF598611    MF598612    MF598613    MF598615    MF598620    MF598625    MF598627    MF598628    MF598633    MF598643    MF598644    MF598645    MF598646    MF598652    MF598654    MF598657    MF598660    MF598661    MF598662    MF598664    MF598665    MF598666    MF598668    MF598670    MF598677    MF598680    MF598682    MF598684    MF598685    MF598686    MF598687    MF598688    MF598691    MF598692    MF598694    MF598695    MF598697    MF598698    MF598701    MF741837    MF741825    MF741826    MF741828    MF741829    MF741831    MF741833    MF741834    MF741835    MF741836    MG011343    MG011352    MG011353    MG011355    MF679172    MG366880    MG912608    MH306207    MH371127    MH432120    MG757593    MG757594    MG757595    MG757596    MG757598    MG757599    MG757600    MG757601    MG757602    MG757603    MH029552    MK129253    MH978888    MK462248    MH259486    MK858156    MK858158    MK858163    AHI48572.1    AHI48662.1    AHY22525.1    AHY22535.1    AID50418.1    AID55092.1    AJD81451.1    AKA63509.1    AKJ80137.2    AKK52582.1    AKK52592.1    AKK52602.1    AKK52612.1    AKL80593.1    AKL80604.1    AKL80615.1    AKN11071.1    AKQ21055.1    AKQ21064.1    AKQ21073.1    ALA49440.1    ALA49825.1    ALA49847.1    ALA49858.1    ALA49869.1    ALA49880.1    ALA49891.1    ALA49913.1    ALA49924.1    ALA49935.1    ALA49979.1    ALA49990.1    ALA50001.1    ALA50012.1    ALA50023.1    ALA50056.1    ALJ54444.1    ALJ54445.1    ALJ54447.1    ALJ54449.1    ALJ54454.1    ALJ54457.1    ALJ54459.1    ALJ54460.1    ALJ54462.1    ALJ54464.1    ALJ54469.1    ALJ54470.1    ALJ54473.1    ALJ54476.1    ALJ54482.1    ALJ54485.1    ALJ54487.1    ALJ54489.1    ALJ54492.1    ALJ54494.1    ALJ54498.1    ALJ54499.1    ALJ54503.1    ALJ54504.1    ALJ54505.1    ALJ54506.1    ALJ54507.1    ALJ54509.1    ALJ54510.1    ALJ54511.1    ALJ54513.1    ALJ54514.1    ALJ54515.1    ALJ54519.1    ALK80242.1    ALT66802.1    ALT66813.1    ALT66824.1    ALW82636.1    ALW82647.1    ALW82658.1    ALW82669.1    ALW82680.1    ALW82702.1    ALW82709.1    ALW82720.1    ALW82731.1    AMQ49015.1    AMQ49026.1    AMQ49037.1    AMQ49048.1    AMQ49059.1    AMQ49070.1    ANF29162.1    ANI69911.1    AQZ41311.1    AQZ41332.1    AQZ41343.1    AQZ41354.1    AQZ41365.1    AQZ41376.1    ASU89921.1    ASU89933.1    ASU90021.1    ASU90032.1    ASU90054.1    ASU90065.1    ASU90109.1    ASU90120.1    ASU90131.1    ASU90153.1    ASU90208.1    ASU90263.1    ASU90285.1    ASU90295.1    ASU90351.1    ASU90461.1    ASU90472.1    ASU90483.1    ASU90494.1    ASU90560.1    ASU90582.1    ASU90615.1    ASU90648.1    ASU90659.1    ASU90670.1    ASU90692.1    ASU90703.1    ASU90714.1    ASU90736.1    ASU90758.1    ASU90835.1    ASU90868.1    ASU90890.1    ASU90912.1    ASU90923.1    ASU90934.1    ASU90945.1    ASU90956.1    ASU90988.1    ASU90999.1    ASU91021.1    ASU91032.1    ASU91054.1    ASU91065.1    ASU91098.1    ASY99778.1    ASY99789.1    ASY99800.1    ASY99820.1    ASY99831.1    ASY99853.1    ASY99873.1    ASY99884.1    ASY99895.1    ASY99906.1    ATG84712.1    