Strain

USA_AVIAN_2004_NC_001451 (Region: USA: Beaudette;  Strain: Avian infectious bronchitis virus, complete genome.;  Date: 2004)

Gene

small virion-associated protein

Description

Annotated in NCBI,  small virion-associated protein

Location

NC_001451(+):24207-24533

GenBank Accession

NP_040834.1

Full name

Envelope small membrane protein      

CDS

ATGAATTTATTGAATAAGTCGCTAGAGGAGAATGGAAGTTTTCTAACAGCGCTTTACATAATTGTAGGATTTTTAGCACTTTATCTTCTAGGTAGAGCACTTCAAGCATTTGTACAGGCTGCTGATGCTTGTTGTTTATTTTGGTATACATGGGTAGTAATTCCAGGAGCTAAGGGTACAGCCTTTGTATACAAGTATACATATGGTAGAAAACTTAACAATCCGGAATTAGAAGCAGTTATTGTTAACGAGTTTCCTAAGAACGGTTGGAATAATAAAAATCCAGCAAATTTTCAAGATGCCCAACGAGACAAATTGTACTCTTGA

Protein

MNLLNKSLEENGSFLTALYIIVGFLALYLLGRALQAFVQAADACCLFWYTWVVIPGAKGTAFVYKYTYGRKLNNPELEAVIVNEFPKNGWNNKNPANFQDAQRDKLYS

Function

Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.

Subunit

Homooligomer. Interacts with the M membrane protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. The cytoplasmic tails of both proteins are important for this function. Interacts with Nucleoprotein.

Similarity

Belongs to the gammacoronaviruses E protein family.

Keywords

Apoptosis   Host Golgi apparatus   Host membrane   Membrane   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Envelope small membrane protein

Uniprot

Q76V92   P05139   Q778S3   Q89894   Q80RZ0   Q5MNY9   + More
Q4ZJT9   A0A0K1RN43   Q6DV52   Q66VA3   E5D0A3   A0A4D6NY96   G0ZGK4   C7S862   Q9J3Q0   A0A346M360   Q9J3P4   Q9J3Q6   Q9J3Q3   Q0ZB51   A0A286LPM0   B7SXP3   Q0ZB43   A0A1L1XGP7   A5Z196   B7SXN5   Q2XV41   B7SXQ1   A0A1L1XHE9   A5Z0T7   Q9J4A7   A0A1W6AWJ5   Q2XV42   K9LVF6   A0A4Y5SXT9   A0A286LPM8   E5D092   A0A023PMY8   C7S7Z3   A0A1L1XH04   A0A1B2RX93   A0A023PN94   Q9J3P7   A0A1L1XGX9   A0A1L1XL68   A0A1L1XGZ0   A0A1L2FT83   Q2XV40   A0A1L1XH03   A5Z0Y5   A0A1L1XGL1   A5Z0Z3   A0A023PN43   B7SXQ6   Q0ZB59   A0A1L4A1M9   A0A1L1XIS0   F1KCQ3   S4SCA7   A0A1L1XGQ3   U5JCL2   P19744   A0A1L1XH14   A0A1L1XIV2   A5Z141   B2MWM2   A0A1L1XGW5   A0A5J6RBI9   Q6R4P2   A0A1L1XHJ6   Q9J3Q9   A0A1L1XL50   A0A1L1XGW8   A0A1L1XH05   D7SCB0   Q91QT0   A0A0D3R3Q6   A0A1L1XHI2   K9N1B2   K9LVP7   A0A1P8SSQ0   A0A1L1XHC0   A0A1L1XHH6   A0A1P8SMU4   A0A1L1XGZ9   A5Z164   A0A1P8VFG1   A0A5J6RDR4   A0A1L1XGT4   A0A1P8SMR7   G3C784   A0A0K0WS08   K9LVJ1   A0A1P8SSM1   D7SCA0   A0A1V0G381   A0A1L1XGZ7   A0A1X9Y2R6   A0A1L1XGZ8   A0A1P8NTN8  

