Strain

CANADA_AVIAN_2007_NC_010800 (Region: Canada;  Strain: Turkey coronavirus, complete genome.;  Date: 2007)

Gene

envelope protein

Description

Annotated in NCBI,  envelope protein

Location

NC_010800(+):24336-24635

GenBank Accession

YP_001941169.1

Full name

Envelope small membrane protein      

CDS

ATGACGAATTTATTGAGTAAATCGCTAGAGGAGAACGGAAGTTTCCTAACAGCAGTTTACATATTTGTTGCATTTGTAGCACTTTACCTATTAGGTAGGGTACTTCAAGCATTTGTACAGACTGCTGATGCTTGTTGTTTGTTTTGGTATACATGGATAGTAGTTCCTGGAGCTAAGGGTGCAGCCTTTGTATACAATTATACATATGGTAAAAAACTTAACAAACCGGAGTTAGAAGCGGTTATTGTTAACGAGTTCCCCAAGAACGGTTGGAATAACAAAAGTCCAGCAAATTTCTAA

Protein

MTNLLSKSLEENGSFLTAVYIFVAFVALYLLGRVLQAFVQTADACCLFWYTWIVVPGAKGAAFVYNYTYGKKLNKPELEAVIVNEFPKNGWNNKSPANF

Function

Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.

Subunit

Homooligomer. Interacts with the M membrane protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. The cytoplasmic tails of both proteins are important for this function. Interacts with Nucleoprotein.

Similarity

Belongs to the gammacoronaviruses E protein family.

Keywords

Apoptosis   Host Golgi apparatus   Host membrane   Membrane   Transmembrane   Transmembrane helix   Reference proteome  

Feature

chain  Envelope small membrane protein

Uniprot

B3FHU8   F4MIP9   C9DSV1   Q8V634   Q91BM9   C1IXZ8   + More
Q6R4P2   B3TD64   A0A286LPL2   A0A4Y5QA10   A0A1L1XH62   Q91BN0   Q5XLA1   P19744   C9DSU0   G3C784   A5Z188   Q9J3Q9   E5D092   G3C7G0   G3C797   B2MWM2   G3C7D5   B7SXQ1   Q9J3Q3   B7SXP3   A0A516UW95   Q9J3Q0   Q9J3P4   A0A3G4BBU5   I1YZI0   Q9J3Q6   E5D0A3   A0A1P8SMR7   Q0ZB43   A0A5J6RDR4   Q6DV52   A0A1U9WSL1   P30248   A4ZCM0   Q0ZB51   B7SXN5   Q9J4B4   H6WEN6   A0A1L1XGS1   A4ZCQ7   A0A221J5S8   C7DZG8   B3TD51   A0A346T2V7   A4ZCS3   Q58J31   K4FVD4   H6WEN9   H6WEN8   A0A2Z5D875   H6WEP0   A0A346M360   C7S862   A0A385LUX5   A0A4D6NY96   A0A385LUY4   A0A0K1RN43   A4ZCJ1   A0A1P8SFL7   A0A1P8VFG1   Q76V92   P05139   A0A3G6IUZ8   A0A1B2RX93   A0A516UWF9   Q80RZ0   A0A068LKH9   A0A191TG89   A0A1L1XGZ9   Q66VA3   A0A1L1XGL1   A0A286LPM8   A0A286LPM0   A0A516UWC5   S4SCA7   A4ZCJ9   Q998S2   A0A1P8NTN8   A0A1L1XGQ3   A5Z196   B7SXQ6   A0A1L1XHI2   Q0ZB59   G0ZGK4   A5Z172   A0A0D4CFB0   A0A346M349   H6WEN5   A0A221J5Q1   Q5MCX3   A0A1L5YN74   A0A1L1XGZ8   F1KCQ3   A0A1L1XH14  

Pubmed

18468711    20022075    21539870    15019237    16927130    24613433    + More
26482289    15183070    18514348    31439703    18295413    19102764    19219402    21909766    16990149    2841803    21994806    11087096    19100792    30714035    22421962    31561498    17364511    17629993    23178317    30526618    1653486    18045937    25843651    28705717    20181858    27938680    30197283    27793730    2995560    3960740    16934878    27108998    15722532   