ATG84811.1    ATG84822.1    ATG84844.1    ATW75478.1    ATY74381.1    AVK87461.1    AWM99582.1    AXG21643.1    AXG21665.1    AXN73393.1    AXN73404.1    AXN73415.1    AXN73426.1    AXN73448.1    AXN73459.1    AXN73470.1    AXN73481.1    AXN73492.1    AXN73503.1    AYO86699.1    AZK15900.1    QBF44115.1    QBF80510.1    QCI31480.1    QCQ28828.1    QCQ28830.1    QCQ28835.1    MF598597    ASU89955.1    KT806021    ALJ54501.1    KX154687    ANF29195.1    MK462253    MK462254    MK462255    QBF80565.1    QBF80576.1    QBF80587.1    MG011347    MK858164    ATG84756.1    QCQ28836.1    KT806049    ALW82691.1    KT806032    ALJ54512.1    KF600652    KT806040    AGV08584.1    ALJ54520.1    KR011263    KR011264    KR011265    KR011266    KT805961    KT805962    KT805963    AKI29255.1    AKI29265.1    AKI29275.1    AKI29284.1    ALJ54441.1    ALJ54442.1    ALJ54443.1    MF598648    MF598667    MF598696    ASU90516.1    ASU90725.1    ASU91043.1    KT805968    KT805985    KT805986    ALJ54448.1    ALJ54465.1    ALJ54466.1    MF598632    ASU90340.1    KT805987    ALJ54467.1    KJ650098    AHX71946.1    MK280984    AZU90731.1    KT806041    ALJ54521.1    KM210277    AJD81440.1    KT225476    ALD51904.1    KT806038    ALJ54518.1    KT806036    ALJ54516.1    MG912607    AVK87450.1    KJ156876    KU242423    KU242424    MF598663    AHI48672.1    ALT66870.1    ALT66880.1    ASU90681.1    MG011348    MG011349    MG011350    ATG84767.1    ATG84778.1    ATG84789.1    KM027277    KT357802    AID55088.1    AMW90844.1    MF598619    MF598621    MF598624    MF598672    MF598675    ASU90197.1    ASU90219.1    ASU90252.1    ASU90780.1    ASU90813.1    KT805973    ALJ54453.1    KT806054    ALW82742.1    MF598631    ASU90329.1    KJ713298    AHY22555.1    MF598641    ASU90439.1    KT868872    KT868876    ALK80261.1    ALK80301.1    KT374050    KT374051    ALB08246.1    ALB08257.1    MK462243    MK462244    MK462245    QBF80455.1    QBF80466.1    QBF80477.1    MF741827    MF741832    ASY99811.1    ASY99864.1    KT368828    KT368843    KT368844    KT368845    KT368849    KT368850    KT368851    KT368855    KT368887    KT368888    KT805995    KT805997    KT805998    KT805999    KT806000    KT806013    KR912189    KR912190    KR912191    KR912192    KR912193    KR912194    KT877351    ALA49385.1    ALA49550.1    ALA49561.1    ALA49572.1    ALA49616.1    ALA49627.1    ALA49638.1    ALA49682.1    ALA50034.1    ALA50045.1    ALJ54475.1    ALJ54477.1    ALJ54478.1    ALJ54479.1    ALJ54480.1    ALJ54493.1    ALJ76282.1    ALL26409.1    KT368825    KT805983    ALA49352.1    ALJ54463.1    KM027255    KM027256    KM027257    KM027258    KM027259    KM027260    KM027261    KM027263    KM027264    KM027265    KM027266    KM027267    KM027269    KM027270    KM027271    KM027272    KM027275    KM027291    KT861629    KT861630    KT861631    KT861633    KT861628    KY581693    MK052676    MK039552    MK039553    AID55066.1    AID55067.1    AID55068.1    AID55069.1    AID55070.1    AID55071.1    AID55072.1    AID55074.1    AID55075.1    AID55076.1    