Pubmed

2995560    1653486    3960740    16934878    11711626    3027249    + More
2829563    16137658    11774531    10756047    12890618    15019237    21539870    15661153    17629993    21909766    23178317    26482289    30526618    15722532    31561498    11087096    17364511    19100792    18295413    20652731    21994806    28495648    28646651    23171741    22966194    2841803    29141204    15183070    16927130    23182435    20556502    28116527    29337625   

EMBL

M29338    AAA46235.1    X59542    X03723    DQ834384    AY851295    + More
AJ311317    CAC39117.1    M95169    M27435    DQ001339    AF470627    FJ904722    AAO33465.1    ADA83560.1    DQ001338    AAY24426.1    AY692454    AAV98207.1    KR902510    AKV63208.1    AY641576    FJ904720    FJ904721    FJ904723    GQ504724    JF828980    KJ425504    KJ435286    KX364296    MH539771    MH539772    MK937830    AAT70076.1    ADA83540.1    ADA83550.1    ADA83570.1    ADP06496.1    AEP84739.1    AHX26067.1    AHX26175.1    ARB66165.1    AZP23933.1    AZP23943.1    QDA76312.1    AY702085    AAU09493.1    GQ504723    MK937828    MK937832    MK887080    MK887086    ADP06489.1    QDA76294.1    QDA76330.1    QEY95685.1    QEY95691.1    MK728875    QCE31536.1    JF274479    AEL12224.1    EU817497    ACJ12837.1    AF206263    AAF67549.1    MG913343    AXQ05204.1    AF206265    AAF67555.1    AF206261    AAF67543.1    AF206262    AAF67546.1    DQ646405    ABG36790.1    MF462335    ASU92399.1    EU822337    ACJ50170.1    DQ646406    ABG36798.1    KJ872787    AJP08731.1    EF602457    KX236001    ABQ84904.1    APY26748.1    EU822336    ACJ50162.1    DQ230831    ABB55443.1    EU822338    ACJ50178.1    KJ872792    AJP08736.1    EF602437    EF602438    EF602439    ABQ84745.1    ABQ84753.1    ABQ84761.1    AF203003    AF317210    EU714028    EU822341    FJ807652    FJ888351    GQ504725    GU393335    JF330899    JF828981    JQ231289    KF188435    KJ425486    KJ425488    KJ425491    KJ425492    KJ425493    KJ425494    KJ425495    KJ425498    KJ425499    KJ425500    KJ425501    KJ425502    KJ425505    KJ425506    KJ425508    KJ425509    KJ425510    KJ425511    KJ425512    KJ435284    KJ435285    KT203557    KT736031    KY588134    KY805845    KY273667    MG763935    MK937829    MK937833    MK887069    MK887070    MK887074    MK887076    MK887079    AAF69119.1    AAL26888.1    ACH72801.1    ACJ50202.1    ACO37569.1    ACQ55233.1    ADP06512.1    ADV71782.1    ADY62555.1    AEP84749.1    AEY99615.1    AGW24532.1    AHX25905.1    AHX25923.1    AHX25950.1    AHX25959.1    AHX25968.1    AHX25977.1    AHX25986.1    AHX26013.1    AHX26022.1    AHX26031.1    AHX26040.1    AHX26049.1    AHX26076.1    AHX26085.1    AHX26103.1    AHX26112.1    AHX26121.1    AHX26130.1    AHX26139.1    AHX26157.1    AHX26166.1    ALE71334.1    AMK51941.1    ARE67875.1    ARS23142.1    ASF20083.1    AVX27615.1    QDA76303.1    QDA76339.1    QEY95674.1    QEY95675.1    QEY95679.1    QEY95681.1    