EMBL

EU095850    GQ427173    GQ427176    ABW81430.1    ACV87239.1    ACV87273.1    + More
FJ904713    ADA83470.1    GQ427175    ACV87262.1    AF318282    AAL37165.1    AF317471    AY942752    FJ904716    FJ904717    FJ904718    FJ904719    GU386375    KC506155    KF411040    KF696629    KJ425485    AAL26893.1    AAX39777.1    ADA83500.1    ADA83510.1    ADA83520.1    ADA83530.1    ADC79654.1    AGJ98440.1    AGZ89675.1    AHB79526.1    AHX25896.1    FJ008695    ACM45232.1    AY514485    AAS00083.1    EU022526    ABW75141.1    MF462334    ASU92391.1    MK878536    QCX19622.1    KM279001    KR265092    AJP08861.1    ART35352.1    AF317209    AY846833    AY942750    EF602440    EF602441    EF602442    EU418975    EU418976    GQ504720    GQ504721    KP868573    KY776700    KY776701    AAL26887.1    AAW56624.1    AAX39771.1    ABQ84769.1    ABQ84777.1    ABQ84785.1    ACB59365.1    ACB59375.1    ADP06456.1    ADP06465.2    ALC78750.1    AVI69447.1    AVI69456.1    AY761141    AAV28725.1    M21515    GQ427174    ACV87251.1    GU393332    ADV71744.1    EF602456    ABQ84896.1    AF206260    AAF67540.1    GQ504722    ADP06478.1    GU393334    GU393338    ADV71819.1    GU393333    ADV71757.1    EU637854    ACC94329.1    GU393336    GU393337    ADV71794.1    EU822338    ACJ50178.1    AF206262    AAF67546.1    EU822337    ACJ50170.1    MK581200    MK581201    QDQ69098.1    QDQ69111.1    AF206263    AAF67549.1    AF206265    AAF67555.1    MH878976    AYS76108.1    JQ088078    AFJ11179.1    AF206261    AAF67543.1    GQ504723    MK937828    MK937832    MK887080    MK887086    ADP06489.1    QDA76294.1    QDA76330.1    QEY95685.1    QEY95691.1    KX252778    APY23536.1    DQ646406    ABG36798.1    MK887078    QEY95683.1    AY641576    FJ904720    FJ904721    FJ904723    GQ504724    JF828980    KJ425504    KJ435286    KX364296    MH539771    MH539772    MK937830    AAT70076.1    ADA83540.1    ADA83550.1    ADA83570.1    ADP06496.1    AEP84739.1    AHX26067.1    AHX26175.1    ARB66165.1    AZP23933.1    AZP23943.1    QDA76312.1    KX389094    AQY55842.1    X59820    DQ490209    ABF61497.1    DQ646405    ABG36790.1    EU822336    ACJ50162.1    AF202998    AAF69112.1    JQ231281    JQ231284    JQ231285    KF377577    KP036502    KP036503    KP036504    KP118880    KP118881    KP118882    KP118884    KP118885    KP118887    KP118888    KP118891    KP118892    KP118893    MK032177    MK032180    MK887072    MK887083    AEY99607.1    AEY99610.1    AEY99611.1    AGY56143.1    AJP16715.1    AJP16724.1    AJP16733.1    AJT47845.1    AJT47854.1    AJT47863.1    AJT47881.1    AJT47890.1    AJT47908.1    AJT47917.1    AJT47944.1    AJT47953.1    AJT47962.1    AZA07827.1    AZA07853.1    QEY95677.1    QEY95688.1    KJ940510    KJ940521    AJP08762.1    AJP08773.1    DQ490214    ABF61534.1    MF421320    ASM61976.1    GQ229232    ACT31316.1    EU022525    ABW75133.1    MG233398    AXT92418.1    DQ490216    ABF61550.1    AY942751    AAX39774.1    JN176213    KU556807    AFK30965.1    APP92758.1    JQ231287    AEY99613.1    JQ231286    AEY99612.1    MH021175    AXB38897.1    JQ231288    AEY99614.1    MG913343    AXQ05204.1    EU817497    ACJ12837.1    MH779856    AYA44694.1    MK728875    QCE31536.1    MH779857    MH779858    MH779859    MH779860    AYA44704.1    KR902510    AKV63208.1    DQ490205    DQ490215    DQ490217    ABF61468.1    ABF61542.1    ABF61558.1    KX272465    APY20697.1    KX275391    APZ73819.1    M29338    AAA46235.1    X59542    X03723    DQ834384    AY851295    MK032179    AZA07845.1    KX668222    AOC59734.1    MK581206    QDQ69176.1    AF470627    FJ904722    AAO33465.1    ADA83560.1    KJ690947    AIE47668.1    KU317090    ANI87714.1    KJ940523    AJP08775.1    AY702085    AAU09493.1    KJ872783    AJP08727.1    MF673729    ASU92407.1    MF462335    ASU92399.1    MK581202    QDQ69124.1    JQ267612    AFN26119.1    DQ490206    ABF61476.1    AJ310640    CAC33182.1    KX185057    APX44050.1    KJ940506    AJP08758.1    EF602457    KX236001    ABQ84904.1    APY26748.1    EU822339    ACJ50186.1    KJ940525    AJP08777.1    DQ646404    ABG36782.1    JF274479    AEL12224.1    EF602454    EF602459    EF602460    ABQ84880.1    ABQ84920.1    ABQ84928.1    KP118883    AJT47872.1    MG913342    AXQ05193.1    JQ231283    AEY99609.1    MF421319    ASM61963.1    AY835636    AAV88488.1    KU556805    APP92732.1    KJ940519    AJP08771.1    JF330898    KJ425489    MG448607    ADY62545.1    AHX25932.1    AVI69522.1    KJ872788    KJ872793    KJ940539    KJ940542    AJP08732.1    AJP08737.1    AJP08791.1    AJP08794.1   