AID55077.1    AID55078.1    AID55080.1    AID55081.1    AID55082.1    AID55083.1    AID55086.1    AID55102.1    ALX27225.1    ALX27226.1    ALX27227.1    ALX27229.1    ALX27243.1    ASU45796.1    AYP10298.1    AYV64549.1    AYV64560.1    MG520075    MG520076    MG546331    AXN73370.1    AYJ71481.1    KJ713297    AHY22545.1    MF598602    ASU90010.1    KT368834    ALA49451.1    KF600630    AGV08467.1    MF598693    ASU91010.1    KT877350    ALL26396.1    KT868877    ALK80311.1    MF598649    ASU90527.1    KX154691    ANF29239.1    MF598617    ASU90175.1    KP405225    KP405227    KT805988    MF598616    MG011341    MH822886    MK462250    AKO69634.1    AKO69636.1    ALJ54468.1    ASU90164.1    ATG84690.1    AYM48030.1    QBF80532.1    KT368829    KT368830    KT368831    KT368832    ALA49396.1    ALA49407.1    ALA49418.1    ALA49429.1    KF186564    KF186566    KF186567    KF186565    KF600623    KF600627    KF600632    KF600636    KF600644    KF600645    KF600647    KF600651    KJ156866    KJ156872    KJ156939    AGN70929.1    AGN70951.1    AGN70962.1    AGN70973.1    AGV08426.1    AGV08444.1    AGV08480.1    AGV08505.1    AGV08535.1    AGV08546.1    AGV08558.1    AGV08573.1    AHI48517.1    AHI48652.1    AHI48711.1    KT368827    KT368856    KT368857    ALA49374.1    ALA49693.1    ALA49704.1    KX154690    MG011345    MG011351    ANF29228.1    ATG84734.1    ATG84800.1    KT806008    KT806017    ALJ54488.1    ALJ54497.1    KT182956    KT182957    AKN11074.1    AKN11075.1    MN403101    QEU56411.1    MF598674    ASU90802.1    KR912187    ALJ76277.1    KT805994    ALJ54474.1    KT806020    ALJ54500.1    KT806011    ALJ54491.1    KX034093    ANC28634.1    KT357810    AMW90852.1    KT368880    KT368881    ALA49957.1    ALA49968.1    MG011361    MG011362    MK858159    ATG84910.1    ATG84921.1    QCQ28831.1    KT805978    KT806003    ALJ54458.1    ALJ54483.1    KP209306    KP209308    KP209309    KP209310    KP209311    KP209313    KY673147    KY581686    KY581688    KY581689    KY581690    KY581691    KY581692    KY581696    KY581697    KY581700    AIY60518.1    AIY60538.1    AIY60548.1    AIY60558.1    AIY60568.1    AIY60588.1    AQZ41283.1    ASU45719.1    ASU45741.1    ASU45752.1    ASU45763.1    ASU45774.1    ASU45785.1    ASU45829.1    ASU45840.1    ASU45873.1    KF961221    KF961222    AHC74088.1    AHC74098.1    KY673146    KY581684    KY581685    AQZ41282.1    ASU45696.1    ASU45708.1    KT029139    AKL59401.1    KT805966    ALJ54446.1    KY673149    AQZ41296.1    KT121581    AKN24830.1    MF598618    ASU90186.1    MF598622    ASU90230.1    KT003530    ALM26400.1    KM027274    AID55085.1    MK858157    QCQ28829.1    MF598608    MF598650    MF598700    ASU90076.1    ASU90538.1    ASU91087.1    KF600628    KJ156874    KJ156910    KJ156942    KJ156901    KP405226    AGV08455.1    AHI48539.1    AHI48561.1    AHI48626.1    AHI48682.1    AKO69635.1    KX154689    MG757604    ANF29217.1    AXN73514.1    MF741830    ASY99842.1    KM027288    AID55099.1    MG546330    AYJ71470.1    KT368890    ALA50067.1   