QEY95684.1    KY626045    MK071267    ARJ35794.1    QCS40643.1    DQ230830    ABB55442.1    JQ267613    JQ920397    AFN26120.1    AFP50277.1    MK937831    QDA76321.1    MF673729    ASU92407.1    GQ504722    ADP06478.1    KJ425487    KY588135    AHX25914.1    ARE67887.1    EU714029    JX853709    MH181793    ACH72807.1    AFY09698.1    QAT77250.1    KJ940518    AJP08770.1    KX668222    AOC59734.1    KJ425507    AHX26094.1    AF206264    AAF67552.1    KJ872795    AJP08739.1    KJ940514    KJ940516    KJ940524    KJ940537    AJP08766.1    AJP08768.1    AJP08776.1    AJP08789.1    KJ940513    KJ940533    AJP08765.1    AJP08785.1    KX266757    AOC59730.1    DQ230832    ABB55444.1    KJ940541    AJP08793.1    EF602443    ABQ84793.1    KJ872783    AJP08727.1    EF602444    FJ807653    HQ850618    JF893452    KF663560    KJ940512    KJ940547    ABQ84801.1    ACO37577.1    AEB00718.1    AEJ80241.1    AHB74002.1    AJP08764.1    AJP08799.1    KJ425497    AHX26004.1    EU822339    ACJ50186.1    DQ646404    ABG36782.1    KX077987    API61793.1    KJ872789    AJP08733.1    JF330898    KJ425489    MG448607    ADY62545.1    AHX25932.1    AVI69522.1    JQ267612    AFN26119.1    KJ940506    AJP08758.1    KC008600    AGK85502.1    M21515    KJ872788    KJ872793    KJ940539    KJ940542    AJP08732.1    AJP08737.1    AJP08791.1    AJP08794.1    KJ940522    AJP08774.1    EF602450    KY799582    ABQ84849.1    AVI69488.1    EU637854    ACC94329.1    KJ872790    KJ872791    AJP08734.1    AJP08735.1    MK887075    MK887077    MK887082    MK887087    QEY95680.1    QEY95682.1    QEY95687.1    QEY95692.1    AY514485    AAS00083.1    KJ940535    AJP08787.1    AF206260    AAF67540.1    KJ940509    KJ940517    KJ940520    AJP08761.1    AJP08769.1    AJP08772.1    KJ872785    AJP08729.1    KJ940526    KJ940527    KJ940528    KJ940530    KJ940544    KJ940545    AJP08778.1    AJP08779.1    AJP08780.1    AJP08782.1    AJP08796.1    AJP08797.1    HM245924    ADI54958.1    AJ311362    CAC39303.1    KP118894    AJR29316.1    KJ940525    AJP08777.1    KC013541    KC119407    AFY11701.1    AFY11710.1    JQ267611    JQ267616    JQ920396    JQ920400    KJ940543    KX252784    AFN26118.1    AFN26123.1    AFP50273.1    AFP50289.1    AJP08795.1    APY23590.1    KX236006    KX236009    APY26792.1    APY26819.1    KJ669722    KM279003    KM279004    KR265091    AJP08744.1    AJP08863.1    AJP08864.1    ART35344.1    KJ940515    AJP08767.1    KX252781    APY23563.1    KJ940523    AJP08775.1    EF602453    KX375808    ABQ84872.1    AQY55833.1    KX275391    APZ73819.1    MK887078    QEY95683.1    KJ940536    AJP08788.1    KX252778    APY23536.1    GU393332    ADV71744.1    KJ940531    KM279005    KP790143    KX721498    KR265087    AJP08783.1    AJP08865.1    AKS25228.1    APW81996.1    JQ267595    JQ267601    JQ267606    JQ920380    JQ920386    AFN26102.1    AFN26108.1    AFN26113.1    AFP50209.1    AFP50233.1    KX236003    APY26766.1    HM245923    JF732903    