Proteomes

UP000106026    UP000123786    UP000167574    UP000145806    UP000112634    UP000104663    + More
UP000119721    UP000121579    UP000124016    UP000130162    UP000137477    UP000155805    UP000167075    UP000160278    UP000099410    UP000102335    UP000107038    UP000139706    UP000149006    UP000151624    UP000098674    UP000160499    UP000101527    UP000129978    UP000131863    UP000146844    UP000130254    UP000119508    UP000160333    UP000139891    UP000132955    UP000098752    UP000104400    UP000107291    UP000117985    UP000149491    UP000161686    UP000165485    UP000169726    UP000149405    UP000100522    UP000105210    UP000105510    UP000109170    UP000111271    UP000117109    UP000121165    UP000124537    UP000136129    UP000142905    UP000146859    UP000147307    UP000149934    UP000170218    UP000117980    UP000107830    UP000151562    UP000007642    UP000096468    UP000101586    UP000159542    UP000108163    UP000122234    UP000149090   

Pfam

PF03620   IBV_3C

Interpro

IPR005296   IBV_3C

ProteinModelPortal

B3FHU8   F4MIP9   C9DSV1   Q8V634   Q91BM9   C1IXZ8   + More
Q6R4P2   B3TD64   A0A286LPL2   A0A4Y5QA10   A0A1L1XH62   Q91BN0   Q5XLA1   P19744   C9DSU0   G3C784   A5Z188   Q9J3Q9   E5D092   G3C7G0   G3C797   B2MWM2   G3C7D5   B7SXQ1   Q9J3Q3   B7SXP3   A0A516UW95   Q9J3Q0   Q9J3P4   A0A3G4BBU5   I1YZI0   Q9J3Q6   E5D0A3   A0A1P8SMR7   Q0ZB43   A0A5J6RDR4   Q6DV52   A0A1U9WSL1   P30248   A4ZCM0   Q0ZB51   B7SXN5   Q9J4B4   H6WEN6   A0A1L1XGS1   A4ZCQ7   A0A221J5S8   C7DZG8   B3TD51   A0A346T2V7   A4ZCS3   Q58J31   K4FVD4   H6WEN9   H6WEN8   A0A2Z5D875   H6WEP0   A0A346M360   C7S862   A0A385LUX5   A0A4D6NY96   A0A385LUY4   A0A0K1RN43   A4ZCJ1   A0A1P8SFL7   A0A1P8VFG1   Q76V92   P05139   A0A3G6IUZ8   A0A1B2RX93   A0A516UWF9   Q80RZ0   A0A068LKH9   A0A191TG89   A0A1L1XGZ9   Q66VA3   A0A1L1XGL1   A0A286LPM8   A0A286LPM0   A0A516UWC5   S4SCA7   A4ZCJ9   Q998S2   A0A1P8NTN8   A0A1L1XGQ3   A5Z196   B7SXQ6   A0A1L1XHI2   Q0ZB59   G0ZGK4   A5Z172   A0A0D4CFB0   A0A346M349   H6WEN5   A0A221J5Q1   Q5MCX3   A0A1L5YN74   A0A1L1XGZ8   F1KCQ3   A0A1L1XH14  

KEGG

vg:6353555    

GO

GO:0046760  P:viral budding from Golgi membrane
GO:0044662  P:disruption by virus of host cell membrane
GO:0016021  C:integral component of membrane
GO:0019031  C:viral envelope
GO:0044178  C:host cell Golgi membrane

From MSLVP

Host nucleus. Host cytoplasm.

From Uniprot

Host Golgi apparatus membrane   The cytoplasmic tail functions as a Golgi complex-targeting signal.   With evidence from 1 publications.

Length:

99

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

42.36812

Exp number, first 60 AAs:

35.34335

Total prob of N-in:

0.29624

POSSIBLE N-term signal

sequence

outside

1  -  14

TMhelix

15  -  32

inside

33  -  44

TMhelix

45  -  67

outside

68  -  99