Proteomes

UP000160415    UP000139997    UP000119765    UP000120438    UP000135014    UP000148657    + More
UP000159930    UP000104220    UP000105272    UP000173448    UP000145741    UP000112279    UP000108030    UP000133615    UP000135429    UP000137346    UP000139800    UP000144938    UP000146144    UP000166310    UP000167575    UP000097149    UP000098933    UP000105311    UP000106595    UP000109122    UP000126763    UP000128076    UP000140611    UP000147342    UP000110836    UP000120697    UP000140819    UP000134122    UP000095864    UP000096875    UP000102966    UP000104540    UP000109666    UP000112022    UP000115322    UP000118563    UP000119223    UP000121965    UP000122049    UP000125198    UP000128184    UP000128186    UP000128651    UP000142239    UP000144056    UP000144472    UP000147538    UP000151795    UP000153269    UP000157492    UP000158935    UP000159306    UP000161565    UP000163035    UP000163895    UP000170921    UP000171516    UP000171892    UP000174054    UP000174558    UP000180347    UP000180348    UP000146591    UP000148810    UP000102098    UP000110604    UP000120083    UP000165587    UP000104075    UP000114773    UP000119183    UP000120625    UP000174530    UP000171389    UP000127946    UP000103178    UP000113724    UP000098431    UP000104003    UP000112676    UP000126955    UP000128936    UP000136645    UP000137287    UP000146604    UP000151733    UP000159793    UP000131256    UP000100765    UP000113762    UP000116785    UP000124216    UP000144709    UP000159190    UP000175153    UP000139500    UP000168352    UP000143263    UP000124793    UP000139687    UP000159414    UP000172503    UP000101567    UP000108647    UP000117251    UP000125629    UP000127508    UP000130711    UP000140498    UP000144449    UP000158466    UP000160534    UP000171868    UP000142730    UP000155319    UP000161712    UP000113143    UP000152659    UP000110817    UP000118636    UP000130850    UP000142709    UP000144516    UP000159028    UP000109767    UP000123963    UP000118772    UP000123861    UP000115754    UP000165701    UP000167295    UP000129301   

PRIDE

K9N5Q8   

Pfam

PF01601   Corona_S2
PF09408   Spike_rec_bind

Interpro

IPR027400   S_HR2
IPR018548   Spike_rcpt-bd
IPR002552   Corona_S2
IPR042578   BETA_CORONA_SPIKE
IPR036326   Spike_rcpt-bd_sf

SUPFAM

SSF143587   SSF143587

Gene 3D

1.20.5.790    

ProteinModelPortal

M1RNL5   K9N5Q8   W5ZZF5   R9UCW7   W6A8L9   A0A0U2GP35   + More
W5ZZM0   K0BRG7   A0A493R163   A0A024E0Q9   A0A291I6B7   A0A140AYZ5   A0A0U2GQI8   T2BAV6   W6A028   A0A2H1YPP7   A0A0U2P188   A0A1W5LGE4   A0A411PBL8   A0A291I635   A0A0U4AGH8   A0A0U2MGK9   T2B9T0   A0A0G2UN32   A0A2D0YXA8   A0A0U2HTD9   A0A2D0YPZ8   A0A0U2MS80   A0A023SFE5   A0A3T0I8D8   A0A0U2INY2   A0A0B5A1M3   A0A0R9USA1   A0A0U2J5U2   A0A0U2NY17   A0A384YDY2   W6A090   A0A291I632   A0A0A0Q4V1   A0A2D0Y7Z5   A0A0U2P155   A0A0U3SQE0   A0A2D0YCE0   A0A023VZC9   A0A2D0YCT4   A0A140AZ15   A0A126G7T9   A0A411PBD4   A0A384VXU1   A0A0P0HBE6   A0A0U2GKS5   A0A0A0Q7F3   A0A3B8DUP5   A0A023VZB8   A0A2D0YNS6   A0A0U2GL10   T2BBH7   A0A2D0YT69   A0A1C8EAZ2   A0A140AZ25   A0A2D0Y9L1   A0A1W5LGL0   A0A2D0Y305   A0A0H4JBS8   A0A0U2GPP3   R9UQ53   A0A0U2GP47   A0A1W5LGJ4   A0A0U2P9D9   A0A141BR51   A0A5J6EDL6   A0A2D0YKN0   A0A0P0GPV1   A0A0U2NE84   A0A0U2NY03   A0A0U2NVR1   A0A168DJZ9   A0A146AAQ5   A0A0U2GMX5   A0A291I6J3   A0A0U2MS90   A0A0A7E695   V9TWK2   A0A2H4KGM2   A0A0G3U597   A0A0U2NQQ0   A0A2H4GWK9   A0A0R7E3J6   A0A2D0YLD5   A0A2D0YPK3   A0A0S1TQ87   A0A0A0Q4T9   A0A4V1ES19   A0A2D0YGK8   T2BB24   A0A1W5LIC4   A0A384WFI4   A0A0A0Q7G4   A0A3B8DTZ0   A0A0U2GR08  

PDB

5W9P     E-value=0,     Score=6709