JQ267596    JQ267598    JQ267602    JQ267617    JQ267619    JQ920381    JQ920383    JQ920387    JQ920401    JQ920403    JX195175    JX195176    KF411041    KF663561    KF853202    KJ128295    KJ435283    KM278999    KM279009    KP118889    KP118890    KP790144    KP790145    KX348115    KX348116    KX219791    KX219792    KX219794    KX219795    KX219798    KX219799    KX219800    KX219801    KX247127    KX247128    KX247129    KX247130    KX185058    KX252773    KX252774    KX252775    KX252776    KX252777    KX252780    KX252782    KX252783    KX252786    KX252787    KX252788    KX252789    KX252790    KX236000    KX236002    KX236004    KX236008    KX236012    KX236013    KX236016    KX302860    KX302862    KX302863    KX302865    KX302867    KX302869    KX302870    KX302871    KX302872    KX302873    KX302874    KX275390    KX275392    KX275394    KX259249    KX259250    KX259251    KX259253    KX259255    KX259256    KX259257    KX372250    KX375805    KX425847    KX434788    KX434790    KX640829    KX364291    KX364292    KX364293    KX364295    KX364299    KX364300    KU949737    KU949738    KU949739    KU949740    KU949741    KU949742    KU949743    KU949744    KU949745    KU949747    KU900738    KU900742    KR265085    KR265088    KY421673    MK032181    MG738154    MG738155    ADI54948.1    AFH35024.1    AFN26103.1    AFN26105.1    AFN26109.1    AFN26124.1    AFN26126.1    AFP50213.1    AFP50221.1    AFP50237.1    AFP50293.1    AFP50301.1    AFQ94216.1    AFQ94225.1    AGZ89684.1    AHB74011.1    AHI85763.1    AHN49813.1    AHX26148.1    AJP08859.1    AJP08869.1    AJT47926.1    AJT47935.1    AKS25237.1    AKS25246.1    APU51850.1    APU51859.1    APV46097.1    APV46106.1    APV46124.1    APV46133.1    APV46160.1    APV46169.1    APV46178.1    APV46187.1    APW85770.1    APW85779.1    APW85788.1    APW85797.1    APX44059.1    APY23491.1    APY23500.1    APY23509.1    APY23518.1    APY23527.1    APY23554.1    APY23572.1    APY23581.1    APY23608.1    APY23617.1    APY23626.1    APY26713.1    APY26721.1    APY26739.1    APY26757.1    APY26775.1    APY26810.1    APY26846.1    APY26855.1    APY26882.1    APZ73655.1    APZ73673.1    APZ73682.1    APZ73700.1    APZ73718.1    APZ73736.1    APZ73745.1    APZ73754.1    APZ73763.1    APZ73772.1    APZ73781.1    APZ73810.1    APZ73828.1    APZ73846.1    AQD20686.1    AQD20695.1    AQD20704.1    AQD20722.1    AQD20740.1    AQD20749.1    AQD20758.1    AQY03971.1    AQY55806.1    AQY55860.1    AQY55869.1    AQY55887.1    AQY55896.1    ARB66120.1    ARB66129.1    ARB66138.1    ARB66156.1    ARB66192.1    ARB66201.1    ARI46223.1    ARI46231.1    ARI46239.1    ARI46247.1    ARI46255.1    ARI46263.1    ARI46271.1    ARI46279.1    ARI46287.1    ARI46303.1    ARS22403.1    ARS22443.1    ART35296.1    ATJ01106.1    AZA07863.1    QAA92380.1    QAA92390.1    KX364294    ARB66147.1    KJ940534    AJP08786.1    KU900743    ARS22453.1    KJ940519    AJP08771.1    KX185057    APX44050.1   

Proteomes

UP000007642    UP000096468    UP000114388    UP000006717    UP000101586    UP000180341    + More
UP000107149    UP000151562    UP000098752    UP000104400    UP000107291    UP000117985    UP000149491    UP000161686    UP000165485    UP000169726    UP000132955    UP000159542    UP000107830    UP000149405    UP000097868    UP000102121    UP000102163    UP000103149    UP000106511    UP000107224    UP000108224    UP000113896    UP000113939    UP000114242    UP000118008    UP000120286    UP000132365    UP000136241    UP000136440    UP000138146    UP000149404    UP000155572    UP000155946    UP000158949    UP000159206    UP000163887    UP000165788    UP000166253    UP000167410    UP000170189    UP000173109    UP000173215    UP000174151    UP000180343    UP000101527    UP000146865    UP000139954    UP000113245    UP000107262    UP000156427    UP000170434    UP000170844    UP000122234    UP000149090    UP000151129    UP000130254    UP000160278    UP000124698    UP000116981    UP000119449    UP000165290    UP000160499    UP000148786    UP000096908    UP000098934    UP000102797    UP000111823    UP000118698    UP000126761    UP000129345    UP000133678    UP000137336    UP000145502    UP000152683    UP000154272    UP000162160   

Pfam

PF03620   IBV_3C

Interpro

IPR005296   IBV_3C

ProteinModelPortal

Q76V92   P05139   Q778S3   Q89894   Q80RZ0   Q5MNY9   + More
Q4ZJT9   A0A0K1RN43   Q6DV52   Q66VA3   E5D0A3   A0A4D6NY96   G0ZGK4   C7S862   Q9J3Q0   A0A346M360   Q9J3P4   Q9J3Q6   Q9J3Q3   Q0ZB51   A0A286LPM0   B7SXP3   Q0ZB43   A0A1L1XGP7   A5Z196   B7SXN5   Q2XV41   B7SXQ1   A0A1L1XHE9   A5Z0T7   Q9J4A7   A0A1W6AWJ5   Q2XV42   K9LVF6   A0A4Y5SXT9   A0A286LPM8   E5D092   A0A023PMY8   C7S7Z3   A0A1L1XH04   A0A1B2RX93   A0A023PN94   Q9J3P7   A0A1L1XGX9   A0A1L1XL68   A0A1L1XGZ0   A0A1L2FT83   Q2XV40   A0A1L1XH03   A5Z0Y5   A0A1L1XGL1   A5Z0Z3   A0A023PN43   B7SXQ6   Q0ZB59   A0A1L4A1M9   A0A1L1XIS0   F1KCQ3   S4SCA7   A0A1L1XGQ3   U5JCL2   P19744   A0A1L1XH14   A0A1L1XIV2   A5Z141   B2MWM2   A0A1L1XGW5   A0A5J6RBI9   Q6R4P2   A0A1L1XHJ6   Q9J3Q9   A0A1L1XL50   A0A1L1XGW8   A0A1L1XH05   D7SCB0   Q91QT0   A0A0D3R3Q6   A0A1L1XHI2   K9N1B2   K9LVP7   A0A1P8SSQ0   A0A1L1XHC0   A0A1L1XHH6   A0A1P8SMU4   A0A1L1XGZ9   A5Z164   A0A1P8VFG1   A0A5J6RDR4   A0A1L1XGT4   A0A1P8SMR7   G3C784   A0A0K0WS08   K9LVJ1   A0A1P8SSM1   D7SCA0   A0A1V0G381   A0A1L1XGZ7   A0A1X9Y2R6   A0A1L1XGZ8   A0A1P8NTN8  

KEGG

vg:1489742    

GO

GO:0044662  P:disruption by virus of host cell membrane
GO:0046760  P:viral budding from Golgi membrane
GO:0016021  C:integral component of membrane
GO:0044178  C:host cell Golgi membrane
GO:0019031  C:viral envelope

From MSLVP

Host nucleus. Host cytoplasm.

From Uniprot

Host Golgi apparatus membrane   The cytoplasmic tail functions as a Golgi complex-targeting signal.   With evidence from 1 publications.

Length:

108

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

39.88914

Exp number, first 60 AAs:

35.72116

Total prob of N-in:

0.63200

POSSIBLE N-term signal

sequence

inside

1  -  12

TMhelix

13  -  35

outside

36  -  44

TMhelix

45  -  64

inside

65  -  108